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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0146
Full Name:
Uncharacterized protein KIAA0146
Alias:
K0146
Type:
Mass (Da):
100298
Number AA:
915
UniProt ID:
Q14159
International Prot ID:
IPI00029021
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
P
R
G
S
R
A
R
G
S
K
R
Site 2
S10
R
G
S
R
A
R
G
S
K
R
K
R
S
W
N
Site 3
S15
R
G
S
K
R
K
R
S
W
N
T
E
C
P
S
Site 4
T18
K
R
K
R
S
W
N
T
E
C
P
S
F
P
G
Site 5
S22
S
W
N
T
E
C
P
S
F
P
G
E
R
P
L
Site 6
S44
R
T
A
G
A
A
A
S
L
S
E
A
W
L
R
Site 7
S60
G
E
G
F
Q
N
T
S
G
N
P
S
L
T
A
Site 8
S64
Q
N
T
S
G
N
P
S
L
T
A
E
E
K
T
Site 9
T66
T
S
G
N
P
S
L
T
A
E
E
K
T
I
T
Site 10
T73
T
A
E
E
K
T
I
T
E
K
H
L
E
L
C
Site 11
T87
C
P
R
P
K
Q
E
T
T
T
S
K
S
T
S
Site 12
T88
P
R
P
K
Q
E
T
T
T
S
K
S
T
S
G
Site 13
S90
P
K
Q
E
T
T
T
S
K
S
T
S
G
L
T
Site 14
S92
Q
E
T
T
T
S
K
S
T
S
G
L
T
D
I
Site 15
S94
T
T
T
S
K
S
T
S
G
L
T
D
I
T
W
Site 16
T97
S
K
S
T
S
G
L
T
D
I
T
W
S
S
S
Site 17
T100
T
S
G
L
T
D
I
T
W
S
S
S
G
S
D
Site 18
S102
G
L
T
D
I
T
W
S
S
S
G
S
D
L
S
Site 19
S103
L
T
D
I
T
W
S
S
S
G
S
D
L
S
D
Site 20
S104
T
D
I
T
W
S
S
S
G
S
D
L
S
D
E
Site 21
S106
I
T
W
S
S
S
G
S
D
L
S
D
E
D
K
Site 22
S109
S
S
S
G
S
D
L
S
D
E
D
K
T
L
S
Site 23
T114
D
L
S
D
E
D
K
T
L
S
Q
L
Q
R
D
Site 24
S116
S
D
E
D
K
T
L
S
Q
L
Q
R
D
E
L
Site 25
S132
F
I
D
W
E
I
D
S
D
R
A
E
A
S
D
Site 26
S138
D
S
D
R
A
E
A
S
D
C
D
E
F
E
D
Site 27
S153
D
E
G
A
V
E
I
S
D
C
A
S
C
A
S
Site 28
S160
S
D
C
A
S
C
A
S
N
Q
S
L
T
S
D
Site 29
S163
A
S
C
A
S
N
Q
S
L
T
S
D
E
K
L
Site 30
S166
A
S
N
Q
S
L
T
S
D
E
K
L
S
E
L
Site 31
S171
L
T
S
D
E
K
L
S
E
L
P
K
P
S
S
Site 32
S178
S
E
L
P
K
P
S
S
I
E
I
L
E
Y
S
Site 33
Y184
S
S
I
E
I
L
E
Y
S
S
D
S
E
K
E
Site 34
S185
S
I
E
I
L
E
Y
S
S
D
S
E
K
E
D
Site 35
S186
I
E
I
L
E
Y
S
S
D
S
E
K
E
D
D
Site 36
S202
E
N
V
L
L
I
D
S
E
S
P
H
K
Y
H
Site 37
S204
V
L
L
I
D
S
E
S
P
H
K
Y
H
V
Q
Site 38
Y208
D
S
E
S
P
H
K
Y
H
V
Q
F
A
S
D
Site 39
T228
E
R
L
I
D
P
R
T
K
S
T
E
T
I
L
Site 40
S230
L
I
D
P
R
T
K
S
T
E
T
I
L
H
T
Site 41
T237
S
T
E
T
I
L
H
T
P
Q
K
P
T
A
K
Site 42
T248
P
T
A
K
F
P
R
T
P
E
N
S
A
K
K
Site 43
S252
F
P
R
T
P
E
N
S
A
K
K
K
L
L
R
Site 44
S275
G
L
Q
N
R
E
R
S
A
I
S
L
W
R
H
Site 45
Y287
W
R
H
Q
C
I
S
Y
Q
K
T
L
S
G
R
Site 46
T290
Q
C
I
S
Y
Q
K
T
L
S
G
R
K
S
G
Site 47
S292
I
S
Y
Q
K
T
L
S
G
R
K
S
G
V
L
Site 48
S296
K
T
L
S
G
R
K
S
G
V
L
T
V
K
I
Site 49
S323
M
C
E
Q
L
L
G
S
P
A
T
S
S
S
Q
Site 50
T326
Q
L
L
G
S
P
A
T
S
S
S
Q
S
V
A
Site 51
S327
L
L
G
S
P
A
T
S
S
S
Q
S
V
A
P
Site 52
S329
G
S
P
A
T
S
S
S
Q
S
V
A
P
R
P
Site 53
S331
P
A
T
S
S
S
Q
S
V
A
P
R
P
G
A
Site 54
Y351
F
T
K
E
T
A
G
Y
L
R
G
R
P
Q
D
Site 55
T359
L
R
G
R
P
Q
D
T
V
R
I
F
P
P
W
Site 56
S394
K
V
V
A
K
E
D
S
E
K
T
C
E
V
Y
Site 57
Y401
S
E
K
T
C
E
V
Y
C
P
D
I
P
L
P
Site 58
T442
S
G
V
A
T
T
G
T
A
W
T
H
G
H
K
Site 59
T457
E
A
K
Q
R
I
P
T
S
T
P
L
R
D
S
Site 60
S458
A
K
Q
R
I
P
T
S
T
P
L
R
D
S
L
Site 61
T459
K
Q
R
I
P
T
S
T
P
L
R
D
S
L
L
Site 62
S464
T
S
T
P
L
R
D
S
L
L
D
V
V
E
S
Site 63
S476
V
E
S
Q
G
A
A
S
W
P
G
A
G
V
R
Site 64
Y490
R
V
V
V
Q
R
V
Y
S
L
P
S
R
D
S
Site 65
S491
V
V
V
Q
R
V
Y
S
L
P
S
R
D
S
T
Site 66
S497
Y
S
L
P
S
R
D
S
T
R
G
Q
Q
G
A
Site 67
T498
S
L
P
S
R
D
S
T
R
G
Q
Q
G
A
S
Site 68
S506
R
G
Q
Q
G
A
S
S
G
H
T
D
P
A
G
Site 69
T509
Q
G
A
S
S
G
H
T
D
P
A
G
T
R
A
Site 70
S537
V
H
L
E
F
T
M
S
K
A
R
Q
L
E
G
Site 71
S546
A
R
Q
L
E
G
K
S
C
S
L
V
G
M
K
Site 72
T572
G
I
F
S
L
I
D
T
L
W
P
P
A
I
P
Site 73
T582
P
P
A
I
P
L
K
T
P
G
R
D
Q
P
C
Site 74
T594
Q
P
C
E
E
I
K
T
H
L
P
P
P
A
L
Site 75
Y603
L
P
P
P
A
L
C
Y
I
L
T
A
H
P
N
Site 76
T606
P
A
L
C
Y
I
L
T
A
H
P
N
L
G
Q
Site 77
Y623
I
I
D
E
D
P
I
Y
K
L
Y
Q
P
P
V
Site 78
Y626
E
D
P
I
Y
K
L
Y
Q
P
P
V
T
R
C
Site 79
T645
L
Q
M
N
D
L
G
T
R
C
S
F
Y
A
T
Site 80
T652
T
R
C
S
F
Y
A
T
V
I
Y
Q
K
P
Q
Site 81
Y655
S
F
Y
A
T
V
I
Y
Q
K
P
Q
L
K
S
Site 82
S662
Y
Q
K
P
Q
L
K
S
L
L
L
L
E
Q
R
Site 83
T679
W
L
L
V
T
D
V
T
L
Q
T
K
E
E
R
Site 84
T693
R
D
P
R
L
P
K
T
L
L
V
Y
V
A
P
Site 85
S816
P
E
D
R
G
A
F
S
C
G
D
C
S
R
V
Site 86
T825
G
D
C
S
R
V
V
T
S
P
V
L
K
R
H
Site 87
S826
D
C
S
R
V
V
T
S
P
V
L
K
R
H
L
Site 88
S869
F
A
A
G
E
D
G
S
Y
E
V
K
S
V
L
Site 89
Y870
A
A
G
E
D
G
S
Y
E
V
K
S
V
L
G
Site 90
S874
D
G
S
Y
E
V
K
S
V
L
G
K
E
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation