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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIM2
Full Name:
Single-minded homolog 2
Alias:
Class E basic helix-loop-helix protein 15
Type:
Mass (Da):
73219
Number AA:
667
UniProt ID:
Q14190
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
K
S
K
N
A
A
K
T
R
R
E
K
E
N
G
Site 2
Y21
E
K
E
N
G
E
F
Y
E
L
A
K
L
L
P
Site 3
S41
T
S
Q
L
D
K
A
S
I
I
R
L
T
T
S
Site 4
T46
K
A
S
I
I
R
L
T
T
S
Y
L
K
M
R
Site 5
S68
G
D
A
W
G
Q
P
S
R
A
G
P
L
D
G
Site 6
Y125
E
L
T
G
N
S
I
Y
E
Y
I
H
P
S
D
Site 7
Y127
T
G
N
S
I
Y
E
Y
I
H
P
S
D
H
D
Site 8
T137
P
S
D
H
D
E
M
T
A
V
L
T
A
H
Q
Site 9
Y154
H
H
H
L
L
Q
E
Y
E
I
E
R
S
F
F
Site 10
T176
A
K
R
N
A
G
L
T
C
S
G
Y
K
V
I
Site 11
Y188
K
V
I
H
C
S
G
Y
L
K
I
R
Q
Y
M
Site 12
Y194
G
Y
L
K
I
R
Q
Y
M
L
D
M
S
L
Y
Site 13
T250
I
F
L
D
S
R
V
T
E
V
T
G
Y
E
P
Site 14
Y255
R
V
T
E
V
T
G
Y
E
P
Q
D
L
I
E
Site 15
Y266
D
L
I
E
K
T
L
Y
H
H
V
H
G
C
D
Site 16
Y294
K
G
Q
V
T
T
K
Y
Y
R
L
L
S
K
R
Site 17
T312
V
W
V
Q
S
Y
A
T
V
V
H
N
S
R
S
Site 18
S317
Y
A
T
V
V
H
N
S
R
S
S
R
P
H
C
Site 19
S319
T
V
V
H
N
S
R
S
S
R
P
H
C
I
V
Site 20
S320
V
V
H
N
S
R
S
S
R
P
H
C
I
V
S
Site 21
S343
E
Y
K
E
L
Q
L
S
L
E
Q
V
S
T
A
Site 22
S348
Q
L
S
L
E
Q
V
S
T
A
K
S
Q
D
S
Site 23
T349
L
S
L
E
Q
V
S
T
A
K
S
Q
D
S
W
Site 24
S352
E
Q
V
S
T
A
K
S
Q
D
S
W
R
T
A
Site 25
S355
S
T
A
K
S
Q
D
S
W
R
T
A
L
S
T
Site 26
S361
D
S
W
R
T
A
L
S
T
S
Q
E
T
R
K
Site 27
T362
S
W
R
T
A
L
S
T
S
Q
E
T
R
K
L
Site 28
T366
A
L
S
T
S
Q
E
T
R
K
L
V
K
P
K
Site 29
T379
P
K
N
T
K
M
K
T
K
L
R
T
N
P
Y
Site 30
Y386
T
K
L
R
T
N
P
Y
P
P
Q
Q
Y
S
S
Site 31
S393
Y
P
P
Q
Q
Y
S
S
F
Q
M
D
K
L
E
Site 32
S410
Q
L
G
N
W
R
A
S
P
P
A
S
A
A
A
Site 33
S414
W
R
A
S
P
P
A
S
A
A
A
P
P
E
L
Site 34
S425
P
P
E
L
Q
P
H
S
E
S
S
D
L
L
Y
Site 35
Y432
S
E
S
S
D
L
L
Y
T
P
S
Y
S
L
P
Site 36
T433
E
S
S
D
L
L
Y
T
P
S
Y
S
L
P
F
Site 37
S435
S
D
L
L
Y
T
P
S
Y
S
L
P
F
S
Y
Site 38
Y436
D
L
L
Y
T
P
S
Y
S
L
P
F
S
Y
H
Site 39
S437
L
L
Y
T
P
S
Y
S
L
P
F
S
Y
H
Y
Site 40
S441
P
S
Y
S
L
P
F
S
Y
H
Y
G
H
F
P
Site 41
Y442
S
Y
S
L
P
F
S
Y
H
Y
G
H
F
P
L
Site 42
Y444
S
L
P
F
S
Y
H
Y
G
H
F
P
L
D
S
Site 43
S451
Y
G
H
F
P
L
D
S
H
V
F
S
S
K
K
Site 44
S455
P
L
D
S
H
V
F
S
S
K
K
P
M
L
P
Site 45
S471
K
F
G
Q
P
Q
G
S
P
C
E
V
A
R
F
Site 46
Y493
S
G
E
C
Q
W
H
Y
A
N
P
L
V
P
S
Site 47
S501
A
N
P
L
V
P
S
S
S
S
P
A
K
N
P
Site 48
S502
N
P
L
V
P
S
S
S
S
P
A
K
N
P
P
Site 49
S503
P
L
V
P
S
S
S
S
P
A
K
N
P
P
E
Site 50
T515
P
P
E
P
P
A
N
T
A
R
H
S
L
V
P
Site 51
S519
P
A
N
T
A
R
H
S
L
V
P
S
Y
E
A
Site 52
S523
A
R
H
S
L
V
P
S
Y
E
A
P
A
A
A
Site 53
Y524
R
H
S
L
V
P
S
Y
E
A
P
A
A
A
V
Site 54
T538
V
R
R
F
G
E
D
T
A
P
P
S
F
P
S
Site 55
S542
G
E
D
T
A
P
P
S
F
P
S
C
G
H
Y
Site 56
Y549
S
F
P
S
C
G
H
Y
R
E
E
P
A
L
G
Site 57
T585
P
E
C
C
A
P
P
T
P
E
A
P
G
A
P
Site 58
S642
A
L
R
L
R
H
P
S
P
A
A
T
S
P
P
Site 59
T646
R
H
P
S
P
A
A
T
S
P
P
G
A
P
L
Site 60
S647
H
P
S
P
A
A
T
S
P
P
G
A
P
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation