KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PDE1C
Full Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Alias:
EC 3.1.4.17; Hcam3; Pde1c; Pde1c protein; Phosphodiesterase 1c, calmodulin-dependent 70kda
Type:
Phosphodiesterase protein
Mass (Da):
80760
Number AA:
709
UniProt ID:
Q14123
International Prot ID:
IPI00215657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004117
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
P
T
K
E
I
E
E
Site 2
S13
K
E
I
E
E
F
E
S
N
S
L
K
Y
L
Q
Site 3
Y18
F
E
S
N
S
L
K
Y
L
Q
P
E
Q
I
E
Site 4
Y37
R
L
R
G
L
R
K
Y
K
K
T
S
Q
R
L
Site 5
T40
G
L
R
K
Y
K
K
T
S
Q
R
L
R
S
L
Site 6
S41
L
R
K
Y
K
K
T
S
Q
R
L
R
S
L
V
Site 7
S46
K
T
S
Q
R
L
R
S
L
V
K
Q
L
E
R
Site 8
T80
E
S
V
Y
I
D
E
T
R
R
L
L
D
T
E
Site 9
T86
E
T
R
R
L
L
D
T
E
D
E
L
S
D
I
Site 10
S91
L
D
T
E
D
E
L
S
D
I
Q
S
D
A
V
Site 11
S95
D
E
L
S
D
I
Q
S
D
A
V
P
S
E
V
Site 12
S108
E
V
R
D
W
L
A
S
T
F
T
R
Q
M
G
Site 13
S121
M
G
M
M
L
R
R
S
D
E
K
P
R
F
K
Site 14
S129
D
E
K
P
R
F
K
S
I
V
H
A
V
Q
A
Site 15
Y144
G
I
F
V
E
R
M
Y
R
R
T
S
N
M
V
Site 16
T147
V
E
R
M
Y
R
R
T
S
N
M
V
G
L
S
Site 17
S148
E
R
M
Y
R
R
T
S
N
M
V
G
L
S
Y
Site 18
S170
L
K
D
V
D
K
W
S
F
D
V
F
S
L
N
Site 19
S175
K
W
S
F
D
V
F
S
L
N
E
A
S
G
D
Site 20
T194
F
I
F
Y
E
L
L
T
R
Y
D
L
I
S
R
Site 21
Y196
F
Y
E
L
L
T
R
Y
D
L
I
S
R
F
K
Site 22
S221
E
A
L
E
V
G
Y
S
K
H
K
N
P
Y
H
Site 23
T239
H
A
A
D
V
T
Q
T
V
H
Y
L
L
Y
K
Site 24
Y245
Q
T
V
H
Y
L
L
Y
K
T
G
V
A
N
W
Site 25
Y270
F
S
A
A
I
H
D
Y
E
H
T
G
T
T
N
Site 26
Y291
R
S
D
P
A
I
L
Y
N
D
R
S
V
L
E
Site 27
S295
A
I
L
Y
N
D
R
S
V
L
E
N
H
H
L
Site 28
S303
V
L
E
N
H
H
L
S
A
A
Y
R
L
L
Q
Site 29
S369
I
E
K
P
K
A
L
S
L
M
L
H
T
A
D
Site 30
S413
A
E
L
G
L
P
F
S
P
L
C
D
R
K
S
Site 31
S420
S
P
L
C
D
R
K
S
T
M
V
A
Q
S
Q
Site 32
T421
P
L
C
D
R
K
S
T
M
V
A
Q
S
Q
V
Site 33
S451
D
M
T
E
K
I
V
S
P
L
I
D
E
T
S
Site 34
T457
V
S
P
L
I
D
E
T
S
Q
T
G
G
T
G
Site 35
S458
S
P
L
I
D
E
T
S
Q
T
G
G
T
G
Q
Site 36
T460
L
I
D
E
T
S
Q
T
G
G
T
G
Q
R
R
Site 37
S468
G
G
T
G
Q
R
R
S
S
L
N
S
I
S
S
Site 38
S469
G
T
G
Q
R
R
S
S
L
N
S
I
S
S
S
Site 39
S472
Q
R
R
S
S
L
N
S
I
S
S
S
D
A
K
Site 40
S474
R
S
S
L
N
S
I
S
S
S
D
A
K
R
S
Site 41
S475
S
S
L
N
S
I
S
S
S
D
A
K
R
S
G
Site 42
S476
S
L
N
S
I
S
S
S
D
A
K
R
S
G
V
Site 43
S481
S
S
S
D
A
K
R
S
G
V
K
T
S
G
S
Site 44
T485
A
K
R
S
G
V
K
T
S
G
S
E
G
S
A
Site 45
S486
K
R
S
G
V
K
T
S
G
S
E
G
S
A
P
Site 46
S488
S
G
V
K
T
S
G
S
E
G
S
A
P
I
N
Site 47
S497
G
S
A
P
I
N
N
S
V
I
S
V
D
Y
K
Site 48
S500
P
I
N
N
S
V
I
S
V
D
Y
K
S
F
K
Site 49
Y503
N
S
V
I
S
V
D
Y
K
S
F
K
A
T
W
Site 50
S505
V
I
S
V
D
Y
K
S
F
K
A
T
W
T
E
Site 51
T511
K
S
F
K
A
T
W
T
E
V
V
H
I
N
R
Site 52
S554
Q
K
E
M
E
A
K
S
Q
A
E
E
G
A
S
Site 53
S569
G
K
A
E
K
K
T
S
G
E
T
K
N
Q
V
Site 54
S584
N
G
T
R
A
N
K
S
D
N
P
R
G
K
N
Site 55
S592
D
N
P
R
G
K
N
S
K
A
E
K
S
S
G
Site 56
S597
K
N
S
K
A
E
K
S
S
G
E
Q
Q
Q
N
Site 57
T614
F
K
D
G
K
N
K
T
D
K
K
D
H
S
N
Site 58
S620
K
T
D
K
K
D
H
S
N
I
G
N
D
S
K
Site 59
T632
D
S
K
K
T
D
G
T
K
Q
R
S
H
G
S
Site 60
S636
T
D
G
T
K
Q
R
S
H
G
S
P
A
P
S
Site 61
S639
T
K
Q
R
S
H
G
S
P
A
P
S
T
S
S
Site 62
S643
S
H
G
S
P
A
P
S
T
S
S
T
C
R
L
Site 63
T644
H
G
S
P
A
P
S
T
S
S
T
C
R
L
T
Site 64
S645
G
S
P
A
P
S
T
S
S
T
C
R
L
T
L
Site 65
S646
S
P
A
P
S
T
S
S
T
C
R
L
T
L
P
Site 66
T647
P
A
P
S
T
S
S
T
C
R
L
T
L
P
V
Site 67
T651
T
S
S
T
C
R
L
T
L
P
V
I
K
P
P
Site 68
Y667
R
H
F
K
R
P
A
Y
A
S
S
S
Y
A
P
Site 69
S669
F
K
R
P
A
Y
A
S
S
S
Y
A
P
S
V
Site 70
S670
K
R
P
A
Y
A
S
S
S
Y
A
P
S
V
S
Site 71
S671
R
P
A
Y
A
S
S
S
Y
A
P
S
V
S
K
Site 72
S675
A
S
S
S
Y
A
P
S
V
S
K
K
T
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation