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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYNC1H1
Full Name:
Cytoplasmic dynein 1 heavy chain 1
Alias:
Cytoplasmic dynein heavy chain 1; DHC1; DNCH1; Dnchc1; DNCL; DNECL; DYHC; DYHC1; Dynein heavy chain, cytosolic; Dynein, cytoplasmic 1, heavy chain 1; HL-3; KIAA0325; P22
Type:
Motor protein
Mass (Da):
532408
Number AA:
4646
UniProt ID:
Q14204
International Prot ID:
IPI00456969
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005868
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042623
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0007052
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
E
P
G
G
G
G
G
Site 2
S13
G
G
G
G
E
D
G
S
A
G
L
E
V
S
A
Site 3
S28
V
Q
N
V
A
D
V
S
V
L
Q
K
H
L
R
Site 4
S60
E
A
A
L
E
E
K
S
A
L
E
Q
M
R
K
Site 5
S70
E
Q
M
R
K
F
L
S
D
P
Q
V
H
T
V
Site 6
T76
L
S
D
P
Q
V
H
T
V
L
V
E
R
S
T
Site 7
T83
T
V
L
V
E
R
S
T
L
K
E
D
V
G
D
Site 8
Y101
E
E
K
E
F
I
S
Y
N
I
N
I
D
I
H
Site 9
Y109
N
I
N
I
D
I
H
Y
G
V
K
S
N
S
L
Site 10
S113
D
I
H
Y
G
V
K
S
N
S
L
A
F
I
K
Site 11
S115
H
Y
G
V
K
S
N
S
L
A
F
I
K
R
T
Site 12
T122
S
L
A
F
I
K
R
T
P
V
I
D
A
D
K
Site 13
S133
D
A
D
K
P
V
S
S
Q
L
R
V
L
T
L
Site 14
T139
S
S
Q
L
R
V
L
T
L
S
E
D
S
P
Y
Site 15
S141
Q
L
R
V
L
T
L
S
E
D
S
P
Y
E
T
Site 16
S144
V
L
T
L
S
E
D
S
P
Y
E
T
L
H
S
Site 17
Y146
T
L
S
E
D
S
P
Y
E
T
L
H
S
F
I
Site 18
T148
S
E
D
S
P
Y
E
T
L
H
S
F
I
S
N
Site 19
S151
S
P
Y
E
T
L
H
S
F
I
S
N
A
V
A
Site 20
S163
A
V
A
P
F
F
K
S
Y
I
R
E
S
G
K
Site 21
Y164
V
A
P
F
F
K
S
Y
I
R
E
S
G
K
A
Site 22
S168
F
K
S
Y
I
R
E
S
G
K
A
D
R
D
G
Site 23
S181
D
G
D
K
M
A
P
S
V
E
K
K
I
A
E
Site 24
Y221
T
N
V
A
K
Q
C
Y
E
R
G
E
K
P
K
Site 25
T240
G
D
K
V
E
D
P
T
F
L
N
Q
L
Q
S
Site 26
S268
K
L
D
R
D
P
A
S
G
T
A
L
Q
E
I
Site 27
S276
G
T
A
L
Q
E
I
S
F
W
L
N
L
E
R
Site 28
Y286
L
N
L
E
R
A
L
Y
R
I
Q
E
K
R
E
Site 29
S294
R
I
Q
E
K
R
E
S
P
E
V
L
L
T
L
Site 30
T313
H
G
K
R
F
H
A
T
V
S
F
D
T
D
T
Site 31
S315
K
R
F
H
A
T
V
S
F
D
T
D
T
G
L
Site 32
T320
T
V
S
F
D
T
D
T
G
L
K
Q
A
L
E
Site 33
T328
G
L
K
Q
A
L
E
T
V
N
D
Y
N
P
L
Site 34
Y332
A
L
E
T
V
N
D
Y
N
P
L
M
K
D
F
Site 35
T362
Q
A
L
V
A
I
F
T
H
L
R
K
I
R
N
Site 36
T370
H
L
R
K
I
R
N
T
K
Y
P
I
Q
R
A
Site 37
Y372
R
K
I
R
N
T
K
Y
P
I
Q
R
A
L
R
Site 38
Y406
R
K
L
M
H
V
A
Y
E
E
F
E
K
V
M
Site 39
Y427
F
Q
T
W
D
D
E
Y
E
K
L
Q
V
L
L
Site 40
Y527
I
E
E
V
N
L
A
Y
E
N
V
K
E
V
D
Site 41
S539
E
V
D
G
L
D
V
S
K
E
G
T
E
A
W
Site 42
T543
L
D
V
S
K
E
G
T
E
A
W
E
A
A
M
Site 43
T562
E
R
I
D
R
V
E
T
R
I
T
A
R
L
R
Site 44
T565
D
R
V
E
T
R
I
T
A
R
L
R
D
Q
L
Site 45
T574
R
L
R
D
Q
L
G
T
A
K
N
A
N
E
M
Site 46
S586
N
E
M
F
R
I
F
S
R
F
N
A
L
F
V
Site 47
Y604
I
R
G
A
I
R
E
Y
Q
T
Q
L
I
Q
R
Site 48
S618
R
V
K
D
D
I
E
S
L
H
D
K
F
K
V
Site 49
Y627
H
D
K
F
K
V
Q
Y
P
Q
S
Q
A
C
K
Site 50
S636
Q
S
Q
A
C
K
M
S
H
V
R
D
L
P
P
Site 51
T659
K
Q
I
D
R
Q
L
T
A
Y
M
K
R
V
E
Site 52
Y661
I
D
R
Q
L
T
A
Y
M
K
R
V
E
D
V
Site 53
S688
K
L
K
Q
D
G
D
S
F
R
M
K
L
N
T
Site 54
S714
Q
Q
R
N
L
G
V
S
G
R
I
F
T
I
E
Site 55
T719
G
V
S
G
R
I
F
T
I
E
S
T
R
V
R
Site 56
S722
G
R
I
F
T
I
E
S
T
R
V
R
G
R
T
Site 57
T723
R
I
F
T
I
E
S
T
R
V
R
G
R
T
G
Site 58
T729
S
T
R
V
R
G
R
T
G
N
V
L
K
L
K
Site 59
T745
N
F
L
P
E
I
I
T
L
S
K
E
V
R
N
Site 60
S747
L
P
E
I
I
T
L
S
K
E
V
R
N
L
K
Site 61
S784
F
A
I
S
L
I
E
S
V
R
T
Y
E
R
T
Site 62
T787
S
L
I
E
S
V
R
T
Y
E
R
T
C
E
K
Site 63
Y788
L
I
E
S
V
R
T
Y
E
R
T
C
E
K
V
Site 64
T791
S
V
R
T
Y
E
R
T
C
E
K
V
E
E
R
Site 65
T800
E
K
V
E
E
R
N
T
I
S
L
L
V
A
G
Site 66
Y832
E
S
Y
K
L
D
P
Y
V
Q
R
L
A
E
T
Site 67
T839
Y
V
Q
R
L
A
E
T
V
F
N
F
Q
E
K
Site 68
S863
K
I
D
L
E
V
R
S
L
E
T
C
M
Y
D
Site 69
T866
L
E
V
R
S
L
E
T
C
M
Y
D
H
K
T
Site 70
Y869
R
S
L
E
T
C
M
Y
D
H
K
T
F
S
E
Site 71
T873
T
C
M
Y
D
H
K
T
F
S
E
I
L
N
R
Site 72
S892
V
D
D
L
N
L
H
S
Y
S
N
L
P
I
W
Site 73
Y893
D
D
L
N
L
H
S
Y
S
N
L
P
I
W
V
Site 74
T940
K
A
E
V
D
M
D
T
D
A
P
Q
V
S
H
Site 75
S946
D
T
D
A
P
Q
V
S
H
K
P
G
G
E
P
Site 76
Y970
R
I
T
N
Q
V
I
Y
L
N
P
P
I
E
E
Site 77
Y980
P
P
I
E
E
C
R
Y
K
L
Y
Q
E
M
F
Site 78
Y983
E
E
C
R
Y
K
L
Y
Q
E
M
F
A
W
K
Site 79
S995
A
W
K
M
V
V
L
S
L
P
R
I
Q
S
Q
Site 80
S1001
L
S
L
P
R
I
Q
S
Q
R
Y
Q
V
G
V
Site 81
Y1004
P
R
I
Q
S
Q
R
Y
Q
V
G
V
H
Y
E
Site 82
Y1010
R
Y
Q
V
G
V
H
Y
E
L
T
E
E
E
K
Site 83
T1013
V
G
V
H
Y
E
L
T
E
E
E
K
F
Y
R
Site 84
Y1019
L
T
E
E
E
K
F
Y
R
N
A
L
T
R
M
Site 85
T1024
K
F
Y
R
N
A
L
T
R
M
P
D
G
P
V
Site 86
Y1069
D
M
Q
A
E
N
I
Y
N
R
L
G
E
D
L
Site 87
T1092
Q
I
R
K
A
R
G
T
F
D
N
A
E
T
K
Site 88
S1114
I
D
Y
G
K
V
Q
S
K
V
N
L
K
Y
D
Site 89
Y1120
Q
S
K
V
N
L
K
Y
D
S
W
H
K
E
V
Site 90
S1129
S
W
H
K
E
V
L
S
K
F
G
Q
M
L
G
Site 91
T1140
Q
M
L
G
S
N
M
T
E
F
H
S
Q
I
S
Site 92
S1144
S
N
M
T
E
F
H
S
Q
I
S
K
S
R
Q
Site 93
S1149
F
H
S
Q
I
S
K
S
R
Q
E
L
E
Q
H
Site 94
S1157
R
Q
E
L
E
Q
H
S
V
D
T
A
S
T
S
Site 95
T1160
L
E
Q
H
S
V
D
T
A
S
T
S
D
A
V
Site 96
S1162
Q
H
S
V
D
T
A
S
T
S
D
A
V
T
F
Site 97
S1164
S
V
D
T
A
S
T
S
D
A
V
T
F
I
T
Site 98
T1168
A
S
T
S
D
A
V
T
F
I
T
Y
V
Q
S
Site 99
T1171
S
D
A
V
T
F
I
T
Y
V
Q
S
L
K
R
Site 100
Y1172
D
A
V
T
F
I
T
Y
V
Q
S
L
K
R
K
Site 101
S1175
T
F
I
T
Y
V
Q
S
L
K
R
K
I
K
Q
Site 102
Y1210
Q
F
P
P
S
W
L
Y
I
D
N
I
E
G
E
Site 103
S1230
D
I
M
R
R
K
D
S
A
I
Q
Q
Q
V
A
Site 104
T1255
R
A
V
E
S
R
T
T
D
L
L
T
D
W
E
Site 105
T1259
S
R
T
T
D
L
L
T
D
W
E
K
T
K
P
Site 106
Y1283
A
L
Q
A
L
T
I
Y
E
G
K
F
G
R
L
Site 107
T1309
E
A
L
E
L
T
D
T
G
L
L
S
G
S
E
Site 108
S1313
L
T
D
T
G
L
L
S
G
S
E
E
R
V
Q
Site 109
S1315
D
T
G
L
L
S
G
S
E
E
R
V
Q
V
A
Site 110
S1334
Q
D
L
K
G
V
W
S
E
L
S
K
V
W
E
Site 111
S1353
M
K
E
Q
P
W
V
S
V
Q
P
R
K
L
R
Site 112
S1372
A
L
L
N
Q
L
K
S
F
P
A
R
L
R
Q
Site 113
Y1380
F
P
A
R
L
R
Q
Y
A
S
Y
E
F
V
Q
Site 114
S1382
A
R
L
R
Q
Y
A
S
Y
E
F
V
Q
R
L
Site 115
Y1383
R
L
R
Q
Y
A
S
Y
E
F
V
Q
R
L
L
Site 116
T1472
Q
I
R
E
V
W
N
T
Y
E
L
D
L
V
N
Site 117
Y1480
Y
E
L
D
L
V
N
Y
Q
N
K
C
R
L
I
Site 118
S1503
K
V
K
E
H
I
N
S
V
S
A
M
K
L
S
Site 119
S1505
K
E
H
I
N
S
V
S
A
M
K
L
S
P
Y
Site 120
S1510
S
V
S
A
M
K
L
S
P
Y
Y
K
V
F
E
Site 121
Y1512
S
A
M
K
L
S
P
Y
Y
K
V
F
E
E
D
Site 122
Y1513
A
M
K
L
S
P
Y
Y
K
V
F
E
E
D
A
Site 123
S1522
V
F
E
E
D
A
L
S
W
E
D
K
L
N
R
Site 124
Y1546
D
V
Q
R
R
W
V
Y
L
E
G
I
F
T
G
Site 125
T1565
K
H
L
L
P
V
E
T
Q
R
F
Q
S
I
S
Site 126
S1570
V
E
T
Q
R
F
Q
S
I
S
T
E
F
L
A
Site 127
S1600
N
I
Q
G
V
Q
R
S
L
E
R
L
A
D
L
Site 128
Y1618
I
Q
K
A
L
G
E
Y
L
E
R
E
R
S
S
Site 129
S1624
E
Y
L
E
R
E
R
S
S
F
P
R
F
Y
F
Site 130
S1625
Y
L
E
R
E
R
S
S
F
P
R
F
Y
F
V
Site 131
Y1630
R
S
S
F
P
R
F
Y
F
V
G
D
E
D
L
Site 132
S1677
N
S
V
V
L
G
I
S
S
R
E
G
E
E
V
Site 133
T1688
G
E
E
V
M
F
K
T
P
V
S
I
T
E
H
Site 134
T1703
P
K
I
N
E
W
L
T
L
V
E
K
E
M
R
Site 135
S1732
E
I
F
G
K
A
T
S
I
D
P
N
T
Y
I
Site 136
T1737
A
T
S
I
D
P
N
T
Y
I
T
W
I
D
K
Site 137
T1764
A
W
S
E
N
V
E
T
A
L
S
S
M
G
G
Site 138
S1767
E
N
V
E
T
A
L
S
S
M
G
G
G
G
D
Site 139
S1768
N
V
E
T
A
L
S
S
M
G
G
G
G
D
A
Site 140
T1813
R
K
L
E
H
L
I
T
E
L
V
H
Q
R
D
Site 141
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Q
R
L
S
I
I
T
Site 293
S3857
T
D
H
T
Q
R
L
S
I
I
T
K
D
L
F
Site 294
T3895
A
R
I
K
L
K
G
T
V
G
E
P
T
Y
D
Site 295
Y3901
G
T
V
G
E
P
T
Y
D
A
E
F
Q
H
F
Site 296
S3917
R
G
N
E
I
V
L
S
A
G
S
T
P
R
I
Site 297
T3928
T
P
R
I
Q
G
L
T
V
E
Q
A
E
A
V
Site 298
S3963
Q
F
G
I
W
L
D
S
S
S
P
E
Q
T
V
Site 299
S3964
F
G
I
W
L
D
S
S
S
P
E
Q
T
V
P
Site 300
S3965
G
I
W
L
D
S
S
S
P
E
Q
T
V
P
Y
Site 301
T3969
D
S
S
S
P
E
Q
T
V
P
Y
L
W
S
E
Site 302
Y3972
S
P
E
Q
T
V
P
Y
L
W
S
E
E
T
P
Site 303
T3978
P
Y
L
W
S
E
E
T
P
A
T
P
I
G
Q
Site 304
T3981
W
S
E
E
T
P
A
T
P
I
G
Q
A
I
H
Site 305
S4016
V
S
T
N
L
G
E
S
F
M
S
I
M
E
Q
Site 306
S4019
N
L
G
E
S
F
M
S
I
M
E
Q
P
L
D
Site 307
S4052
S
V
P
G
Y
D
A
S
G
H
V
E
D
L
A
Site 308
T4086
Q
A
D
K
A
I
N
T
A
V
K
S
G
R
W
Site 309
T4127
A
C
F
R
L
F
L
T
M
E
I
N
P
K
V
Site 310
S4167
T
F
S
S
I
P
V
S
R
I
C
K
S
P
N
Site 311
S4172
P
V
S
R
I
C
K
S
P
N
E
R
A
R
L
Site 312
Y4180
P
N
E
R
A
R
L
Y
F
L
L
A
W
F
H
Site 313
Y4196
I
I
Q
E
R
L
R
Y
A
P
L
G
W
S
K
Site 314
Y4205
P
L
G
W
S
K
K
Y
E
F
G
E
S
D
L
Site 315
S4210
K
K
Y
E
F
G
E
S
D
L
R
S
A
C
D
Site 316
S4214
F
G
E
S
D
L
R
S
A
C
D
T
V
D
T
Site 317
T4218
D
L
R
S
A
C
D
T
V
D
T
W
L
D
D
Site 318
T4221
S
A
C
D
T
V
D
T
W
L
D
D
T
A
K
Site 319
T4226
V
D
T
W
L
D
D
T
A
K
G
R
Q
N
I
Site 320
S4234
A
K
G
R
Q
N
I
S
P
D
K
I
P
W
S
Site 321
S4241
S
P
D
K
I
P
W
S
A
L
K
T
L
M
A
Site 322
S4250
L
K
T
L
M
A
Q
S
I
Y
G
G
R
V
D
Site 323
T4267
F
D
Q
R
L
L
N
T
F
L
E
R
L
F
T
Site 324
T4274
T
F
L
E
R
L
F
T
T
R
S
F
D
S
E
Site 325
S4277
E
R
L
F
T
T
R
S
F
D
S
E
F
K
L
Site 326
S4280
F
T
T
R
S
F
D
S
E
F
K
L
A
C
K
Site 327
T4315
W
V
E
L
L
P
D
T
Q
T
P
S
W
L
G
Site 328
T4317
E
L
L
P
D
T
Q
T
P
S
W
L
G
L
P
Site 329
S4319
L
P
D
T
Q
T
P
S
W
L
G
L
P
N
N
Site 330
Y4357
E
D
E
D
D
L
A
Y
A
E
T
E
K
K
T
Site 331
T4360
D
D
L
A
Y
A
E
T
E
K
K
T
R
T
D
Site 332
T4364
Y
A
E
T
E
K
K
T
R
T
D
S
T
S
D
Site 333
T4366
E
T
E
K
K
T
R
T
D
S
T
S
D
G
R
Site 334
S4368
E
K
K
T
R
T
D
S
T
S
D
G
R
P
A
Site 335
T4369
K
K
T
R
T
D
S
T
S
D
G
R
P
A
W
Site 336
S4370
K
T
R
T
D
S
T
S
D
G
R
P
A
W
M
Site 337
T4379
G
R
P
A
W
M
R
T
L
H
T
T
A
S
N
Site 338
T4394
W
L
H
L
I
P
Q
T
L
S
H
L
K
R
T
Site 339
S4396
H
L
I
P
Q
T
L
S
H
L
K
R
T
V
E
Site 340
Y4447
G
K
K
K
Q
T
N
Y
L
R
T
L
I
N
E
Site 341
S4463
V
K
G
I
L
P
R
S
W
S
H
Y
T
V
P
Site 342
S4465
G
I
L
P
R
S
W
S
H
Y
T
V
P
A
G
Site 343
Y4467
L
P
R
S
W
S
H
Y
T
V
P
A
G
M
T
Site 344
T4468
P
R
S
W
S
H
Y
T
V
P
A
G
M
T
V
Site 345
Y4527
Y
I
T
A
T
R
Q
Y
V
A
Q
A
N
S
W
Site 346
S4535
V
A
Q
A
N
S
W
S
L
E
E
L
C
L
E
Site 347
S4576
T
C
N
N
N
K
L
S
L
S
N
A
I
S
T
Site 348
S4578
N
N
N
K
L
S
L
S
N
A
I
S
T
A
L
Site 349
T4583
S
L
S
N
A
I
S
T
A
L
P
L
T
Q
L
Site 350
T4588
I
S
T
A
L
P
L
T
Q
L
R
W
V
K
Q
Site 351
T4596
Q
L
R
W
V
K
Q
T
N
T
E
K
K
A
S
Site 352
S4603
T
N
T
E
K
K
A
S
V
V
T
L
P
V
Y
Site 353
T4614
L
P
V
Y
L
N
F
T
R
A
D
L
I
F
T
Site 354
S4634
A
T
K
E
D
P
R
S
F
Y
E
R
G
V
A
Site 355
Y4636
K
E
D
P
R
S
F
Y
E
R
G
V
A
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation