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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAMLD1
Full Name:
Mastermind-like domain-containing protein 1
Alias:
F18
Type:
Mass (Da):
83213
Number AA:
774
UniProt ID:
Q13495
International Prot ID:
IPI00013425
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
E
P
R
K
L
Q
E
S
G
K
K
P
S
W
M
Site 2
S45
W
M
E
E
E
D
L
S
F
L
Y
K
S
S
P
Site 3
Y48
E
E
D
L
S
F
L
Y
K
S
S
P
G
R
K
Site 4
S50
D
L
S
F
L
Y
K
S
S
P
G
R
K
H
Q
Site 5
S51
L
S
F
L
Y
K
S
S
P
G
R
K
H
Q
G
Site 6
T59
P
G
R
K
H
Q
G
T
V
K
R
R
Q
E
E
Site 7
Y79
P
D
M
A
D
G
G
Y
P
N
K
I
K
R
P
Site 8
S102
M
G
P
G
A
H
P
S
T
A
C
A
E
L
Q
Site 9
T103
G
P
G
A
H
P
S
T
A
C
A
E
L
Q
V
Site 10
Y162
L
K
G
P
T
V
P
Y
Y
E
K
I
N
S
V
Site 11
Y163
K
G
P
T
V
P
Y
Y
E
K
I
N
S
V
P
Site 12
S168
P
Y
Y
E
K
I
N
S
V
P
A
V
D
Q
E
Site 13
S190
L
T
K
I
Q
D
P
S
P
N
E
L
D
L
E
Site 14
T216
V
L
D
H
P
Q
A
T
L
S
T
T
P
K
P
Site 15
S218
D
H
P
Q
A
T
L
S
T
T
P
K
P
S
V
Site 16
T220
P
Q
A
T
L
S
T
T
P
K
P
S
V
Q
M
Site 17
S224
L
S
T
T
P
K
P
S
V
Q
M
S
H
L
E
Site 18
S228
P
K
P
S
V
Q
M
S
H
L
E
S
L
A
S
Site 19
S232
V
Q
M
S
H
L
E
S
L
A
S
S
K
E
F
Site 20
S235
S
H
L
E
S
L
A
S
S
K
E
F
A
S
S
Site 21
S236
H
L
E
S
L
A
S
S
K
E
F
A
S
S
C
Site 22
S241
A
S
S
K
E
F
A
S
S
C
S
Q
V
T
G
Site 23
S242
S
S
K
E
F
A
S
S
C
S
Q
V
T
G
M
Site 24
S244
K
E
F
A
S
S
C
S
Q
V
T
G
M
S
L
Site 25
S250
C
S
Q
V
T
G
M
S
L
Q
I
P
S
S
S
Site 26
S255
G
M
S
L
Q
I
P
S
S
S
T
G
I
S
Y
Site 27
S256
M
S
L
Q
I
P
S
S
S
T
G
I
S
Y
S
Site 28
S257
S
L
Q
I
P
S
S
S
T
G
I
S
Y
S
I
Site 29
S261
P
S
S
S
T
G
I
S
Y
S
I
P
S
T
S
Site 30
Y262
S
S
S
T
G
I
S
Y
S
I
P
S
T
S
K
Site 31
S263
S
S
T
G
I
S
Y
S
I
P
S
T
S
K
Q
Site 32
S266
G
I
S
Y
S
I
P
S
T
S
K
Q
I
V
S
Site 33
T267
I
S
Y
S
I
P
S
T
S
K
Q
I
V
S
P
Site 34
S268
S
Y
S
I
P
S
T
S
K
Q
I
V
S
P
S
Site 35
S273
S
T
S
K
Q
I
V
S
P
S
S
S
M
A
Q
Site 36
S275
S
K
Q
I
V
S
P
S
S
S
M
A
Q
S
K
Site 37
S276
K
Q
I
V
S
P
S
S
S
M
A
Q
S
K
S
Site 38
S277
Q
I
V
S
P
S
S
S
M
A
Q
S
K
S
Q
Site 39
S281
P
S
S
S
M
A
Q
S
K
S
Q
V
Q
A
M
Site 40
S283
S
S
M
A
Q
S
K
S
Q
V
Q
A
M
L
P
Site 41
S313
Q
L
K
A
L
A
A
S
K
Q
G
S
A
T
K
Site 42
S317
L
A
A
S
K
Q
G
S
A
T
K
Q
Q
G
P
Site 43
T325
A
T
K
Q
Q
G
P
T
P
S
W
S
G
L
P
Site 44
S327
K
Q
Q
G
P
T
P
S
W
S
G
L
P
P
P
Site 45
S329
Q
G
P
T
P
S
W
S
G
L
P
P
P
G
L
Site 46
S337
G
L
P
P
P
G
L
S
P
P
Y
R
P
V
P
Site 47
Y340
P
P
G
L
S
P
P
Y
R
P
V
P
S
P
H
Site 48
S345
P
P
Y
R
P
V
P
S
P
H
P
P
P
L
P
Site 49
S361
P
P
P
P
P
P
F
S
P
Q
S
L
M
V
S
Site 50
T374
V
S
C
M
S
S
N
T
L
S
G
S
T
L
R
Site 51
S376
C
M
S
S
N
T
L
S
G
S
T
L
R
G
S
Site 52
S378
S
S
N
T
L
S
G
S
T
L
R
G
S
P
N
Site 53
T379
S
N
T
L
S
G
S
T
L
R
G
S
P
N
A
Site 54
S383
S
G
S
T
L
R
G
S
P
N
A
L
L
S
S
Site 55
S389
G
S
P
N
A
L
L
S
S
M
T
S
S
S
N
Site 56
S390
S
P
N
A
L
L
S
S
M
T
S
S
S
N
A
Site 57
S412
Y
A
P
E
K
L
P
S
P
A
L
T
Q
Q
P
Site 58
T416
K
L
P
S
P
A
L
T
Q
Q
P
Q
F
G
P
Site 59
S425
Q
P
Q
F
G
P
Q
S
S
I
L
A
N
L
M
Site 60
S426
P
Q
F
G
P
Q
S
S
I
L
A
N
L
M
S
Site 61
T438
L
M
S
S
T
I
K
T
P
Q
G
H
L
M
S
Site 62
S445
T
P
Q
G
H
L
M
S
A
L
P
A
S
N
P
Site 63
S450
L
M
S
A
L
P
A
S
N
P
G
P
S
P
P
Site 64
S455
P
A
S
N
P
G
P
S
P
P
Y
R
P
E
K
Site 65
Y458
N
P
G
P
S
P
P
Y
R
P
E
K
L
S
S
Site 66
S464
P
Y
R
P
E
K
L
S
S
P
G
L
P
Q
Q
Site 67
S465
Y
R
P
E
K
L
S
S
P
G
L
P
Q
Q
S
Site 68
S472
S
P
G
L
P
Q
Q
S
F
T
P
Q
C
S
L
Site 69
T474
G
L
P
Q
Q
S
F
T
P
Q
C
S
L
I
R
Site 70
S478
Q
S
F
T
P
Q
C
S
L
I
R
S
L
T
P
Site 71
S482
P
Q
C
S
L
I
R
S
L
T
P
T
S
N
L
Site 72
T486
L
I
R
S
L
T
P
T
S
N
L
L
S
Q
Q
Site 73
S487
I
R
S
L
T
P
T
S
N
L
L
S
Q
Q
Q
Site 74
S491
T
P
T
S
N
L
L
S
Q
Q
Q
Q
Q
Q
Q
Site 75
S511
N
V
I
F
K
P
I
S
S
N
S
S
K
T
L
Site 76
S512
V
I
F
K
P
I
S
S
N
S
S
K
T
L
S
Site 77
S514
F
K
P
I
S
S
N
S
S
K
T
L
S
M
I
Site 78
S515
K
P
I
S
S
N
S
S
K
T
L
S
M
I
M
Site 79
T517
I
S
S
N
S
S
K
T
L
S
M
I
M
Q
Q
Site 80
S519
S
N
S
S
K
T
L
S
M
I
M
Q
Q
G
M
Site 81
S530
Q
Q
G
M
A
S
S
S
P
G
A
T
E
P
F
Site 82
T534
A
S
S
S
P
G
A
T
E
P
F
T
F
G
N
Site 83
T538
P
G
A
T
E
P
F
T
F
G
N
T
K
P
L
Site 84
S546
F
G
N
T
K
P
L
S
H
F
V
S
E
P
G
Site 85
S550
K
P
L
S
H
F
V
S
E
P
G
P
Q
K
M
Site 86
S559
P
G
P
Q
K
M
P
S
M
P
T
T
S
R
Q
Site 87
T562
Q
K
M
P
S
M
P
T
T
S
R
Q
P
S
L
Site 88
T563
K
M
P
S
M
P
T
T
S
R
Q
P
S
L
L
Site 89
S564
M
P
S
M
P
T
T
S
R
Q
P
S
L
L
H
Site 90
S568
P
T
T
S
R
Q
P
S
L
L
H
Y
L
Q
Q
Site 91
Y572
R
Q
P
S
L
L
H
Y
L
Q
Q
P
T
P
T
Site 92
T577
L
H
Y
L
Q
Q
P
T
P
T
Q
A
S
S
A
Site 93
S583
P
T
P
T
Q
A
S
S
A
T
A
S
S
T
A
Site 94
S587
Q
A
S
S
A
T
A
S
S
T
A
T
A
T
L
Site 95
T591
A
T
A
S
S
T
A
T
A
T
L
Q
L
Q
Q
Site 96
S627
Q
P
Q
R
F
Q
R
S
V
A
S
D
S
M
P
Site 97
S632
Q
R
S
V
A
S
D
S
M
P
A
L
P
R
Q
Site 98
S653
A
W
T
S
A
A
S
S
V
K
P
Q
H
Q
H
Site 99
S663
P
Q
H
Q
H
G
N
S
F
T
S
R
Q
D
P
Site 100
S676
D
P
Q
P
G
D
V
S
P
S
N
I
T
H
V
Site 101
S698
E
A
R
H
P
Q
V
S
L
G
R
Q
P
P
S
Site 102
S705
S
L
G
R
Q
P
P
S
C
Q
A
L
G
S
E
Site 103
S711
P
S
C
Q
A
L
G
S
E
S
F
L
P
G
S
Site 104
S718
S
E
S
F
L
P
G
S
S
F
A
H
E
L
A
Site 105
S719
E
S
F
L
P
G
S
S
F
A
H
E
L
A
R
Site 106
T728
A
H
E
L
A
R
V
T
S
S
Y
S
T
S
E
Site 107
S729
H
E
L
A
R
V
T
S
S
Y
S
T
S
E
A
Site 108
S730
E
L
A
R
V
T
S
S
Y
S
T
S
E
A
A
Site 109
Y731
L
A
R
V
T
S
S
Y
S
T
S
E
A
A
P
Site 110
S732
A
R
V
T
S
S
Y
S
T
S
E
A
A
P
W
Site 111
T733
R
V
T
S
S
Y
S
T
S
E
A
A
P
W
G
Site 112
S734
V
T
S
S
Y
S
T
S
E
A
A
P
W
G
S
Site 113
S741
S
E
A
A
P
W
G
S
W
D
P
K
A
W
R
Site 114
T761
L
L
P
S
C
D
A
T
A
R
G
T
E
I
R
Site 115
T765
C
D
A
T
A
R
G
T
E
I
R
S
Y
G
N
Site 116
S769
A
R
G
T
E
I
R
S
Y
G
N
D
P
_
_
Site 117
Y770
R
G
T
E
I
R
S
Y
G
N
D
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation