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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Autotaxin
Full Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Alias:
ATX; Ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; ENPP2; LysoPLD; NPP2; NPPase; PD-I alpha; PD-IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2
Type:
EC 3.6.1.9; EC 3.1.4.1; EC 3.1.4.39; Lipid Metabolism - ether lipid; Phosphodiesterase
Mass (Da):
99004
Number AA:
863
UniProt ID:
Q13822
International Prot ID:
IPI00156171
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0047391
GO:0046872
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006928
GO:0006935
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
R
R
S
S
F
Q
S
C
Q
I
I
S
L
F
Site 2
T45
G
W
E
E
G
P
P
T
V
L
S
D
S
P
W
Site 3
S48
E
G
P
P
T
V
L
S
D
S
P
W
T
N
I
Site 4
S50
P
P
T
V
L
S
D
S
P
W
T
N
I
S
G
Site 5
T53
V
L
S
D
S
P
W
T
N
I
S
G
S
C
K
Site 6
Y134
R
G
D
C
C
T
N
Y
Q
V
V
C
K
G
E
Site 7
S177
S
V
D
G
F
R
A
S
Y
M
K
K
G
S
K
Site 8
Y178
V
D
G
F
R
A
S
Y
M
K
K
G
S
K
V
Site 9
S194
P
N
I
E
K
L
R
S
C
G
T
H
S
P
Y
Site 10
T197
E
K
L
R
S
C
G
T
H
S
P
Y
M
R
P
Site 11
S199
L
R
S
C
G
T
H
S
P
Y
M
R
P
V
Y
Site 12
Y201
S
C
G
T
H
S
P
Y
M
R
P
V
Y
P
T
Site 13
Y206
S
P
Y
M
R
P
V
Y
P
T
K
T
F
P
N
Site 14
T208
Y
M
R
P
V
Y
P
T
K
T
F
P
N
L
Y
Site 15
T210
R
P
V
Y
P
T
K
T
F
P
N
L
Y
T
L
Site 16
T216
K
T
F
P
N
L
Y
T
L
A
T
G
L
Y
P
Site 17
S225
A
T
G
L
Y
P
E
S
H
G
I
V
G
N
S
Site 18
Y234
G
I
V
G
N
S
M
Y
D
P
V
F
D
A
T
Site 19
T241
Y
D
P
V
F
D
A
T
F
H
L
R
G
R
E
Site 20
T263
G
G
Q
P
L
W
I
T
A
T
K
Q
G
V
K
Site 21
T288
P
H
E
R
R
I
L
T
I
L
Q
W
L
T
L
Site 22
T294
L
T
I
L
Q
W
L
T
L
P
D
H
E
R
P
Site 23
S302
L
P
D
H
E
R
P
S
V
Y
A
F
Y
S
E
Site 24
Y304
D
H
E
R
P
S
V
Y
A
F
Y
S
E
Q
P
Site 25
S308
P
S
V
Y
A
F
Y
S
E
Q
P
D
F
S
G
Site 26
S314
Y
S
E
Q
P
D
F
S
G
H
K
Y
G
P
F
Site 27
Y318
P
D
F
S
G
H
K
Y
G
P
F
G
P
E
M
Site 28
T370
E
D
V
T
C
D
R
T
E
F
L
S
N
Y
L
Site 29
Y376
R
T
E
F
L
S
N
Y
L
T
N
V
D
D
I
Site 30
T378
E
F
L
S
N
Y
L
T
N
V
D
D
I
T
L
Site 31
T389
D
I
T
L
V
P
G
T
L
G
R
I
R
S
K
Site 32
S395
G
T
L
G
R
I
R
S
K
F
S
N
N
A
K
Site 33
Y403
K
F
S
N
N
A
K
Y
D
P
K
A
I
I
A
Site 34
Y424
P
D
Q
H
F
K
P
Y
L
K
Q
H
L
P
K
Site 35
Y435
H
L
P
K
R
L
H
Y
A
N
N
R
R
I
E
Site 36
Y462
A
R
K
P
L
D
V
Y
K
K
P
S
G
K
C
Site 37
T486
N
K
V
N
S
M
Q
T
V
F
V
G
Y
G
P
Site 38
T494
V
F
V
G
Y
G
P
T
F
K
Y
K
T
K
V
Site 39
Y497
G
Y
G
P
T
F
K
Y
K
T
K
V
P
P
F
Site 40
S530
P
N
N
G
T
H
G
S
L
N
H
L
L
R
T
Site 41
T537
S
L
N
H
L
L
R
T
N
T
F
R
P
T
M
Site 42
T539
N
H
L
L
R
T
N
T
F
R
P
T
M
P
E
Site 43
T543
R
T
N
T
F
R
P
T
M
P
E
E
V
T
R
Site 44
Y553
E
E
V
T
R
P
N
Y
P
G
I
M
Y
L
Q
Site 45
Y558
P
N
Y
P
G
I
M
Y
L
Q
S
D
F
D
L
Site 46
T588
E
L
N
K
R
L
H
T
K
G
S
T
E
E
R
Site 47
S591
K
R
L
H
T
K
G
S
T
E
E
R
H
L
L
Site 48
T592
R
L
H
T
K
G
S
T
E
E
R
H
L
L
Y
Site 49
Y599
T
E
E
R
H
L
L
Y
G
R
P
A
V
L
Y
Site 50
Y606
Y
G
R
P
A
V
L
Y
R
T
R
Y
D
I
L
Site 51
Y610
A
V
L
Y
R
T
R
Y
D
I
L
Y
H
T
D
Site 52
Y614
R
T
R
Y
D
I
L
Y
H
T
D
F
E
S
G
Site 53
T616
R
Y
D
I
L
Y
H
T
D
F
E
S
G
Y
S
Site 54
Y622
H
T
D
F
E
S
G
Y
S
E
I
F
L
M
P
Site 55
T635
M
P
L
W
T
S
Y
T
V
S
K
Q
A
E
V
Site 56
S637
L
W
T
S
Y
T
V
S
K
Q
A
E
V
S
S
Site 57
S644
S
K
Q
A
E
V
S
S
V
P
D
H
L
T
S
Site 58
T650
S
S
V
P
D
H
L
T
S
C
V
R
P
D
V
Site 59
S651
S
V
P
D
H
L
T
S
C
V
R
P
D
V
R
Site 60
S660
V
R
P
D
V
R
V
S
P
S
F
S
Q
N
C
Site 61
S662
P
D
V
R
V
S
P
S
F
S
Q
N
C
L
A
Site 62
S664
V
R
V
S
P
S
F
S
Q
N
C
L
A
Y
K
Site 63
Y678
K
N
D
K
Q
M
S
Y
G
F
L
F
P
P
Y
Site 64
Y685
Y
G
F
L
F
P
P
Y
L
S
S
S
P
E
A
Site 65
S687
F
L
F
P
P
Y
L
S
S
S
P
E
A
K
Y
Site 66
S688
L
F
P
P
Y
L
S
S
S
P
E
A
K
Y
D
Site 67
S689
F
P
P
Y
L
S
S
S
P
E
A
K
Y
D
A
Site 68
Y694
S
S
S
P
E
A
K
Y
D
A
F
L
V
T
N
Site 69
Y715
A
F
K
R
V
W
N
Y
F
Q
R
V
L
V
K
Site 70
Y724
Q
R
V
L
V
K
K
Y
A
S
E
R
N
G
V
Site 71
S726
V
L
V
K
K
Y
A
S
E
R
N
G
V
N
V
Site 72
S735
R
N
G
V
N
V
I
S
G
P
I
F
D
Y
D
Site 73
Y741
I
S
G
P
I
F
D
Y
D
Y
D
G
L
H
D
Site 74
Y743
G
P
I
F
D
Y
D
Y
D
G
L
H
D
T
E
Site 75
T749
D
Y
D
G
L
H
D
T
E
D
K
I
K
Q
Y
Site 76
Y756
T
E
D
K
I
K
Q
Y
V
E
G
S
S
I
P
Site 77
S761
K
Q
Y
V
E
G
S
S
I
P
V
P
T
H
Y
Site 78
T779
I
T
S
C
L
D
F
T
Q
P
A
D
K
C
D
Site 79
S793
D
G
P
L
S
V
S
S
F
I
L
P
H
R
P
Site 80
S808
D
N
E
E
S
C
N
S
S
E
D
E
S
K
W
Site 81
S809
N
E
E
S
C
N
S
S
E
D
E
S
K
W
V
Site 82
S813
C
N
S
S
E
D
E
S
K
W
V
E
E
L
M
Site 83
T824
E
E
L
M
K
M
H
T
A
R
V
R
D
I
E
Site 84
S835
R
D
I
E
H
L
T
S
L
D
F
F
R
K
T
Site 85
T842
S
L
D
F
F
R
K
T
S
R
S
Y
P
E
I
Site 86
S843
L
D
F
F
R
K
T
S
R
S
Y
P
E
I
L
Site 87
S845
F
F
R
K
T
S
R
S
Y
P
E
I
L
T
L
Site 88
Y846
F
R
K
T
S
R
S
Y
P
E
I
L
T
L
K
Site 89
T851
R
S
Y
P
E
I
L
T
L
K
T
Y
L
H
T
Site 90
T854
P
E
I
L
T
L
K
T
Y
L
H
T
Y
E
S
Site 91
Y855
E
I
L
T
L
K
T
Y
L
H
T
Y
E
S
E
Site 92
Y859
L
K
T
Y
L
H
T
Y
E
S
E
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation