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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOC2B
Full Name:
Double C2-like domain-containing protein beta
Alias:
Doc2-beta; DOC2BL; Double C2-like domain-containing beta; Double C2-like domains, beta
Type:
Lipid binding protein
Mass (Da):
45949
Number AA:
412
UniProt ID:
Q14184
International Prot ID:
IPI00020684
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0008021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005544
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
R
R
R
G
E
K
A
T
I
S
I
Q
E
H
M
Site 2
S13
R
G
E
K
A
T
I
S
I
Q
E
H
M
A
I
Site 3
Y36
P
I
K
Q
I
S
D
Y
F
P
R
F
P
R
G
Site 4
S71
V
A
G
A
G
R
R
S
P
S
D
G
A
R
E
Site 5
S73
G
A
G
R
R
S
P
S
D
G
A
R
E
D
D
Site 6
S92
Q
L
F
G
A
Y
G
S
S
P
G
P
S
P
G
Site 7
S93
L
F
G
A
Y
G
S
S
P
G
P
S
P
G
P
Site 8
S97
Y
G
S
S
P
G
P
S
P
G
P
S
P
A
R
Site 9
S101
P
G
P
S
P
G
P
S
P
A
R
P
P
A
K
Site 10
Y119
D
E
P
D
A
D
G
Y
E
S
D
D
C
T
A
Site 11
S121
P
D
A
D
G
Y
E
S
D
D
C
T
A
L
G
Site 12
T125
G
Y
E
S
D
D
C
T
A
L
G
T
L
D
F
Site 13
S133
A
L
G
T
L
D
F
S
L
L
Y
D
Q
E
N
Site 14
Y136
T
L
D
F
S
L
L
Y
D
Q
E
N
N
A
L
Site 15
Y165
H
N
G
L
A
D
P
Y
V
K
L
H
L
L
P
Site 16
S175
L
H
L
L
P
G
A
S
K
A
N
K
L
R
T
Site 17
T184
A
N
K
L
R
T
K
T
L
R
N
T
L
N
P
Site 18
T188
R
T
K
T
L
R
N
T
L
N
P
T
W
N
E
Site 19
T198
P
T
W
N
E
T
L
T
Y
Y
G
I
T
D
E
Site 20
Y199
T
W
N
E
T
L
T
Y
Y
G
I
T
D
E
D
Site 21
T211
D
E
D
M
I
R
K
T
L
R
I
S
V
C
D
Site 22
S215
I
R
K
T
L
R
I
S
V
C
D
E
D
K
F
Site 23
T245
L
K
P
N
H
T
K
T
F
N
I
C
L
E
K
Site 24
T259
K
Q
L
P
V
D
K
T
E
D
K
S
L
E
E
Site 25
S263
V
D
K
T
E
D
K
S
L
E
E
R
G
R
I
Site 26
S273
E
R
G
R
I
L
I
S
L
K
Y
S
S
Q
K
Site 27
Y276
R
I
L
I
S
L
K
Y
S
S
Q
K
Q
G
L
Site 28
Y301
A
A
M
D
A
N
G
Y
S
D
P
Y
V
K
T
Site 29
Y305
A
N
G
Y
S
D
P
Y
V
K
T
Y
L
R
P
Site 30
T308
Y
S
D
P
Y
V
K
T
Y
L
R
P
D
V
D
Site 31
Y309
S
D
P
Y
V
K
T
Y
L
R
P
D
V
D
K
Site 32
S318
R
P
D
V
D
K
K
S
K
H
K
T
A
V
K
Site 33
T322
D
K
K
S
K
H
K
T
A
V
K
K
K
T
L
Site 34
T328
K
T
A
V
K
K
K
T
L
N
P
E
F
N
E
Site 35
Y339
E
F
N
E
E
F
C
Y
E
I
K
H
G
D
L
Site 36
S350
H
G
D
L
A
K
K
S
L
E
V
T
V
W
D
Site 37
T354
A
K
K
S
L
E
V
T
V
W
D
Y
D
I
G
Site 38
Y358
L
E
V
T
V
W
D
Y
D
I
G
K
S
N
D
Site 39
T400
K
R
I
E
R
W
H
T
L
T
S
E
L
P
G
Site 40
T402
I
E
R
W
H
T
L
T
S
E
L
P
G
A
V
Site 41
S403
E
R
W
H
T
L
T
S
E
L
P
G
A
V
L
Site 42
S411
E
L
P
G
A
V
L
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation