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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2B1
Full Name:
Translation initiation factor eIF-2B subunit alpha
Alias:
EI2BA; EIF2B; EIF-2B; EIF-2B GDP-GTP exchange factor; EIF-2B GDP-GTP exchange factor subunit alpha; EIF2BA; EIF-2Balpha; Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Translation initiation factor eIF-2B alpha
Type:
Translation
Mass (Da):
33712
Number AA:
305
UniProt ID:
Q14232
International Prot ID:
IPI00221300
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003743
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
GO:0006413
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
D
D
K
E
L
I
E
Y
F
K
S
Q
M
K
E
Site 2
S12
E
L
I
E
Y
F
K
S
Q
M
K
E
D
P
D
Site 3
T29
S
A
V
A
A
I
R
T
L
L
E
F
L
K
R
Site 4
T41
L
K
R
D
K
G
E
T
I
Q
G
L
R
A
N
Site 5
S80
L
R
F
I
S
L
A
S
L
E
Y
S
D
Y
S
Site 6
Y83
I
S
L
A
S
L
E
Y
S
D
Y
S
K
C
K
Site 7
S84
S
L
A
S
L
E
Y
S
D
Y
S
K
C
K
K
Site 8
Y86
A
S
L
E
Y
S
D
Y
S
K
C
K
K
I
M
Site 9
S105
E
L
F
L
R
R
I
S
L
S
R
N
K
I
A
Site 10
S107
F
L
R
R
I
S
L
S
R
N
K
I
A
D
L
Site 11
T127
K
D
G
A
T
I
L
T
H
A
Y
S
R
V
V
Site 12
Y130
A
T
I
L
T
H
A
Y
S
R
V
V
L
R
V
Site 13
S149
V
A
A
K
K
R
F
S
V
Y
V
T
E
S
Q
Site 14
Y151
A
K
K
R
F
S
V
Y
V
T
E
S
Q
P
D
Site 15
T153
K
R
F
S
V
Y
V
T
E
S
Q
P
D
L
S
Site 16
S155
F
S
V
Y
V
T
E
S
Q
P
D
L
S
G
K
Site 17
S160
T
E
S
Q
P
D
L
S
G
K
K
M
A
K
A
Site 18
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Site 19
Y252
D
V
P
D
K
F
K
Y
K
A
D
T
L
K
V
Site 20
T256
K
F
K
Y
K
A
D
T
L
K
V
A
Q
T
G
Site 21
Y275
E
E
H
P
W
V
D
Y
T
A
P
S
L
I
T
Site 22
T276
E
H
P
W
V
D
Y
T
A
P
S
L
I
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation