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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP1A4
Full Name:
Sodium/potassium-transporting ATPase subunit alpha-4
Alias:
AT1A4; ATP1A1; ATP1AL2; ATPase, Na+/K+ transporting, alpha 4; ATPase, Na+/K+ transporting, alpha 4 polypeptide; MGC25056; Na(+)/K(+) ATPase alpha-4; Sodium pump subunit alpha-4; Sodium/potassium-transporting ATPase alpha-4
Type:
EC 3.6.3.9; Membrane protein, integral; Hydrolase; Transporter; Motility/polarity/chemotaxis
Mass (Da):
114166
Number AA:
1029
UniProt ID:
Q13733
International Prot ID:
IPI00252122
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005890
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0015077
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015991
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
L
W
G
K
K
G
T
V
A
P
H
D
Q
S
Site 2
S16
T
V
A
P
H
D
Q
S
P
R
R
R
P
K
K
Site 3
T55
V
M
D
D
H
K
L
T
L
E
E
L
S
T
K
Site 4
S60
K
L
T
L
E
E
L
S
T
K
Y
S
V
D
L
Site 5
T61
L
T
L
E
E
L
S
T
K
Y
S
V
D
L
T
Site 6
S64
E
E
L
S
T
K
Y
S
V
D
L
T
K
G
H
Site 7
T68
T
K
Y
S
V
D
L
T
K
G
H
S
H
Q
R
Site 8
S72
V
D
L
T
K
G
H
S
H
Q
R
A
K
E
I
Site 9
T87
L
T
R
G
G
P
N
T
V
T
P
P
P
T
T
Site 10
T89
R
G
G
P
N
T
V
T
P
P
P
T
T
P
E
Site 11
T94
T
V
T
P
P
P
T
T
P
E
W
V
K
F
C
Site 12
Y128
V
A
Y
S
I
Q
I
Y
F
N
E
E
P
T
K
Site 13
Y157
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
Site 14
S162
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
Site 15
S163
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
Site 16
S168
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Site 17
S215
P
A
D
L
R
L
I
S
A
Q
G
C
K
V
D
Site 18
S224
Q
G
C
K
V
D
N
S
S
L
T
G
E
S
E
Site 19
S225
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Site 20
T227
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
S
Site 21
S230
N
S
S
L
T
G
E
S
E
P
Q
S
R
S
P
Site 22
S234
T
G
E
S
E
P
Q
S
R
S
P
D
F
T
H
Site 23
S236
E
S
E
P
Q
S
R
S
P
D
F
T
H
E
N
Site 24
T240
Q
S
R
S
P
D
F
T
H
E
N
P
L
E
T
Site 25
T374
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
Site 26
S377
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
Site 27
T378
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
Site 28
S379
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
Site 29
T380
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
Site 30
S383
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Site 31
T386
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
Site 32
T390
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
Site 33
Y406
M
W
F
D
M
T
V
Y
E
A
D
T
T
E
E
Site 34
T411
T
V
Y
E
A
D
T
T
E
E
Q
T
G
K
T
Site 35
T418
T
E
E
Q
T
G
K
T
F
T
K
S
S
D
T
Site 36
S423
G
K
T
F
T
K
S
S
D
T
W
F
M
L
A
Site 37
T455
L
P
I
A
K
R
A
T
T
G
D
A
S
E
S
Site 38
T456
P
I
A
K
R
A
T
T
G
D
A
S
E
S
A
Site 39
S473
K
F
I
E
Q
S
Y
S
S
V
A
E
M
R
E
Site 40
Y496
P
F
N
S
T
N
K
Y
Q
M
S
I
H
L
R
Site 41
S506
S
I
H
L
R
E
D
S
S
Q
T
H
V
L
M
Site 42
S507
I
H
L
R
E
D
S
S
Q
T
H
V
L
M
M
Site 43
S536
L
L
N
G
Q
E
Y
S
M
N
D
E
M
K
E
Site 44
Y549
K
E
A
F
Q
N
A
Y
L
E
L
G
G
L
G
Site 45
S572
L
N
L
P
S
S
F
S
K
G
F
P
F
N
T
Site 46
T579
S
K
G
F
P
F
N
T
D
E
I
N
F
P
M
Site 47
S641
A
K
G
V
G
I
I
S
E
G
T
E
T
A
E
Site 48
T646
I
I
S
E
G
T
E
T
A
E
E
V
A
A
R
Site 49
S681
A
E
L
K
D
I
Q
S
K
Q
L
D
Q
I
L
Site 50
S728
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
Site 51
S748
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
Site 52
T785
L
K
K
S
I
M
Y
T
L
T
S
N
I
P
E
Site 53
S835
L
A
Y
E
S
A
E
S
D
I
M
K
R
L
P
Site 54
T847
R
L
P
R
N
P
K
T
D
N
L
V
N
H
R
Site 55
Y900
R
L
H
W
E
D
K
Y
L
N
D
L
E
D
S
Site 56
Y908
L
N
D
L
E
D
S
Y
G
Q
Q
W
T
Y
E
Site 57
Y914
S
Y
G
Q
Q
W
T
Y
E
Q
R
K
V
V
E
Site 58
S943
Q
W
A
D
L
I
I
S
K
T
R
R
N
S
L
Site 59
T945
A
D
L
I
I
S
K
T
R
R
N
S
L
F
Q
Site 60
S949
I
S
K
T
R
R
N
S
L
F
Q
Q
G
M
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation