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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIPK1
Full Name:
Receptor-interacting serine/threonine-protein kinase 1
Alias:
EC 2.7.11.1; RIK1; RIP
Type:
Protein-serine kinase, TKL group, RIPK family
Mass (Da):
75931
Number AA:
671
UniProt ID:
Q13546
International Prot ID:
IPI00013773
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0031264
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0070513
GO:0005123
PhosphoSite+
KinaseNET
Biological Process:
GO:0007249
GO:0007257
GO:0008633
Phosida
TranscriptoNet
STRING
Kinexus Products
Receptor-interacting protein-serine kinase 1 Y384 phosphosite-specific antibody AB-PK795#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK795#Receptor-interacting protein-serine kinase 1 (E381-Y387, human) pY384 phosphopeptide - Powder PE-04APH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APH99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
Site 2
S15
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
Site 3
S20
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
Site 4
S25
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
Site 5
S32
S
G
G
F
G
K
V
S
L
C
F
H
R
T
Q
Site 6
T38
V
S
L
C
F
H
R
T
Q
G
L
M
I
M
K
Site 7
T46
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
Site 8
S73
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
Site 9
Y94
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
Site 10
S109
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
Site 11
T110
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
Site 12
T182
E
L
R
E
V
D
G
T
A
K
K
N
G
G
T
Site 13
Y191
K
K
N
G
G
T
L
Y
Y
M
A
P
E
H
L
Site 14
Y192
K
N
G
G
T
L
Y
Y
M
A
P
E
H
L
N
Site 15
S209
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
Site 16
T253
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
Site 17
Y255
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
Site 18
T277
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
Site 19
Y289
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
Site 20
S291
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
Site 21
S296
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
Site 22
S303
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
Site 23
S309
K
S
L
K
K
E
Y
S
N
E
N
A
V
V
K
Site 24
S320
A
V
V
K
R
M
Q
S
L
Q
L
D
C
V
A
Site 25
S330
L
D
C
V
A
V
P
S
S
R
S
N
S
A
T
Site 26
S331
D
C
V
A
V
P
S
S
R
S
N
S
A
T
E
Site 27
S333
V
A
V
P
S
S
R
S
N
S
A
T
E
Q
P
Site 28
S335
V
P
S
S
R
S
N
S
A
T
E
Q
P
G
S
Site 29
T337
S
S
R
S
N
S
A
T
E
Q
P
G
S
L
H
Site 30
S342
S
A
T
E
Q
P
G
S
L
H
S
S
Q
G
L
Site 31
S345
E
Q
P
G
S
L
H
S
S
Q
G
L
G
M
G
Site 32
S346
Q
P
G
S
L
H
S
S
Q
G
L
G
M
G
P
Site 33
S357
G
M
G
P
V
E
E
S
W
F
A
P
S
L
E
Site 34
S362
E
E
S
W
F
A
P
S
L
E
H
P
Q
E
E
Site 35
S373
P
Q
E
E
N
E
P
S
L
Q
S
K
L
Q
D
Site 36
Y384
K
L
Q
D
E
A
N
Y
H
L
Y
G
S
R
M
Receptor-interacting protein-serine kinase 1 Y384 phosphosite-specific antibody AB-PK795#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK795#Receptor-interacting protein-serine kinase 1 (E381-Y387, human) pY384 phosphopeptide - Powder PE-04APH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APH99
Site 37
Y387
D
E
A
N
Y
H
L
Y
G
S
R
M
D
R
Q
Site 38
S389
A
N
Y
H
L
Y
G
S
R
M
D
R
Q
T
K
Site 39
T395
G
S
R
M
D
R
Q
T
K
Q
Q
P
R
Q
N
Site 40
Y405
Q
P
R
Q
N
V
A
Y
N
R
E
E
E
R
R
Site 41
S416
E
E
R
R
R
R
V
S
H
D
P
F
A
Q
Q
Site 42
Y426
P
F
A
Q
Q
R
P
Y
E
N
F
Q
N
T
E
Site 43
T437
Q
N
T
E
G
K
G
T
A
Y
S
S
A
A
S
Site 44
Y439
T
E
G
K
G
T
A
Y
S
S
A
A
S
H
G
Site 45
S440
E
G
K
G
T
A
Y
S
S
A
A
S
H
G
N
Site 46
S441
G
K
G
T
A
Y
S
S
A
A
S
H
G
N
A
Site 47
S444
T
A
Y
S
S
A
A
S
H
G
N
A
V
H
Q
Site 48
S453
G
N
A
V
H
Q
P
S
G
L
T
S
Q
P
Q
Site 49
S457
H
Q
P
S
G
L
T
S
Q
P
Q
V
L
Y
Q
Site 50
Y463
T
S
Q
P
Q
V
L
Y
Q
N
N
G
L
Y
S
Site 51
Y469
L
Y
Q
N
N
G
L
Y
S
S
H
G
F
G
T
Site 52
S470
Y
Q
N
N
G
L
Y
S
S
H
G
F
G
T
R
Site 53
S471
Q
N
N
G
L
Y
S
S
H
G
F
G
T
R
P
Site 54
T483
T
R
P
L
D
P
G
T
A
G
P
R
V
W
Y
Site 55
Y490
T
A
G
P
R
V
W
Y
R
P
I
P
S
H
M
Site 56
S499
P
I
P
S
H
M
P
S
L
H
N
I
P
V
P
Site 57
Y510
I
P
V
P
E
T
N
Y
L
G
N
T
P
T
M
Site 58
T514
E
T
N
Y
L
G
N
T
P
T
M
P
F
S
S
Site 59
T516
N
Y
L
G
N
T
P
T
M
P
F
S
S
L
P
Site 60
S520
N
T
P
T
M
P
F
S
S
L
P
P
T
D
E
Site 61
S521
T
P
T
M
P
F
S
S
L
P
P
T
D
E
S
Site 62
T525
P
F
S
S
L
P
P
T
D
E
S
I
K
Y
T
Site 63
S528
S
L
P
P
T
D
E
S
I
K
Y
T
I
Y
N
Site 64
Y531
P
T
D
E
S
I
K
Y
T
I
Y
N
S
T
G
Site 65
T532
T
D
E
S
I
K
Y
T
I
Y
N
S
T
G
I
Site 66
Y534
E
S
I
K
Y
T
I
Y
N
S
T
G
I
Q
I
Site 67
T552
N
Y
M
E
I
G
G
T
S
S
S
L
L
D
S
Site 68
S555
E
I
G
G
T
S
S
S
L
L
D
S
T
N
T
Site 69
S559
T
S
S
S
L
L
D
S
T
N
T
N
F
K
E
Site 70
T560
S
S
S
L
L
D
S
T
N
T
N
F
K
E
E
Site 71
Y572
K
E
E
P
A
A
K
Y
Q
A
I
F
D
N
T
Site 72
S581
A
I
F
D
N
T
T
S
L
T
D
K
H
L
D
Site 73
T608
C
A
R
K
L
G
F
T
Q
S
Q
I
D
E
I
Site 74
S610
R
K
L
G
F
T
Q
S
Q
I
D
E
I
D
H
Site 75
Y619
I
D
E
I
D
H
D
Y
E
R
D
G
L
K
E
Site 76
Y629
D
G
L
K
E
K
V
Y
Q
M
L
Q
K
W
V
Site 77
S657
A
Q
A
L
H
Q
C
S
R
I
D
L
L
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation