KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TTL12
Full Name:
Tubulin--tyrosine ligase-like protein 12
Alias:
KIAA0153; LOC23170; Tubulin tyrosine ligase-like family, member 12
Type:
Unknown function
Mass (Da):
74404
Number AA:
644
UniProt ID:
Q14166
International Prot ID:
IPI00029048
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004835
GO:0004835
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
R
R
P
A
E
R
S
S
P
G
Q
T
P
E
Site 2
S16
R
R
P
A
E
R
S
S
P
G
Q
T
P
E
E
Site 3
T20
E
R
S
S
P
G
Q
T
P
E
E
G
A
Q
A
Site 4
S42
H
G
P
A
L
R
A
S
G
V
P
E
R
Y
W
Site 5
Y48
A
S
G
V
P
E
R
Y
W
G
R
L
L
H
K
Site 6
S107
K
V
I
V
T
R
E
S
G
L
Q
A
A
H
P
Site 7
Y177
M
W
K
F
N
Q
T
Y
Q
L
A
H
G
T
A
Site 8
Y192
E
E
K
M
P
V
W
Y
I
M
D
E
F
G
S
Site 9
T234
W
P
L
R
D
L
D
T
G
E
E
V
T
R
D
Site 10
Y244
E
V
T
R
D
F
A
Y
G
E
T
D
P
L
I
Site 11
S268
P
T
D
M
L
D
L
S
S
C
T
P
E
P
P
Site 12
S269
T
D
M
L
D
L
S
S
C
T
P
E
P
P
A
Site 13
T271
M
L
D
L
S
S
C
T
P
E
P
P
A
E
H
Site 14
Y279
P
E
P
P
A
E
H
Y
Q
A
I
L
E
E
N
Site 15
Y308
H
G
H
I
F
K
V
Y
T
D
V
Q
Q
V
A
Site 16
T309
G
H
I
F
K
V
Y
T
D
V
Q
Q
V
A
S
Site 17
T319
Q
Q
V
A
S
S
L
T
H
P
R
F
T
L
T
Site 18
T324
S
L
T
H
P
R
F
T
L
T
Q
S
E
A
D
Site 19
T326
T
H
P
R
F
T
L
T
Q
S
E
A
D
A
D
Site 20
S328
P
R
F
T
L
T
Q
S
E
A
D
A
D
I
L
Site 21
Y344
N
F
S
H
F
K
D
Y
R
K
L
S
Q
E
R
Site 22
S348
F
K
D
Y
R
K
L
S
Q
E
R
P
G
V
L
Site 23
T390
G
P
P
W
L
P
R
T
F
N
L
R
T
E
L
Site 24
T395
P
R
T
F
N
L
R
T
E
L
P
Q
F
V
S
Site 25
Y403
E
L
P
Q
F
V
S
Y
F
Q
Q
R
E
R
W
Site 26
T432
R
S
L
D
T
H
V
T
K
S
L
H
S
I
I
Site 27
S434
L
D
T
H
V
T
K
S
L
H
S
I
I
R
H
Site 28
S437
H
V
T
K
S
L
H
S
I
I
R
H
R
E
S
Site 29
S444
S
I
I
R
H
R
E
S
T
P
K
V
V
S
K
Site 30
T445
I
I
R
H
R
E
S
T
P
K
V
V
S
K
Y
Site 31
S450
E
S
T
P
K
V
V
S
K
Y
I
E
S
P
V
Site 32
Y473
K
V
K
F
D
I
R
Y
I
V
L
L
R
S
V
Site 33
Y508
A
L
N
D
L
D
D
Y
E
K
H
F
T
V
M
Site 34
Y517
K
H
F
T
V
M
N
Y
D
P
D
V
V
L
K
Site 35
Y539
I
P
E
F
E
K
Q
Y
P
E
F
P
W
T
D
Site 36
Y574
P
P
L
G
L
C
D
Y
P
S
S
R
A
M
Y
Site 37
S577
G
L
C
D
Y
P
S
S
R
A
M
Y
A
V
D
Site 38
Y581
Y
P
S
S
R
A
M
Y
A
V
D
L
M
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation