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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTMR2
Full Name:
Myotubularin-related protein 2
Alias:
CMT4B; EC 3.1.3.-; KIAA1073; Myotubularin related protein 2; Myotubularin-related 2
Type:
Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose
Mass (Da):
73381
Number AA:
643
UniProt ID:
Q13614
International Prot ID:
IPI00014307
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004437
GO:0004725
GO:0008138
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
T
S
S
S
C
E
S
L
G
Site 2
S5
_
_
_
M
E
T
S
S
S
C
E
S
L
G
S
Site 3
S6
_
_
M
E
K
S
S
S
C
E
S
L
G
S
Q
Site 4
S9
E
T
S
S
S
C
E
S
L
G
S
Q
P
A
A
Site 5
S12
S
S
C
E
S
L
G
S
Q
P
A
A
A
R
P
Site 6
S21
P
A
A
A
R
P
P
S
V
D
S
L
S
S
A
Site 7
S24
A
R
P
P
S
V
D
S
L
S
S
A
S
T
S
Site 8
S26
P
P
S
V
D
S
L
S
S
A
S
T
S
H
S
Site 9
S27
P
S
V
D
S
L
S
S
A
S
T
S
H
S
E
Site 10
S29
V
D
S
L
S
S
A
S
T
S
H
S
E
N
S
Site 11
T30
D
S
L
S
S
A
S
T
S
H
S
E
N
S
V
Site 12
S31
S
L
S
S
A
S
T
S
H
S
E
N
S
V
H
Site 13
S33
S
S
A
S
T
S
H
S
E
N
S
V
H
T
K
Site 14
S36
S
T
S
H
S
E
N
S
V
H
T
K
S
A
S
Site 15
S41
E
N
S
V
H
T
K
S
A
S
V
V
S
S
D
Site 16
S43
S
V
H
T
K
S
A
S
V
V
S
S
D
S
I
Site 17
S46
T
K
S
A
S
V
V
S
S
D
S
I
S
T
S
Site 18
S47
K
S
A
S
V
V
S
S
D
S
I
S
T
S
A
Site 19
S49
A
S
V
V
S
S
D
S
I
S
T
S
A
D
N
Site 20
S51
V
V
S
S
D
S
I
S
T
S
A
D
N
F
S
Site 21
S53
S
S
D
S
I
S
T
S
A
D
N
F
S
P
D
Site 22
S58
S
T
S
A
D
N
F
S
P
D
L
R
V
L
R
Site 23
S67
D
L
R
V
L
R
E
S
N
K
L
A
E
M
E
Site 24
T104
F
T
G
A
V
R
G
T
L
T
V
T
N
Y
R
Site 25
T106
G
A
V
R
G
T
L
T
V
T
N
Y
R
L
Y
Site 26
T108
V
R
G
T
L
T
V
T
N
Y
R
L
Y
F
K
Site 27
Y110
G
T
L
T
V
T
N
Y
R
L
Y
F
K
S
M
Site 28
Y113
T
V
T
N
Y
R
L
Y
F
K
S
M
E
R
D
Site 29
S116
N
Y
R
L
Y
F
K
S
M
E
R
D
P
P
F
Site 30
S142
V
E
K
I
G
G
A
S
S
R
G
E
N
S
Y
Site 31
S143
E
K
I
G
G
A
S
S
R
G
E
N
S
Y
G
Site 32
S148
A
S
S
R
G
E
N
S
Y
G
L
E
T
V
C
Site 33
Y149
S
S
R
G
E
N
S
Y
G
L
E
T
V
C
K
Site 34
T153
E
N
S
Y
G
L
E
T
V
C
K
D
I
R
N
Site 35
S174
P
E
G
R
T
R
R
S
I
F
E
N
L
M
K
Site 36
Y182
I
F
E
N
L
M
K
Y
A
F
P
V
S
N
N
Site 37
Y197
L
P
L
F
A
F
E
Y
K
E
V
F
P
E
N
Site 38
Y209
P
E
N
G
W
K
L
Y
D
P
L
L
E
Y
R
Site 39
Y215
L
Y
D
P
L
L
E
Y
R
R
Q
G
I
P
N
Site 40
T228
P
N
E
S
W
R
I
T
K
I
N
E
R
Y
E
Site 41
S260
E
E
L
K
R
V
A
S
F
R
S
R
G
R
I
Site 42
S263
K
R
V
A
S
F
R
S
R
G
R
I
P
V
L
Site 43
S271
R
G
R
I
P
V
L
S
W
I
H
P
E
S
Q
Site 44
T280
I
H
P
E
S
Q
A
T
I
T
R
C
S
Q
P
Site 45
T282
P
E
S
Q
A
T
I
T
R
C
S
Q
P
M
V
Site 46
S292
S
Q
P
M
V
G
V
S
G
K
R
S
K
E
D
Site 47
S296
V
G
V
S
G
K
R
S
K
E
D
E
K
Y
L
Site 48
Y302
R
S
K
E
D
E
K
Y
L
Q
A
I
M
D
S
Site 49
S339
A
K
G
G
G
Y
E
S
E
D
A
Y
Q
N
A
Site 50
Y343
G
Y
E
S
E
D
A
Y
Q
N
A
E
L
V
F
Site 51
S362
N
I
H
V
M
R
E
S
L
R
K
L
K
E
I
Site 52
Y371
R
K
L
K
E
I
V
Y
P
N
I
E
E
T
H
Site 53
S408
R
I
A
D
K
V
E
S
G
K
T
S
V
V
V
Site 54
T411
D
K
V
E
S
G
K
T
S
V
V
V
H
C
S
Site 55
S412
K
V
E
S
G
K
T
S
V
V
V
H
C
S
D
Site 56
T424
C
S
D
G
W
D
R
T
A
Q
L
T
S
L
A
Site 57
Y438
A
M
L
M
L
D
G
Y
Y
R
T
I
R
G
F
Site 58
Y439
M
L
M
L
D
G
Y
Y
R
T
I
R
G
F
E
Site 59
S455
L
V
E
K
E
W
L
S
F
G
H
R
F
Q
L
Site 60
S477
N
H
A
D
A
D
R
S
P
V
F
L
Q
F
I
Site 61
S524
F
G
T
F
L
C
N
S
E
Q
Q
R
G
K
E
Site 62
T537
K
E
N
L
P
K
R
T
V
S
L
W
S
Y
I
Site 63
S539
N
L
P
K
R
T
V
S
L
W
S
Y
I
N
S
Site 64
S542
K
R
T
V
S
L
W
S
Y
I
N
S
Q
L
E
Site 65
Y543
R
T
V
S
L
W
S
Y
I
N
S
Q
L
E
D
Site 66
S546
S
L
W
S
Y
I
N
S
Q
L
E
D
F
T
N
Site 67
T552
N
S
Q
L
E
D
F
T
N
P
L
Y
G
S
Y
Site 68
Y556
E
D
F
T
N
P
L
Y
G
S
Y
S
N
H
V
Site 69
S560
N
P
L
Y
G
S
Y
S
N
H
V
L
Y
P
V
Site 70
Y565
S
Y
S
N
H
V
L
Y
P
V
A
S
M
R
H
Site 71
Y580
L
E
L
W
V
G
Y
Y
I
R
W
N
P
R
M
Site 72
S619
E
E
L
Q
R
E
I
S
N
R
S
T
S
S
S
Site 73
S622
Q
R
E
I
S
N
R
S
T
S
S
S
E
R
A
Site 74
T623
R
E
I
S
N
R
S
T
S
S
S
E
R
A
S
Site 75
S624
E
I
S
N
R
S
T
S
S
S
E
R
A
S
S
Site 76
S625
I
S
N
R
S
T
S
S
S
E
R
A
S
S
P
Site 77
S626
S
N
R
S
T
S
S
S
E
R
A
S
S
P
A
Site 78
S630
T
S
S
S
E
R
A
S
S
P
A
Q
C
V
T
Site 79
S631
S
S
S
E
R
A
S
S
P
A
Q
C
V
T
P
Site 80
T637
S
S
P
A
Q
C
V
T
P
V
Q
T
V
V
_
Site 81
T641
Q
C
V
T
P
V
Q
T
V
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation