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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDCD11
Full Name:
Protein RRP5 homolog
Alias:
ALG-4; KIAA0185; NFBP; NF-kappa-B-binding protein; Programmed cell death 11; Programmed cell death protein 11; RRP5; RRP5 protein
Type:
RNA binding protein
Mass (Da):
208701
Number AA:
1871
UniProt ID:
Q14690
International Prot ID:
IPI00400922
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006364
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
N
L
E
E
S
F
P
R
G
G
T
R
Site 2
T13
E
S
F
P
R
G
G
T
R
K
I
H
K
P
E
Site 3
S36
Q
D
N
L
F
D
I
S
T
E
E
G
S
T
K
Site 4
T37
D
N
L
F
D
I
S
T
E
E
G
S
T
K
R
Site 5
T42
I
S
T
E
E
G
S
T
K
R
K
K
S
Q
K
Site 6
S47
G
S
T
K
R
K
K
S
Q
K
G
P
A
K
T
Site 7
S64
L
K
I
E
K
R
E
S
S
K
S
A
R
E
K
Site 8
S65
K
I
E
K
R
E
S
S
K
S
A
R
E
K
F
Site 9
S67
E
K
R
E
S
S
K
S
A
R
E
K
F
E
I
Site 10
S76
R
E
K
F
E
I
L
S
V
E
S
L
C
E
G
Site 11
Y119
V
T
E
I
C
D
A
Y
T
K
K
L
N
E
Q
Site 12
T159
V
V
S
S
L
G
I
T
D
R
G
K
K
S
V
Site 13
S165
I
T
D
R
G
K
K
S
V
K
L
S
L
N
P
Site 14
S169
G
K
K
S
V
K
L
S
L
N
P
K
N
V
N
Site 15
S180
K
N
V
N
R
V
L
S
A
E
A
L
K
P
G
Site 16
T193
P
G
M
L
L
T
G
T
V
S
S
L
E
D
H
Site 17
Y202
S
S
L
E
D
H
G
Y
L
V
D
I
G
V
D
Site 18
Y223
P
L
L
K
A
Q
E
Y
I
R
Q
K
N
K
G
Site 19
Y238
A
K
L
K
V
G
Q
Y
L
N
C
I
V
E
K
Site 20
S254
K
G
N
G
G
V
V
S
L
S
V
G
H
S
E
Site 21
T264
V
G
H
S
E
V
S
T
A
I
A
T
E
Q
Q
Site 22
T292
K
A
Q
V
Q
K
V
T
P
F
G
L
T
L
N
Site 23
Y321
D
P
K
K
A
G
T
Y
F
S
N
Q
A
V
R
Site 24
S323
K
K
A
G
T
Y
F
S
N
Q
A
V
R
A
C
Site 25
T357
L
Q
P
G
R
P
L
T
R
L
S
C
Q
N
L
Site 26
S360
G
R
P
L
T
R
L
S
C
Q
N
L
G
A
V
Site 27
T383
F
F
K
K
A
G
A
T
F
R
L
K
D
G
V
Site 28
S397
V
L
A
Y
A
R
L
S
H
L
S
D
S
K
N
Site 29
S400
Y
A
R
L
S
H
L
S
D
S
K
N
V
F
N
Site 30
S402
R
L
S
H
L
S
D
S
K
N
V
F
N
P
E
Site 31
Y424
H
K
C
R
I
I
D
Y
S
Q
M
D
E
L
A
Site 32
S425
K
C
R
I
I
D
Y
S
Q
M
D
E
L
A
L
Site 33
S438
A
L
L
S
L
R
T
S
I
I
E
A
Q
Y
L
Site 34
Y444
T
S
I
I
E
A
Q
Y
L
R
Y
H
D
I
E
Site 35
Y447
I
E
A
Q
Y
L
R
Y
H
D
I
E
P
G
A
Site 36
T459
P
G
A
V
V
K
G
T
V
L
T
I
K
S
Y
Site 37
T462
V
V
K
G
T
V
L
T
I
K
S
Y
G
M
L
Site 38
T520
E
A
K
K
L
M
M
T
L
K
K
T
L
I
E
Site 39
S528
L
K
K
T
L
I
E
S
K
L
P
V
I
T
C
Site 40
Y536
K
L
P
V
I
T
C
Y
A
D
A
K
P
G
L
Site 41
T545
D
A
K
P
G
L
Q
T
H
G
F
I
I
R
V
Site 42
S575
L
V
P
K
H
E
L
S
T
E
Y
I
P
D
P
Site 43
Y587
P
D
P
E
R
V
F
Y
T
G
Q
V
V
K
V
Site 44
S602
V
V
L
N
C
E
P
S
K
E
R
M
L
L
S
Site 45
S609
S
K
E
R
M
L
L
S
F
K
L
S
S
D
P
Site 46
S613
M
L
L
S
F
K
L
S
S
D
P
E
P
K
K
Site 47
S626
K
K
E
P
A
G
H
S
Q
K
K
G
K
A
I
Site 48
T666
N
I
R
A
F
L
P
T
S
H
L
S
D
H
V
Site 49
T713
R
K
P
A
L
V
S
T
V
E
G
G
Q
D
P
Site 50
S724
G
Q
D
P
K
N
F
S
E
I
H
P
G
M
L
Site 51
S738
L
L
I
G
F
V
K
S
I
K
D
Y
G
V
F
Site 52
Y742
F
V
K
S
I
K
D
Y
G
V
F
I
Q
F
P
Site 53
S768
M
S
D
K
F
V
T
S
T
S
D
H
F
V
E
Site 54
S770
D
K
F
V
T
S
T
S
D
H
F
V
E
G
Q
Site 55
S796
E
K
Q
R
M
L
L
S
L
R
L
S
D
C
G
Site 56
S827
E
E
L
Q
G
V
R
S
L
M
S
N
R
D
S
Site 57
S830
Q
G
V
R
S
L
M
S
N
R
D
S
V
L
I
Site 58
S861
Q
E
V
L
E
D
G
S
V
V
F
S
G
G
P
Site 59
Y879
L
V
L
K
A
S
R
Y
H
R
A
G
Q
E
V
Site 60
S926
A
R
K
L
R
K
G
S
E
H
Q
A
I
V
Q
Site 61
S954
T
G
H
L
A
A
F
S
L
T
S
H
L
N
D
Site 62
T962
L
T
S
H
L
N
D
T
F
R
F
D
S
E
K
Site 63
S967
N
D
T
F
R
F
D
S
E
K
L
Q
V
G
Q
Site 64
T979
V
G
Q
G
V
S
L
T
L
K
T
T
E
P
G
Site 65
T1002
E
G
P
A
A
K
R
T
M
R
P
T
Q
K
D
Site 66
T1006
A
K
R
T
M
R
P
T
Q
K
D
S
E
T
V
Site 67
T1012
P
T
Q
K
D
S
E
T
V
D
E
D
E
E
V
Site 68
T1024
E
E
V
D
P
A
L
T
V
G
T
I
K
K
H
Site 69
S1077
D
D
V
P
E
G
T
S
P
T
T
K
L
K
V
Site 70
T1089
L
K
V
G
K
T
V
T
A
R
V
I
G
G
R
Site 71
T1100
I
G
G
R
D
M
K
T
F
K
Y
L
P
I
S
Site 72
Y1103
R
D
M
K
T
F
K
Y
L
P
I
S
H
P
R
Site 73
S1107
T
F
K
Y
L
P
I
S
H
P
R
F
V
R
T
Site 74
T1114
S
H
P
R
F
V
R
T
I
P
E
L
S
V
R
Site 75
S1119
V
R
T
I
P
E
L
S
V
R
P
S
E
L
E
Site 76
S1123
P
E
L
S
V
R
P
S
E
L
E
D
G
H
T
Site 77
T1130
S
E
L
E
D
G
H
T
A
L
N
T
H
S
V
Site 78
T1134
D
G
H
T
A
L
N
T
H
S
V
S
P
M
E
Site 79
S1136
H
T
A
L
N
T
H
S
V
S
P
M
E
K
I
Site 80
S1138
A
L
N
T
H
S
V
S
P
M
E
K
I
K
Q
Site 81
Y1146
P
M
E
K
I
K
Q
Y
Q
A
G
Q
T
V
T
Site 82
T1206
V
G
Q
A
L
R
A
T
V
V
G
P
D
S
S
Site 83
T1247
V
T
P
N
E
G
L
T
V
S
F
P
F
G
K
Site 84
S1249
P
N
E
G
L
T
V
S
F
P
F
G
K
I
G
Site 85
S1264
T
V
S
I
F
H
M
S
D
S
Y
S
E
T
P
Site 86
S1266
S
I
F
H
M
S
D
S
Y
S
E
T
P
L
E
Site 87
Y1267
I
F
H
M
S
D
S
Y
S
E
T
P
L
E
D
Site 88
S1268
F
H
M
S
D
S
Y
S
E
T
P
L
E
D
F
Site 89
T1270
M
S
D
S
Y
S
E
T
P
L
E
D
F
V
P
Site 90
Y1284
P
Q
K
V
V
R
C
Y
I
L
S
T
A
D
N
Site 91
T1294
S
T
A
D
N
V
L
T
L
S
L
R
S
S
R
Site 92
S1296
A
D
N
V
L
T
L
S
L
R
S
S
R
T
N
Site 93
S1299
V
L
T
L
S
L
R
S
S
R
T
N
P
E
T
Site 94
S1300
L
T
L
S
L
R
S
S
R
T
N
P
E
T
K
Site 95
T1302
L
S
L
R
S
S
R
T
N
P
E
T
K
S
K
Site 96
T1306
S
S
R
T
N
P
E
T
K
S
K
V
E
D
P
Site 97
S1308
R
T
N
P
E
T
K
S
K
V
E
D
P
E
I
Site 98
Y1330
E
G
Q
L
L
R
G
Y
V
G
S
I
Q
P
H
Site 99
S1346
V
F
F
R
L
G
P
S
V
V
G
L
A
R
Y
Site 100
Y1353
S
V
V
G
L
A
R
Y
S
H
V
S
Q
H
S
Site 101
S1354
V
V
G
L
A
R
Y
S
H
V
S
Q
H
S
P
Site 102
S1357
L
A
R
Y
S
H
V
S
Q
H
S
P
S
K
K
Site 103
S1360
Y
S
H
V
S
Q
H
S
P
S
K
K
A
L
Y
Site 104
S1362
H
V
S
Q
H
S
P
S
K
K
A
L
Y
N
K
Site 105
Y1367
S
P
S
K
K
A
L
Y
N
K
H
L
P
E
G
Site 106
T1378
L
P
E
G
K
L
L
T
A
R
V
L
R
L
N
Site 107
S1394
Q
K
N
L
V
E
L
S
F
L
P
G
D
T
G
Site 108
T1400
L
S
F
L
P
G
D
T
G
K
P
D
V
L
S
Site 109
S1407
T
G
K
P
D
V
L
S
A
S
L
E
G
Q
L
Site 110
S1409
K
P
D
V
L
S
A
S
L
E
G
Q
L
T
K
Site 111
T1415
A
S
L
E
G
Q
L
T
K
Q
E
E
R
K
T
Site 112
T1422
T
K
Q
E
E
R
K
T
E
A
E
E
R
D
Q
Site 113
S1454
Q
E
E
V
E
M
P
S
K
E
K
Q
Q
P
Q
Site 114
S1476
G
G
R
E
C
R
E
S
G
S
E
Q
E
R
V
Site 115
S1478
R
E
C
R
E
S
G
S
E
Q
E
R
V
S
K
Site 116
S1484
G
S
E
Q
E
R
V
S
K
K
P
K
K
A
G
Site 117
S1493
K
P
K
K
A
G
L
S
E
E
D
D
S
L
V
Site 118
S1498
G
L
S
E
E
D
D
S
L
V
D
V
Y
Y
R
Site 119
Y1503
D
D
S
L
V
D
V
Y
Y
R
E
G
K
E
E
Site 120
Y1504
D
S
L
V
D
V
Y
Y
R
E
G
K
E
E
A
Site 121
T1514
G
K
E
E
A
E
E
T
N
V
L
P
K
E
K
Site 122
S1534
E
A
P
R
L
Q
L
S
S
G
F
A
W
N
V
Site 123
S1535
A
P
R
L
Q
L
S
S
G
F
A
W
N
V
G
Site 124
S1557
L
P
P
L
A
E
S
S
D
S
E
E
D
E
K
Site 125
S1559
P
L
A
E
S
S
D
S
E
E
D
E
K
P
H
Site 126
S1589
Q
K
A
E
K
E
L
S
R
I
E
E
A
L
M
Site 127
S1604
D
P
G
R
Q
P
E
S
A
D
D
F
D
R
L
Site 128
S1614
D
F
D
R
L
V
L
S
S
P
N
S
S
I
L
Site 129
S1650
E
R
A
L
K
T
I
S
F
R
E
E
Q
E
K
Site 130
Y1671
L
L
N
L
E
N
M
Y
G
S
Q
E
S
L
T
Site 131
S1673
N
L
E
N
M
Y
G
S
Q
E
S
L
T
K
V
Site 132
S1676
N
M
Y
G
S
Q
E
S
L
T
K
V
F
E
R
Site 133
Y1687
V
F
E
R
A
V
Q
Y
N
E
P
L
K
V
F
Site 134
Y1701
F
L
H
L
A
D
I
Y
A
K
S
E
K
F
Q
Site 135
S1704
L
A
D
I
Y
A
K
S
E
K
F
Q
E
A
G
Site 136
Y1714
F
Q
E
A
G
E
L
Y
N
R
M
L
K
R
F
Site 137
Y1731
E
K
A
V
W
I
K
Y
G
A
F
L
L
R
R
Site 138
S1739
G
A
F
L
L
R
R
S
Q
A
A
A
S
H
R
Site 139
S1744
R
R
S
Q
A
A
A
S
H
R
V
L
Q
R
A
Site 140
S1757
R
A
L
E
C
L
P
S
K
E
H
V
D
V
I
Site 141
T1787
A
K
A
I
F
E
N
T
L
S
T
Y
P
K
R
Site 142
S1789
A
I
F
E
N
T
L
S
T
Y
P
K
R
T
D
Site 143
Y1791
F
E
N
T
L
S
T
Y
P
K
R
T
D
V
W
Site 144
T1795
L
S
T
Y
P
K
R
T
D
V
W
S
V
Y
I
Site 145
Y1801
R
T
D
V
W
S
V
Y
I
D
M
T
I
K
H
Site 146
S1825
F
E
R
V
I
H
L
S
L
A
P
K
R
M
K
Site 147
Y1838
M
K
F
F
F
K
R
Y
L
D
Y
E
K
Q
H
Site 148
Y1841
F
F
K
R
Y
L
D
Y
E
K
Q
H
G
T
E
Site 149
Y1861
V
K
A
K
A
L
E
Y
V
E
A
K
S
S
V
Site 150
S1866
L
E
Y
V
E
A
K
S
S
V
L
E
D
_
_
Site 151
S1867
E
Y
V
E
A
K
S
S
V
L
E
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation