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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TP53BP2
Full Name:
Apoptosis-stimulating of p53 protein 2
Alias:
53BP2; Apoptosis stimulating of p53 protein 2; ASP2; ASPP2; Bbp; Bcl2-binding protein; P53-binding protein 2; PPP1R13A; Renal carcinoma antigen NY-REN-51; Tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2
Type:
Transcription, coactivator/corepressor
Mass (Da):
125616
Number AA:
1128
UniProt ID:
Q13625
International Prot ID:
IPI00186808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0017124
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007049
GO:0006917
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
M
P
M
F
L
T
V
Y
L
S
N
N
E
Q
H
Site 2
T18
S
N
N
E
Q
H
F
T
E
V
P
V
T
P
E
Site 3
T23
H
F
T
E
V
P
V
T
P
E
T
I
C
R
D
Site 4
S41
L
C
K
E
P
G
E
S
D
C
H
L
A
E
V
Site 5
S52
L
A
E
V
W
C
G
S
E
R
P
V
A
D
N
Site 6
S71
D
V
L
Q
R
F
G
S
Q
R
N
E
V
R
F
Site 7
S92
P
P
G
R
D
I
V
S
G
P
R
S
Q
D
P
Site 8
S96
D
I
V
S
G
P
R
S
Q
D
P
S
L
K
R
Site 9
S100
G
P
R
S
Q
D
P
S
L
K
R
N
G
V
K
Site 10
Y112
G
V
K
V
P
G
E
Y
R
R
K
E
N
G
V
Site 11
S121
R
K
E
N
G
V
N
S
P
R
M
D
L
T
L
Site 12
T127
N
S
P
R
M
D
L
T
L
A
E
L
Q
E
M
Site 13
S206
H
V
E
Q
K
R
L
S
N
G
K
L
V
E
E
Site 14
S233
R
E
L
V
L
A
V
S
K
V
E
E
L
T
R
Site 15
S252
L
K
N
G
R
I
D
S
H
H
D
N
Q
S
A
Site 16
Y267
V
A
E
L
D
R
L
Y
K
E
L
Q
L
R
N
Site 17
S296
E
C
L
N
K
R
N
S
E
V
A
V
M
D
K
Site 18
S328
Q
K
E
N
L
P
V
S
S
D
G
N
L
P
Q
Site 19
S329
K
E
N
L
P
V
S
S
D
G
N
L
P
Q
Q
Site 20
Y350
R
V
A
A
V
G
P
Y
I
Q
S
S
T
M
P
Site 21
S354
V
G
P
Y
I
Q
S
S
T
M
P
R
M
P
S
Site 22
T355
G
P
Y
I
Q
S
S
T
M
P
R
M
P
S
R
Site 23
S361
S
T
M
P
R
M
P
S
R
P
E
L
L
V
K
Site 24
S375
K
P
A
L
P
D
G
S
L
V
I
Q
A
S
E
Site 25
T389
E
G
P
M
K
I
Q
T
L
P
N
M
R
S
G
Site 26
S395
Q
T
L
P
N
M
R
S
G
A
A
S
Q
T
K
Site 27
S399
N
M
R
S
G
A
A
S
Q
T
K
G
S
K
I
Site 28
S414
H
P
V
G
P
D
W
S
P
S
N
A
D
L
F
Site 29
S416
V
G
P
D
W
S
P
S
N
A
D
L
F
P
S
Site 30
S423
S
N
A
D
L
F
P
S
Q
G
S
A
S
V
P
Site 31
S426
D
L
F
P
S
Q
G
S
A
S
V
P
Q
S
T
Site 32
S428
F
P
S
Q
G
S
A
S
V
P
Q
S
T
G
N
Site 33
S432
G
S
A
S
V
P
Q
S
T
G
N
A
L
D
Q
Site 34
S458
E
K
K
V
R
P
F
S
M
F
D
A
V
D
Q
Site 35
S466
M
F
D
A
V
D
Q
S
N
A
P
P
S
F
G
Site 36
S471
D
Q
S
N
A
P
P
S
F
G
T
L
R
K
N
Site 37
T474
N
A
P
P
S
F
G
T
L
R
K
N
Q
S
S
Site 38
S480
G
T
L
R
K
N
Q
S
S
E
D
I
L
R
D
Site 39
S481
T
L
R
K
N
Q
S
S
E
D
I
L
R
D
A
Site 40
Y513
P
K
Q
I
N
L
P
Y
F
G
Q
T
N
Q
P
Site 41
S522
G
Q
T
N
Q
P
P
S
D
I
K
P
D
G
S
Site 42
S529
S
D
I
K
P
D
G
S
S
Q
Q
L
S
T
V
Site 43
S530
D
I
K
P
D
G
S
S
Q
Q
L
S
T
V
V
Site 44
S534
D
G
S
S
Q
Q
L
S
T
V
V
P
S
M
G
Site 45
T535
G
S
S
Q
Q
L
S
T
V
V
P
S
M
G
T
Site 46
S539
Q
L
S
T
V
V
P
S
M
G
T
K
P
K
P
Site 47
S556
Q
Q
P
R
V
L
L
S
P
S
I
P
S
V
G
Site 48
S558
P
R
V
L
L
S
P
S
I
P
S
V
G
Q
D
Site 49
S561
L
L
S
P
S
I
P
S
V
G
Q
D
Q
T
L
Site 50
T567
P
S
V
G
Q
D
Q
T
L
S
P
G
S
K
Q
Site 51
S569
V
G
Q
D
Q
T
L
S
P
G
S
K
Q
E
S
Site 52
S572
D
Q
T
L
S
P
G
S
K
Q
E
S
P
P
A
Site 53
S576
S
P
G
S
K
Q
E
S
P
P
A
A
A
V
R
Site 54
T586
A
A
A
V
R
P
F
T
P
Q
P
S
K
D
T
Site 55
S590
R
P
F
T
P
Q
P
S
K
D
T
L
L
P
P
Site 56
T593
T
P
Q
P
S
K
D
T
L
L
P
P
F
R
K
Site 57
T603
P
P
F
R
K
P
Q
T
V
A
A
S
S
I
Y
Site 58
S607
K
P
Q
T
V
A
A
S
S
I
Y
S
M
Y
T
Site 59
Y610
T
V
A
A
S
S
I
Y
S
M
Y
T
Q
Q
Q
Site 60
S611
V
A
A
S
S
I
Y
S
M
Y
T
Q
Q
Q
A
Site 61
Y613
A
S
S
I
Y
S
M
Y
T
Q
Q
Q
A
P
G
Site 62
T614
S
S
I
Y
S
M
Y
T
Q
Q
Q
A
P
G
K
Site 63
S629
N
F
Q
Q
A
V
Q
S
A
L
T
K
T
H
T
Site 64
T634
V
Q
S
A
L
T
K
T
H
T
R
G
P
H
F
Site 65
T636
S
A
L
T
K
T
H
T
R
G
P
H
F
S
S
Site 66
S642
H
T
R
G
P
H
F
S
S
V
Y
G
K
P
V
Site 67
S643
T
R
G
P
H
F
S
S
V
Y
G
K
P
V
I
Site 68
Y645
G
P
H
F
S
S
V
Y
G
K
P
V
I
A
A
Site 69
Y664
Q
Q
H
P
E
N
I
Y
S
N
S
Q
G
K
P
Site 70
S665
Q
H
P
E
N
I
Y
S
N
S
Q
G
K
P
G
Site 71
S667
P
E
N
I
Y
S
N
S
Q
G
K
P
G
S
P
Site 72
S673
N
S
Q
G
K
P
G
S
P
E
P
E
T
E
P
Site 73
T678
P
G
S
P
E
P
E
T
E
P
V
S
S
V
Q
Site 74
S682
E
P
E
T
E
P
V
S
S
V
Q
E
N
H
E
Site 75
S683
P
E
T
E
P
V
S
S
V
Q
E
N
H
E
N
Site 76
S698
E
R
I
P
R
P
L
S
P
T
K
L
L
P
F
Site 77
T700
I
P
R
P
L
S
P
T
K
L
L
P
F
L
S
Site 78
S707
T
K
L
L
P
F
L
S
N
P
Y
R
N
Q
S
Site 79
S714
S
N
P
Y
R
N
Q
S
D
A
D
L
E
A
L
Site 80
S726
E
A
L
R
K
K
L
S
N
A
P
R
P
L
K
Site 81
S736
P
R
P
L
K
K
R
S
S
I
T
E
P
E
G
Site 82
S737
R
P
L
K
K
R
S
S
I
T
E
P
E
G
P
Site 83
Y754
P
N
I
Q
K
L
L
Y
Q
R
T
T
I
A
A
Site 84
S769
M
E
T
I
S
V
P
S
Y
P
S
K
S
A
S
Site 85
Y770
E
T
I
S
V
P
S
Y
P
S
K
S
A
S
V
Site 86
S772
I
S
V
P
S
Y
P
S
K
S
A
S
V
T
A
Site 87
S774
V
P
S
Y
P
S
K
S
A
S
V
T
A
S
S
Site 88
S776
S
Y
P
S
K
S
A
S
V
T
A
S
S
E
S
Site 89
T778
P
S
K
S
A
S
V
T
A
S
S
E
S
P
V
Site 90
S780
K
S
A
S
V
T
A
S
S
E
S
P
V
E
I
Site 91
S781
S
A
S
V
T
A
S
S
E
S
P
V
E
I
Q
Site 92
S783
S
V
T
A
S
S
E
S
P
V
E
I
Q
N
P
Site 93
Y791
P
V
E
I
Q
N
P
Y
L
H
V
E
P
E
K
Site 94
S802
E
P
E
K
E
V
V
S
L
V
P
E
S
L
S
Site 95
S809
S
L
V
P
E
S
L
S
P
E
D
V
G
N
A
Site 96
S817
P
E
D
V
G
N
A
S
T
E
N
S
D
M
P
Site 97
S821
G
N
A
S
T
E
N
S
D
M
P
A
P
S
P
Site 98
S827
N
S
D
M
P
A
P
S
P
G
L
D
Y
E
P
Site 99
Y832
A
P
S
P
G
L
D
Y
E
P
E
G
V
P
D
Site 100
S841
P
E
G
V
P
D
N
S
P
N
L
Q
N
N
P
Site 101
Y862
A
P
H
V
L
D
V
Y
L
E
E
Y
P
P
Y
Site 102
Y866
L
D
V
Y
L
E
E
Y
P
P
Y
P
P
P
P
Site 103
Y869
Y
L
E
E
Y
P
P
Y
P
P
P
P
Y
P
S
Site 104
Y874
P
P
Y
P
P
P
P
Y
P
S
G
E
P
E
G
Site 105
S876
Y
P
P
P
P
Y
P
S
G
E
P
E
G
P
G
Site 106
S886
P
E
G
P
G
E
D
S
V
S
M
R
P
P
E
Site 107
S888
G
P
G
E
D
S
V
S
M
R
P
P
E
I
T
Site 108
T895
S
M
R
P
P
E
I
T
G
Q
V
S
L
P
P
Site 109
S899
P
E
I
T
G
Q
V
S
L
P
P
G
K
R
T
Site 110
T911
K
R
T
N
L
R
K
T
G
S
E
R
I
A
H
Site 111
S913
T
N
L
R
K
T
G
S
E
R
I
A
H
G
M
Site 112
Y947
D
L
V
Q
R
I
I
Y
E
V
D
D
P
S
L
Site 113
S953
I
Y
E
V
D
D
P
S
L
P
N
D
E
G
I
Site 114
S990
V
N
V
N
A
A
D
S
D
G
W
T
P
L
H
Site 115
T994
A
A
D
S
D
G
W
T
P
L
H
C
A
A
S
Site 116
T1028
M
T
Y
S
D
M
Q
T
A
A
D
K
C
E
E
Site 117
T1041
E
E
M
E
E
G
Y
T
Q
C
S
Q
F
L
Y
Site 118
Y1048
T
Q
C
S
Q
F
L
Y
G
V
Q
E
K
M
G
Site 119
Y1068
V
I
Y
A
L
W
D
Y
E
P
Q
N
D
D
E
Site 120
Y1108
R
L
N
D
K
E
G
Y
V
P
R
N
L
L
G
Site 121
Y1117
P
R
N
L
L
G
L
Y
P
R
I
K
P
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation