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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSG2
Full Name:
Desmoglein-2
Alias:
CDHF5; Desmoglein 2; Desmoglein-2; HDGC
Type:
Calcium-binding protein; Adhesion
Mass (Da):
122294
Number AA:
1118
UniProt ID:
Q14126
International Prot ID:
IPI00028931
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0005911
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007156
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
G
L
H
L
Q
V
L
S
T
R
N
E
N
K
L
Site 2
Y207
I
V
S
L
E
P
A
Y
P
P
V
F
Y
L
N
Site 3
Y212
P
A
Y
P
P
V
F
Y
L
N
K
D
T
G
E
Site 4
Y221
N
K
D
T
G
E
I
Y
T
T
S
V
T
L
D
Site 5
Y235
D
R
E
E
H
S
S
Y
T
L
T
V
E
A
R
Site 6
T291
N
Q
V
N
V
E
V
T
R
I
K
V
F
D
A
Site 7
S363
N
K
A
A
F
H
K
S
I
R
S
K
Y
K
P
Site 8
S366
A
F
H
K
S
I
R
S
K
Y
K
P
T
P
I
Site 9
T371
I
R
S
K
Y
K
P
T
P
I
P
I
K
V
K
Site 10
T484
P
R
K
T
I
T
G
T
V
L
I
N
V
E
D
Site 11
S551
W
K
I
A
R
Q
E
S
T
S
V
L
L
Q
Q
Site 12
T552
K
I
A
R
Q
E
S
T
S
V
L
L
Q
Q
S
Site 13
S553
I
A
R
Q
E
S
T
S
V
L
L
Q
Q
S
E
Site 14
S559
T
S
V
L
L
Q
Q
S
E
K
K
L
G
R
S
Site 15
T645
G
K
G
A
K
G
F
T
P
I
P
G
T
I
E
Site 16
T650
G
F
T
P
I
P
G
T
I
E
M
L
H
P
W
Site 17
S671
P
E
D
K
V
V
P
S
F
L
P
V
D
Q
G
Site 18
S680
L
P
V
D
Q
G
G
S
L
V
G
R
N
G
V
Site 19
T695
G
G
M
A
K
E
A
T
M
K
G
S
S
S
A
Site 20
S699
K
E
A
T
M
K
G
S
S
S
A
S
I
V
K
Site 21
S700
E
A
T
M
K
G
S
S
S
A
S
I
V
K
G
Site 22
S701
A
T
M
K
G
S
S
S
A
S
I
V
K
G
Q
Site 23
S703
M
K
G
S
S
S
A
S
I
V
K
G
Q
H
E
Site 24
S723
G
R
W
E
E
H
R
S
L
L
S
G
R
A
T
Site 25
S726
E
E
H
R
S
L
L
S
G
R
A
T
Q
F
T
Site 26
T730
S
L
L
S
G
R
A
T
Q
F
T
G
A
T
G
Site 27
T744
G
A
I
M
T
T
E
T
T
K
T
A
R
A
T
Site 28
T745
A
I
M
T
T
E
T
T
K
T
A
R
A
T
G
Site 29
T747
M
T
T
E
T
T
K
T
A
R
A
T
G
A
S
Site 30
T751
T
T
K
T
A
R
A
T
G
A
S
R
D
M
A
Site 31
S754
T
A
R
A
T
G
A
S
R
D
M
A
G
A
Q
Site 32
Y775
N
E
E
F
L
R
N
Y
F
T
D
K
A
A
S
Site 33
T777
E
F
L
R
N
Y
F
T
D
K
A
A
S
Y
T
Site 34
S782
Y
F
T
D
K
A
A
S
Y
T
E
E
D
E
N
Site 35
Y783
F
T
D
K
A
A
S
Y
T
E
E
D
E
N
H
Site 36
S800
K
D
C
L
L
V
Y
S
Q
E
E
T
E
S
L
Site 37
T804
L
V
Y
S
Q
E
E
T
E
S
L
N
A
S
I
Site 38
S806
Y
S
Q
E
E
T
E
S
L
N
A
S
I
G
C
Site 39
T859
E
Q
R
Q
K
P
A
T
E
T
S
M
N
T
A
Site 40
S862
Q
K
P
A
T
E
T
S
M
N
T
A
S
H
S
Site 41
T865
A
T
E
T
S
M
N
T
A
S
H
S
L
C
E
Site 42
S869
S
M
N
T
A
S
H
S
L
C
E
Q
T
M
V
Site 43
T874
S
H
S
L
C
E
Q
T
M
V
N
S
E
N
T
Site 44
S878
C
E
Q
T
M
V
N
S
E
N
T
Y
S
S
G
Site 45
T881
T
M
V
N
S
E
N
T
Y
S
S
G
S
S
F
Site 46
Y882
M
V
N
S
E
N
T
Y
S
S
G
S
S
F
P
Site 47
S883
V
N
S
E
N
T
Y
S
S
G
S
S
F
P
V
Site 48
S884
N
S
E
N
T
Y
S
S
G
S
S
F
P
V
P
Site 49
S887
N
T
Y
S
S
G
S
S
F
P
V
P
K
S
L
Site 50
S893
S
S
F
P
V
P
K
S
L
Q
E
A
N
A
E
Site 51
T903
E
A
N
A
E
K
V
T
Q
E
I
V
T
E
R
Site 52
S911
Q
E
I
V
T
E
R
S
V
S
S
R
Q
A
Q
Site 53
S913
I
V
T
E
R
S
V
S
S
R
Q
A
Q
K
V
Site 54
T922
R
Q
A
Q
K
V
A
T
P
L
P
D
P
M
A
Site 55
T936
A
S
R
N
V
I
A
T
E
T
S
Y
V
T
G
Site 56
S944
E
T
S
Y
V
T
G
S
T
M
P
P
T
T
V
Site 57
T950
G
S
T
M
P
P
T
T
V
I
L
G
P
S
Q
Site 58
S960
L
G
P
S
Q
P
Q
S
L
I
V
T
E
R
V
Site 59
T964
Q
P
Q
S
L
I
V
T
E
R
V
Y
A
P
A
Site 60
Y968
L
I
V
T
E
R
V
Y
A
P
A
S
T
L
V
Site 61
S972
E
R
V
Y
A
P
A
S
T
L
V
D
Q
P
Y
Site 62
T973
R
V
Y
A
P
A
S
T
L
V
D
Q
P
Y
A
Site 63
Y979
S
T
L
V
D
Q
P
Y
A
N
E
G
T
V
V
Site 64
T984
Q
P
Y
A
N
E
G
T
V
V
V
T
E
R
V
Site 65
S999
I
Q
P
H
G
G
G
S
N
P
L
E
G
T
Q
Site 66
T1005
G
S
N
P
L
E
G
T
Q
H
L
Q
D
V
P
Site 67
Y1013
Q
H
L
Q
D
V
P
Y
V
M
V
R
E
R
E
Site 68
S1021
V
M
V
R
E
R
E
S
F
L
A
P
S
S
G
Site 69
S1026
R
E
S
F
L
A
P
S
S
G
V
Q
P
T
L
Site 70
S1055
E
R
V
L
A
P
A
S
T
L
Q
S
S
Y
Q
Site 71
T1056
R
V
L
A
P
A
S
T
L
Q
S
S
Y
Q
I
Site 72
S1059
A
P
A
S
T
L
Q
S
S
Y
Q
I
P
T
E
Site 73
S1060
P
A
S
T
L
Q
S
S
Y
Q
I
P
T
E
N
Site 74
Y1061
A
S
T
L
Q
S
S
Y
Q
I
P
T
E
N
S
Site 75
T1070
I
P
T
E
N
S
M
T
A
R
N
T
T
V
S
Site 76
T1074
N
S
M
T
A
R
N
T
T
V
S
G
A
G
V
Site 77
T1075
S
M
T
A
R
N
T
T
V
S
G
A
G
V
P
Site 78
S1077
T
A
R
N
T
T
V
S
G
A
G
V
P
G
P
Site 79
S1093
P
D
F
G
L
E
E
S
G
H
S
N
S
T
I
Site 80
S1096
G
L
E
E
S
G
H
S
N
S
T
I
T
T
S
Site 81
S1098
E
E
S
G
H
S
N
S
T
I
T
T
S
S
T
Site 82
T1099
E
S
G
H
S
N
S
T
I
T
T
S
S
T
R
Site 83
T1102
H
S
N
S
T
I
T
T
S
S
T
R
V
T
K
Site 84
S1103
S
N
S
T
I
T
T
S
S
T
R
V
T
K
H
Site 85
S1104
N
S
T
I
T
T
S
S
T
R
V
T
K
H
S
Site 86
T1108
T
T
S
S
T
R
V
T
K
H
S
T
V
Q
H
Site 87
S1111
S
T
R
V
T
K
H
S
T
V
Q
H
S
Y
S
Site 88
T1112
T
R
V
T
K
H
S
T
V
Q
H
S
Y
S
_
Site 89
S1116
K
H
S
T
V
Q
H
S
Y
S
_
_
_
_
_
Site 90
Y1117
H
S
T
V
Q
H
S
Y
S
_
_
_
_
_
_
Site 91
S1118
S
T
V
Q
H
S
Y
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation