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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RasGRF1
Full Name:
Ras-specific guanine nucleotide-releasing factor 1
Alias:
CDC25; CDC25L; GNRP; GRF1; GRF55; Guanine nucleotide releasing protein; H-GRF55; P140 Ras-GRF; PP13187; Ras protein-specific guanine nucleotide-releasing factor 1; RASGRF1; Ras-specific nucleotide exchange factor CDC25; RGRF1
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
145383
Number AA:
1275
UniProt ID:
Q13972
International Prot ID:
IPI00016784
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0030426
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0032863
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
L
L
A
R
K
D
G
T
R
K
G
Y
L
S
K
Site 2
Y28
K
D
G
T
R
K
G
Y
L
S
K
R
S
S
D
Site 3
S30
G
T
R
K
G
Y
L
S
K
R
S
S
D
N
T
Site 4
S34
G
Y
L
S
K
R
S
S
D
N
T
K
W
Q
T
Site 5
Y53
L
L
Q
N
L
L
F
Y
F
E
S
D
S
S
S
Site 6
S56
N
L
L
F
Y
F
E
S
D
S
S
S
R
P
S
Site 7
S58
L
F
Y
F
E
S
D
S
S
S
R
P
S
G
L
Site 8
S59
F
Y
F
E
S
D
S
S
S
R
P
S
G
L
Y
Site 9
S60
Y
F
E
S
D
S
S
S
R
P
S
G
L
Y
L
Site 10
S63
S
D
S
S
S
R
P
S
G
L
Y
L
L
E
G
Site 11
S78
C
V
C
D
R
A
P
S
P
K
P
A
L
S
A
Site 12
S84
P
S
P
K
P
A
L
S
A
K
E
P
L
E
K
Site 13
Y94
E
P
L
E
K
Q
H
Y
F
T
V
N
F
S
H
Site 14
T96
L
E
K
Q
H
Y
F
T
V
N
F
S
H
E
N
Site 15
T155
Q
I
V
E
T
E
K
T
V
A
K
Q
L
R
Q
Site 16
S190
K
D
N
E
R
I
Q
S
T
Q
T
V
A
P
N
Site 17
T193
E
R
I
Q
S
T
Q
T
V
A
P
N
D
E
D
Site 18
S201
V
A
P
N
D
E
D
S
D
I
K
K
I
K
K
Site 19
S211
K
K
I
K
K
V
Q
S
F
L
R
G
W
L
C
Site 20
Y229
W
K
T
I
I
Q
D
Y
I
R
S
P
H
A
D
Site 21
S232
I
I
Q
D
Y
I
R
S
P
H
A
D
S
M
R
Site 22
S237
I
R
S
P
H
A
D
S
M
R
K
R
N
Q
V
Site 23
S275
R
P
L
R
M
A
A
S
S
K
K
P
P
I
T
Site 24
S276
P
L
R
M
A
A
S
S
K
K
P
P
I
T
H
Site 25
T282
S
S
K
K
P
P
I
T
H
D
D
V
S
S
I
Site 26
S287
P
I
T
H
D
D
V
S
S
I
F
L
N
S
E
Site 27
S288
I
T
H
D
D
V
S
S
I
F
L
N
S
E
T
Site 28
Y333
L
L
P
M
L
N
I
Y
Q
E
F
V
R
N
H
Site 29
T373
K
P
D
C
E
E
R
T
L
E
T
F
L
T
Y
Site 30
T376
C
E
E
R
T
L
E
T
F
L
T
Y
P
M
F
Site 31
T399
L
H
D
V
L
A
H
T
P
H
E
H
V
E
R
Site 32
S408
H
E
H
V
E
R
N
S
L
D
Y
A
K
S
K
Site 33
Y411
V
E
R
N
S
L
D
Y
A
K
S
K
L
E
E
Site 34
S414
N
S
L
D
Y
A
K
S
K
L
E
E
L
S
R
Site 35
S428
R
I
M
H
D
E
V
S
E
T
E
N
I
R
K
Site 36
T430
M
H
D
E
V
S
E
T
E
N
I
R
K
N
L
Site 37
T453
G
C
E
I
L
L
D
T
S
Q
T
F
V
R
Q
Site 38
S454
C
E
I
L
L
D
T
S
Q
T
F
V
R
Q
G
Site 39
S462
Q
T
F
V
R
Q
G
S
L
I
Q
V
P
M
S
Site 40
S469
S
L
I
Q
V
P
M
S
E
K
G
K
I
T
R
Site 41
S481
I
T
R
G
R
L
G
S
L
S
L
E
K
E
G
Site 42
S483
R
G
R
L
G
S
L
S
L
E
K
E
G
E
R
Site 43
T513
S
G
G
K
L
H
L
T
K
N
G
V
I
S
L
Site 44
S531
T
L
L
E
E
P
E
S
T
E
E
E
A
K
G
Site 45
T532
L
L
E
E
P
E
S
T
E
E
E
A
K
G
S
Site 46
S539
T
E
E
E
A
K
G
S
G
Q
D
I
D
H
L
Site 47
T615
I
K
R
T
R
E
G
T
R
E
A
E
M
S
R
Site 48
S621
G
T
R
E
A
E
M
S
R
S
D
A
S
L
Y
Site 49
S623
R
E
A
E
M
S
R
S
D
A
S
L
Y
C
D
Site 50
S626
E
M
S
R
S
D
A
S
L
Y
C
D
D
V
D
Site 51
Y628
S
R
S
D
A
S
L
Y
C
D
D
V
D
I
R
Site 52
S642
R
F
S
K
T
M
N
S
C
K
V
L
Q
I
R
Site 53
S652
V
L
Q
I
R
Y
A
S
V
E
R
L
L
E
R
Site 54
T661
E
R
L
L
E
R
L
T
D
L
R
F
L
S
I
Site 55
S709
I
P
A
R
W
L
R
S
L
E
L
L
F
A
S
Site 56
Y724
G
Q
N
N
K
L
L
Y
G
E
P
P
K
S
P
Site 57
S730
L
Y
G
E
P
P
K
S
P
R
A
T
R
K
F
Site 58
T734
P
P
K
S
P
R
A
T
R
K
F
S
S
P
P
Site 59
S738
P
R
A
T
R
K
F
S
S
P
P
P
L
S
I
Site 60
S739
R
A
T
R
K
F
S
S
P
P
P
L
S
I
T
Site 61
S744
F
S
S
P
P
P
L
S
I
T
K
T
S
S
P
Site 62
T746
S
P
P
P
L
S
I
T
K
T
S
S
P
S
R
Site 63
T748
P
P
L
S
I
T
K
T
S
S
P
S
R
R
R
Site 64
S749
P
L
S
I
T
K
T
S
S
P
S
R
R
R
K
Site 65
S750
L
S
I
T
K
T
S
S
P
S
R
R
R
K
L
Site 66
S752
I
T
K
T
S
S
P
S
R
R
R
K
L
I
S
Site 67
S759
S
R
R
R
K
L
I
S
L
N
I
P
I
I
T
Site 68
S776
K
A
L
D
L
A
G
S
L
S
C
N
S
N
G
Site 69
S778
L
D
L
A
G
S
L
S
C
N
S
N
G
Y
T
Site 70
S781
A
G
S
L
S
C
N
S
N
G
Y
T
S
M
Y
Site 71
Y784
L
S
C
N
S
N
G
Y
T
S
M
Y
S
A
M
Site 72
T785
S
C
N
S
N
G
Y
T
S
M
Y
S
A
M
S
Site 73
Y788
S
N
G
Y
T
S
M
Y
S
A
M
S
P
F
S
Site 74
S789
N
G
Y
T
S
M
Y
S
A
M
S
P
F
S
K
Site 75
S792
T
S
M
Y
S
A
M
S
P
F
S
K
A
T
L
Site 76
S795
Y
S
A
M
S
P
F
S
K
A
T
L
D
T
S
Site 77
T798
M
S
P
F
S
K
A
T
L
D
T
S
K
L
Y
Site 78
S802
S
K
A
T
L
D
T
S
K
L
Y
V
S
S
S
Site 79
Y805
T
L
D
T
S
K
L
Y
V
S
S
S
F
T
N
Site 80
S809
S
K
L
Y
V
S
S
S
F
T
N
K
I
P
D
Site 81
T811
L
Y
V
S
S
S
F
T
N
K
I
P
D
E
G
Site 82
T820
K
I
P
D
E
G
D
T
T
P
E
K
P
E
D
Site 83
T821
I
P
D
E
G
D
T
T
P
E
K
P
E
D
P
Site 84
S829
P
E
K
P
E
D
P
S
A
L
S
K
Q
S
S
Site 85
S832
P
E
D
P
S
A
L
S
K
Q
S
S
E
V
S
Site 86
S835
P
S
A
L
S
K
Q
S
S
E
V
S
M
R
E
Site 87
S836
S
A
L
S
K
Q
S
S
E
V
S
M
R
E
E
Site 88
S839
S
K
Q
S
S
E
V
S
M
R
E
E
S
D
I
Site 89
S844
E
V
S
M
R
E
E
S
D
I
D
Q
N
Q
S
Site 90
S851
S
D
I
D
Q
N
Q
S
D
D
G
D
T
E
T
Site 91
T856
N
Q
S
D
D
G
D
T
E
T
S
P
T
K
S
Site 92
T858
S
D
D
G
D
T
E
T
S
P
T
K
S
P
T
Site 93
S859
D
D
G
D
T
E
T
S
P
T
K
S
P
T
T
Site 94
T861
G
D
T
E
T
S
P
T
K
S
P
T
T
P
K
Site 95
S863
T
E
T
S
P
T
K
S
P
T
T
P
K
S
V
Site 96
T865
T
S
P
T
K
S
P
T
T
P
K
S
V
K
N
Site 97
T866
S
P
T
K
S
P
T
T
P
K
S
V
K
N
K
Site 98
S869
K
S
P
T
T
P
K
S
V
K
N
K
N
S
S
Site 99
S875
K
S
V
K
N
K
N
S
S
E
F
P
L
F
S
Site 100
S876
S
V
K
N
K
N
S
S
E
F
P
L
F
S
Y
Site 101
S903
D
N
N
R
S
A
L
S
A
A
S
A
F
A
I
Site 102
T919
T
A
G
A
N
E
G
T
P
N
K
E
K
Y
R
Site 103
Y925
G
T
P
N
K
E
K
Y
R
R
M
S
L
A
S
Site 104
S929
K
E
K
Y
R
R
M
S
L
A
S
A
G
F
P
Site 105
S932
Y
R
R
M
S
L
A
S
A
G
F
P
P
D
Q
Site 106
T973
K
H
S
Q
D
F
E
T
N
D
E
L
K
C
K
Site 107
T1010
A
N
I
I
R
T
L
T
Q
E
D
P
G
D
N
Site 108
Y1061
L
V
F
K
K
I
P
Y
E
E
F
F
G
Q
G
Site 109
T1078
K
L
E
K
N
E
R
T
P
Y
I
M
K
T
T
Site 110
Y1080
E
K
N
E
R
T
P
Y
I
M
K
T
T
K
H
Site 111
S1092
T
K
H
F
N
D
I
S
N
L
I
A
S
E
I
Site 112
S1097
D
I
S
N
L
I
A
S
E
I
I
R
N
E
D
Site 113
S1110
E
D
I
N
A
R
V
S
A
I
E
K
W
V
A
Site 114
S1141
I
T
S
S
M
N
R
S
A
I
F
R
L
K
K
Site 115
T1149
A
I
F
R
L
K
K
T
W
L
K
V
S
K
Q
Site 116
S1169
D
K
L
Q
K
L
V
S
S
E
G
R
F
K
N
Site 117
S1170
K
L
Q
K
L
V
S
S
E
G
R
F
K
N
L
Site 118
T1206
L
A
F
I
E
E
G
T
P
N
Y
T
E
D
G
Site 119
Y1209
I
E
E
G
T
P
N
Y
T
E
D
G
L
V
N
Site 120
T1236
E
I
R
Q
F
Q
Q
T
A
Y
K
I
E
H
Q
Site 121
Y1249
H
Q
A
K
V
T
Q
Y
L
L
D
Q
S
F
V
Site 122
S1254
T
Q
Y
L
L
D
Q
S
F
V
M
D
E
E
S
Site 123
S1261
S
F
V
M
D
E
E
S
L
Y
E
S
S
L
R
Site 124
Y1263
V
M
D
E
E
S
L
Y
E
S
S
L
R
I
E
Site 125
S1265
D
E
E
S
L
Y
E
S
S
L
R
I
E
P
K
Site 126
S1266
E
E
S
L
Y
E
S
S
L
R
I
E
P
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation