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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKRNP5
Full Name:
Putative E3 ubiquitin-protein ligase makorin-4
Alias:
MKRN4; RNF64; ZNF127L1
Type:
Uncharacterized protein
Mass (Da):
52910
Number AA:
485
UniProt ID:
Q13434
International Prot ID:
IPI00006148
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
V
S
P
T
P
I
P
T
V
T
A
P
S
P
R
Site 2
S52
A
G
G
G
V
G
G
S
D
G
S
D
G
S
G
Site 3
S55
G
V
G
G
S
D
G
S
D
G
S
G
G
R
G
Site 4
S58
G
S
D
G
S
D
G
S
G
G
R
G
D
S
G
Site 5
S64
G
S
G
G
R
G
D
S
G
A
Y
D
G
S
G
Site 6
Y67
G
R
G
D
S
G
A
Y
D
G
S
G
A
C
G
Site 7
S70
D
S
G
A
Y
D
G
S
G
A
C
G
G
S
D
Site 8
S76
G
S
G
A
C
G
G
S
D
A
C
D
G
S
G
Site 9
S82
G
S
D
A
C
D
G
S
G
D
S
S
G
D
S
Site 10
S85
A
C
D
G
S
G
D
S
S
G
D
S
W
T
K
Site 11
S86
C
D
G
S
G
D
S
S
G
D
S
W
T
K
Q
Site 12
S89
S
G
D
S
S
G
D
S
W
T
K
Q
V
T
C
Site 13
T91
D
S
S
G
D
S
W
T
K
Q
V
T
C
R
Y
Site 14
Y98
T
K
Q
V
T
C
R
Y
F
K
Y
G
I
C
K
Site 15
Y101
V
T
C
R
Y
F
K
Y
G
I
C
K
E
G
D
Site 16
Y112
K
E
G
D
N
C
R
Y
S
H
D
L
S
D
R
Site 17
S113
E
G
D
N
C
R
Y
S
H
D
L
S
D
R
L
Site 18
S117
C
R
Y
S
H
D
L
S
D
R
L
C
G
V
V
Site 19
T155
K
Q
E
E
A
T
A
T
E
L
T
T
K
S
S
Site 20
T158
E
A
T
A
T
E
L
T
T
K
S
S
L
A
A
Site 21
S161
A
T
E
L
T
T
K
S
S
L
A
A
S
S
S
Site 22
S162
T
E
L
T
T
K
S
S
L
A
A
S
S
S
L
Site 23
T181
G
P
L
V
E
M
N
T
N
E
A
E
S
R
N
Site 24
S189
N
E
A
E
S
R
N
S
N
F
A
T
V
V
A
Site 25
T193
S
R
N
S
N
F
A
T
V
V
A
G
S
E
D
Site 26
Y213
E
F
V
P
G
Q
P
Y
C
G
R
T
V
P
S
Site 27
T217
G
Q
P
Y
C
G
R
T
V
P
S
C
T
E
A
Site 28
T222
G
R
T
V
P
S
C
T
E
A
P
L
Q
G
S
Site 29
S229
T
E
A
P
L
Q
G
S
V
T
K
E
E
S
E
Site 30
T231
A
P
L
Q
G
S
V
T
K
E
E
S
E
E
E
Site 31
S235
G
S
V
T
K
E
E
S
E
E
E
Q
T
A
V
Site 32
T240
E
E
S
E
E
E
Q
T
A
V
E
T
K
K
Q
Site 33
Y251
T
K
K
Q
L
C
P
Y
A
A
V
G
Q
C
R
Site 34
Y265
R
Y
G
E
N
C
V
Y
L
H
G
D
L
C
D
Site 35
S305
H
E
K
D
M
E
F
S
F
A
V
Q
R
S
K
Site 36
Y324
G
I
C
M
E
V
V
Y
E
K
A
N
P
N
E
Site 37
S354
K
C
I
R
K
W
R
S
A
K
E
F
E
S
R
Site 38
S360
R
S
A
K
E
F
E
S
R
I
V
K
S
C
P
Site 39
Y396
K
Q
K
L
I
Q
K
Y
K
E
A
M
S
N
K
Site 40
Y407
M
S
N
K
A
C
K
Y
F
D
E
G
R
G
S
Site 41
Y427
N
C
F
Y
K
H
M
Y
P
D
G
R
R
E
E
Site 42
T442
P
Q
R
Q
Q
V
G
T
S
S
R
N
P
G
Q
Site 43
S443
Q
R
Q
Q
V
G
T
S
S
R
N
P
G
Q
Q
Site 44
S464
F
F
E
E
G
A
N
S
N
P
F
D
D
E
E
Site 45
T475
D
D
E
E
E
A
V
T
F
E
L
G
E
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation