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Updated November 2019
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Protein Info
Short Name:
SHROOM2
Full Name:
Protein Shroom2
Alias:
apical protein of Xenopus-like; apical protein, Xenopus laevis-like; apical protein-like (Xenopus laevis); apical-like protein; APX homolog of Xenopus; APXL; DKFZp781J074; HSAPXL; SHRM2; shroom family member 2
Type:
Channel, sodium
Mass (Da):
176410
Number AA:
1616
UniProt ID:
Q13796
International Prot ID:
IPI00015180
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0005913
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0015280
GO:0008013
PhosphoSite+
KinaseNET
Biological Process:
GO:0045176
GO:0007420
GO:0016477
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T40
G
G
A
P
W
G
F
T
L
K
G
G
R
E
H
Site 2
S108
K
L
V
V
K
R
R
S
E
L
G
W
R
P
H
Site 3
T120
R
P
H
S
W
H
A
T
K
F
S
D
S
H
P
Site 4
S123
S
W
H
A
T
K
F
S
D
S
H
P
E
L
A
Site 5
S125
H
A
T
K
F
S
D
S
H
P
E
L
A
A
S
Site 6
S132
S
H
P
E
L
A
A
S
P
F
T
S
T
S
G
Site 7
S136
L
A
A
S
P
F
T
S
T
S
G
C
P
S
W
Site 8
S138
A
S
P
F
T
S
T
S
G
C
P
S
W
S
G
Site 9
S142
T
S
T
S
G
C
P
S
W
S
G
R
H
H
A
Site 10
S144
T
S
G
C
P
S
W
S
G
R
H
H
A
S
S
Site 11
S150
W
S
G
R
H
H
A
S
S
S
S
H
D
L
S
Site 12
S151
S
G
R
H
H
A
S
S
S
S
H
D
L
S
S
Site 13
S152
G
R
H
H
A
S
S
S
S
H
D
L
S
S
S
Site 14
S153
R
H
H
A
S
S
S
S
H
D
L
S
S
S
W
Site 15
S157
S
S
S
S
H
D
L
S
S
S
W
E
Q
T
N
Site 16
S158
S
S
S
H
D
L
S
S
S
W
E
Q
T
N
L
Site 17
S159
S
S
H
D
L
S
S
S
W
E
Q
T
N
L
Q
Site 18
T163
L
S
S
S
W
E
Q
T
N
L
Q
R
T
L
D
Site 19
T168
E
Q
T
N
L
Q
R
T
L
D
H
F
S
S
L
Site 20
S173
Q
R
T
L
D
H
F
S
S
L
G
S
V
D
S
Site 21
S174
R
T
L
D
H
F
S
S
L
G
S
V
D
S
L
Site 22
S177
D
H
F
S
S
L
G
S
V
D
S
L
D
H
P
Site 23
S180
S
S
L
G
S
V
D
S
L
D
H
P
S
S
R
Site 24
S185
V
D
S
L
D
H
P
S
S
R
L
S
V
A
K
Site 25
S186
D
S
L
D
H
P
S
S
R
L
S
V
A
K
S
Site 26
S189
D
H
P
S
S
R
L
S
V
A
K
S
N
S
S
Site 27
S193
S
R
L
S
V
A
K
S
N
S
S
I
D
H
L
Site 28
S195
L
S
V
A
K
S
N
S
S
I
D
H
L
G
S
Site 29
S196
S
V
A
K
S
N
S
S
I
D
H
L
G
S
H
Site 30
S202
S
S
I
D
H
L
G
S
H
S
K
R
D
S
A
Site 31
S204
I
D
H
L
G
S
H
S
K
R
D
S
A
Y
G
Site 32
S208
G
S
H
S
K
R
D
S
A
Y
G
S
F
S
T
Site 33
Y210
H
S
K
R
D
S
A
Y
G
S
F
S
T
S
S
Site 34
S212
K
R
D
S
A
Y
G
S
F
S
T
S
S
S
T
Site 35
S214
D
S
A
Y
G
S
F
S
T
S
S
S
T
P
D
Site 36
T215
S
A
Y
G
S
F
S
T
S
S
S
T
P
D
H
Site 37
S216
A
Y
G
S
F
S
T
S
S
S
T
P
D
H
T
Site 38
S217
Y
G
S
F
S
T
S
S
S
T
P
D
H
T
L
Site 39
S218
G
S
F
S
T
S
S
S
T
P
D
H
T
L
S
Site 40
T219
S
F
S
T
S
S
S
T
P
D
H
T
L
S
K
Site 41
T223
S
S
S
T
P
D
H
T
L
S
K
A
D
T
S
Site 42
S225
S
T
P
D
H
T
L
S
K
A
D
T
S
S
A
Site 43
T229
H
T
L
S
K
A
D
T
S
S
A
E
N
I
L
Site 44
S231
L
S
K
A
D
T
S
S
A
E
N
I
L
Y
T
Site 45
S266
Q
G
S
E
E
K
L
S
C
F
P
P
R
V
P
Site 46
S276
P
P
R
V
P
G
D
S
G
K
G
P
R
P
E
Site 47
Y284
G
K
G
P
R
P
E
Y
N
A
E
P
K
L
A
Site 48
Y303
S
N
F
G
P
V
W
Y
V
P
D
K
K
K
A
Site 49
S312
P
D
K
K
K
A
P
S
S
P
P
P
P
P
P
Site 50
S313
D
K
K
K
A
P
S
S
P
P
P
P
P
P
P
Site 51
S323
P
P
P
P
P
L
R
S
D
S
F
A
A
T
K
Site 52
S325
P
P
P
L
R
S
D
S
F
A
A
T
K
S
H
Site 53
T329
R
S
D
S
F
A
A
T
K
S
H
E
K
A
Q
Site 54
S331
D
S
F
A
A
T
K
S
H
E
K
A
Q
G
P
Site 55
T366
G
D
R
R
P
E
L
T
D
R
P
W
R
S
A
Site 56
S372
L
T
D
R
P
W
R
S
A
H
P
G
S
L
G
Site 57
S377
W
R
S
A
H
P
G
S
L
G
K
G
S
G
G
Site 58
S382
P
G
S
L
G
K
G
S
G
G
P
G
C
P
Q
Site 59
S396
Q
E
A
H
A
D
G
S
W
P
P
S
K
D
G
Site 60
S400
A
D
G
S
W
P
P
S
K
D
G
A
S
S
R
Site 61
S405
P
P
S
K
D
G
A
S
S
R
L
Q
A
S
L
Site 62
S406
P
S
K
D
G
A
S
S
R
L
Q
A
S
L
S
Site 63
S411
A
S
S
R
L
Q
A
S
L
S
S
S
D
V
R
Site 64
S413
S
R
L
Q
A
S
L
S
S
S
D
V
R
F
P
Site 65
S415
L
Q
A
S
L
S
S
S
D
V
R
F
P
Q
S
Site 66
S422
S
D
V
R
F
P
Q
S
P
H
S
G
R
H
P
Site 67
S425
R
F
P
Q
S
P
H
S
G
R
H
P
P
L
Y
Site 68
Y432
S
G
R
H
P
P
L
Y
S
D
H
S
P
L
C
Site 69
S433
G
R
H
P
P
L
Y
S
D
H
S
P
L
C
A
Site 70
S436
P
P
L
Y
S
D
H
S
P
L
C
A
D
S
L
Site 71
S442
H
S
P
L
C
A
D
S
L
G
Q
E
P
G
A
Site 72
S451
G
Q
E
P
G
A
A
S
F
Q
N
D
S
P
P
Site 73
S456
A
A
S
F
Q
N
D
S
P
P
Q
V
R
G
L
Site 74
S464
P
P
Q
V
R
G
L
S
S
C
D
Q
K
L
G
Site 75
S465
P
Q
V
R
G
L
S
S
C
D
Q
K
L
G
S
Site 76
S472
S
C
D
Q
K
L
G
S
G
W
Q
G
P
R
P
Site 77
S497
L
W
A
G
C
W
P
S
D
T
A
L
G
A
L
Site 78
T511
L
E
S
L
P
P
P
T
V
G
Q
S
P
R
H
Site 79
S515
P
P
P
T
V
G
Q
S
P
R
H
H
L
P
Q
Site 80
T532
G
P
P
D
A
R
E
T
G
R
C
Y
P
L
D
Site 81
Y536
A
R
E
T
G
R
C
Y
P
L
D
K
G
A
E
Site 82
S556
A
Q
E
P
P
R
A
S
R
A
E
K
A
S
Q
Site 83
S562
A
S
R
A
E
K
A
S
Q
R
L
A
A
S
I
Site 84
T570
Q
R
L
A
A
S
I
T
W
A
D
G
E
S
S
Site 85
S576
I
T
W
A
D
G
E
S
S
R
I
C
P
Q
E
Site 86
T584
S
R
I
C
P
Q
E
T
P
L
L
H
S
L
T
Site 87
T591
T
P
L
L
H
S
L
T
Q
E
G
K
R
R
P
Site 88
S600
E
G
K
R
R
P
E
S
S
P
E
D
S
A
T
Site 89
S601
G
K
R
R
P
E
S
S
P
E
D
S
A
T
R
Site 90
S605
P
E
S
S
P
E
D
S
A
T
R
P
P
P
F
Site 91
T607
S
S
P
E
D
S
A
T
R
P
P
P
F
D
A
Site 92
S623
V
G
K
P
T
R
R
S
D
R
F
A
T
T
L
Site 93
T628
R
R
S
D
R
F
A
T
T
L
R
N
E
I
Q
Site 94
T629
R
S
D
R
F
A
T
T
L
R
N
E
I
Q
M
Site 95
S644
H
R
A
K
L
Q
K
S
R
S
T
V
A
L
T
Site 96
S646
A
K
L
Q
K
S
R
S
T
V
A
L
T
A
A
Site 97
T647
K
L
Q
K
S
R
S
T
V
A
L
T
A
A
G
Site 98
T660
A
G
E
A
E
D
G
T
G
R
W
R
A
G
L
Site 99
T695
Q
A
R
V
L
R
A
T
S
F
K
R
R
D
L
Site 100
S696
A
R
V
L
R
A
T
S
F
K
R
R
D
L
D
Site 101
Y710
D
P
N
P
G
D
L
Y
P
E
S
L
E
H
R
Site 102
S713
P
G
D
L
Y
P
E
S
L
E
H
R
M
G
D
Site 103
S737
A
G
L
A
Q
P
P
S
S
T
S
G
G
P
H
Site 104
S738
G
L
A
Q
P
P
S
S
T
S
G
G
P
H
P
Site 105
S740
A
Q
P
P
S
S
T
S
G
G
P
H
P
P
R
Site 106
T755
I
G
G
R
R
R
F
T
A
E
Q
K
L
K
S
Site 107
S762
T
A
E
Q
K
L
K
S
Y
S
E
P
E
K
M
Site 108
Y763
A
E
Q
K
L
K
S
Y
S
E
P
E
K
M
N
Site 109
S764
E
Q
K
L
K
S
Y
S
E
P
E
K
M
N
E
Site 110
T775
K
M
N
E
V
G
L
T
R
G
Y
S
P
H
Q
Site 111
Y778
E
V
G
L
T
R
G
Y
S
P
H
Q
H
P
R
Site 112
S779
V
G
L
T
R
G
Y
S
P
H
Q
H
P
R
T
Site 113
T786
S
P
H
Q
H
P
R
T
S
E
D
T
V
G
T
Site 114
S787
P
H
Q
H
P
R
T
S
E
D
T
V
G
T
F
Site 115
T790
H
P
R
T
S
E
D
T
V
G
T
F
A
D
R
Site 116
T793
T
S
E
D
T
V
G
T
F
A
D
R
W
K
F
Site 117
T804
R
W
K
F
F
E
E
T
S
K
P
V
P
Q
R
Site 118
T831
D
K
P
E
R
P
R
T
A
G
R
T
C
E
G
Site 119
T835
R
P
R
T
A
G
R
T
C
E
G
T
E
P
W
Site 120
T839
A
G
R
T
C
E
G
T
E
P
W
S
R
T
T
Site 121
S843
C
E
G
T
E
P
W
S
R
T
T
S
L
G
D
Site 122
T846
T
E
P
W
S
R
T
T
S
L
G
D
S
L
N
Site 123
S847
E
P
W
S
R
T
T
S
L
G
D
S
L
N
A
Site 124
S851
R
T
T
S
L
G
D
S
L
N
A
H
S
A
A
Site 125
S864
A
A
E
K
A
G
T
S
D
L
P
R
R
L
G
Site 126
T872
D
L
P
R
R
L
G
T
F
A
E
Y
Q
A
S
Site 127
Y876
R
L
G
T
F
A
E
Y
Q
A
S
W
K
E
Q
Site 128
S891
R
K
P
L
E
A
R
S
S
G
R
C
H
S
A
Site 129
S892
K
P
L
E
A
R
S
S
G
R
C
H
S
A
D
Site 130
S897
R
S
S
G
R
C
H
S
A
D
D
I
L
D
V
Site 131
S905
A
D
D
I
L
D
V
S
L
D
P
Q
E
R
P
Site 132
S919
P
Q
H
V
H
G
R
S
R
S
S
P
S
T
D
Site 133
S921
H
V
H
G
R
S
R
S
S
P
S
T
D
H
Y
Site 134
S922
V
H
G
R
S
R
S
S
P
S
T
D
H
Y
K
Site 135
T925
R
S
R
S
S
P
S
T
D
H
Y
K
Q
E
A
Site 136
Y928
S
S
P
S
T
D
H
Y
K
Q
E
A
S
V
E
Site 137
S952
E
P
R
E
E
L
P
S
A
V
R
A
E
E
G
Site 138
T962
R
A
E
E
G
Q
S
T
P
R
Q
A
D
A
Q
Site 139
S974
D
A
Q
C
R
E
G
S
P
G
S
Q
Q
H
P
Site 140
S977
C
R
E
G
S
P
G
S
Q
Q
H
P
P
S
Q
Site 141
S983
G
S
Q
Q
H
P
P
S
Q
K
A
P
N
P
P
Site 142
T991
Q
K
A
P
N
P
P
T
F
S
E
L
S
H
C
Site 143
S996
P
P
T
F
S
E
L
S
H
C
R
G
A
P
E
Site 144
T1014
E
G
R
G
R
A
G
T
L
P
R
D
Y
R
Y
Site 145
Y1019
A
G
T
L
P
R
D
Y
R
Y
S
E
E
S
T
Site 146
Y1021
T
L
P
R
D
Y
R
Y
S
E
E
S
T
P
A
Site 147
S1022
L
P
R
D
Y
R
Y
S
E
E
S
T
P
A
D
Site 148
S1025
D
Y
R
Y
S
E
E
S
T
P
A
D
L
G
P
Site 149
T1026
Y
R
Y
S
E
E
S
T
P
A
D
L
G
P
R
Site 150
S1036
D
L
G
P
R
A
Q
S
P
G
S
P
L
H
A
Site 151
S1039
P
R
A
Q
S
P
G
S
P
L
H
A
R
G
Q
Site 152
S1048
L
H
A
R
G
Q
D
S
W
P
V
S
S
A
L
Site 153
S1052
G
Q
D
S
W
P
V
S
S
A
L
L
S
K
R
Site 154
S1053
Q
D
S
W
P
V
S
S
A
L
L
S
K
R
P
Site 155
S1057
P
V
S
S
A
L
L
S
K
R
P
A
P
Q
R
Site 156
Y1075
P
K
R
E
P
R
R
Y
R
A
T
D
G
A
P
Site 157
T1078
E
P
R
R
Y
R
A
T
D
G
A
P
A
D
A
Site 158
T1096
V
L
G
R
P
F
P
T
P
S
P
A
S
L
D
Site 159
S1098
G
R
P
F
P
T
P
S
P
A
S
L
D
V
Y
Site 160
Y1105
S
P
A
S
L
D
V
Y
V
A
R
L
S
L
S
Site 161
S1114
A
R
L
S
L
S
H
S
P
S
V
F
S
S
A
Site 162
S1116
L
S
L
S
H
S
P
S
V
F
S
S
A
Q
P
Site 163
S1120
H
S
P
S
V
F
S
S
A
Q
P
Q
D
T
P
Site 164
T1126
S
S
A
Q
P
Q
D
T
P
K
A
T
V
C
E
Site 165
T1130
P
Q
D
T
P
K
A
T
V
C
E
R
G
S
Q
Site 166
S1136
A
T
V
C
E
R
G
S
Q
H
V
S
G
D
A
Site 167
S1140
E
R
G
S
Q
H
V
S
G
D
A
S
R
P
L
Site 168
S1144
Q
H
V
S
G
D
A
S
R
P
L
P
E
A
L
Site 169
T1163
Q
Q
H
L
R
L
Q
T
A
T
M
E
T
S
R
Site 170
T1165
H
L
R
L
Q
T
A
T
M
E
T
S
R
S
P
Site 171
S1169
Q
T
A
T
M
E
T
S
R
S
P
S
P
Q
F
Site 172
S1171
A
T
M
E
T
S
R
S
P
S
P
Q
F
A
P
Site 173
S1173
M
E
T
S
R
S
P
S
P
Q
F
A
P
Q
K
Site 174
T1182
Q
F
A
P
Q
K
L
T
D
K
P
P
L
L
I
Site 175
S1194
L
L
I
Q
D
E
D
S
T
R
I
E
R
V
M
Site 176
T1205
E
R
V
M
D
N
N
T
T
V
K
M
V
P
I
Site 177
T1206
R
V
M
D
N
N
T
T
V
K
M
V
P
I
K
Site 178
S1219
I
K
I
V
H
S
E
S
Q
P
E
K
E
S
R
Site 179
S1228
P
E
K
E
S
R
Q
S
L
A
C
P
A
E
P
Site 180
T1249
L
E
K
D
Q
I
K
T
L
S
T
S
E
Q
F
Site 181
S1251
K
D
Q
I
K
T
L
S
T
S
E
Q
F
Y
S
Site 182
S1253
Q
I
K
T
L
S
T
S
E
Q
F
Y
S
R
F
Site 183
Y1257
L
S
T
S
E
Q
F
Y
S
R
F
C
L
Y
T
Site 184
S1258
S
T
S
E
Q
F
Y
S
R
F
C
L
Y
T
R
Site 185
Y1263
F
Y
S
R
F
C
L
Y
T
R
Q
G
A
E
P
Site 186
T1264
Y
S
R
F
C
L
Y
T
R
Q
G
A
E
P
E
Site 187
T1286
A
E
P
Q
P
L
G
T
Q
V
P
P
E
K
D
Site 188
T1296
P
P
E
K
D
R
C
T
S
P
P
G
L
S
Y
Site 189
S1297
P
E
K
D
R
C
T
S
P
P
G
L
S
Y
M
Site 190
S1302
C
T
S
P
P
G
L
S
Y
M
K
A
K
E
K
Site 191
S1316
K
T
V
E
D
L
K
S
E
E
L
A
R
E
I
Site 192
S1329
E
I
V
G
K
D
K
S
L
A
D
I
L
D
P
Site 193
S1373
K
L
L
P
K
I
P
S
P
R
S
T
E
E
R
Site 194
S1376
P
K
I
P
S
P
R
S
T
E
E
R
K
E
E
Site 195
T1377
K
I
P
S
P
R
S
T
E
E
R
K
E
E
P
Site 196
S1385
E
E
R
K
E
E
P
S
V
P
A
A
V
S
L
Site 197
S1396
A
V
S
L
A
T
N
S
T
Y
Y
S
T
S
A
Site 198
T1397
V
S
L
A
T
N
S
T
Y
Y
S
T
S
A
P
Site 199
Y1398
S
L
A
T
N
S
T
Y
Y
S
T
S
A
P
K
Site 200
S1400
A
T
N
S
T
Y
Y
S
T
S
A
P
K
A
E
Site 201
S1425
Q
Q
E
H
E
E
D
S
G
S
D
L
D
H
D
Site 202
S1427
E
H
E
E
D
S
G
S
D
L
D
H
D
L
S
Site 203
S1434
S
D
L
D
H
D
L
S
V
K
K
Q
E
L
I
Site 204
S1443
K
K
Q
E
L
I
E
S
I
S
R
K
L
Q
V
Site 205
S1457
V
L
R
E
A
R
E
S
L
L
E
D
V
Q
A
Site 206
S1483
V
K
G
V
C
K
P
S
E
F
D
K
F
R
M
Site 207
S1504
K
V
V
N
L
L
L
S
L
S
G
R
L
A
R
Site 208
S1506
V
N
L
L
L
S
L
S
G
R
L
A
R
V
E
Site 209
S1524
N
N
L
D
D
G
A
S
P
G
D
R
Q
S
L
Site 210
S1530
A
S
P
G
D
R
Q
S
L
L
E
K
Q
R
V
Site 211
S1568
D
I
L
A
N
Y
L
S
E
E
S
L
A
D
Y
Site 212
S1571
A
N
Y
L
S
E
E
S
L
A
D
Y
E
H
F
Site 213
Y1575
S
E
E
S
L
A
D
Y
E
H
F
V
K
M
K
Site 214
S1583
E
H
F
V
K
M
K
S
A
L
I
I
E
Q
R
Site 215
S1609
Q
L
K
C
L
L
D
S
L
Q
P
E
R
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation