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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ch-TOG
Full Name:
Cytoskeleton-associated protein 5
Alias:
Ch-TOG; Ch-TOG protein; CKAP5; Colonic and hepatic tumor over-expressed protein; CTOG; Cytoskeleton associated protein 5; KIAA0097; TOG; TOGp
Type:
Cell cycle regulation
Mass (Da):
225495
Number AA:
2032
UniProt ID:
Q14008
International Prot ID:
IPI00028275
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0050658
GO:0051301
GO:0051297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
K
L
W
K
A
R
L
S
G
Y
E
E
A
L
K
Site 2
S43
Q
K
I
K
D
E
K
S
P
E
W
S
K
F
L
Site 3
S47
D
E
K
S
P
E
W
S
K
F
L
G
L
I
K
Site 4
S95
E
V
V
S
G
V
V
S
K
V
F
N
Q
P
K
Site 5
S153
E
T
L
R
K
A
L
S
E
F
G
S
K
I
I
Site 6
S175
V
L
P
K
L
F
E
S
R
E
K
A
V
R
D
Site 7
S208
P
P
L
Q
N
I
N
S
V
Q
L
K
E
L
E
Site 8
T223
E
E
W
V
K
L
P
T
S
A
P
R
P
T
R
Site 9
S224
E
W
V
K
L
P
T
S
A
P
R
P
T
R
F
Site 10
T229
P
T
S
A
P
R
P
T
R
F
L
R
S
Q
Q
Site 11
S234
R
P
T
R
F
L
R
S
Q
Q
E
L
E
A
K
Site 12
S247
A
K
L
E
Q
Q
Q
S
A
G
G
D
A
E
G
Site 13
Y268
E
V
P
Q
I
D
A
Y
E
L
L
E
A
V
E
Site 14
Y285
S
K
L
P
K
D
F
Y
D
K
I
E
A
K
K
Site 15
S302
E
R
K
E
A
L
E
S
V
E
V
L
I
K
N
Site 16
Y317
P
K
L
E
A
G
D
Y
A
D
L
V
K
A
L
Site 17
T393
D
A
I
F
L
T
T
T
L
Q
N
I
S
E
D
Site 18
S417
P
T
I
K
Q
Q
T
S
L
F
I
A
R
S
F
Site 19
S423
T
S
L
F
I
A
R
S
F
R
H
C
T
A
S
Site 20
T428
A
R
S
F
R
H
C
T
A
S
T
L
P
K
S
Site 21
S430
S
F
R
H
C
T
A
S
T
L
P
K
S
L
L
Site 22
T431
F
R
H
C
T
A
S
T
L
P
K
S
L
L
K
Site 23
S451
L
L
K
H
I
N
D
S
A
P
E
V
R
D
A
Site 24
T521
F
K
P
L
P
G
R
T
A
A
S
G
A
A
G
Site 25
T532
G
A
A
G
D
K
D
T
K
D
I
S
A
P
K
Site 26
S536
D
K
D
T
K
D
I
S
A
P
K
P
G
P
L
Site 27
T571
G
G
A
G
N
T
G
T
K
N
K
K
G
L
E
Site 28
S588
E
I
V
E
P
E
L
S
I
E
V
C
E
E
K
Site 29
S610
T
C
I
Q
L
L
D
S
S
N
W
K
E
R
L
Site 30
T677
Q
K
G
N
F
S
K
T
S
A
Q
V
V
L
D
Site 31
S678
K
G
N
F
S
K
T
S
A
Q
V
V
L
D
G
Site 32
S725
Q
V
V
S
M
A
F
S
Q
K
N
P
K
N
Q
Site 33
S733
Q
K
N
P
K
N
Q
S
E
T
L
N
W
L
S
Site 34
S803
D
E
K
P
A
L
L
S
Q
I
D
A
E
F
E
Site 35
S816
F
E
K
M
Q
G
Q
S
P
P
A
P
T
R
G
Site 36
S825
P
A
P
T
R
G
I
S
K
H
S
T
S
G
T
Site 37
S828
T
R
G
I
S
K
H
S
T
S
G
T
D
E
G
Site 38
T829
R
G
I
S
K
H
S
T
S
G
T
D
E
G
E
Site 39
S830
G
I
S
K
H
S
T
S
G
T
D
E
G
E
D
Site 40
T832
S
K
H
S
T
S
G
T
D
E
G
E
D
G
D
Site 41
S845
G
D
E
P
D
D
G
S
N
D
V
V
D
L
L
Site 42
S858
L
L
P
R
T
E
I
S
D
K
I
T
S
E
L
Site 43
T862
T
E
I
S
D
K
I
T
S
E
L
V
S
K
I
Site 44
S863
E
I
S
D
K
I
T
S
E
L
V
S
K
I
G
Site 45
S867
K
I
T
S
E
L
V
S
K
I
G
D
K
N
W
Site 46
S912
L
K
G
R
L
N
D
S
N
K
I
L
V
Q
Q
Site 47
S984
W
L
E
G
E
D
L
S
E
E
L
K
K
E
N
Site 48
T1008
W
L
A
E
K
L
P
T
L
R
S
T
P
T
D
Site 49
S1011
E
K
L
P
T
L
R
S
T
P
T
D
L
I
L
Site 50
S1065
T
G
K
L
K
P
T
S
K
D
Q
V
L
A
M
Site 51
T1088
P
A
K
P
A
P
P
T
K
A
T
S
K
P
M
Site 52
T1091
P
A
P
P
T
K
A
T
S
K
P
M
G
G
S
Site 53
S1092
A
P
P
T
K
A
T
S
K
P
M
G
G
S
A
Site 54
S1107
P
A
K
F
Q
P
A
S
A
P
A
E
D
C
I
Site 55
S1115
A
P
A
E
D
C
I
S
S
S
T
E
P
K
P
Site 56
S1117
A
E
D
C
I
S
S
S
T
E
P
K
P
D
P
Site 57
S1134
A
K
A
P
G
L
S
S
K
A
K
S
A
Q
G
Site 58
S1138
G
L
S
S
K
A
K
S
A
Q
G
K
K
M
P
Site 59
S1157
L
K
E
D
E
D
K
S
G
P
I
F
I
V
V
Site 60
T1187
V
L
K
W
N
F
T
T
P
R
D
E
Y
I
E
Site 61
Y1192
F
T
T
P
R
D
E
Y
I
E
Q
L
K
T
Q
Site 62
T1198
E
Y
I
E
Q
L
K
T
Q
M
S
S
C
V
A
Site 63
S1201
E
Q
L
K
T
Q
M
S
S
C
V
A
K
W
L
Site 64
T1273
E
Y
L
K
L
L
F
T
L
L
S
E
E
E
Y
Site 65
S1276
K
L
L
F
T
L
L
S
E
E
E
Y
H
L
T
Site 66
Y1280
T
L
L
S
E
E
E
Y
H
L
T
E
N
E
A
Site 67
T1283
S
E
E
E
Y
H
L
T
E
N
E
A
S
S
F
Site 68
S1288
H
L
T
E
N
E
A
S
S
F
I
P
Y
L
V
Site 69
Y1320
L
N
R
M
C
L
V
Y
P
A
S
K
M
F
P
Site 70
T1333
F
P
F
I
M
E
G
T
K
S
K
N
S
K
Q
Site 71
S1335
F
I
M
E
G
T
K
S
K
N
S
K
Q
R
A
Site 72
S1338
E
G
T
K
S
K
N
S
K
Q
R
A
E
C
L
Site 73
T1363
G
M
N
V
C
Q
P
T
P
G
K
A
L
K
E
Site 74
S1414
N
L
S
E
K
D
M
S
M
L
E
E
R
I
K
Site 75
S1423
L
E
E
R
I
K
R
S
A
K
R
P
S
A
A
Site 76
S1428
K
R
S
A
K
R
P
S
A
A
P
I
K
Q
V
Site 77
S1446
P
Q
R
A
Q
N
I
S
S
N
A
N
M
L
R
Site 78
S1461
K
G
P
A
E
D
M
S
S
K
L
N
Q
A
R
Site 79
S1462
G
P
A
E
D
M
S
S
K
L
N
Q
A
R
S
Site 80
S1469
S
K
L
N
Q
A
R
S
M
S
G
H
P
E
A
Site 81
S1471
L
N
Q
A
R
S
M
S
G
H
P
E
A
A
Q
Site 82
T1497
E
I
E
N
D
N
G
T
V
R
C
E
M
P
E
Site 83
S1528
E
P
K
I
R
A
V
S
P
H
F
D
D
M
H
Site 84
Y1596
F
M
Q
L
R
L
I
Y
N
T
H
M
A
D
E
Site 85
T1598
Q
L
R
L
I
Y
N
T
H
M
A
D
E
K
L
Site 86
S1635
E
S
L
A
R
E
A
S
T
G
V
L
K
D
L
Site 87
S1679
V
V
K
V
L
E
K
S
D
Q
T
N
I
L
S
Site 88
T1699
L
Q
D
S
L
L
A
T
A
S
S
P
K
F
S
Site 89
S1701
D
S
L
L
A
T
A
S
S
P
K
F
S
E
L
Site 90
S1753
E
K
L
K
Q
C
K
S
E
F
P
I
R
T
L
Site 91
T1780
P
K
I
L
D
H
L
T
M
I
D
N
K
N
E
Site 92
T1805
M
K
H
S
M
D
Q
T
G
S
K
S
D
K
E
Site 93
S1807
H
S
M
D
Q
T
G
S
K
S
D
K
E
T
E
Site 94
S1809
M
D
Q
T
G
S
K
S
D
K
E
T
E
K
G
Site 95
T1813
G
S
K
S
D
K
E
T
E
K
G
A
S
R
I
Site 96
S1824
A
S
R
I
D
E
K
S
S
K
A
K
V
N
D
Site 97
T1846
K
I
G
S
K
E
N
T
K
E
G
L
A
E
L
Site 98
Y1854
K
E
G
L
A
E
L
Y
E
Y
K
K
K
Y
S
Site 99
Y1856
G
L
A
E
L
Y
E
Y
K
K
K
Y
S
D
A
Site 100
S1861
Y
E
Y
K
K
K
Y
S
D
A
D
I
E
P
F
Site 101
S1873
E
P
F
L
K
N
S
S
Q
F
F
Q
S
Y
V
Site 102
S1878
N
S
S
Q
F
F
Q
S
Y
V
E
R
G
L
R
Site 103
Y1879
S
S
Q
F
F
Q
S
Y
V
E
R
G
L
R
V
Site 104
S1898
R
E
G
K
G
R
I
S
T
S
T
G
I
S
P
Site 105
T1899
E
G
K
G
R
I
S
T
S
T
G
I
S
P
Q
Site 106
S1900
G
K
G
R
I
S
T
S
T
G
I
S
P
Q
M
Site 107
T1901
K
G
R
I
S
T
S
T
G
I
S
P
Q
M
E
Site 108
S1904
I
S
T
S
T
G
I
S
P
Q
M
E
V
T
C
Site 109
T1910
I
S
P
Q
M
E
V
T
C
V
P
T
P
T
S
Site 110
S1920
P
T
P
T
S
T
V
S
S
I
G
N
T
N
G
Site 111
S1921
T
P
T
S
T
V
S
S
I
G
N
T
N
G
E
Site 112
S1933
N
G
E
E
V
G
P
S
V
Y
L
E
R
L
K
Site 113
Y1935
E
E
V
G
P
S
V
Y
L
E
R
L
K
I
L
Site 114
T1960
Q
D
D
R
P
P
L
T
S
L
L
S
K
P
A
Site 115
S1961
D
D
R
P
P
L
T
S
L
L
S
K
P
A
V
Site 116
S1980
S
S
T
D
M
L
H
S
K
L
S
Q
L
R
E
Site 117
S1983
D
M
L
H
S
K
L
S
Q
L
R
E
S
R
E
Site 118
S1988
K
L
S
Q
L
R
E
S
R
E
Q
H
Q
H
S
Site 119
S1995
S
R
E
Q
H
Q
H
S
D
L
D
S
N
Q
T
Site 120
S1999
H
Q
H
S
D
L
D
S
N
Q
T
H
S
S
G
Site 121
T2002
S
D
L
D
S
N
Q
T
H
S
S
G
T
V
T
Site 122
S2005
D
S
N
Q
T
H
S
S
G
T
V
T
S
S
S
Site 123
T2007
N
Q
T
H
S
S
G
T
V
T
S
S
S
S
T
Site 124
T2009
T
H
S
S
G
T
V
T
S
S
S
S
T
A
N
Site 125
S2010
H
S
S
G
T
V
T
S
S
S
S
T
A
N
I
Site 126
S2011
S
S
G
T
V
T
S
S
S
S
T
A
N
I
D
Site 127
S2012
S
G
T
V
T
S
S
S
S
T
A
N
I
D
D
Site 128
S2029
K
R
L
E
R
I
K
S
S
R
K
_
_
_
_
Site 129
S2030
R
L
E
R
I
K
S
S
R
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation