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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0133
Full Name:
Unhealthy ribosome biogenesis protein 2 homolog
Alias:
Type:
Mass (Da):
170526
Number AA:
1524
UniProt ID:
Q14146
International Prot ID:
IPI00028980
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
V
Y
S
G
I
S
L
K
L
K
Site 2
S14
G
I
S
L
K
L
K
S
K
T
T
S
W
E
D
Site 3
T16
S
L
K
L
K
S
K
T
T
S
W
E
D
K
L
Site 4
S18
K
L
K
S
K
T
T
S
W
E
D
K
L
K
L
Site 5
S51
L
L
D
W
A
R
Q
S
L
V
A
F
Y
K
K
Site 6
Y56
R
Q
S
L
V
A
F
Y
K
K
K
L
E
L
K
Site 7
T92
N
L
L
K
N
G
K
T
I
N
L
Q
I
S
L
Site 8
S111
N
E
R
V
A
E
F
S
L
S
G
S
Q
R
N
Site 9
S113
R
V
A
E
F
S
L
S
G
S
Q
R
N
I
C
Site 10
S156
L
L
S
Q
L
C
W
S
A
C
R
Q
P
E
G
Site 11
T198
R
R
A
F
G
D
V
T
A
H
L
L
Q
P
C
Site 12
S230
G
Q
L
R
Q
V
L
S
R
D
I
R
S
Q
I
Site 13
S235
V
L
S
R
D
I
R
S
Q
I
E
A
M
F
R
Site 14
S253
F
Q
P
E
L
L
S
S
Y
K
E
G
L
L
D
Site 15
T268
Q
Q
Q
G
D
V
K
T
G
A
M
K
N
L
L
Site 16
T280
N
L
L
A
P
M
D
T
V
L
N
R
L
V
D
Site 17
S314
L
Y
K
L
F
L
D
S
Y
F
K
E
G
N
Q
Site 18
Y315
Y
K
L
F
L
D
S
Y
F
K
E
G
N
Q
L
Site 19
S338
L
F
G
C
L
K
I
S
H
L
Q
E
E
Q
S
Site 20
S345
S
H
L
Q
E
E
Q
S
K
A
L
S
T
S
D
Site 21
S349
E
E
Q
S
K
A
L
S
T
S
D
W
T
T
E
Site 22
S351
Q
S
K
A
L
S
T
S
D
W
T
T
E
L
L
Site 23
T355
L
S
T
S
D
W
T
T
E
L
L
V
V
E
Q
Site 24
Y390
E
E
A
Q
F
R
F
Y
R
H
V
A
E
L
L
Site 25
T455
A
Q
E
A
L
I
R
T
V
F
Q
T
Y
A
K
Site 26
T513
P
P
S
Q
I
L
D
T
W
S
L
V
L
E
K
Site 27
S515
S
Q
I
L
D
T
W
S
L
V
L
E
K
F
Q
Site 28
S559
N
M
R
S
L
D
S
S
T
P
L
P
I
V
R
Site 29
T560
M
R
S
L
D
S
S
T
P
L
P
I
V
R
R
Site 30
Y627
F
S
L
N
C
S
Q
Y
H
S
M
S
G
P
L
Site 31
S629
L
N
C
S
Q
Y
H
S
M
S
G
P
L
I
G
Site 32
T653
S
L
L
P
G
V
K
T
Q
H
W
K
K
I
E
Site 33
Y678
T
Y
C
L
E
Q
L
Y
L
Q
K
M
K
R
T
Site 34
T689
M
K
R
T
L
M
Q
T
S
F
R
S
E
G
A
Site 35
S690
K
R
T
L
M
Q
T
S
F
R
S
E
G
A
I
Site 36
S699
R
S
E
G
A
I
Q
S
L
R
C
D
A
A
F
Site 37
S710
D
A
A
F
I
I
G
S
G
R
K
S
L
N
Q
Site 38
S714
I
I
G
S
G
R
K
S
L
N
Q
R
T
T
A
Site 39
T720
K
S
L
N
Q
R
T
T
A
S
W
D
G
Q
V
Site 40
S722
L
N
Q
R
T
T
A
S
W
D
G
Q
V
G
M
Site 41
S779
M
G
K
A
Q
E
V
S
I
D
E
E
A
Y
I
Site 42
T787
I
D
E
E
A
Y
I
T
L
E
K
I
S
K
A
Site 43
S825
S
C
S
S
I
L
C
S
G
A
Q
R
D
S
G
Site 44
S831
C
S
G
A
Q
R
D
S
G
L
V
S
Q
Q
L
Site 45
S835
Q
R
D
S
G
L
V
S
Q
Q
L
P
W
L
F
Site 46
Y951
T
C
Y
Q
L
L
G
Y
L
Q
K
G
K
S
A
Site 47
S957
G
Y
L
Q
K
G
K
S
A
R
S
V
F
K
I
Site 48
S960
Q
K
G
K
S
A
R
S
V
F
K
I
M
Y
G
Site 49
S983
T
S
L
F
R
A
S
S
R
F
L
I
E
M
D
Site 50
S1031
R
K
I
T
A
F
L
S
S
S
K
P
Y
T
E
Site 51
S1033
I
T
A
F
L
S
S
S
K
P
Y
T
E
A
A
Site 52
Y1036
F
L
S
S
S
K
P
Y
T
E
A
A
S
S
K
Site 53
T1037
L
S
S
S
K
P
Y
T
E
A
A
S
S
K
Q
Site 54
S1042
P
Y
T
E
A
A
S
S
K
Q
L
E
N
Q
N
Site 55
S1140
R
D
G
G
A
D
I
S
Q
G
S
D
R
T
L
Site 56
S1143
G
A
D
I
S
Q
G
S
D
R
T
L
L
S
H
Site 57
S1149
G
S
D
R
T
L
L
S
H
V
A
L
Y
Q
G
Site 58
S1197
E
L
H
P
K
K
D
S
V
F
T
S
M
F
H
Site 59
S1201
K
K
D
S
V
F
T
S
M
F
H
S
V
R
R
Site 60
T1220
P
E
I
P
V
Q
V
T
Q
D
I
E
P
H
L
Site 61
S1288
P
L
S
G
E
K
A
S
L
L
W
R
A
C
P
Site 62
S1309
T
L
L
N
R
E
A
S
Q
E
Q
P
V
S
L
Site 63
Y1363
D
H
L
K
P
L
E
Y
G
S
V
F
P
R
L
Site 64
S1365
L
K
P
L
E
Y
G
S
V
F
P
R
L
H
N
Site 65
S1402
S
F
N
R
L
V
F
S
V
M
R
E
G
R
Q
Site 66
S1414
G
R
Q
K
D
K
G
S
I
D
D
L
P
T
V
Site 67
Y1432
A
R
L
V
E
R
M
Y
S
H
I
A
A
R
A
Site 68
S1433
R
L
V
E
R
M
Y
S
H
I
A
A
R
A
E
Site 69
S1492
D
V
Q
F
L
R
A
S
L
Q
P
G
M
R
D
Site 70
Y1505
R
D
I
F
K
E
L
Y
N
D
Y
L
K
Y
H
Site 71
Y1508
F
K
E
L
Y
N
D
Y
L
K
Y
H
K
A
K
Site 72
Y1511
L
Y
N
D
Y
L
K
Y
H
K
A
K
H
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation