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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIP12
Full Name:
Probable E3 ubiquitin-protein ligase TRIP12
Alias:
KIAA0045; Thyroid hormone receptor interactor 12; Thyroid receptor interacting protein 12; Thyroid receptor-interacting protein 12; TRIB; TRIPC
Type:
EC 6.3.2.-; Ubiquitin conjugating system; Nuclear receptor co-regulator; Ligase
Mass (Da):
220434
Number AA:
1992
UniProt ID:
Q14669
International Prot ID:
IPI00032342
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0046966
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0016567
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
N
N
N
P
G
G
S
L
R
R
S
Q
R
N
Site 2
S16
P
G
G
S
L
R
R
S
Q
R
N
T
A
G
A
Site 3
T20
L
R
R
S
Q
R
N
T
A
G
A
Q
P
Q
D
Site 4
S29
G
A
Q
P
Q
D
D
S
I
G
G
R
S
C
S
Site 5
S34
D
D
S
I
G
G
R
S
C
S
S
S
S
A
V
Site 6
S38
G
G
R
S
C
S
S
S
S
A
V
I
V
P
Q
Site 7
S39
G
R
S
C
S
S
S
S
A
V
I
V
P
Q
P
Site 8
T54
E
D
P
D
R
A
N
T
S
E
R
Q
K
T
G
Site 9
S55
D
P
D
R
A
N
T
S
E
R
Q
K
T
G
Q
Site 10
T60
N
T
S
E
R
Q
K
T
G
Q
V
P
K
K
D
Site 11
S75
N
S
R
G
V
K
R
S
A
S
P
D
Y
N
R
Site 12
S77
R
G
V
K
R
S
A
S
P
D
Y
N
R
T
N
Site 13
Y80
K
R
S
A
S
P
D
Y
N
R
T
N
S
P
S
Site 14
T83
A
S
P
D
Y
N
R
T
N
S
P
S
S
A
K
Site 15
S85
P
D
Y
N
R
T
N
S
P
S
S
A
K
K
P
Site 16
S87
Y
N
R
T
N
S
P
S
S
A
K
K
P
K
A
Site 17
S88
N
R
T
N
S
P
S
S
A
K
K
P
K
A
L
Site 18
T98
K
P
K
A
L
Q
H
T
E
S
P
S
E
T
N
Site 19
S100
K
A
L
Q
H
T
E
S
P
S
E
T
N
K
P
Site 20
S102
L
Q
H
T
E
S
P
S
E
T
N
K
P
H
S
Site 21
T104
H
T
E
S
P
S
E
T
N
K
P
H
S
K
S
Site 22
S109
S
E
T
N
K
P
H
S
K
S
K
K
R
H
L
Site 23
S111
T
N
K
P
H
S
K
S
K
K
R
H
L
D
Q
Site 24
S124
D
Q
E
Q
Q
L
K
S
A
Q
S
P
S
T
S
Site 25
S127
Q
Q
L
K
S
A
Q
S
P
S
T
S
K
A
H
Site 26
S129
L
K
S
A
Q
S
P
S
T
S
K
A
H
T
R
Site 27
S131
S
A
Q
S
P
S
T
S
K
A
H
T
R
K
S
Site 28
T135
P
S
T
S
K
A
H
T
R
K
S
G
A
T
G
Site 29
S138
S
K
A
H
T
R
K
S
G
A
T
G
G
S
R
Site 30
T141
H
T
R
K
S
G
A
T
G
G
S
R
S
Q
K
Site 31
S146
G
A
T
G
G
S
R
S
Q
K
R
K
R
T
E
Site 32
T152
R
S
Q
K
R
K
R
T
E
S
S
C
V
K
S
Site 33
S154
Q
K
R
K
R
T
E
S
S
C
V
K
S
G
S
Site 34
S155
K
R
K
R
T
E
S
S
C
V
K
S
G
S
G
Site 35
S159
T
E
S
S
C
V
K
S
G
S
G
S
E
S
T
Site 36
S161
S
S
C
V
K
S
G
S
G
S
E
S
T
G
A
Site 37
S163
C
V
K
S
G
S
G
S
E
S
T
G
A
E
E
Site 38
S165
K
S
G
S
G
S
E
S
T
G
A
E
E
R
S
Site 39
S172
S
T
G
A
E
E
R
S
A
K
P
T
K
L
A
Site 40
T176
E
E
R
S
A
K
P
T
K
L
A
S
K
S
A
Site 41
S180
A
K
P
T
K
L
A
S
K
S
A
T
S
A
K
Site 42
S182
P
T
K
L
A
S
K
S
A
T
S
A
K
A
G
Site 43
T184
K
L
A
S
K
S
A
T
S
A
K
A
G
C
S
Site 44
S191
T
S
A
K
A
G
C
S
T
I
T
D
S
S
S
Site 45
T192
S
A
K
A
G
C
S
T
I
T
D
S
S
S
A
Site 46
T194
K
A
G
C
S
T
I
T
D
S
S
S
A
A
S
Site 47
S196
G
C
S
T
I
T
D
S
S
S
A
A
S
T
S
Site 48
S197
C
S
T
I
T
D
S
S
S
A
A
S
T
S
S
Site 49
S198
S
T
I
T
D
S
S
S
A
A
S
T
S
S
S
Site 50
S201
T
D
S
S
S
A
A
S
T
S
S
S
S
S
A
Site 51
T202
D
S
S
S
A
A
S
T
S
S
S
S
S
A
V
Site 52
S203
S
S
S
A
A
S
T
S
S
S
S
S
A
V
A
Site 53
S204
S
S
A
A
S
T
S
S
S
S
S
A
V
A
S
Site 54
S205
S
A
A
S
T
S
S
S
S
S
A
V
A
S
A
Site 55
S206
A
A
S
T
S
S
S
S
S
A
V
A
S
A
S
Site 56
S207
A
S
T
S
S
S
S
S
A
V
A
S
A
S
S
Site 57
S211
S
S
S
S
A
V
A
S
A
S
S
T
V
P
P
Site 58
S234
D
Q
N
K
A
R
R
S
R
S
A
S
S
P
S
Site 59
S236
N
K
A
R
R
S
R
S
A
S
S
P
S
P
R
Site 60
S238
A
R
R
S
R
S
A
S
S
P
S
P
R
R
S
Site 61
S239
R
R
S
R
S
A
S
S
P
S
P
R
R
S
S
Site 62
S241
S
R
S
A
S
S
P
S
P
R
R
S
S
R
E
Site 63
S245
S
S
P
S
P
R
R
S
S
R
E
K
E
Q
S
Site 64
S246
S
P
S
P
R
R
S
S
R
E
K
E
Q
S
K
Site 65
S252
S
S
R
E
K
E
Q
S
K
T
G
G
S
S
K
Site 66
T254
R
E
K
E
Q
S
K
T
G
G
S
S
K
F
D
Site 67
S267
F
D
W
A
A
R
F
S
P
K
V
S
L
P
K
Site 68
S271
A
R
F
S
P
K
V
S
L
P
K
T
K
L
S
Site 69
T275
P
K
V
S
L
P
K
T
K
L
S
L
P
G
S
Site 70
S278
S
L
P
K
T
K
L
S
L
P
G
S
S
K
S
Site 71
S282
T
K
L
S
L
P
G
S
S
K
S
E
T
S
K
Site 72
S283
K
L
S
L
P
G
S
S
K
S
E
T
S
K
P
Site 73
S285
S
L
P
G
S
S
K
S
E
T
S
K
P
G
P
Site 74
T287
P
G
S
S
K
S
E
T
S
K
P
G
P
S
G
Site 75
S288
G
S
S
K
S
E
T
S
K
P
G
P
S
G
L
Site 76
S301
G
L
Q
A
K
L
A
S
L
R
K
S
T
K
K
Site 77
S305
K
L
A
S
L
R
K
S
T
K
K
R
S
E
S
Site 78
T306
L
A
S
L
R
K
S
T
K
K
R
S
E
S
P
Site 79
S310
R
K
S
T
K
K
R
S
E
S
P
P
A
E
L
Site 80
S312
S
T
K
K
R
S
E
S
P
P
A
E
L
P
S
Site 81
S319
S
P
P
A
E
L
P
S
L
R
R
S
T
R
Q
Site 82
S323
E
L
P
S
L
R
R
S
T
R
Q
K
T
T
G
Site 83
T324
L
P
S
L
R
R
S
T
R
Q
K
T
T
G
S
Site 84
T328
R
R
S
T
R
Q
K
T
T
G
S
C
A
S
T
Site 85
T329
R
S
T
R
Q
K
T
T
G
S
C
A
S
T
S
Site 86
S331
T
R
Q
K
T
T
G
S
C
A
S
T
S
R
R
Site 87
S334
K
T
T
G
S
C
A
S
T
S
R
R
G
S
G
Site 88
T335
T
T
G
S
C
A
S
T
S
R
R
G
S
G
L
Site 89
S336
T
G
S
C
A
S
T
S
R
R
G
S
G
L
G
Site 90
S340
A
S
T
S
R
R
G
S
G
L
G
K
R
G
A
Site 91
S361
E
K
M
A
D
P
E
S
N
Q
E
A
V
N
S
Site 92
S368
S
N
Q
E
A
V
N
S
S
A
A
R
T
D
E
Site 93
T373
V
N
S
S
A
A
R
T
D
E
A
P
Q
G
A
Site 94
T388
A
G
A
V
G
M
T
T
S
G
E
S
E
S
D
Site 95
S389
G
A
V
G
M
T
T
S
G
E
S
E
S
D
D
Site 96
S392
G
M
T
T
S
G
E
S
E
S
D
D
S
E
M
Site 97
S394
T
T
S
G
E
S
E
S
D
D
S
E
M
G
R
Site 98
S397
G
E
S
E
S
D
D
S
E
M
G
R
L
Q
A
Site 99
S424
G
P
L
G
P
R
M
S
Q
L
F
H
R
T
I
Site 100
S433
L
F
H
R
T
I
G
S
G
A
S
S
K
A
Q
Site 101
S437
T
I
G
S
G
A
S
S
K
A
Q
Q
L
L
Q
Site 102
S449
L
L
Q
G
L
Q
A
S
D
E
S
Q
Q
L
Q
Site 103
Y507
H
A
C
R
A
L
T
Y
M
M
E
A
L
P
R
Site 104
S550
L
T
A
L
E
M
L
S
R
R
H
S
K
A
I
Site 105
S554
E
M
L
S
R
R
H
S
K
A
I
L
Q
A
G
Site 106
T608
A
D
S
L
P
L
L
T
Q
R
L
T
H
Q
D
Site 107
T612
P
L
L
T
Q
R
L
T
H
Q
D
K
K
S
V
Site 108
S618
L
T
H
Q
D
K
K
S
V
E
S
T
C
L
C
Site 109
T622
D
K
K
S
V
E
S
T
C
L
C
F
A
R
L
Site 110
T650
V
A
S
K
D
L
L
T
N
V
Q
Q
L
L
V
Site 111
T684
L
M
C
S
N
C
P
T
L
A
V
Q
L
M
K
Site 112
S720
Q
I
D
L
V
P
R
S
P
Q
E
L
Y
E
L
Site 113
Y725
P
R
S
P
Q
E
L
Y
E
L
T
S
L
I
C
Site 114
T758
K
K
G
N
A
Q
N
T
D
G
A
I
W
Q
W
Site 115
Y775
D
R
G
L
W
H
P
Y
N
R
I
D
S
R
I
Site 116
T792
Q
I
N
E
D
T
G
T
A
R
A
I
Q
R
K
Site 117
S806
K
P
N
P
L
A
N
S
N
T
S
G
Y
S
E
Site 118
T808
N
P
L
A
N
S
N
T
S
G
Y
S
E
S
K
Site 119
S809
P
L
A
N
S
N
T
S
G
Y
S
E
S
K
K
Site 120
Y811
A
N
S
N
T
S
G
Y
S
E
S
K
K
D
D
Site 121
S833
E
D
P
E
L
A
K
S
F
I
K
T
L
F
G
Site 122
S849
L
Y
E
V
Y
S
S
S
A
G
P
A
V
R
H
Site 123
S918
Q
K
L
P
D
I
F
S
V
Y
F
R
R
E
G
Site 124
S936
Q
V
K
H
L
A
E
S
E
S
L
L
T
S
P
Site 125
S938
K
H
L
A
E
S
E
S
L
L
T
S
P
P
K
Site 126
T941
A
E
S
E
S
L
L
T
S
P
P
K
A
C
T
Site 127
S942
E
S
E
S
L
L
T
S
P
P
K
A
C
T
N
Site 128
T948
T
S
P
P
K
A
C
T
N
G
S
G
S
M
G
Site 129
S951
P
K
A
C
T
N
G
S
G
S
M
G
S
T
T
Site 130
S953
A
C
T
N
G
S
G
S
M
G
S
T
T
S
V
Site 131
S956
N
G
S
G
S
M
G
S
T
T
S
V
S
S
G
Site 132
T957
G
S
G
S
M
G
S
T
T
S
V
S
S
G
T
Site 133
T958
S
G
S
M
G
S
T
T
S
V
S
S
G
T
A
Site 134
S959
G
S
M
G
S
T
T
S
V
S
S
G
T
A
T
Site 135
S977
H
A
A
A
D
L
G
S
P
S
L
Q
H
S
R
Site 136
S979
A
A
D
L
G
S
P
S
L
Q
H
S
R
D
D
Site 137
S983
G
S
P
S
L
Q
H
S
R
D
D
S
L
D
L
Site 138
S987
L
Q
H
S
R
D
D
S
L
D
L
S
P
Q
G
Site 139
S991
R
D
D
S
L
D
L
S
P
Q
G
R
L
S
D
Site 140
S997
L
S
P
Q
G
R
L
S
D
V
L
K
R
K
R
Site 141
Y1015
R
G
P
R
R
P
K
Y
S
P
P
R
D
D
D
Site 142
S1016
G
P
R
R
P
K
Y
S
P
P
R
D
D
D
K
Site 143
S1030
K
V
D
N
Q
A
K
S
P
T
T
T
Q
S
P
Site 144
T1032
D
N
Q
A
K
S
P
T
T
T
Q
S
P
K
S
Site 145
T1034
Q
A
K
S
P
T
T
T
Q
S
P
K
S
S
F
Site 146
S1036
K
S
P
T
T
T
Q
S
P
K
S
S
F
L
A
Site 147
S1039
T
T
T
Q
S
P
K
S
S
F
L
A
S
L
N
Site 148
S1040
T
T
Q
S
P
K
S
S
F
L
A
S
L
N
P
Site 149
S1044
P
K
S
S
F
L
A
S
L
N
P
K
T
W
G
Site 150
T1049
L
A
S
L
N
P
K
T
W
G
R
L
S
T
Q
Site 151
S1054
P
K
T
W
G
R
L
S
T
Q
S
N
S
N
N
Site 152
T1055
K
T
W
G
R
L
S
T
Q
S
N
S
N
N
I
Site 153
S1057
W
G
R
L
S
T
Q
S
N
S
N
N
I
E
P
Site 154
T1067
N
N
I
E
P
A
R
T
A
G
G
S
G
L
A
Site 155
S1071
P
A
R
T
A
G
G
S
G
L
A
R
A
A
S
Site 156
S1078
S
G
L
A
R
A
A
S
K
D
T
I
S
N
N
Site 157
S1083
A
A
S
K
D
T
I
S
N
N
R
E
K
I
K
Site 158
Y1104
A
H
K
F
V
E
R
Y
F
S
S
E
N
M
D
Site 159
S1106
K
F
V
E
R
Y
F
S
S
E
N
M
D
G
S
Site 160
S1113
S
S
E
N
M
D
G
S
N
P
A
L
N
V
L
Site 161
S1154
I
V
S
E
S
D
V
S
S
F
E
I
Q
H
S
Site 162
S1155
V
S
E
S
D
V
S
S
F
E
I
Q
H
S
G
Site 163
S1161
S
S
F
E
I
Q
H
S
G
F
V
K
Q
L
L
Site 164
Y1170
F
V
K
Q
L
L
L
Y
L
T
S
K
S
E
K
Site 165
S1173
Q
L
L
L
Y
L
T
S
K
S
E
K
D
A
V
Site 166
S1175
L
L
Y
L
T
S
K
S
E
K
D
A
V
S
R
Site 167
S1181
K
S
E
K
D
A
V
S
R
E
I
R
L
K
R
Site 168
S1195
R
F
L
H
V
F
F
S
S
P
L
P
G
E
E
Site 169
S1241
V
K
V
H
D
F
P
S
G
N
G
T
G
G
S
Site 170
T1245
D
F
P
S
G
N
G
T
G
G
S
F
S
L
N
Site 171
S1248
S
G
N
G
T
G
G
S
F
S
L
N
R
G
S
Site 172
S1250
N
G
T
G
G
S
F
S
L
N
R
G
S
Q
A
Site 173
S1255
S
F
S
L
N
R
G
S
Q
A
L
K
F
F
N
Site 174
Y1307
R
Y
L
V
V
R
G
Y
G
R
V
R
E
D
D
Site 175
S1317
V
R
E
D
D
E
D
S
D
D
D
G
S
D
E
Site 176
S1322
E
D
S
D
D
D
G
S
D
E
E
I
D
E
S
Site 177
S1329
S
D
E
E
I
D
E
S
L
A
A
Q
F
L
N
Site 178
Y1360
L
P
Y
N
M
T
V
Y
Q
A
V
R
Q
F
S
Site 179
S1367
Y
Q
A
V
R
Q
F
S
I
Q
A
E
D
E
R
Site 180
S1376
Q
A
E
D
E
R
E
S
T
D
D
E
S
N
P
Site 181
T1377
A
E
D
E
R
E
S
T
D
D
E
S
N
P
L
Site 182
S1381
R
E
S
T
D
D
E
S
N
P
L
G
R
A
G
Site 183
T1393
R
A
G
I
W
T
K
T
H
T
I
W
Y
K
P
Site 184
S1407
P
V
R
E
D
E
E
S
N
K
D
C
V
G
G
Site 185
T1421
G
K
R
G
R
A
Q
T
A
P
T
K
T
S
P
Site 186
T1426
A
Q
T
A
P
T
K
T
S
P
R
N
A
K
K
Site 187
S1427
Q
T
A
P
T
K
T
S
P
R
N
A
K
K
H
Site 188
S1445
W
H
D
G
V
C
P
S
V
S
N
P
L
E
V
Site 189
Y1453
V
S
N
P
L
E
V
Y
L
I
P
T
P
P
E
Site 190
T1463
P
T
P
P
E
N
I
T
F
E
D
P
S
L
D
Site 191
Y1489
S
R
Y
W
Y
Y
L
Y
D
N
A
M
C
K
E
Site 192
T1500
M
C
K
E
I
I
P
T
S
E
F
I
N
S
K
Site 193
S1501
C
K
E
I
I
P
T
S
E
F
I
N
S
K
L
Site 194
T1532
G
N
I
P
T
W
L
T
E
L
G
K
T
C
P
Site 195
Y1552
D
T
R
Q
M
L
F
Y
V
T
A
F
D
R
D
Site 196
T1568
A
M
Q
R
L
L
D
T
N
P
E
I
N
Q
S
Site 197
S1575
T
N
P
E
I
N
Q
S
D
S
Q
D
S
R
V
Site 198
S1577
P
E
I
N
Q
S
D
S
Q
D
S
R
V
A
P
Site 199
T1592
R
L
D
R
K
K
R
T
V
N
R
E
E
L
L
Site 200
S1604
E
L
L
K
Q
A
E
S
V
M
Q
D
L
G
S
Site 201
Y1620
R
A
M
L
E
I
Q
Y
E
N
E
V
G
T
G
Site 202
S1639
L
E
F
Y
A
L
V
S
Q
E
L
Q
R
A
D
Site 203
T1656
L
W
R
G
E
E
V
T
L
S
N
P
K
G
S
Site 204
S1658
R
G
E
E
V
T
L
S
N
P
K
G
S
Q
E
Site 205
S1663
T
L
S
N
P
K
G
S
Q
E
G
T
K
Y
I
Site 206
T1667
P
K
G
S
Q
E
G
T
K
Y
I
Q
N
L
Q
Site 207
Y1669
G
S
Q
E
G
T
K
Y
I
Q
N
L
Q
G
L
Site 208
Y1723
L
P
L
G
L
P
F
Y
K
W
M
L
R
Q
E
Site 209
T1731
K
W
M
L
R
Q
E
T
S
L
T
S
H
D
L
Site 210
S1732
W
M
L
R
Q
E
T
S
L
T
S
H
D
L
F
Site 211
T1734
L
R
Q
E
T
S
L
T
S
H
D
L
F
D
I
Site 212
S1735
R
Q
E
T
S
L
T
S
H
D
L
F
D
I
D
Site 213
S1767
K
R
L
E
Q
D
K
S
Q
T
K
E
S
L
Q
Site 214
S1772
D
K
S
Q
T
K
E
S
L
Q
Y
A
L
E
T
Site 215
Y1775
Q
T
K
E
S
L
Q
Y
A
L
E
T
L
T
M
Site 216
T1814
G
G
K
D
I
P
V
T
I
H
N
L
E
E
Y
Site 217
S1840
G
V
S
R
Q
F
D
S
F
R
D
G
F
E
S
Site 218
S1847
S
F
R
D
G
F
E
S
V
F
P
L
S
H
L
Site 219
Y1856
F
P
L
S
H
L
Q
Y
F
Y
P
E
E
L
D
Site 220
Y1858
L
S
H
L
Q
Y
F
Y
P
E
E
L
D
Q
L
Site 221
S1869
L
D
Q
L
L
C
G
S
K
A
D
T
W
D
A
Site 222
T1873
L
C
G
S
K
A
D
T
W
D
A
K
T
L
M
Site 223
Y1889
C
C
R
P
D
H
G
Y
T
H
D
S
R
A
V
Site 224
S1904
K
F
L
F
E
I
L
S
S
F
D
N
E
Q
Q
Site 225
S1905
F
L
F
E
I
L
S
S
F
D
N
E
Q
Q
R
Site 226
T1937
R
S
L
N
P
P
L
T
I
V
R
K
T
F
E
Site 227
T1942
P
L
T
I
V
R
K
T
F
E
S
T
E
N
P
Site 228
S1945
I
V
R
K
T
F
E
S
T
E
N
P
D
D
F
Site 229
Y1968
N
Y
L
K
L
P
D
Y
S
S
I
E
I
M
R
Site 230
S1970
L
K
L
P
D
Y
S
S
I
E
I
M
R
E
K
Site 231
S1988
A
A
R
E
G
Q
Q
S
F
H
L
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation