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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LPIN1
Full Name:
Phosphatidate phosphatase LPIN1
Alias:
KIAA0188; Lipin 1; Lipin-1
Type:
Phosphatase, lipid
Mass (Da):
98664
Number AA:
890
UniProt ID:
Q14693
International Prot ID:
IPI00032388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045444
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
L
A
G
Q
V
F
V
T
V
K
E
L
Y
K
G
Site 2
S46
P
N
G
N
L
Q
C
S
P
F
H
V
R
F
G
Site 3
S60
G
K
M
G
V
L
R
S
R
E
K
V
V
D
I
Site 4
S106
I
P
M
H
L
A
T
S
P
I
L
S
E
G
A
Site 5
S110
L
A
T
S
P
I
L
S
E
G
A
S
R
M
E
Site 6
S114
P
I
L
S
E
G
A
S
R
M
E
C
Q
L
K
Site 7
S124
E
C
Q
L
K
R
G
S
V
D
R
M
R
G
L
Site 8
S134
R
M
R
G
L
D
P
S
T
P
A
Q
V
I
A
Site 9
T135
M
R
G
L
D
P
S
T
P
A
Q
V
I
A
P
Site 10
S143
P
A
Q
V
I
A
P
S
E
T
P
S
S
S
S
Site 11
T145
Q
V
I
A
P
S
E
T
P
S
S
S
S
V
V
Site 12
S147
I
A
P
S
E
T
P
S
S
S
S
V
V
K
K
Site 13
S148
A
P
S
E
T
P
S
S
S
S
V
V
K
K
R
Site 14
S149
P
S
E
T
P
S
S
S
S
V
V
K
K
R
R
Site 15
S150
S
E
T
P
S
S
S
S
V
V
K
K
R
R
K
Site 16
S162
R
R
K
R
R
R
K
S
Q
L
D
S
L
K
R
Site 17
S166
R
R
K
S
Q
L
D
S
L
K
R
D
D
N
M
Site 18
T175
K
R
D
D
N
M
N
T
S
E
D
E
D
M
F
Site 19
S176
R
D
D
N
M
N
T
S
E
D
E
D
M
F
P
Site 20
S187
D
M
F
P
I
E
M
S
S
D
E
A
M
E
L
Site 21
S188
M
F
P
I
E
M
S
S
D
E
A
M
E
L
L
Site 22
S197
E
A
M
E
L
L
E
S
S
R
T
L
P
N
D
Site 23
T200
E
L
L
E
S
S
R
T
L
P
N
D
I
P
P
Site 24
S218
D
I
P
E
E
N
L
S
L
A
V
I
Y
P
Q
Site 25
S226
L
A
V
I
Y
P
Q
S
A
S
Y
P
N
S
D
Site 26
S228
V
I
Y
P
Q
S
A
S
Y
P
N
S
D
R
E
Site 27
Y229
I
Y
P
Q
S
A
S
Y
P
N
S
D
R
E
W
Site 28
S232
Q
S
A
S
Y
P
N
S
D
R
E
W
S
P
T
Site 29
S237
P
N
S
D
R
E
W
S
P
T
P
S
P
S
G
Site 30
T239
S
D
R
E
W
S
P
T
P
S
P
S
G
S
R
Site 31
S241
R
E
W
S
P
T
P
S
P
S
G
S
R
P
S
Site 32
S243
W
S
P
T
P
S
P
S
G
S
R
P
S
T
P
Site 33
S245
P
T
P
S
P
S
G
S
R
P
S
T
P
K
S
Site 34
S248
S
P
S
G
S
R
P
S
T
P
K
S
D
S
E
Site 35
T249
P
S
G
S
R
P
S
T
P
K
S
D
S
E
L
Site 36
S252
S
R
P
S
T
P
K
S
D
S
E
L
V
S
K
Site 37
S254
P
S
T
P
K
S
D
S
E
L
V
S
K
S
T
Site 38
S258
K
S
D
S
E
L
V
S
K
S
T
E
R
T
G
Site 39
S260
D
S
E
L
V
S
K
S
T
E
R
T
G
Q
K
Site 40
T261
S
E
L
V
S
K
S
T
E
R
T
G
Q
K
N
Site 41
T264
V
S
K
S
T
E
R
T
G
Q
K
N
P
E
M
Site 42
S284
E
L
P
Q
A
A
K
S
S
S
P
H
K
M
K
Site 43
S286
P
Q
A
A
K
S
S
S
P
H
K
M
K
E
S
Site 44
S293
S
P
H
K
M
K
E
S
S
P
L
S
S
R
K
Site 45
S294
P
H
K
M
K
E
S
S
P
L
S
S
R
K
I
Site 46
S297
M
K
E
S
S
P
L
S
S
R
K
I
C
D
K
Site 47
S298
K
E
S
S
P
L
S
S
R
K
I
C
D
K
S
Site 48
S312
S
H
F
Q
A
I
H
S
E
S
S
D
T
F
S
Site 49
S314
F
Q
A
I
H
S
E
S
S
D
T
F
S
D
Q
Site 50
S315
Q
A
I
H
S
E
S
S
D
T
F
S
D
Q
S
Site 51
T317
I
H
S
E
S
S
D
T
F
S
D
Q
S
P
T
Site 52
S319
S
E
S
S
D
T
F
S
D
Q
S
P
T
L
V
Site 53
S322
S
D
T
F
S
D
Q
S
P
T
L
V
G
G
A
Site 54
S368
I
E
E
L
K
P
P
S
A
S
V
V
Q
T
A
Site 55
S370
E
L
K
P
P
S
A
S
V
V
Q
T
A
N
K
Site 56
T374
P
S
A
S
V
V
Q
T
A
N
K
T
D
S
P
Site 57
T378
V
V
Q
T
A
N
K
T
D
S
P
S
R
K
R
Site 58
S380
Q
T
A
N
K
T
D
S
P
S
R
K
R
D
K
Site 59
S382
A
N
K
T
D
S
P
S
R
K
R
D
K
R
S
Site 60
Y398
H
L
G
A
D
G
V
Y
L
D
D
L
T
D
M
Site 61
T403
G
V
Y
L
D
D
L
T
D
M
D
P
E
V
A
Site 62
Y413
D
P
E
V
A
A
L
Y
F
P
K
N
G
D
P
Site 63
S428
S
G
L
A
K
H
A
S
D
N
G
A
R
S
A
Site 64
S434
A
S
D
N
G
A
R
S
A
N
Q
S
P
Q
S
Site 65
S438
G
A
R
S
A
N
Q
S
P
Q
S
V
G
S
S
Site 66
S441
S
A
N
Q
S
P
Q
S
V
G
S
S
G
V
D
Site 67
S444
Q
S
P
Q
S
V
G
S
S
G
V
D
S
G
V
Site 68
S445
S
P
Q
S
V
G
S
S
G
V
D
S
G
V
E
Site 69
S449
V
G
S
S
G
V
D
S
G
V
E
S
T
S
D
Site 70
S453
G
V
D
S
G
V
E
S
T
S
D
G
L
R
D
Site 71
S473
I
S
L
C
G
G
L
S
D
H
R
E
I
T
K
Site 72
T479
L
S
D
H
R
E
I
T
K
D
A
F
L
E
Q
Site 73
S489
A
F
L
E
Q
A
V
S
Y
Q
Q
F
V
D
N
Site 74
Y513
V
V
K
I
G
S
K
Y
Y
N
W
T
T
A
A
Site 75
T537
Q
K
P
L
P
K
A
T
V
E
S
I
M
R
D
Site 76
T562
F
S
W
R
G
R
N
T
T
I
K
E
E
S
K
Site 77
T563
S
W
R
G
R
N
T
T
I
K
E
E
S
K
P
Site 78
S589
G
E
Q
P
P
Q
L
S
L
A
T
R
V
K
H
Site 79
S598
A
T
R
V
K
H
E
S
S
S
S
D
E
E
R
Site 80
S599
T
R
V
K
H
E
S
S
S
S
D
E
E
R
A
Site 81
S600
R
V
K
H
E
S
S
S
S
D
E
E
R
A
A
Site 82
S601
V
K
H
E
S
S
S
S
D
E
E
R
A
A
A
Site 83
T627
P
N
V
S
Y
K
K
T
L
R
L
T
S
E
Q
Site 84
T631
Y
K
K
T
L
R
L
T
S
E
Q
L
K
S
L
Site 85
S632
K
K
T
L
R
L
T
S
E
Q
L
K
S
L
K
Site 86
S637
L
T
S
E
Q
L
K
S
L
K
L
K
N
G
P
Site 87
S650
G
P
N
D
V
V
F
S
V
T
T
Q
Y
Q
G
Site 88
T684
S
D
I
D
G
T
I
T
R
S
D
T
L
G
H
Site 89
S686
I
D
G
T
I
T
R
S
D
T
L
G
H
I
L
Site 90
T688
G
T
I
T
R
S
D
T
L
G
H
I
L
P
T
Site 91
T701
P
T
L
G
K
D
W
T
H
Q
G
I
A
K
L
Site 92
Y709
H
Q
G
I
A
K
L
Y
H
K
V
S
Q
N
G
Site 93
S713
A
K
L
Y
H
K
V
S
Q
N
G
Y
K
F
L
Site 94
Y717
H
K
V
S
Q
N
G
Y
K
F
L
Y
C
S
A
Site 95
Y721
Q
N
G
Y
K
F
L
Y
C
S
A
R
A
I
G
Site 96
Y736
M
A
D
M
T
R
G
Y
L
H
W
V
N
E
R
Site 97
T745
H
W
V
N
E
R
G
T
V
L
P
Q
G
P
L
Site 98
T791
K
N
L
F
F
P
N
T
E
P
F
Y
A
A
F
Site 99
Y795
F
P
N
T
E
P
F
Y
A
A
F
G
N
R
P
Site 100
Y806
G
N
R
P
A
D
V
Y
S
Y
K
Q
V
G
V
Site 101
S807
N
R
P
A
D
V
Y
S
Y
K
Q
V
G
V
S
Site 102
Y808
R
P
A
D
V
Y
S
Y
K
Q
V
G
V
S
L
Site 103
T820
V
S
L
N
R
I
F
T
V
N
P
K
G
E
L
Site 104
T834
L
V
Q
E
H
A
K
T
N
I
S
S
Y
V
R
Site 105
S856
V
F
P
L
L
K
R
S
H
S
S
D
F
P
C
Site 106
S858
P
L
L
K
R
S
H
S
S
D
F
P
C
S
D
Site 107
S864
H
S
S
D
F
P
C
S
D
T
F
S
N
F
T
Site 108
T871
S
D
T
F
S
N
F
T
F
W
R
E
P
L
P
Site 109
S887
F
E
N
Q
D
I
H
S
A
S
A
_
_
_
_
Site 110
S889
N
Q
D
I
H
S
A
S
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation