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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNJ12
Full Name:
ATP-sensitive inward rectifier potassium channel 12
Alias:
Hkir2.2x; IRK; IRK1; IRK2; Kcnj12x; KCNJN1; Kir2.2; Kir2.2v; Potassium inwardly-rectifying channel, subfamily J, member 12
Type:
Mass (Da):
49001
Number AA:
433
UniProt ID:
Q14500
International Prot ID:
IPI00450699
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005242
GO:0008200
GO:0015459
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006936
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
ATP-sensitive inward rectifier potassium channel 12 pan-specific antibody AB-NN278-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN278-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
A
A
S
R
A
N
P
Y
S
I
V
S
S
E
E
Site 2
S11
A
S
R
A
N
P
Y
S
I
V
S
S
E
E
D
Site 3
S15
N
P
Y
S
I
V
S
S
E
E
D
G
L
H
L
Site 4
T38
F
G
N
G
K
V
H
T
R
R
R
C
R
N
R
Site 5
S64
F
A
N
M
D
E
K
S
Q
R
Y
L
A
D
M
Site 6
T121
P
A
E
G
R
G
R
T
P
C
V
M
Q
V
H
Site 7
T193
R
P
K
K
R
A
Q
T
L
L
F
S
H
N
A
Site 8
S221
R
V
G
N
L
R
K
S
H
I
V
E
A
H
V
Site 9
T238
Q
L
I
K
P
R
V
T
E
E
G
E
Y
I
P
Site 10
Y243
R
V
T
E
E
G
E
Y
I
P
L
D
Q
I
D
Site 11
S278
L
H
E
I
D
E
A
S
P
L
F
G
I
S
R
Site 12
T290
I
S
R
Q
D
L
E
T
D
D
F
E
I
V
V
Site 13
T310
V
E
A
T
A
M
T
T
Q
A
R
S
S
Y
L
Site 14
S315
M
T
T
Q
A
R
S
S
Y
L
A
N
E
I
L
Site 15
Y316
T
T
Q
A
R
S
S
Y
L
A
N
E
I
L
W
Site 16
Y338
L
F
E
E
K
N
Q
Y
K
I
D
Y
S
H
F
Site 17
Y342
K
N
Q
Y
K
I
D
Y
S
H
F
H
K
T
Y
Site 18
T348
D
Y
S
H
F
H
K
T
Y
E
V
P
S
T
P
Site 19
Y349
Y
S
H
F
H
K
T
Y
E
V
P
S
T
P
R
Site 20
S353
H
K
T
Y
E
V
P
S
T
P
R
C
S
A
K
Site 21
T354
K
T
Y
E
V
P
S
T
P
R
C
S
A
K
D
Site 22
S358
V
P
S
T
P
R
C
S
A
K
D
L
V
E
N
Site 23
S371
E
N
K
F
L
L
P
S
A
N
S
F
C
Y
E
Site 24
S385
E
N
E
L
A
F
L
S
R
D
E
E
D
E
A
Site 25
S400
D
G
D
Q
D
G
R
S
R
D
G
L
S
P
Q
Site 26
S405
G
R
S
R
D
G
L
S
P
Q
A
R
H
D
F
Site 27
Y427
G
V
L
E
Q
R
P
Y
R
R
E
S
E
I
_
Site 28
S431
Q
R
P
Y
R
R
E
S
E
I
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation