KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CUL2
Full Name:
Cullin-2
Alias:
CUL-2; Cullin 2
Type:
Cell cycle regulation, Ubiquitin conjugating system
Mass (Da):
86983
Number AA:
745
UniProt ID:
Q13617
International Prot ID:
IPI00014311
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031461
Uniprot
OncoNet
Molecular Function:
GO:0031625
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0007050
GO:0008629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
R
V
V
D
F
D
E
T
W
N
K
L
L
T
T
Site 2
Y29
K
A
V
V
M
L
E
Y
V
E
R
A
T
W
N
Site 3
T34
L
E
Y
V
E
R
A
T
W
N
D
R
F
S
D
Site 4
Y43
N
D
R
F
S
D
I
Y
A
L
C
V
A
Y
P
Site 5
Y58
E
P
L
G
E
R
L
Y
T
E
T
K
I
F
L
Site 6
T59
P
L
G
E
R
L
Y
T
E
T
K
I
F
L
E
Site 7
T61
G
E
R
L
Y
T
E
T
K
I
F
L
E
N
H
Site 8
Y87
E
E
Q
V
L
V
M
Y
H
R
Y
W
E
E
Y
Site 9
Y90
V
L
V
M
Y
H
R
Y
W
E
E
Y
S
K
G
Site 10
Y94
Y
H
R
Y
W
E
E
Y
S
K
G
A
D
Y
M
Site 11
Y100
E
Y
S
K
G
A
D
Y
M
D
C
L
Y
R
Y
Site 12
Y105
A
D
Y
M
D
C
L
Y
R
Y
L
N
T
Q
F
Site 13
Y107
Y
M
D
C
L
Y
R
Y
L
N
T
Q
F
I
K
Site 14
Y125
L
T
E
A
D
L
Q
Y
G
Y
G
G
V
D
M
Site 15
Y194
S
F
V
H
V
E
Q
Y
K
K
K
F
P
L
K
Site 16
Y203
K
K
F
P
L
K
F
Y
Q
E
I
F
E
S
P
Site 17
S209
F
Y
Q
E
I
F
E
S
P
F
L
T
E
T
G
Site 18
T213
I
F
E
S
P
F
L
T
E
T
G
E
Y
Y
K
Site 19
Y218
F
L
T
E
T
G
E
Y
Y
K
Q
E
A
S
N
Site 20
S230
A
S
N
L
L
Q
E
S
N
C
S
Q
Y
M
E
Site 21
S233
L
L
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
Site 22
Y235
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Site 23
Y253
E
E
I
R
C
R
K
Y
L
H
P
S
S
Y
T
Site 24
S258
R
K
Y
L
H
P
S
S
Y
T
K
V
I
H
E
Site 25
Y259
K
Y
L
H
P
S
S
Y
T
K
V
I
H
E
C
Site 26
T327
H
D
E
G
L
R
A
T
S
N
L
T
Q
E
N
Site 27
S328
D
E
G
L
R
A
T
S
N
L
T
Q
E
N
M
Site 28
T356
K
F
V
Q
L
I
N
T
V
L
N
G
D
Q
H
Site 29
S366
N
G
D
Q
H
F
M
S
A
L
D
K
A
L
T
Site 30
T373
S
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
Site 31
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Site 32
Y378
A
L
T
S
V
V
N
Y
R
E
P
K
S
V
C
Site 33
S383
V
N
Y
R
E
P
K
S
V
C
K
A
P
E
L
Site 34
Y394
A
P
E
L
L
A
K
Y
C
D
N
L
L
K
K
Site 35
T416
N
E
V
E
D
R
L
T
S
F
I
T
V
F
K
Site 36
S417
E
V
E
D
R
L
T
S
F
I
T
V
F
K
Y
Site 37
T420
D
R
L
T
S
F
I
T
V
F
K
Y
I
D
D
Site 38
Y435
K
D
V
F
Q
K
F
Y
A
R
M
L
A
K
R
Site 39
S448
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Site 40
Y467
K
L
K
Q
A
C
G
Y
E
F
T
S
K
L
H
Site 41
Y477
T
S
K
L
H
R
M
Y
T
D
M
S
V
S
A
Site 42
T478
S
K
L
H
R
M
Y
T
D
M
S
V
S
A
D
Site 43
S481
H
R
M
Y
T
D
M
S
V
S
A
D
L
N
N
Site 44
T499
N
F
I
K
N
Q
D
T
V
I
D
L
G
I
S
Site 45
T520
Q
A
G
A
W
P
L
T
Q
A
P
S
S
T
F
Site 46
S525
P
L
T
Q
A
P
S
S
T
F
A
I
P
Q
E
Site 47
T526
L
T
Q
A
P
S
S
T
F
A
I
P
Q
E
L
Site 48
S536
I
P
Q
E
L
E
K
S
V
Q
M
F
E
L
F
Site 49
Y544
V
Q
M
F
E
L
F
Y
S
Q
H
F
S
G
R
Site 50
Y558
R
K
L
T
W
L
H
Y
L
C
T
G
E
V
K
Site 51
Y568
T
G
E
V
K
M
N
Y
L
G
K
P
Y
V
A
Site 52
S591
V
L
L
A
F
N
N
S
E
T
V
S
Y
K
E
Site 53
S595
F
N
N
S
E
T
V
S
Y
K
E
L
Q
D
S
Site 54
Y596
N
N
S
E
T
V
S
Y
K
E
L
Q
D
S
T
Site 55
S602
S
Y
K
E
L
Q
D
S
T
Q
M
N
E
K
E
Site 56
T611
Q
M
N
E
K
E
L
T
K
T
I
K
S
L
L
Site 57
T613
N
E
K
E
L
T
K
T
I
K
S
L
L
D
V
Site 58
S636
K
E
D
I
D
A
E
S
S
F
S
L
N
M
N
Site 59
S637
E
D
I
D
A
E
S
S
F
S
L
N
M
N
F
Site 60
S639
I
D
A
E
S
S
F
S
L
N
M
N
F
S
S
Site 61
S645
F
S
L
N
M
N
F
S
S
K
R
T
K
F
K
Site 62
S646
S
L
N
M
N
F
S
S
K
R
T
K
F
K
I
Site 63
S656
T
K
F
K
I
T
T
S
M
Q
K
D
T
P
Q
Site 64
T661
T
T
S
M
Q
K
D
T
P
Q
E
M
E
Q
T
Site 65
T668
T
P
Q
E
M
E
Q
T
R
S
A
V
D
E
D
Site 66
S670
Q
E
M
E
Q
T
R
S
A
V
D
E
D
R
K
Site 67
Y679
V
D
E
D
R
K
M
Y
L
Q
A
A
I
V
R
Site 68
S705
A
L
I
Q
E
V
I
S
Q
S
R
A
R
F
N
Site 69
S707
I
Q
E
V
I
S
Q
S
R
A
R
F
N
P
S
Site 70
S714
S
R
A
R
F
N
P
S
I
S
M
I
K
K
C
Site 71
S716
A
R
F
N
P
S
I
S
M
I
K
K
C
I
E
Site 72
Y730
E
V
L
I
D
K
Q
Y
I
E
R
S
Q
A
S
Site 73
S734
D
K
Q
Y
I
E
R
S
Q
A
S
A
D
E
Y
Site 74
Y741
S
Q
A
S
A
D
E
Y
S
Y
V
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation