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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLA2
Full Name:
DNA polymerase alpha subunit B
Alias:
DNA pol alpha B; DNA polymerase alpha 70 kDa; DNA polymerase alpha 70 kDa subunit; DNA polymerase B; DPO2; DPOA2; FLJ21662; Polymerase (DNA directed) alpha 2 (70kD subunit)
Type:
Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; DNA replication
Mass (Da):
65948
Number AA:
598
UniProt ID:
Q14181
International Prot ID:
IPI00290272
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0005658
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0006139
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
L
T
S
E
I
L
N
S
F
E
H
E
F
L
S
Site 2
S71
S
F
E
H
E
F
L
S
K
R
L
S
K
A
R
Site 3
S75
E
F
L
S
K
R
L
S
K
A
R
H
S
T
C
Site 4
S80
R
L
S
K
A
R
H
S
T
C
K
D
S
G
H
Site 5
T81
L
S
K
A
R
H
S
T
C
K
D
S
G
H
A
Site 6
S112
E
E
E
I
L
L
N
S
Y
T
T
P
S
K
G
Site 7
Y113
E
E
I
L
L
N
S
Y
T
T
P
S
K
G
S
Site 8
T114
E
I
L
L
N
S
Y
T
T
P
S
K
G
S
Q
Site 9
T115
I
L
L
N
S
Y
T
T
P
S
K
G
S
Q
K
Site 10
S120
Y
T
T
P
S
K
G
S
Q
K
R
A
I
S
T
Site 11
S126
G
S
Q
K
R
A
I
S
T
P
E
T
P
L
T
Site 12
T127
S
Q
K
R
A
I
S
T
P
E
T
P
L
T
K
Site 13
T130
R
A
I
S
T
P
E
T
P
L
T
K
R
S
V
Site 14
T133
S
T
P
E
T
P
L
T
K
R
S
V
S
T
R
Site 15
S136
E
T
P
L
T
K
R
S
V
S
T
R
S
P
H
Site 16
S138
P
L
T
K
R
S
V
S
T
R
S
P
H
Q
L
Site 17
T139
L
T
K
R
S
V
S
T
R
S
P
H
Q
L
L
Site 18
S141
K
R
S
V
S
T
R
S
P
H
Q
L
L
S
P
Site 19
S147
R
S
P
H
Q
L
L
S
P
S
S
F
S
P
S
Site 20
S149
P
H
Q
L
L
S
P
S
S
F
S
P
S
A
T
Site 21
S150
H
Q
L
L
S
P
S
S
F
S
P
S
A
T
P
Site 22
S152
L
L
S
P
S
S
F
S
P
S
A
T
P
S
Q
Site 23
S154
S
P
S
S
F
S
P
S
A
T
P
S
Q
K
Y
Site 24
T156
S
S
F
S
P
S
A
T
P
S
Q
K
Y
N
S
Site 25
S158
F
S
P
S
A
T
P
S
Q
K
Y
N
S
R
S
Site 26
Y161
S
A
T
P
S
Q
K
Y
N
S
R
S
N
R
G
Site 27
S165
S
Q
K
Y
N
S
R
S
N
R
G
E
V
V
T
Site 28
T172
S
N
R
G
E
V
V
T
S
F
G
L
A
Q
G
Site 29
S181
F
G
L
A
Q
G
V
S
W
S
G
R
G
G
A
Site 30
S183
L
A
Q
G
V
S
W
S
G
R
G
G
A
G
N
Site 31
S192
R
G
G
A
G
N
I
S
L
K
V
L
G
C
P
Site 32
S208
A
L
T
G
S
Y
K
S
M
F
Q
K
L
P
D
Site 33
S229
C
K
I
E
E
L
G
S
E
L
K
E
H
Y
K
Site 34
S261
L
G
Q
I
G
C
D
S
N
G
K
L
N
N
K
Site 35
S269
N
G
K
L
N
N
K
S
V
I
L
E
G
D
R
Site 36
S279
L
E
G
D
R
E
H
S
S
G
A
Q
I
P
V
Site 37
S280
E
G
D
R
E
H
S
S
G
A
Q
I
P
V
D
Site 38
S289
A
Q
I
P
V
D
L
S
E
L
K
E
Y
S
L
Site 39
Y294
D
L
S
E
L
K
E
Y
S
L
F
P
G
Q
V
Site 40
T317
T
G
R
K
L
V
A
T
K
L
Y
E
G
V
P
Site 41
Y328
E
G
V
P
L
P
F
Y
Q
P
T
E
E
D
A
Site 42
S352
A
C
G
P
Y
T
T
S
D
S
I
T
Y
D
P
Site 43
S354
G
P
Y
T
T
S
D
S
I
T
Y
D
P
L
L
Site 44
T356
Y
T
T
S
D
S
I
T
Y
D
P
L
L
D
L
Site 45
T413
L
R
T
I
I
E
G
T
R
S
S
G
S
H
L
Site 46
S418
E
G
T
R
S
S
G
S
H
L
V
F
V
P
S
Site 47
S425
S
H
L
V
F
V
P
S
L
R
D
V
H
H
E
Site 48
Y435
D
V
H
H
E
P
V
Y
P
Q
P
P
F
S
Y
Site 49
S441
V
Y
P
Q
P
P
F
S
Y
S
D
L
S
R
E
Site 50
S443
P
Q
P
P
F
S
Y
S
D
L
S
R
E
D
K
Site 51
S446
P
F
S
Y
S
D
L
S
R
E
D
K
K
Q
V
Site 52
S457
K
K
Q
V
Q
F
V
S
E
P
C
S
L
S
I
Site 53
S486
H
L
G
A
E
E
I
S
S
S
S
G
T
S
D
Site 54
S487
L
G
A
E
E
I
S
S
S
S
G
T
S
D
R
Site 55
S488
G
A
E
E
I
S
S
S
S
G
T
S
D
R
F
Site 56
T491
E
I
S
S
S
S
G
T
S
D
R
F
S
R
I
Site 57
S492
I
S
S
S
S
G
T
S
D
R
F
S
R
I
L
Site 58
S496
S
G
T
S
D
R
F
S
R
I
L
K
H
I
L
Site 59
T504
R
I
L
K
H
I
L
T
Q
R
S
Y
Y
P
L
Site 60
S507
K
H
I
L
T
Q
R
S
Y
Y
P
L
Y
P
P
Site 61
Y508
H
I
L
T
Q
R
S
Y
Y
P
L
Y
P
P
Q
Site 62
Y509
I
L
T
Q
R
S
Y
Y
P
L
Y
P
P
Q
E
Site 63
Y512
Q
R
S
Y
Y
P
L
Y
P
P
Q
E
D
M
A
Site 64
Y522
Q
E
D
M
A
I
D
Y
E
S
F
Y
V
Y
A
Site 65
Y528
D
Y
E
S
F
Y
V
Y
A
Q
L
P
V
T
P
Site 66
T563
C
V
N
P
G
R
L
T
K
G
Q
V
G
G
T
Site 67
T570
T
K
G
Q
V
G
G
T
F
A
R
L
Y
L
R
Site 68
Y575
G
G
T
F
A
R
L
Y
L
R
R
P
A
A
D
Site 69
S588
A
D
G
A
E
R
Q
S
P
C
I
A
V
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation