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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HES1
Full Name:
Transcription factor HES-1
Alias:
Hairy; hairy-like; HES-1; HHL; HL; HRY; transcription factor HES-1
Type:
Mass (Da):
29541
Number AA:
280
UniProt ID:
Q14469
International Prot ID:
IPI00030964
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
D
I
M
E
K
N
S
S
S
P
V
A
A
T
Site 2
S11
D
I
M
E
K
N
S
S
S
P
V
A
A
T
P
Site 3
S12
I
M
E
K
N
S
S
S
P
V
A
A
T
P
A
Site 4
T17
S
S
S
P
V
A
A
T
P
A
S
V
N
T
T
Site 5
S20
P
V
A
A
T
P
A
S
V
N
T
T
P
D
K
Site 6
T24
T
P
A
S
V
N
T
T
P
D
K
P
K
T
A
Site 7
T30
T
T
P
D
K
P
K
T
A
S
E
H
R
K
S
Site 8
S32
P
D
K
P
K
T
A
S
E
H
R
K
S
S
K
Site 9
S37
T
A
S
E
H
R
K
S
S
K
P
I
M
E
K
Site 10
S38
A
S
E
H
R
K
S
S
K
P
I
M
E
K
R
Site 11
S53
R
R
A
R
I
N
E
S
L
S
Q
L
K
T
L
Site 12
S69
L
D
A
L
K
K
D
S
S
R
H
S
K
L
E
Site 13
S70
D
A
L
K
K
D
S
S
R
H
S
K
L
E
K
Site 14
S73
K
K
D
S
S
R
H
S
K
L
E
K
A
D
I
Site 15
T84
K
A
D
I
L
E
M
T
V
K
H
L
R
N
L
Site 16
S105
A
A
L
S
T
D
P
S
V
L
G
K
Y
R
A
Site 17
Y110
D
P
S
V
L
G
K
Y
R
A
G
F
S
E
C
Site 18
S126
N
E
V
T
R
F
L
S
T
C
E
G
V
N
T
Site 19
T133
S
T
C
E
G
V
N
T
E
V
R
T
R
L
L
Site 20
Y155
T
Q
I
N
A
M
T
Y
P
G
Q
P
H
P
A
Site 21
S207
G
A
P
C
K
L
G
S
Q
A
G
E
A
A
K
Site 22
Y248
S
G
P
V
I
P
V
Y
T
S
N
S
G
T
S
Site 23
S252
I
P
V
Y
T
S
N
S
G
T
S
V
G
P
N
Site 24
T254
V
Y
T
S
N
S
G
T
S
V
G
P
N
A
V
Site 25
S262
S
V
G
P
N
A
V
S
P
S
S
G
P
S
L
Site 26
S264
G
P
N
A
V
S
P
S
S
G
P
S
L
T
A
Site 27
S265
P
N
A
V
S
P
S
S
G
P
S
L
T
A
D
Site 28
S268
V
S
P
S
S
G
P
S
L
T
A
D
S
M
W
Site 29
T270
P
S
S
G
P
S
L
T
A
D
S
M
W
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation