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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WRN
Full Name:
Werner syndrome ATP-dependent helicase
Alias:
RECQ3; RECQL2; RECQL3; Werner syndrome (RECQL2); Werner Syndrome helicase; Werner syndrome, RecQ helicase-like
Type:
Helicase; EC 3.6.1.-; Cell cycle regulation; DNA repair; DNA binding protein
Mass (Da):
162495
Number AA:
1432
UniProt ID:
Q14191
International Prot ID:
IPI00029107
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008408
GO:0005524
GO:0043140
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0000731
GO:0006284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
R
K
A
C
V
R
K
S
V
F
E
D
D
L
P
Site 2
S56
F
T
G
S
I
V
Y
S
Y
D
A
S
D
C
S
Site 3
Y57
T
G
S
I
V
Y
S
Y
D
A
S
D
C
S
F
Site 4
S60
I
V
Y
S
Y
D
A
S
D
C
S
F
L
S
E
Site 5
S63
S
Y
D
A
S
D
C
S
F
L
S
E
D
I
S
Site 6
S70
S
F
L
S
E
D
I
S
M
S
L
S
D
G
D
Site 7
Y89
D
M
E
W
P
P
L
Y
N
R
G
K
L
G
K
Site 8
T172
A
N
K
K
L
K
C
T
E
T
W
S
L
N
S
Site 9
T174
K
K
L
K
C
T
E
T
W
S
L
N
S
L
V
Site 10
S176
L
K
C
T
E
T
W
S
L
N
S
L
V
K
H
Site 11
S179
T
E
T
W
S
L
N
S
L
V
K
H
L
L
G
Site 12
S194
K
Q
L
L
K
D
K
S
I
R
C
S
N
W
S
Site 13
S198
K
D
K
S
I
R
C
S
N
W
S
K
F
P
L
Site 14
S201
S
I
R
C
S
N
W
S
K
F
P
L
T
E
D
Site 15
T206
N
W
S
K
F
P
L
T
E
D
Q
K
L
Y
A
Site 16
Y212
L
T
E
D
Q
K
L
Y
A
A
T
D
A
Y
A
Site 17
T233
N
L
E
I
L
D
D
T
V
Q
R
F
A
I
N
Site 18
S248
K
E
E
E
I
L
L
S
D
M
N
K
Q
L
T
Site 19
S256
D
M
N
K
Q
L
T
S
I
S
E
E
V
M
D
Site 20
S258
N
K
Q
L
T
S
I
S
E
E
V
M
D
L
A
Site 21
S273
K
H
L
P
H
A
F
S
K
L
E
N
P
R
R
Site 22
S282
L
E
N
P
R
R
V
S
I
L
L
K
D
I
S
Site 23
S289
S
I
L
L
K
D
I
S
E
N
L
Y
S
L
R
Site 24
Y293
K
D
I
S
E
N
L
Y
S
L
R
R
M
I
I
Site 25
S294
D
I
S
E
N
L
Y
S
L
R
R
M
I
I
G
Site 26
S302
L
R
R
M
I
I
G
S
T
N
I
E
T
E
L
Site 27
T307
I
G
S
T
N
I
E
T
E
L
R
P
S
N
N
Site 28
S312
I
E
T
E
L
R
P
S
N
N
L
N
L
L
S
Site 29
S319
S
N
N
L
N
L
L
S
F
E
D
S
T
T
G
Site 30
S323
N
L
L
S
F
E
D
S
T
T
G
G
V
Q
Q
Site 31
T325
L
S
F
E
D
S
T
T
G
G
V
Q
Q
K
Q
Site 32
T346
L
I
H
V
E
D
E
T
W
D
P
T
L
D
H
Site 33
T350
E
D
E
T
W
D
P
T
L
D
H
L
A
K
H
Site 34
S394
M
E
R
A
C
L
M
S
L
D
I
T
E
H
E
Site 35
S409
L
Q
I
L
E
Q
Q
S
Q
E
E
Y
L
S
D
Site 36
Y413
E
Q
Q
S
Q
E
E
Y
L
S
D
I
A
Y
K
Site 37
S415
Q
S
Q
E
E
Y
L
S
D
I
A
Y
K
S
T
Site 38
Y419
E
Y
L
S
D
I
A
Y
K
S
T
E
H
L
S
Site 39
S421
L
S
D
I
A
Y
K
S
T
E
H
L
S
P
N
Site 40
T422
S
D
I
A
Y
K
S
T
E
H
L
S
P
N
D
Site 41
S426
Y
K
S
T
E
H
L
S
P
N
D
N
E
N
D
Site 42
T434
P
N
D
N
E
N
D
T
S
Y
V
I
E
S
D
Site 43
S435
N
D
N
E
N
D
T
S
Y
V
I
E
S
D
E
Site 44
Y436
D
N
E
N
D
T
S
Y
V
I
E
S
D
E
D
Site 45
S440
D
T
S
Y
V
I
E
S
D
E
D
L
E
M
E
Site 46
S453
M
E
M
L
K
H
L
S
P
N
D
N
E
N
D
Site 47
S478
L
E
M
E
M
L
K
S
L
E
N
L
N
S
G
Site 48
S484
K
S
L
E
N
L
N
S
G
T
V
E
P
T
H
Site 49
T486
L
E
N
L
N
S
G
T
V
E
P
T
H
S
K
Site 50
S492
G
T
V
E
P
T
H
S
K
C
L
K
M
E
R
Site 51
T538
A
P
N
E
E
Q
V
T
C
L
K
M
Y
F
G
Site 52
Y543
Q
V
T
C
L
K
M
Y
F
G
H
S
S
F
K
Site 53
S559
V
Q
W
K
V
I
H
S
V
L
E
E
R
R
D
Site 54
Y583
G
K
S
L
C
F
Q
Y
P
P
V
Y
V
G
K
Site 55
T629
A
Q
S
E
N
V
L
T
D
I
K
L
G
K
Y
Site 56
Y636
T
D
I
K
L
G
K
Y
R
I
V
Y
V
T
P
Site 57
Y640
L
G
K
Y
R
I
V
Y
V
T
P
E
Y
C
S
Site 58
T642
K
Y
R
I
V
Y
V
T
P
E
Y
C
S
G
N
Site 59
S683
W
G
H
D
F
R
D
S
F
R
K
L
G
S
L
Site 60
S689
D
S
F
R
K
L
G
S
L
K
T
A
L
P
M
Site 61
S709
L
T
A
T
A
S
S
S
I
R
E
D
I
V
R
Site 62
T726
N
L
R
N
P
Q
I
T
C
T
G
F
D
R
P
Site 63
T728
R
N
P
Q
I
T
C
T
G
F
D
R
P
N
L
Site 64
Y736
G
F
D
R
P
N
L
Y
L
E
V
R
R
K
T
Site 65
T743
Y
L
E
V
R
R
K
T
G
N
I
L
Q
D
L
Site 66
S759
P
F
L
V
K
T
S
S
H
W
E
F
E
G
P
Site 67
Y770
F
E
G
P
T
I
I
Y
C
P
S
R
K
M
T
Site 68
T777
Y
C
P
S
R
K
M
T
Q
Q
V
T
G
E
L
Site 69
S790
E
L
R
K
L
N
L
S
C
G
T
Y
H
A
G
Site 70
S799
G
T
Y
H
A
G
M
S
F
S
T
R
K
D
I
Site 71
S801
Y
H
A
G
M
S
F
S
T
R
K
D
I
H
H
Site 72
Y839
D
I
R
Q
V
I
H
Y
G
A
P
K
D
M
E
Site 73
Y849
P
K
D
M
E
S
Y
Y
Q
E
I
G
R
A
G
Site 74
S862
A
G
R
D
G
L
Q
S
S
C
H
V
L
W
A
Site 75
S863
G
R
D
G
L
Q
S
S
C
H
V
L
W
A
P
Site 76
Y891
R
N
E
K
F
R
L
Y
K
L
K
M
M
A
K
Site 77
Y902
M
M
A
K
M
E
K
Y
L
H
S
S
R
C
R
Site 78
S905
K
M
E
K
Y
L
H
S
S
R
C
R
R
Q
I
Site 79
S915
C
R
R
Q
I
I
L
S
H
F
E
D
K
Q
V
Site 80
Y947
R
S
R
L
D
H
C
Y
S
M
D
D
S
E
D
Site 81
S948
S
R
L
D
H
C
Y
S
M
D
D
S
E
D
T
Site 82
T955
S
M
D
D
S
E
D
T
S
W
D
F
G
P
Q
Site 83
S956
M
D
D
S
E
D
T
S
W
D
F
G
P
Q
A
Site 84
S968
P
Q
A
F
K
L
L
S
A
V
D
I
L
G
E
Site 85
S989
P
I
L
F
L
R
G
S
N
S
Q
R
L
A
D
Site 86
S991
L
F
L
R
G
S
N
S
Q
R
L
A
D
Q
Y
Site 87
Y998
S
Q
R
L
A
D
Q
Y
R
R
H
S
L
F
G
Site 88
S1002
A
D
Q
Y
R
R
H
S
L
F
G
T
G
K
D
Site 89
T1006
R
R
H
S
L
F
G
T
G
K
D
Q
T
E
S
Site 90
T1056
N
W
L
H
K
A
N
T
E
S
Q
S
L
I
L
Site 91
S1058
L
H
K
A
N
T
E
S
Q
S
L
I
L
Q
A
Site 92
S1078
P
K
K
F
L
L
P
S
S
K
T
V
S
S
G
Site 93
S1079
K
K
F
L
L
P
S
S
K
T
V
S
S
G
T
Site 94
T1081
F
L
L
P
S
S
K
T
V
S
S
G
T
K
E
Site 95
S1083
L
P
S
S
K
T
V
S
S
G
T
K
E
H
C
Site 96
S1084
P
S
S
K
T
V
S
S
G
T
K
E
H
C
Y
Site 97
Y1091
S
G
T
K
E
H
C
Y
N
Q
V
P
V
E
L
Site 98
S1099
N
Q
V
P
V
E
L
S
T
E
K
K
S
N
L
Site 99
S1104
E
L
S
T
E
K
K
S
N
L
E
K
L
Y
S
Site 100
S1111
S
N
L
E
K
L
Y
S
Y
K
P
C
D
K
I
Site 101
S1119
Y
K
P
C
D
K
I
S
S
G
S
N
I
S
K
Site 102
S1120
K
P
C
D
K
I
S
S
G
S
N
I
S
K
K
Site 103
S1122
C
D
K
I
S
S
G
S
N
I
S
K
K
S
I
Site 104
S1128
G
S
N
I
S
K
K
S
I
M
V
Q
S
P
E
Site 105
S1133
K
K
S
I
M
V
Q
S
P
E
K
A
Y
S
S
Site 106
S1139
Q
S
P
E
K
A
Y
S
S
S
Q
P
V
I
S
Site 107
S1140
S
P
E
K
A
Y
S
S
S
Q
P
V
I
S
A
Site 108
S1141
P
E
K
A
Y
S
S
S
Q
P
V
I
S
A
Q
Site 109
S1146
S
S
S
Q
P
V
I
S
A
Q
E
Q
E
T
Q
Site 110
T1193
D
M
A
K
M
R
P
T
T
V
E
N
V
K
R
Site 111
T1194
M
A
K
M
R
P
T
T
V
E
N
V
K
R
I
Site 112
S1205
V
K
R
I
D
G
V
S
E
G
K
A
A
M
L
Site 113
T1244
K
P
Q
E
E
Q
K
T
S
L
V
A
K
N
K
Site 114
S1245
P
Q
E
E
Q
K
T
S
L
V
A
K
N
K
I
Site 115
S1256
K
N
K
I
C
T
L
S
Q
S
M
A
I
T
Y
Site 116
T1262
L
S
Q
S
M
A
I
T
Y
S
L
F
Q
E
K
Site 117
S1264
Q
S
M
A
I
T
Y
S
L
F
Q
E
K
K
M
Site 118
S1275
E
K
K
M
P
L
K
S
I
A
E
S
R
I
L
Site 119
S1292
M
T
I
G
M
H
L
S
Q
A
V
K
A
G
C
Site 120
T1309
D
L
E
R
A
G
L
T
P
E
V
Q
K
I
I
Site 121
S1327
I
R
N
P
P
V
N
S
D
M
S
K
I
S
L
Site 122
S1330
P
P
V
N
S
D
M
S
K
I
S
L
I
R
M
Site 123
S1361
I
L
K
H
G
P
D
S
G
L
Q
P
S
C
D
Site 124
S1366
P
D
S
G
L
Q
P
S
C
D
V
N
K
R
R
Site 125
S1378
K
R
R
C
F
P
G
S
E
E
I
C
S
S
S
Site 126
S1383
P
G
S
E
E
I
C
S
S
S
K
R
S
K
E
Site 127
S1384
G
S
E
E
I
C
S
S
S
K
R
S
K
E
E
Site 128
S1385
S
E
E
I
C
S
S
S
K
R
S
K
E
E
V
Site 129
S1388
I
C
S
S
S
K
R
S
K
E
E
V
G
I
N
Site 130
T1396
K
E
E
V
G
I
N
T
E
T
S
S
A
E
R
Site 131
S1400
G
I
N
T
E
T
S
S
A
E
R
K
R
R
L
Site 132
T1425
S
K
K
L
M
D
K
T
K
R
G
G
L
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation