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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KEAP1
Full Name:
Kelch-like ECH-associated protein 1
Alias:
Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19
Type:
Endoplasmic reticulum; Transcription regulation
Mass (Da):
69666
Number AA:
624
UniProt ID:
Q14145
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
Q
P
D
P
R
P
S
G
A
G
A
C
C
R
Site 2
S21
C
R
F
L
P
L
Q
S
Q
C
P
E
G
A
G
Site 3
Y33
G
A
G
D
A
V
M
Y
A
S
T
E
C
K
A
Site 4
T43
T
E
C
K
A
E
V
T
P
S
Q
H
G
N
R
Site 5
S45
C
K
A
E
V
T
P
S
Q
H
G
N
R
T
F
Site 6
T51
P
S
Q
H
G
N
R
T
F
S
Y
T
L
E
D
Site 7
S53
Q
H
G
N
R
T
F
S
Y
T
L
E
D
H
T
Site 8
Y54
H
G
N
R
T
F
S
Y
T
L
E
D
H
T
K
Site 9
T55
G
N
R
T
F
S
Y
T
L
E
D
H
T
K
Q
Site 10
T60
S
Y
T
L
E
D
H
T
K
Q
A
F
G
I
M
Site 11
S73
I
M
N
E
L
R
L
S
Q
Q
L
C
D
V
T
Site 12
T80
S
Q
Q
L
C
D
V
T
L
Q
V
K
Y
Q
D
Site 13
Y85
D
V
T
L
Q
V
K
Y
Q
D
A
P
A
A
Q
Site 14
Y141
E
R
L
I
E
F
A
Y
T
A
S
I
S
M
G
Site 15
Y206
L
H
Q
R
A
R
E
Y
I
Y
M
H
F
G
E
Site 16
Y208
Q
R
A
R
E
Y
I
Y
M
H
F
G
E
V
A
Site 17
Y263
D
C
E
Q
R
R
F
Y
V
Q
A
L
L
R
A
Site 18
S275
L
R
A
V
R
C
H
S
L
T
P
N
F
L
Q
Site 19
T277
A
V
R
C
H
S
L
T
P
N
F
L
Q
M
Q
Site 20
S293
Q
K
C
E
I
L
Q
S
D
S
R
C
K
D
Y
Site 21
S295
C
E
I
L
Q
S
D
S
R
C
K
D
Y
L
V
Site 22
Y300
S
D
S
R
C
K
D
Y
L
V
K
I
F
E
E
Site 23
T309
V
K
I
F
E
E
L
T
L
H
K
P
T
Q
V
Site 24
Y329
P
K
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Site 25
Y334
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
Site 26
S338
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
Site 27
S340
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
Site 28
Y341
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
Site 29
Y345
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
Site 30
S383
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
Site 31
T388
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Site 32
S390
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
Site 33
S391
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
Site 34
Y396
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
Site 35
S410
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
Site 36
Y443
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
Site 37
T481
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
Site 38
S486
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
Site 39
Y490
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
Site 40
Y491
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
Site 41
S533
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
Site 42
Y537
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
Site 43
T541
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
Site 44
T545
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
Site 45
S555
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Site 46
T560
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
Site 47
Y567
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
Site 48
Y572
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
Site 49
T576
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Site 50
S580
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
Site 51
Y584
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
Site 52
T588
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
Site 53
S592
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
Site 54
T598
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
Site 55
S599
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
Site 56
T609
S
G
V
G
V
A
V
T
M
E
P
C
R
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation