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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIN1
Full Name:
Ras and Rab interactor 1
Alias:
Ras inhibitor JC99; Ras interaction/interference protein 1
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
84099
Number AA:
783
UniProt ID:
Q13671
International Prot ID:
IPI00014454
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0006897
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
P
G
E
S
G
A
G
Site 2
S7
_
M
E
S
P
G
E
S
G
A
G
S
P
G
A
Site 3
S11
P
G
E
S
G
A
G
S
P
G
A
P
S
P
S
Site 4
S16
A
G
S
P
G
A
P
S
P
S
S
F
T
T
G
Site 5
S18
S
P
G
A
P
S
P
S
S
F
T
T
G
H
L
Site 6
S19
P
G
A
P
S
P
S
S
F
T
T
G
H
L
A
Site 7
T22
P
S
P
S
S
F
T
T
G
H
L
A
R
E
K
Site 8
Y36
K
P
A
Q
D
P
L
Y
D
V
P
N
A
S
G
Site 9
S42
L
Y
D
V
P
N
A
S
G
G
Q
A
G
G
P
Site 10
S57
Q
R
P
G
R
V
V
S
L
R
E
R
L
L
L
Site 11
T90
L
R
T
E
P
P
G
T
F
L
V
R
K
S
N
Site 12
S96
G
T
F
L
V
R
K
S
N
T
R
Q
C
Q
A
Site 13
S112
C
M
R
L
P
E
A
S
G
P
S
F
V
S
S
Site 14
S115
L
P
E
A
S
G
P
S
F
V
S
S
H
Y
I
Site 15
S118
A
S
G
P
S
F
V
S
S
H
Y
I
L
E
S
Site 16
S119
S
G
P
S
F
V
S
S
H
Y
I
L
E
S
P
Site 17
Y121
P
S
F
V
S
S
H
Y
I
L
E
S
P
G
G
Site 18
S125
S
S
H
Y
I
L
E
S
P
G
G
V
S
L
E
Site 19
S130
L
E
S
P
G
G
V
S
L
E
G
S
E
L
M
Site 20
Y148
L
V
Q
L
I
C
A
Y
C
H
T
R
D
I
L
Site 21
S188
G
I
E
F
W
S
S
S
L
N
I
K
A
Q
R
Site 22
S210
L
P
Q
L
K
A
R
S
P
Q
E
L
D
Q
G
Site 23
S244
K
R
E
K
F
K
R
S
F
K
V
R
V
S
T
Site 24
S250
R
S
F
K
V
R
V
S
T
E
T
S
S
P
L
Site 25
T251
S
F
K
V
R
V
S
T
E
T
S
S
P
L
S
Site 26
T253
K
V
R
V
S
T
E
T
S
S
P
L
S
P
P
Site 27
S254
V
R
V
S
T
E
T
S
S
P
L
S
P
P
A
Site 28
S255
R
V
S
T
E
T
S
S
P
L
S
P
P
A
V
Site 29
S258
T
E
T
S
S
P
L
S
P
P
A
V
P
P
P
Site 30
S276
V
L
P
G
A
V
P
S
Q
T
E
R
L
P
P
Site 31
T278
P
G
A
V
P
S
Q
T
E
R
L
P
P
C
Q
Site 32
S291
C
Q
L
L
R
R
E
S
S
V
G
Y
R
V
P
Site 33
S292
Q
L
L
R
R
E
S
S
V
G
Y
R
V
P
A
Site 34
Y295
R
R
E
S
S
V
G
Y
R
V
P
A
G
S
G
Site 35
S301
G
Y
R
V
P
A
G
S
G
P
S
L
P
P
M
Site 36
S310
P
S
L
P
P
M
P
S
L
Q
E
V
D
C
G
Site 37
S318
L
Q
E
V
D
C
G
S
P
S
S
S
E
E
E
Site 38
S320
E
V
D
C
G
S
P
S
S
S
E
E
E
G
V
Site 39
S321
V
D
C
G
S
P
S
S
S
E
E
E
G
V
P
Site 40
S322
D
C
G
S
P
S
S
S
E
E
E
G
V
P
G
Site 41
S330
E
E
E
G
V
P
G
S
R
G
S
P
A
T
S
Site 42
S333
G
V
P
G
S
R
G
S
P
A
T
S
P
H
L
Site 43
T336
G
S
R
G
S
P
A
T
S
P
H
L
G
R
R
Site 44
S337
S
R
G
S
P
A
T
S
P
H
L
G
R
R
R
Site 45
S349
R
R
R
P
L
L
R
S
M
S
A
A
F
C
S
Site 46
S351
R
P
L
L
R
S
M
S
A
A
F
C
S
L
L
Site 47
S356
S
M
S
A
A
F
C
S
L
L
A
P
E
R
Q
Site 48
T377
A
L
M
Q
D
R
H
T
A
A
G
Q
L
V
Q
Site 49
T388
Q
L
V
Q
D
L
L
T
Q
V
R
A
G
P
E
Site 50
S407
Q
G
I
R
Q
A
L
S
R
A
R
A
M
L
S
Site 51
S414
S
R
A
R
A
M
L
S
A
E
L
G
P
E
K
Site 52
S424
L
G
P
E
K
L
L
S
P
K
R
L
E
H
V
Site 53
S439
L
E
K
S
L
H
C
S
V
L
K
P
L
R
P
Site 54
S461
R
R
L
A
A
D
G
S
L
G
R
L
A
E
G
Site 55
S482
Q
G
P
G
A
F
G
S
H
L
S
L
P
S
P
Site 56
S488
G
S
H
L
S
L
P
S
P
V
E
L
E
Q
V
Site 57
T505
K
L
L
Q
L
L
R
T
Y
S
P
S
A
Q
V
Site 58
Y506
L
L
Q
L
L
R
T
Y
S
P
S
A
Q
V
K
Site 59
S507
L
Q
L
L
R
T
Y
S
P
S
A
Q
V
K
R
Site 60
S509
L
L
R
T
Y
S
P
S
A
Q
V
K
R
L
L
Site 61
S569
M
S
E
L
L
E
P
S
L
L
T
G
E
G
G
Site 62
Y578
L
T
G
E
G
G
Y
Y
L
T
S
L
S
A
S
Site 63
T597
S
G
L
G
Q
A
H
T
L
P
L
S
P
V
Q
Site 64
S601
Q
A
H
T
L
P
L
S
P
V
Q
E
L
R
R
Site 65
S609
P
V
Q
E
L
R
R
S
L
S
L
W
E
Q
R
Site 66
S611
Q
E
L
R
R
S
L
S
L
W
E
Q
R
R
L
Site 67
T621
E
Q
R
R
L
P
A
T
H
C
F
Q
H
L
L
Site 68
Y632
Q
H
L
L
R
V
A
Y
Q
D
P
S
S
G
C
Site 69
S636
R
V
A
Y
Q
D
P
S
S
G
C
T
S
K
T
Site 70
S637
V
A
Y
Q
D
P
S
S
G
C
T
S
K
T
L
Site 71
S641
D
P
S
S
G
C
T
S
K
T
L
A
V
P
P
Site 72
T643
S
S
G
C
T
S
K
T
L
A
V
P
P
E
A
Site 73
T666
C
A
T
K
F
R
V
T
Q
P
N
T
F
G
L
Site 74
T670
F
R
V
T
Q
P
N
T
F
G
L
F
L
Y
K
Site 75
Y676
N
T
F
G
L
F
L
Y
K
E
Q
G
Y
H
R
Site 76
Y681
F
L
Y
K
E
Q
G
Y
H
R
L
P
P
G
A
Site 77
T696
L
A
H
R
L
P
T
T
G
Y
L
V
Y
R
R
Site 78
Y698
H
R
L
P
T
T
G
Y
L
V
Y
R
R
A
E
Site 79
Y701
P
T
T
G
Y
L
V
Y
R
R
A
E
W
P
E
Site 80
T709
R
R
A
E
W
P
E
T
Q
G
A
V
T
E
E
Site 81
S719
A
V
T
E
E
E
G
S
G
Q
S
E
A
R
S
Site 82
S722
E
E
E
G
S
G
Q
S
E
A
R
S
R
G
E
Site 83
S726
S
G
Q
S
E
A
R
S
R
G
E
E
Q
G
C
Site 84
S744
G
D
A
G
V
K
A
S
P
R
D
I
R
E
Q
Site 85
S752
P
R
D
I
R
E
Q
S
E
T
T
A
E
G
G
Site 86
T754
D
I
R
E
Q
S
E
T
T
A
E
G
G
Q
G
Site 87
S778
G
E
P
E
A
E
G
S
R
A
A
E
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation