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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPP2
Full Name:
MAGUK p55 subfamily member 2
Alias:
Discs large homolog 2; Discs large homologue 2; Discs large, 2; Discs large, homolog 2; DKFZp686J2189; DKFZp761D0712; DLG2; Membrane protein, palmitoylated 2; Palmitoylated membrane protein 2
Type:
Adapter/scaffold protein
Mass (Da):
64581
Number AA:
576
UniProt ID:
Q14168
International Prot ID:
IPI00217808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0004385
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
V
A
A
T
N
S
E
T
A
M
Q
Q
V
L
D
Site 2
S21
Q
V
L
D
N
L
G
S
L
P
S
A
T
G
A
Site 3
S24
D
N
L
G
S
L
P
S
A
T
G
A
A
E
L
Site 4
S42
F
L
R
G
I
M
E
S
P
I
V
R
S
L
A
Site 5
Y68
N
V
F
V
P
M
K
Y
M
L
K
Y
F
G
A
Site 6
Y72
P
M
K
Y
M
L
K
Y
F
G
A
H
E
R
L
Site 7
S110
A
Q
L
A
E
Q
S
S
T
A
A
E
L
A
H
Site 8
T111
Q
L
A
E
Q
S
S
T
A
A
E
L
A
H
I
Site 9
S126
L
Q
E
P
H
F
Q
S
L
L
E
T
H
D
S
Site 10
T130
H
F
Q
S
L
L
E
T
H
D
S
V
A
S
K
Site 11
S133
S
L
L
E
T
H
D
S
V
A
S
K
T
Y
E
Site 12
T138
H
D
S
V
A
S
K
T
Y
E
T
P
P
P
S
Site 13
Y139
D
S
V
A
S
K
T
Y
E
T
P
P
P
S
P
Site 14
T141
V
A
S
K
T
Y
E
T
P
P
P
S
P
G
L
Site 15
S145
T
Y
E
T
P
P
P
S
P
G
L
D
P
T
F
Site 16
T151
P
S
P
G
L
D
P
T
F
S
N
Q
P
V
P
Site 17
S153
P
G
L
D
P
T
F
S
N
Q
P
V
P
P
D
Site 18
T170
R
M
V
G
I
R
K
T
A
G
E
H
L
G
V
Site 19
T178
A
G
E
H
L
G
V
T
F
R
V
E
G
G
E
Site 20
S219
V
N
G
Q
P
V
G
S
D
P
R
A
L
Q
E
Site 21
Y243
I
L
K
I
L
P
S
Y
Q
E
P
H
L
P
R
Site 22
Y260
F
V
K
C
H
F
D
Y
D
P
A
R
D
S
L
Site 23
S266
D
Y
D
P
A
R
D
S
L
I
P
C
K
E
A
Site 24
S309
G
S
A
G
L
I
P
S
Q
L
L
E
E
K
R
Site 25
T327
V
K
R
D
L
E
L
T
P
N
S
G
T
L
C
Site 26
S330
D
L
E
L
T
P
N
S
G
T
L
C
G
S
L
Site 27
T332
E
L
T
P
N
S
G
T
L
C
G
S
L
S
G
Site 28
S336
N
S
G
T
L
C
G
S
L
S
G
K
K
K
K
Site 29
S338
G
T
L
C
G
S
L
S
G
K
K
K
K
R
M
Site 30
Y347
K
K
K
K
R
M
M
Y
L
T
T
K
N
A
E
Site 31
T349
K
K
R
M
M
Y
L
T
T
K
N
A
E
F
D
Site 32
Y363
D
R
H
E
L
L
I
Y
E
E
V
A
R
M
P
Site 33
T376
M
P
P
F
R
R
K
T
L
V
L
I
G
A
Q
Site 34
S389
A
Q
G
V
G
R
R
S
L
K
N
K
L
I
M
Site 35
Y402
I
M
W
D
P
D
R
Y
G
T
T
V
P
Y
T
Site 36
T404
W
D
P
D
R
Y
G
T
T
V
P
Y
T
S
R
Site 37
T405
D
P
D
R
Y
G
T
T
V
P
Y
T
S
R
R
Site 38
Y408
R
Y
G
T
T
V
P
Y
T
S
R
R
P
K
D
Site 39
T409
Y
G
T
T
V
P
Y
T
S
R
R
P
K
D
S
Site 40
S410
G
T
T
V
P
Y
T
S
R
R
P
K
D
S
E
Site 41
S416
T
S
R
R
P
K
D
S
E
R
E
G
Q
G
Y
Site 42
Y423
S
E
R
E
G
Q
G
Y
S
F
V
S
R
G
E
Site 43
S424
E
R
E
G
Q
G
Y
S
F
V
S
R
G
E
M
Site 44
Y440
A
D
V
R
A
G
R
Y
L
E
H
G
E
Y
E
Site 45
Y446
R
Y
L
E
H
G
E
Y
E
G
N
L
Y
G
T
Site 46
Y451
G
E
Y
E
G
N
L
Y
G
T
R
I
D
S
I
Site 47
T499
I
E
A
P
D
F
E
T
L
R
A
M
N
R
A
Site 48
S510
M
N
R
A
A
L
E
S
G
I
S
T
K
Q
L
Site 49
T525
T
E
A
D
L
R
R
T
V
E
E
S
S
R
I
Site 50
S529
L
R
R
T
V
E
E
S
S
R
I
Q
R
G
Y
Site 51
S530
R
R
T
V
E
E
S
S
R
I
Q
R
G
Y
G
Site 52
Y536
S
S
R
I
Q
R
G
Y
G
H
Y
F
D
L
C
Site 53
Y539
I
Q
R
G
Y
G
H
Y
F
D
L
C
L
V
N
Site 54
S547
F
D
L
C
L
V
N
S
N
L
E
R
T
F
R
Site 55
T552
V
N
S
N
L
E
R
T
F
R
E
L
Q
T
A
Site 56
T565
T
A
M
E
K
L
R
T
E
P
Q
W
V
P
V
Site 57
Y576
W
V
P
V
S
W
V
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation