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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKP1
Full Name:
Plakophilin-1
Alias:
B6P; Band-6 protein; Band-6-protein; Ectodermal dysplasia/skin fragility syndrome; Plakophilin 1
Type:
Adhesion
Mass (Da):
82861
Number AA:
747
UniProt ID:
Q13835
International Prot ID:
IPI00071509
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030057
GO:0005882
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0019215
GO:0004871
GO:0030280
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007275
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
N
H
S
P
L
K
T
A
L
A
Site 2
T8
M
N
H
S
P
L
K
T
A
L
A
Y
E
C
F
Site 3
Y12
P
L
K
T
A
L
A
Y
E
C
F
Q
D
Q
D
Site 4
S21
C
F
Q
D
Q
D
N
S
T
L
A
L
P
S
D
Site 5
T22
F
Q
D
Q
D
N
S
T
L
A
L
P
S
D
Q
Site 6
T33
P
S
D
Q
K
M
K
T
G
T
S
G
R
Q
R
Site 7
T35
D
Q
K
M
K
T
G
T
S
G
R
Q
R
V
Q
Site 8
S36
Q
K
M
K
T
G
T
S
G
R
Q
R
V
Q
E
Site 9
S54
M
T
V
K
R
Q
K
S
K
S
S
Q
S
S
T
Site 10
S56
V
K
R
Q
K
S
K
S
S
Q
S
S
T
L
S
Site 11
S57
K
R
Q
K
S
K
S
S
Q
S
S
T
L
S
H
Site 12
S59
Q
K
S
K
S
S
Q
S
S
T
L
S
H
S
N
Site 13
S60
K
S
K
S
S
Q
S
S
T
L
S
H
S
N
R
Site 14
T61
S
K
S
S
Q
S
S
T
L
S
H
S
N
R
G
Site 15
S63
S
S
Q
S
S
T
L
S
H
S
N
R
G
S
M
Site 16
S65
Q
S
S
T
L
S
H
S
N
R
G
S
M
Y
D
Site 17
S69
L
S
H
S
N
R
G
S
M
Y
D
G
L
A
D
Site 18
Y71
H
S
N
R
G
S
M
Y
D
G
L
A
D
N
Y
Site 19
Y78
Y
D
G
L
A
D
N
Y
N
Y
G
T
T
S
R
Site 20
Y80
G
L
A
D
N
Y
N
Y
G
T
T
S
R
S
S
Site 21
T82
A
D
N
Y
N
Y
G
T
T
S
R
S
S
Y
Y
Site 22
T83
D
N
Y
N
Y
G
T
T
S
R
S
S
Y
Y
S
Site 23
S84
N
Y
N
Y
G
T
T
S
R
S
S
Y
Y
S
K
Site 24
S86
N
Y
G
T
T
S
R
S
S
Y
Y
S
K
F
Q
Site 25
S87
Y
G
T
T
S
R
S
S
Y
Y
S
K
F
Q
A
Site 26
Y88
G
T
T
S
R
S
S
Y
Y
S
K
F
Q
A
G
Site 27
Y89
T
T
S
R
S
S
Y
Y
S
K
F
Q
A
G
N
Site 28
S90
T
S
R
S
S
Y
Y
S
K
F
Q
A
G
N
G
Site 29
S98
K
F
Q
A
G
N
G
S
W
G
Y
P
I
Y
N
Site 30
Y101
A
G
N
G
S
W
G
Y
P
I
Y
N
G
T
L
Site 31
Y104
G
S
W
G
Y
P
I
Y
N
G
T
L
K
R
E
Site 32
T107
G
Y
P
I
Y
N
G
T
L
K
R
E
P
D
N
Site 33
S118
E
P
D
N
R
R
F
S
S
Y
S
Q
M
E
N
Site 34
S119
P
D
N
R
R
F
S
S
Y
S
Q
M
E
N
W
Site 35
Y120
D
N
R
R
F
S
S
Y
S
Q
M
E
N
W
S
Site 36
S121
N
R
R
F
S
S
Y
S
Q
M
E
N
W
S
R
Site 37
S127
Y
S
Q
M
E
N
W
S
R
H
Y
P
R
G
S
Site 38
S134
S
R
H
Y
P
R
G
S
C
N
T
T
G
A
G
Site 39
T137
Y
P
R
G
S
C
N
T
T
G
A
G
S
D
I
Site 40
T138
P
R
G
S
C
N
T
T
G
A
G
S
D
I
C
Site 41
S142
C
N
T
T
G
A
G
S
D
I
C
F
M
Q
K
Site 42
S153
F
M
Q
K
I
K
A
S
R
S
E
P
D
L
Y
Site 43
S155
Q
K
I
K
A
S
R
S
E
P
D
L
Y
C
D
Site 44
Y160
S
R
S
E
P
D
L
Y
C
D
P
R
G
T
L
Site 45
T166
L
Y
C
D
P
R
G
T
L
R
K
G
T
L
G
Site 46
T171
R
G
T
L
R
K
G
T
L
G
S
K
G
Q
K
Site 47
S174
L
R
K
G
T
L
G
S
K
G
Q
K
T
T
Q
Site 48
T179
L
G
S
K
G
Q
K
T
T
Q
N
R
Y
S
F
Site 49
T180
G
S
K
G
Q
K
T
T
Q
N
R
Y
S
F
Y
Site 50
Y184
Q
K
T
T
Q
N
R
Y
S
F
Y
S
T
C
S
Site 51
S185
K
T
T
Q
N
R
Y
S
F
Y
S
T
C
S
G
Site 52
Y187
T
Q
N
R
Y
S
F
Y
S
T
C
S
G
Q
K
Site 53
S188
Q
N
R
Y
S
F
Y
S
T
C
S
G
Q
K
A
Site 54
T189
N
R
Y
S
F
Y
S
T
C
S
G
Q
K
A
I
Site 55
S191
Y
S
F
Y
S
T
C
S
G
Q
K
A
I
K
K
Site 56
S205
K
C
P
V
R
P
P
S
C
A
S
K
Q
D
P
Site 57
S208
V
R
P
P
S
C
A
S
K
Q
D
P
V
Y
I
Site 58
Y214
A
S
K
Q
D
P
V
Y
I
P
P
I
S
C
N
Site 59
S219
P
V
Y
I
P
P
I
S
C
N
K
D
L
S
F
Site 60
S225
I
S
C
N
K
D
L
S
F
G
H
S
R
A
S
Site 61
S229
K
D
L
S
F
G
H
S
R
A
S
S
K
I
C
Site 62
S232
S
F
G
H
S
R
A
S
S
K
I
C
S
E
D
Site 63
S233
F
G
H
S
R
A
S
S
K
I
C
S
E
D
I
Site 64
S237
R
A
S
S
K
I
C
S
E
D
I
E
C
S
G
Site 65
Y253
T
I
P
K
A
V
Q
Y
L
S
S
Q
D
E
K
Site 66
S255
P
K
A
V
Q
Y
L
S
S
Q
D
E
K
Y
Q
Site 67
S256
K
A
V
Q
Y
L
S
S
Q
D
E
K
Y
Q
A
Site 68
Y261
L
S
S
Q
D
E
K
Y
Q
A
I
G
A
Y
Y
Site 69
Y284
E
S
A
K
Q
Q
V
Y
Q
L
G
G
I
C
K
Site 70
S298
K
L
V
D
L
L
R
S
P
N
Q
N
V
Q
Q
Site 71
S318
L
R
N
L
V
F
R
S
T
T
N
K
L
E
T
Site 72
T319
R
N
L
V
F
R
S
T
T
N
K
L
E
T
R
Site 73
T320
N
L
V
F
R
S
T
T
N
K
L
E
T
R
R
Site 74
T325
S
T
T
N
K
L
E
T
R
R
Q
N
G
I
R
Site 75
S336
N
G
I
R
E
A
V
S
L
L
R
R
T
G
N
Site 76
T341
A
V
S
L
L
R
R
T
G
N
A
E
I
Q
K
Site 77
T351
A
E
I
Q
K
Q
L
T
G
L
L
W
N
L
S
Site 78
S358
T
G
L
L
W
N
L
S
S
T
D
E
L
K
E
Site 79
S359
G
L
L
W
N
L
S
S
T
D
E
L
K
E
E
Site 80
S384
D
R
V
I
I
P
F
S
G
W
C
D
G
N
S
Site 81
T428
A
L
V
P
Q
R
A
T
S
S
R
V
N
L
S
Site 82
S429
L
V
P
Q
R
A
T
S
S
R
V
N
L
S
S
Site 83
S430
V
P
Q
R
A
T
S
S
R
V
N
L
S
S
A
Site 84
S435
T
S
S
R
V
N
L
S
S
A
D
A
G
R
Q
Site 85
S436
S
S
R
V
N
L
S
S
A
D
A
G
R
Q
T
Site 86
T443
S
A
D
A
G
R
Q
T
M
R
N
Y
S
G
L
Site 87
Y447
G
R
Q
T
M
R
N
Y
S
G
L
I
D
S
L
Site 88
S448
R
Q
T
M
R
N
Y
S
G
L
I
D
S
L
M
Site 89
S453
N
Y
S
G
L
I
D
S
L
M
A
Y
V
Q
N
Site 90
S483
M
C
V
L
H
N
L
S
Y
R
L
D
A
E
V
Site 91
T492
R
L
D
A
E
V
P
T
R
Y
R
Q
L
E
Y
Site 92
Y499
T
R
Y
R
Q
L
E
Y
N
A
R
N
A
Y
T
Site 93
Y505
E
Y
N
A
R
N
A
Y
T
E
K
S
S
T
G
Site 94
T506
Y
N
A
R
N
A
Y
T
E
K
S
S
T
G
C
Site 95
S509
R
N
A
Y
T
E
K
S
S
T
G
C
F
S
N
Site 96
T511
A
Y
T
E
K
S
S
T
G
C
F
S
N
K
S
Site 97
S515
K
S
S
T
G
C
F
S
N
K
S
D
K
M
M
Site 98
S518
T
G
C
F
S
N
K
S
D
K
M
M
N
N
N
Site 99
Y526
D
K
M
M
N
N
N
Y
D
C
P
L
P
E
E
Site 100
T535
C
P
L
P
E
E
E
T
N
P
K
G
S
G
W
Site 101
Y544
P
K
G
S
G
W
L
Y
H
S
D
A
I
R
T
Site 102
S546
G
S
G
W
L
Y
H
S
D
A
I
R
T
Y
L
Site 103
Y552
H
S
D
A
I
R
T
Y
L
N
L
M
G
K
S
Site 104
S578
A
L
Q
N
L
T
A
S
K
G
L
M
S
S
G
Site 105
S609
R
L
L
Q
S
G
N
S
D
V
V
R
S
G
A
Site 106
S614
G
N
S
D
V
V
R
S
G
A
S
L
L
S
N
Site 107
S617
D
V
V
R
S
G
A
S
L
L
S
N
M
S
R
Site 108
S620
R
S
G
A
S
L
L
S
N
M
S
R
H
P
L
Site 109
S623
A
S
L
L
S
N
M
S
R
H
P
L
L
H
R
Site 110
T641
N
Q
V
F
P
E
V
T
R
L
L
T
S
H
T
Site 111
T645
P
E
V
T
R
L
L
T
S
H
T
G
N
T
S
Site 112
S646
E
V
T
R
L
L
T
S
H
T
G
N
T
S
N
Site 113
T648
T
R
L
L
T
S
H
T
G
N
T
S
N
S
E
Site 114
S652
T
S
H
T
G
N
T
S
N
S
E
D
I
L
S
Site 115
S654
H
T
G
N
T
S
N
S
E
D
I
L
S
S
A
Site 116
S659
S
N
S
E
D
I
L
S
S
A
C
Y
T
V
R
Site 117
S660
N
S
E
D
I
L
S
S
A
C
Y
T
V
R
N
Site 118
Y663
D
I
L
S
S
A
C
Y
T
V
R
N
L
M
A
Site 119
T664
I
L
S
S
A
C
Y
T
V
R
N
L
M
A
S
Site 120
S671
T
V
R
N
L
M
A
S
Q
P
Q
L
A
K
Q
Site 121
Y679
Q
P
Q
L
A
K
Q
Y
F
S
S
S
M
L
N
Site 122
S681
Q
L
A
K
Q
Y
F
S
S
S
M
L
N
N
I
Site 123
S682
L
A
K
Q
Y
F
S
S
S
M
L
N
N
I
I
Site 124
S695
I
I
N
L
C
R
S
S
A
S
P
K
A
A
E
Site 125
S697
N
L
C
R
S
S
A
S
P
K
A
A
E
A
A
Site 126
S709
E
A
A
R
L
L
L
S
D
M
W
S
S
K
E
Site 127
S739
G
T
L
A
G
A
N
S
L
R
N
F
T
S
R
Site 128
S745
N
S
L
R
N
F
T
S
R
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation