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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BIRC2
Full Name:
Baculoviral IAP repeat-containing protein 2
Alias:
API1; Apoptosis inhibitor 1; Baculoviral IAP repeat-containing 2; CIAP1; C-IAP1; IAP B; IAP2; Iap-2; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger 48; RNF48; TNFR2-TRAF-signaling complex 2
Type:
Mass (Da):
69900
Number AA:
UniProt ID:
Q13490
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007166
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
Q
R
L
F
P
G
P
S
Y
Q
N
I
K
S
I
Site 2
Y15
R
L
F
P
G
P
S
Y
Q
N
I
K
S
I
M
Site 3
S20
P
S
Y
Q
N
I
K
S
I
M
E
D
S
T
I
Site 4
S25
I
K
S
I
M
E
D
S
T
I
L
S
D
W
T
Site 5
T26
K
S
I
M
E
D
S
T
I
L
S
D
W
T
N
Site 6
S29
M
E
D
S
T
I
L
S
D
W
T
N
S
N
K
Site 7
T32
S
T
I
L
S
D
W
T
N
S
N
K
Q
K
M
Site 8
Y41
S
N
K
Q
K
M
K
Y
D
F
S
C
E
L
Y
Site 9
Y48
Y
D
F
S
C
E
L
Y
R
M
S
T
Y
S
T
Site 10
S51
S
C
E
L
Y
R
M
S
T
Y
S
T
F
P
A
Site 11
T52
C
E
L
Y
R
M
S
T
Y
S
T
F
P
A
G
Site 12
S54
L
Y
R
M
S
T
Y
S
T
F
P
A
G
V
P
Site 13
T55
Y
R
M
S
T
Y
S
T
F
P
A
G
V
P
V
Site 14
S66
G
V
P
V
S
E
R
S
L
A
R
A
G
F
Y
Site 15
Y74
L
A
R
A
G
F
Y
Y
T
G
V
N
D
K
V
Site 16
S98
D
N
W
K
L
G
D
S
P
I
Q
K
H
K
Q
Site 17
Y107
I
Q
K
H
K
Q
L
Y
P
S
C
S
F
I
Q
Site 18
S111
K
Q
L
Y
P
S
C
S
F
I
Q
N
L
V
S
Site 19
S120
I
Q
N
L
V
S
A
S
L
G
S
T
S
K
N
Site 20
S123
L
V
S
A
S
L
G
S
T
S
K
N
T
S
P
Site 21
T124
V
S
A
S
L
G
S
T
S
K
N
T
S
P
M
Site 22
S125
S
A
S
L
G
S
T
S
K
N
T
S
P
M
R
Site 23
S129
G
S
T
S
K
N
T
S
P
M
R
N
S
F
A
Site 24
S134
N
T
S
P
M
R
N
S
F
A
H
S
L
S
P
Site 25
S138
M
R
N
S
F
A
H
S
L
S
P
T
L
E
H
Site 26
S140
N
S
F
A
H
S
L
S
P
T
L
E
H
S
S
Site 27
T142
F
A
H
S
L
S
P
T
L
E
H
S
S
L
F
Site 28
S146
L
S
P
T
L
E
H
S
S
L
F
S
G
S
Y
Site 29
S147
S
P
T
L
E
H
S
S
L
F
S
G
S
Y
S
Site 30
S150
L
E
H
S
S
L
F
S
G
S
Y
S
S
L
S
Site 31
S152
H
S
S
L
F
S
G
S
Y
S
S
L
S
P
N
Site 32
Y153
S
S
L
F
S
G
S
Y
S
S
L
S
P
N
P
Site 33
S154
S
L
F
S
G
S
Y
S
S
L
S
P
N
P
L
Site 34
S155
L
F
S
G
S
Y
S
S
L
S
P
N
P
L
N
Site 35
S157
S
G
S
Y
S
S
L
S
P
N
P
L
N
S
R
Site 36
S163
L
S
P
N
P
L
N
S
R
A
V
E
D
I
S
Site 37
S170
S
R
A
V
E
D
I
S
S
S
R
T
N
P
Y
Site 38
S171
R
A
V
E
D
I
S
S
S
R
T
N
P
Y
S
Site 39
S172
A
V
E
D
I
S
S
S
R
T
N
P
Y
S
Y
Site 40
T174
E
D
I
S
S
S
R
T
N
P
Y
S
Y
A
M
Site 41
S178
S
S
R
T
N
P
Y
S
Y
A
M
S
T
E
E
Site 42
S182
N
P
Y
S
Y
A
M
S
T
E
E
A
R
F
L
Site 43
T190
T
E
E
A
R
F
L
T
Y
H
M
W
P
L
T
Site 44
T197
T
Y
H
M
W
P
L
T
F
L
S
P
S
E
L
Site 45
S228
F
A
C
G
G
K
L
S
N
W
E
P
K
D
D
Site 46
S238
E
P
K
D
D
A
M
S
E
H
R
R
H
F
P
Site 47
S253
N
C
P
F
L
E
N
S
L
E
T
L
R
F
S
Site 48
T256
F
L
E
N
S
L
E
T
L
R
F
S
I
S
N
Site 49
S260
S
L
E
T
L
R
F
S
I
S
N
L
S
M
Q
Site 50
S262
E
T
L
R
F
S
I
S
N
L
S
M
Q
T
H
Site 51
S265
R
F
S
I
S
N
L
S
M
Q
T
H
A
A
R
Site 52
Y278
A
R
M
R
T
F
M
Y
W
P
S
S
V
P
V
Site 53
S281
R
T
F
M
Y
W
P
S
S
V
P
V
Q
P
E
Site 54
Y296
Q
L
A
S
A
G
F
Y
Y
V
G
R
N
D
D
Site 55
Y297
L
A
S
A
G
F
Y
Y
V
G
R
N
D
D
V
Site 56
Y352
V
D
E
I
Q
G
R
Y
P
H
L
L
E
Q
L
Site 57
S361
H
L
L
E
Q
L
L
S
T
S
D
T
T
G
E
Site 58
T365
Q
L
L
S
T
S
D
T
T
G
E
E
N
A
D
Site 59
S384
H
F
G
P
G
E
S
S
S
E
D
A
V
M
M
Site 60
S385
F
G
P
G
E
S
S
S
E
D
A
V
M
M
N
Site 61
T419
T
V
Q
S
K
I
L
T
T
G
E
N
Y
K
T
Site 62
T426
T
T
G
E
N
Y
K
T
V
N
D
I
V
S
A
Site 63
S455
K
Q
A
E
E
M
A
S
D
D
L
S
L
I
R
Site 64
S459
E
M
A
S
D
D
L
S
L
I
R
K
N
R
M
Site 65
T500
H
D
I
I
K
Q
K
T
Q
I
P
L
Q
A
R
Site 66
Y536
K
E
I
D
S
T
L
Y
K
N
L
F
V
D
K
Site 67
Y547
F
V
D
K
N
M
K
Y
I
P
T
E
D
V
S
Site 68
T550
K
N
M
K
Y
I
P
T
E
D
V
S
G
L
S
Site 69
S554
Y
I
P
T
E
D
V
S
G
L
S
L
E
E
Q
Site 70
S557
T
E
D
V
S
G
L
S
L
E
E
Q
L
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation