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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INPP5A
Full Name:
Type I inositol-1,4,5-trisphosphate 5-phosphatase
Alias:
43 kDa inositol polyphosphate 5-phosphatase; 5PTase; CTCL tumor antigen HD-CL-02; EC 3.1.3.56; I5P1
Type:
Mass (Da):
47820
Number AA:
412
UniProt ID:
Q14642
International Prot ID:
IPI00032262
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
Uniprot
OncoNet
Molecular Function:
GO:0042731
GO:0004445
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
L
V
T
A
N
V
G
S
L
F
D
D
P
E
N
Site 2
Y38
K
N
W
L
R
E
F
Y
Q
V
V
H
T
H
K
Site 3
Y61
Q
E
F
G
G
K
N
Y
E
A
S
M
S
H
V
Site 4
S66
K
N
Y
E
A
S
M
S
H
V
D
K
F
V
K
Site 5
S77
K
F
V
K
E
L
L
S
S
D
A
M
K
E
Y
Site 6
S78
F
V
K
E
L
L
S
S
D
A
M
K
E
Y
N
Site 7
Y84
S
S
D
A
M
K
E
Y
N
R
A
R
V
Y
L
Site 8
Y90
E
Y
N
R
A
R
V
Y
L
D
E
N
Y
K
S
Site 9
Y95
R
V
Y
L
D
E
N
Y
K
S
Q
E
H
F
T
Site 10
S97
Y
L
D
E
N
Y
K
S
Q
E
H
F
T
A
L
Site 11
T102
Y
K
S
Q
E
H
F
T
A
L
G
S
F
Y
F
Site 12
S106
E
H
F
T
A
L
G
S
F
Y
F
L
H
E
S
Site 13
Y118
H
E
S
L
K
N
I
Y
Q
F
D
F
K
A
K
Site 14
Y127
F
D
F
K
A
K
K
Y
R
K
V
A
G
K
E
Site 15
S137
V
A
G
K
E
I
Y
S
D
T
L
E
S
T
P
Site 16
T139
G
K
E
I
Y
S
D
T
L
E
S
T
P
M
L
Site 17
T143
Y
S
D
T
L
E
S
T
P
M
L
E
K
E
K
Site 18
Y155
K
E
K
F
P
Q
D
Y
F
P
E
C
K
W
S
Site 19
S200
V
A
W
E
T
S
P
S
V
Y
S
G
I
R
H
Site 20
S203
E
T
S
P
S
V
Y
S
G
I
R
H
K
A
L
Site 21
Y227
Q
R
F
E
K
V
S
Y
F
V
F
G
D
F
N
Site 22
S239
D
F
N
F
R
L
D
S
K
S
V
V
E
T
L
Site 23
S241
N
F
R
L
D
S
K
S
V
V
E
T
L
C
T
Site 24
T245
D
S
K
S
V
V
E
T
L
C
T
K
A
T
M
Site 25
S271
V
K
L
I
F
R
E
S
D
N
D
R
K
V
M
Site 26
Y288
L
E
K
K
L
F
D
Y
F
N
Q
E
V
F
R
Site 27
S310
L
E
F
D
K
E
L
S
V
F
K
D
R
L
Y
Site 28
Y317
S
V
F
K
D
R
L
Y
E
L
D
I
S
F
P
Site 29
S322
R
L
Y
E
L
D
I
S
F
P
P
S
Y
P
Y
Site 30
S326
L
D
I
S
F
P
P
S
Y
P
Y
S
E
D
A
Site 31
Y327
D
I
S
F
P
P
S
Y
P
Y
S
E
D
A
R
Site 32
S330
F
P
P
S
Y
P
Y
S
E
D
A
R
Q
G
E
Site 33
Y339
D
A
R
Q
G
E
Q
Y
M
N
T
R
C
P
A
Site 34
S356
D
R
I
L
M
S
P
S
A
K
E
L
V
L
R
Site 35
S364
A
K
E
L
V
L
R
S
E
S
E
E
K
V
V
Site 36
S366
E
L
V
L
R
S
E
S
E
E
K
V
V
T
Y
Site 37
T372
E
S
E
E
K
V
V
T
Y
D
H
I
G
P
N
Site 38
Y373
S
E
E
K
V
V
T
Y
D
H
I
G
P
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation