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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HZF2
Full Name:
Zinc finger protein 267
Alias:
Z267; Zinc finger protein HZF2; ZN267; ZNF267
Type:
Transcription protein
Mass (Da):
87448
Number AA:
743
UniProt ID:
Q14586
International Prot ID:
IPI00479998
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
D
V
A
V
E
F
S
L
E
E
W
E
H
L
Site 2
Y29
E
P
A
Q
K
N
L
Y
Q
D
V
M
L
E
N
Site 3
S42
E
N
Y
R
N
L
V
S
L
G
L
V
V
S
K
Site 4
T54
V
S
K
P
D
L
I
T
F
L
E
Q
R
K
E
Site 5
S67
K
E
P
W
N
V
K
S
E
E
T
V
A
I
Q
Site 6
S79
A
I
Q
P
D
V
F
S
H
Y
N
K
D
L
L
Site 7
Y81
Q
P
D
V
F
S
H
Y
N
K
D
L
L
T
E
Site 8
T87
H
Y
N
K
D
L
L
T
E
H
C
T
E
A
S
Site 9
S94
T
E
H
C
T
E
A
S
F
Q
K
V
I
S
R
Site 10
S100
A
S
F
Q
K
V
I
S
R
R
H
G
S
C
D
Site 11
S105
V
I
S
R
R
H
G
S
C
D
L
E
N
L
H
Site 12
Y129
C
E
G
H
N
G
C
Y
D
E
K
T
F
K
Y
Site 13
Y136
Y
D
E
K
T
F
K
Y
D
Q
F
D
E
S
S
Site 14
S142
K
Y
D
Q
F
D
E
S
S
V
E
S
L
F
H
Site 15
S143
Y
D
Q
F
D
E
S
S
V
E
S
L
F
H
Q
Site 16
S146
F
D
E
S
S
V
E
S
L
F
H
Q
Q
I
L
Site 17
Y165
K
S
Y
N
F
D
Q
Y
R
K
V
F
T
H
S
Site 18
T170
D
Q
Y
R
K
V
F
T
H
S
S
L
L
N
Q
Site 19
S173
R
K
V
F
T
H
S
S
L
L
N
Q
Q
E
E
Site 20
Y190
I
W
G
K
H
H
I
Y
D
K
T
S
V
L
F
Site 21
T193
K
H
H
I
Y
D
K
T
S
V
L
F
R
Q
V
Site 22
S201
S
V
L
F
R
Q
V
S
T
L
N
S
Y
R
N
Site 23
S205
R
Q
V
S
T
L
N
S
Y
R
N
V
F
I
G
Site 24
Y206
Q
V
S
T
L
N
S
Y
R
N
V
F
I
G
E
Site 25
Y216
V
F
I
G
E
K
N
Y
H
C
N
N
S
E
K
Site 26
T224
H
C
N
N
S
E
K
T
L
N
Q
S
S
S
P
Site 27
S228
S
E
K
T
L
N
Q
S
S
S
P
K
N
H
Q
Site 28
S230
K
T
L
N
Q
S
S
S
P
K
N
H
Q
E
N
Site 29
Y238
P
K
N
H
Q
E
N
Y
F
L
E
K
Q
Y
K
Site 30
Y300
N
S
Y
S
Y
N
K
Y
D
K
D
L
S
Q
S
Site 31
S305
N
K
Y
D
K
D
L
S
Q
S
S
N
L
R
K
Site 32
S308
D
K
D
L
S
Q
S
S
N
L
R
K
Q
I
I
Site 33
Y322
I
H
N
E
E
K
P
Y
K
C
E
K
C
G
D
Site 34
S330
K
C
E
K
C
G
D
S
L
N
H
S
L
H
L
Site 35
S334
C
G
D
S
L
N
H
S
L
H
L
T
Q
H
Q
Site 36
T338
L
N
H
S
L
H
L
T
Q
H
Q
I
I
P
T
Site 37
Y350
I
P
T
E
E
K
P
Y
K
W
K
E
C
G
K
Site 38
S364
K
V
F
N
L
N
C
S
L
Y
L
T
K
Q
Q
Site 39
Y366
F
N
L
N
C
S
L
Y
L
T
K
Q
Q
Q
I
Site 40
T368
L
N
C
S
L
Y
L
T
K
Q
Q
Q
I
D
T
Site 41
Y380
I
D
T
G
E
N
L
Y
K
C
K
A
C
S
K
Site 42
S386
L
Y
K
C
K
A
C
S
K
S
F
T
R
S
S
Site 43
S388
K
C
K
A
C
S
K
S
F
T
R
S
S
N
L
Site 44
T390
K
A
C
S
K
S
F
T
R
S
S
N
L
I
V
Site 45
S392
C
S
K
S
F
T
R
S
S
N
L
I
V
H
Q
Site 46
S393
S
K
S
F
T
R
S
S
N
L
I
V
H
Q
R
Site 47
T403
I
V
H
Q
R
I
H
T
G
E
K
P
Y
K
C
Site 48
Y408
I
H
T
G
E
K
P
Y
K
C
K
E
C
G
K
Site 49
S420
C
G
K
A
F
R
C
S
S
Y
L
T
K
H
K
Site 50
S421
G
K
A
F
R
C
S
S
Y
L
T
K
H
K
R
Site 51
Y422
K
A
F
R
C
S
S
Y
L
T
K
H
K
R
I
Site 52
T424
F
R
C
S
S
Y
L
T
K
H
K
R
I
H
T
Site 53
T431
T
K
H
K
R
I
H
T
G
E
K
P
Y
K
C
Site 54
S449
G
K
A
F
N
R
S
S
C
L
T
Q
H
Q
T
Site 55
T452
F
N
R
S
S
C
L
T
Q
H
Q
T
T
H
T
Site 56
Y464
T
H
T
G
E
K
L
Y
K
C
K
V
C
S
K
Site 57
S470
L
Y
K
C
K
V
C
S
K
S
Y
A
R
S
S
Site 58
S472
K
C
K
V
C
S
K
S
Y
A
R
S
S
N
L
Site 59
Y473
C
K
V
C
S
K
S
Y
A
R
S
S
N
L
I
Site 60
S476
C
S
K
S
Y
A
R
S
S
N
L
I
M
H
Q
Site 61
S477
S
K
S
Y
A
R
S
S
N
L
I
M
H
Q
R
Site 62
T487
I
M
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 63
Y492
V
H
T
G
E
K
P
Y
K
C
K
E
C
G
K
Site 64
S502
K
E
C
G
K
V
F
S
R
S
S
C
L
T
Q
Site 65
S504
C
G
K
V
F
S
R
S
S
C
L
T
Q
H
R
Site 66
S505
G
K
V
F
S
R
S
S
C
L
T
Q
H
R
K
Site 67
T508
F
S
R
S
S
C
L
T
Q
H
R
K
I
H
T
Site 68
Y520
I
H
T
G
E
N
L
Y
K
C
K
V
C
A
K
Site 69
T543
I
V
H
E
R
I
H
T
G
E
K
P
Y
K
C
Site 70
Y559
E
C
G
K
A
F
P
Y
S
S
H
L
I
R
H
Site 71
S561
G
K
A
F
P
Y
S
S
H
L
I
R
H
Y
R
Site 72
Y567
S
S
H
L
I
R
H
Y
R
I
H
T
G
E
K
Site 73
T571
I
R
H
Y
R
I
H
T
G
E
K
P
Y
K
C
Site 74
S582
P
Y
K
C
K
A
C
S
K
S
F
S
D
S
S
Site 75
S584
K
C
K
A
C
S
K
S
F
S
D
S
S
G
L
Site 76
S586
K
A
C
S
K
S
F
S
D
S
S
G
L
S
V
Site 77
S588
C
S
K
S
F
S
D
S
S
G
L
S
V
H
R
Site 78
S589
S
K
S
F
S
D
S
S
G
L
S
V
H
R
R
Site 79
S592
F
S
D
S
S
G
L
S
V
H
R
R
T
H
T
Site 80
T597
G
L
S
V
H
R
R
T
H
T
G
E
K
P
Y
Site 81
T599
S
V
H
R
R
T
H
T
G
E
K
P
Y
T
C
Site 82
Y604
T
H
T
G
E
K
P
Y
T
C
K
E
C
G
K
Site 83
T605
H
T
G
E
K
P
Y
T
C
K
E
C
G
K
A
Site 84
S614
K
E
C
G
K
A
F
S
Y
S
S
D
V
I
Q
Site 85
Y615
E
C
G
K
A
F
S
Y
S
S
D
V
I
Q
H
Site 86
S616
C
G
K
A
F
S
Y
S
S
D
V
I
Q
H
R
Site 87
S617
G
K
A
F
S
Y
S
S
D
V
I
Q
H
R
R
Site 88
T627
I
Q
H
R
R
I
H
T
G
Q
R
P
Y
K
C
Site 89
Y632
I
H
T
G
Q
R
P
Y
K
C
E
E
C
G
K
Site 90
Y643
E
C
G
K
A
F
N
Y
R
S
Y
L
T
T
H
Site 91
S645
G
K
A
F
N
Y
R
S
Y
L
T
T
H
Q
R
Site 92
Y646
K
A
F
N
Y
R
S
Y
L
T
T
H
Q
R
S
Site 93
T649
N
Y
R
S
Y
L
T
T
H
Q
R
S
H
T
G
Site 94
S653
Y
L
T
T
H
Q
R
S
H
T
G
E
R
P
Y
Site 95
T655
T
T
H
Q
R
S
H
T
G
E
R
P
Y
K
C
Site 96
Y660
S
H
T
G
E
R
P
Y
K
C
E
E
C
G
K
Site 97
S673
G
K
A
F
N
S
R
S
Y
L
T
T
H
R
R
Site 98
Y674
K
A
F
N
S
R
S
Y
L
T
T
H
R
R
R
Site 99
T677
N
S
R
S
Y
L
T
T
H
R
R
R
H
T
G
Site 100
T683
T
T
H
R
R
R
H
T
G
E
R
P
Y
K
C
Site 101
Y688
R
H
T
G
E
R
P
Y
K
C
D
E
C
G
K
Site 102
S698
D
E
C
G
K
A
F
S
Y
R
S
Y
L
T
T
Site 103
Y699
E
C
G
K
A
F
S
Y
R
S
Y
L
T
T
H
Site 104
S701
G
K
A
F
S
Y
R
S
Y
L
T
T
H
R
R
Site 105
Y702
K
A
F
S
Y
R
S
Y
L
T
T
H
R
R
S
Site 106
T704
F
S
Y
R
S
Y
L
T
T
H
R
R
S
H
S
Site 107
T705
S
Y
R
S
Y
L
T
T
H
R
R
S
H
S
G
Site 108
S709
Y
L
T
T
H
R
R
S
H
S
G
E
R
P
Y
Site 109
S711
T
T
H
R
R
S
H
S
G
E
R
P
Y
K
C
Site 110
Y716
S
H
S
G
E
R
P
Y
K
C
E
E
C
G
K
Site 111
S729
G
K
A
F
N
S
R
S
Y
L
I
A
H
Q
R
Site 112
Y730
K
A
F
N
S
R
S
Y
L
I
A
H
Q
R
S
Site 113
S737
Y
L
I
A
H
Q
R
S
H
T
R
E
K
L
_
Site 114
T739
I
A
H
Q
R
S
H
T
R
E
K
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation