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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IL16
Full Name:
Pro-interleukin-16
Alias:
HsT19289; IL-16; Interleukin 16; LCF; Lymphocyte chemoattractant factor; Neural interleukin-16; PrIL-16
Type:
Cytokine
Mass (Da):
141752
Number AA:
1332
UniProt ID:
Q14005
International Prot ID:
IPI00853332
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005615
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005125
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0044419
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
H
S
R
A
G
K
S
R
K
S
A
K
F
R
Site 2
S13
R
A
G
K
S
R
K
S
A
K
F
R
S
I
S
Site 3
S18
R
K
S
A
K
F
R
S
I
S
R
S
L
M
L
Site 4
S20
S
A
K
F
R
S
I
S
R
S
L
M
L
C
N
Site 5
S22
K
F
R
S
I
S
R
S
L
M
L
C
N
A
K
Site 6
T30
L
M
L
C
N
A
K
T
S
D
D
G
S
S
P
Site 7
S31
M
L
C
N
A
K
T
S
D
D
G
S
S
P
D
Site 8
S35
A
K
T
S
D
D
G
S
S
P
D
E
K
Y
P
Site 9
S36
K
T
S
D
D
G
S
S
P
D
E
K
Y
P
D
Site 10
Y41
G
S
S
P
D
E
K
Y
P
D
P
F
E
I
S
Site 11
S48
Y
P
D
P
F
E
I
S
L
A
Q
G
K
E
G
Site 12
S59
G
K
E
G
I
F
H
S
S
V
Q
L
A
D
T
Site 13
T66
S
S
V
Q
L
A
D
T
S
E
A
G
P
S
S
Site 14
S67
S
V
Q
L
A
D
T
S
E
A
G
P
S
S
V
Site 15
S72
D
T
S
E
A
G
P
S
S
V
P
D
L
A
L
Site 16
S106
R
I
F
F
M
K
E
S
S
T
A
S
S
R
E
Site 17
S107
I
F
F
M
K
E
S
S
T
A
S
S
R
E
K
Site 18
S110
M
K
E
S
S
T
A
S
S
R
E
K
P
G
K
Site 19
S111
K
E
S
S
T
A
S
S
R
E
K
P
G
K
L
Site 20
S122
P
G
K
L
E
A
Q
S
S
N
F
L
F
P
K
Site 21
S123
G
K
L
E
A
Q
S
S
N
F
L
F
P
K
A
Site 22
S137
A
C
H
Q
R
A
R
S
N
S
T
S
V
N
P
Site 23
S139
H
Q
R
A
R
S
N
S
T
S
V
N
P
Y
C
Site 24
T140
Q
R
A
R
S
N
S
T
S
V
N
P
Y
C
T
Site 25
S141
R
A
R
S
N
S
T
S
V
N
P
Y
C
T
R
Site 26
Y145
N
S
T
S
V
N
P
Y
C
T
R
E
I
D
F
Site 27
S158
D
F
P
M
T
K
K
S
A
A
P
T
D
R
Q
Site 28
T162
T
K
K
S
A
A
P
T
D
R
Q
P
Y
S
L
Site 29
Y167
A
P
T
D
R
Q
P
Y
S
L
C
S
N
R
K
Site 30
S168
P
T
D
R
Q
P
Y
S
L
C
S
N
R
K
S
Site 31
S171
R
Q
P
Y
S
L
C
S
N
R
K
S
L
S
Q
Site 32
S175
S
L
C
S
N
R
K
S
L
S
Q
Q
L
D
C
Site 33
S177
C
S
N
R
K
S
L
S
Q
Q
L
D
C
P
A
Site 34
T190
P
A
G
K
A
A
G
T
S
R
P
T
R
S
L
Site 35
T194
A
A
G
T
S
R
P
T
R
S
L
S
T
A
Q
Site 36
S196
G
T
S
R
P
T
R
S
L
S
T
A
Q
L
V
Site 37
S198
S
R
P
T
R
S
L
S
T
A
Q
L
V
Q
P
Site 38
T296
Q
A
K
K
G
L
L
T
L
T
V
R
T
R
L
Site 39
S308
T
R
L
T
A
P
P
S
L
C
S
H
L
S
P
Site 40
S322
P
P
L
C
R
S
L
S
S
S
T
C
I
T
K
Site 41
S324
L
C
R
S
L
S
S
S
T
C
I
T
K
D
S
Site 42
T328
L
S
S
S
T
C
I
T
K
D
S
S
S
F
A
Site 43
S331
S
T
C
I
T
K
D
S
S
S
F
A
L
E
S
Site 44
S333
C
I
T
K
D
S
S
S
F
A
L
E
S
P
S
Site 45
S338
S
S
S
F
A
L
E
S
P
S
A
P
I
S
T
Site 46
S340
S
F
A
L
E
S
P
S
A
P
I
S
T
A
K
Site 47
S344
E
S
P
S
A
P
I
S
T
A
K
P
N
Y
R
Site 48
S391
V
H
T
L
S
P
G
S
V
A
H
L
D
G
R
Site 49
S438
G
P
V
P
I
I
V
S
R
H
P
D
P
Q
V
Site 50
S471
G
K
E
R
H
Q
W
S
L
E
G
V
K
R
L
Site 51
S480
E
G
V
K
R
L
E
S
S
W
H
G
R
P
T
Site 52
S481
G
V
K
R
L
E
S
S
W
H
G
R
P
T
L
Site 53
T487
S
S
W
H
G
R
P
T
L
E
K
E
R
E
K
Site 54
S496
E
K
E
R
E
K
N
S
A
P
P
H
R
R
A
Site 55
S510
A
Q
K
V
M
I
R
S
S
S
D
S
S
Y
M
Site 56
S511
Q
K
V
M
I
R
S
S
S
D
S
S
Y
M
S
Site 57
S512
K
V
M
I
R
S
S
S
D
S
S
Y
M
S
G
Site 58
S514
M
I
R
S
S
S
D
S
S
Y
M
S
G
S
P
Site 59
S515
I
R
S
S
S
D
S
S
Y
M
S
G
S
P
G
Site 60
Y516
R
S
S
S
D
S
S
Y
M
S
G
S
P
G
G
Site 61
S518
S
S
D
S
S
Y
M
S
G
S
P
G
G
S
P
Site 62
S520
D
S
S
Y
M
S
G
S
P
G
G
S
P
G
S
Site 63
S524
M
S
G
S
P
G
G
S
P
G
S
G
S
A
E
Site 64
S527
S
P
G
G
S
P
G
S
G
S
A
E
K
P
S
Site 65
S529
G
G
S
P
G
S
G
S
A
E
K
P
S
S
D
Site 66
S534
S
G
S
A
E
K
P
S
S
D
V
D
I
S
T
Site 67
S535
G
S
A
E
K
P
S
S
D
V
D
I
S
T
H
Site 68
S540
P
S
S
D
V
D
I
S
T
H
S
P
S
L
P
Site 69
T541
S
S
D
V
D
I
S
T
H
S
P
S
L
P
L
Site 70
S543
D
V
D
I
S
T
H
S
P
S
L
P
L
A
R
Site 71
S545
D
I
S
T
H
S
P
S
L
P
L
A
R
E
P
Site 72
S566
S
S
R
L
P
Q
E
S
P
P
L
P
E
S
R
Site 73
S572
E
S
P
P
L
P
E
S
R
D
S
H
P
P
L
Site 74
S575
P
L
P
E
S
R
D
S
H
P
P
L
R
L
K
Site 75
S584
P
P
L
R
L
K
K
S
F
E
I
L
V
R
K
Site 76
S594
I
L
V
R
K
P
M
S
S
K
P
K
P
P
P
Site 77
S595
L
V
R
K
P
M
S
S
K
P
K
P
P
P
R
Site 78
Y604
P
K
P
P
P
R
K
Y
F
K
S
D
S
D
P
Site 79
S607
P
P
R
K
Y
F
K
S
D
S
D
P
Q
K
S
Site 80
S609
R
K
Y
F
K
S
D
S
D
P
Q
K
S
L
E
Site 81
S614
S
D
S
D
P
Q
K
S
L
E
E
R
E
N
S
Site 82
S621
S
L
E
E
R
E
N
S
S
C
S
S
G
H
T
Site 83
S622
L
E
E
R
E
N
S
S
C
S
S
G
H
T
P
Site 84
S625
R
E
N
S
S
C
S
S
G
H
T
P
P
T
C
Site 85
T628
S
S
C
S
S
G
H
T
P
P
T
C
G
Q
E
Site 86
T631
S
S
G
H
T
P
P
T
C
G
Q
E
A
R
E
Site 87
T649
L
L
L
P
Q
E
D
T
A
G
R
S
P
S
A
Site 88
S653
Q
E
D
T
A
G
R
S
P
S
A
S
A
G
C
Site 89
S655
D
T
A
G
R
S
P
S
A
S
A
G
C
P
G
Site 90
S657
A
G
R
S
P
S
A
S
A
G
C
P
G
P
G
Site 91
T669
G
P
G
I
G
P
Q
T
K
S
S
T
E
G
E
Site 92
S671
G
I
G
P
Q
T
K
S
S
T
E
G
E
P
G
Site 93
S672
I
G
P
Q
T
K
S
S
T
E
G
E
P
G
W
Site 94
S683
E
P
G
W
R
R
A
S
P
V
T
Q
T
S
P
Site 95
T686
W
R
R
A
S
P
V
T
Q
T
S
P
I
K
H
Site 96
S689
A
S
P
V
T
Q
T
S
P
I
K
H
P
L
L
Site 97
Y704
K
R
Q
A
R
M
D
Y
S
F
D
T
T
A
E
Site 98
S705
R
Q
A
R
M
D
Y
S
F
D
T
T
A
E
D
Site 99
T709
M
D
Y
S
F
D
T
T
A
E
D
P
W
V
R
Site 100
S743
M
P
L
Q
P
N
A
S
L
N
E
E
E
G
T
Site 101
T750
S
L
N
E
E
E
G
T
Q
G
H
P
D
G
T
Site 102
T757
T
Q
G
H
P
D
G
T
P
P
K
L
D
T
A
Site 103
T763
G
T
P
P
K
L
D
T
A
N
G
T
P
K
V
Site 104
T767
K
L
D
T
A
N
G
T
P
K
V
Y
K
S
A
Site 105
S773
G
T
P
K
V
Y
K
S
A
D
S
S
T
V
K
Site 106
S777
V
Y
K
S
A
D
S
S
T
V
K
K
G
P
P
Site 107
T778
Y
K
S
A
D
S
S
T
V
K
K
G
P
P
V
Site 108
S795
K
P
A
W
F
R
Q
S
L
K
G
L
R
N
R
Site 109
S804
K
G
L
R
N
R
A
S
D
P
R
G
L
P
D
Site 110
S815
G
L
P
D
P
A
L
S
T
Q
P
A
P
A
S
Site 111
S822
S
T
Q
P
A
P
A
S
R
E
H
L
G
S
H
Site 112
S828
A
S
R
E
H
L
G
S
H
I
R
A
S
S
S
Site 113
S833
L
G
S
H
I
R
A
S
S
S
S
S
S
I
R
Site 114
S834
G
S
H
I
R
A
S
S
S
S
S
S
I
R
Q
Site 115
S835
S
H
I
R
A
S
S
S
S
S
S
I
R
Q
R
Site 116
S836
H
I
R
A
S
S
S
S
S
S
I
R
Q
R
I
Site 117
S837
I
R
A
S
S
S
S
S
S
I
R
Q
R
I
S
Site 118
S838
R
A
S
S
S
S
S
S
I
R
Q
R
I
S
S
Site 119
S844
S
S
I
R
Q
R
I
S
S
F
E
T
F
G
S
Site 120
S845
S
I
R
Q
R
I
S
S
F
E
T
F
G
S
S
Site 121
T848
Q
R
I
S
S
F
E
T
F
G
S
S
Q
L
P
Site 122
S851
S
S
F
E
T
F
G
S
S
Q
L
P
D
K
G
Site 123
S852
S
F
E
T
F
G
S
S
Q
L
P
D
K
G
A
Site 124
S863
D
K
G
A
Q
R
L
S
L
Q
P
S
S
G
E
Site 125
S867
Q
R
L
S
L
Q
P
S
S
G
E
A
A
K
P
Site 126
S868
R
L
S
L
Q
P
S
S
G
E
A
A
K
P
L
Site 127
S884
K
H
E
E
G
R
F
S
G
L
L
G
R
G
A
Site 128
T894
L
G
R
G
A
A
P
T
L
V
P
Q
Q
P
E
Site 129
S905
Q
Q
P
E
Q
V
L
S
S
G
S
P
A
A
S
Site 130
S906
Q
P
E
Q
V
L
S
S
G
S
P
A
A
S
E
Site 131
S908
E
Q
V
L
S
S
G
S
P
A
A
S
E
A
R
Site 132
S912
S
S
G
S
P
A
A
S
E
A
R
D
P
G
V
Site 133
S920
E
A
R
D
P
G
V
S
E
S
P
P
P
G
R
Site 134
S922
R
D
P
G
V
S
E
S
P
P
P
G
R
Q
P
Site 135
T933
G
R
Q
P
N
Q
K
T
L
P
P
G
P
D
P
Site 136
S946
D
P
L
L
R
L
L
S
T
Q
A
E
E
S
Q
Site 137
T947
P
L
L
R
L
L
S
T
Q
A
E
E
S
Q
G
Site 138
S952
L
S
T
Q
A
E
E
S
Q
G
P
V
L
K
M
Site 139
S961
G
P
V
L
K
M
P
S
Q
R
A
R
S
F
P
Site 140
S966
M
P
S
Q
R
A
R
S
F
P
L
T
R
S
Q
Site 141
T970
R
A
R
S
F
P
L
T
R
S
Q
S
C
E
T
Site 142
S972
R
S
F
P
L
T
R
S
Q
S
C
E
T
K
L
Site 143
S974
F
P
L
T
R
S
Q
S
C
E
T
K
L
L
D
Site 144
T984
T
K
L
L
D
E
K
T
S
K
L
Y
S
I
S
Site 145
S985
K
L
L
D
E
K
T
S
K
L
Y
S
I
S
S
Site 146
S989
E
K
T
S
K
L
Y
S
I
S
S
Q
V
S
S
Site 147
S991
T
S
K
L
Y
S
I
S
S
Q
V
S
S
A
V
Site 148
T1014
S
S
I
S
C
A
Q
T
P
C
I
P
K
E
G
Site 149
S1023
C
I
P
K
E
G
A
S
P
T
S
S
S
N
E
Site 150
S1026
K
E
G
A
S
P
T
S
S
S
N
E
D
S
A
Site 151
S1027
E
G
A
S
P
T
S
S
S
N
E
D
S
A
A
Site 152
S1028
G
A
S
P
T
S
S
S
N
E
D
S
A
A
N
Site 153
S1032
T
S
S
S
N
E
D
S
A
A
N
G
S
A
E
Site 154
S1037
E
D
S
A
A
N
G
S
A
E
T
S
A
L
D
Site 155
S1041
A
N
G
S
A
E
T
S
A
L
D
T
G
F
S
Site 156
S1048
S
A
L
D
T
G
F
S
L
N
L
S
E
L
R
Site 157
S1052
T
G
F
S
L
N
L
S
E
L
R
E
Y
T
E
Site 158
Y1057
N
L
S
E
L
R
E
Y
T
E
G
L
T
E
A
Site 159
T1058
L
S
E
L
R
E
Y
T
E
G
L
T
E
A
K
Site 160
S1073
E
D
D
D
G
D
H
S
S
L
Q
S
G
Q
S
Site 161
S1074
D
D
D
G
D
H
S
S
L
Q
S
G
Q
S
V
Site 162
S1077
G
D
H
S
S
L
Q
S
G
Q
S
V
I
S
L
Site 163
S1083
Q
S
G
Q
S
V
I
S
L
L
S
S
E
E
L
Site 164
S1151
V
F
P
N
G
L
A
S
Q
E
G
T
I
Q
K
Site 165
T1155
G
L
A
S
Q
E
G
T
I
Q
K
G
N
E
V
Site 166
S1164
Q
K
G
N
E
V
L
S
I
N
G
K
S
L
K
Site 167
S1169
V
L
S
I
N
G
K
S
L
K
G
T
T
H
H
Site 168
S1208
E
A
M
P
D
L
N
S
S
T
D
S
A
A
S
Site 169
S1209
A
M
P
D
L
N
S
S
T
D
S
A
A
S
A
Site 170
T1210
M
P
D
L
N
S
S
T
D
S
A
A
S
A
S
Site 171
S1212
D
L
N
S
S
T
D
S
A
A
S
A
S
A
A
Site 172
S1215
S
S
T
D
S
A
A
S
A
S
A
A
S
D
V
Site 173
S1223
A
S
A
A
S
D
V
S
V
E
S
T
A
E
A
Site 174
S1247
M
S
A
G
L
G
F
S
L
E
G
G
K
G
S
Site 175
S1254
S
L
E
G
G
K
G
S
L
H
G
D
K
P
L
Site 176
T1262
L
H
G
D
K
P
L
T
I
N
R
I
F
K
G
Site 177
S1272
R
I
F
K
G
A
A
S
E
Q
S
E
T
V
Q
Site 178
S1275
K
G
A
A
S
E
Q
S
E
T
V
Q
P
G
D
Site 179
T1277
A
A
S
E
Q
S
E
T
V
Q
P
G
D
E
I
Site 180
S1320
T
I
V
I
R
R
K
S
L
Q
S
K
E
T
T
Site 181
S1323
I
R
R
K
S
L
Q
S
K
E
T
T
A
A
G
Site 182
T1327
S
L
Q
S
K
E
T
T
A
A
G
D
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation