KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IKZF1
Full Name:
DNA-binding protein Ikaros
Alias:
DNA-binding protein Ikaros; HIk-1; Hs.54452; Ik1; Ikar; Ikaros; IKAROS; IKAROS family zinc finger 1; Ikzf1; Lyf1; LyF-1; Lymphoid transcription factor LyF-1; Zinc finger protein, subfamily 1A, 1 (Ikaros); Znfn1a1
Type:
Transcription factor
Mass (Da):
57528
Number AA:
519
UniProt ID:
Q13422
International Prot ID:
IPI00013232
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007498
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
D
E
G
Q
D
M
S
Q
V
S
G
K
E
S
Site 2
S13
G
Q
D
M
S
Q
V
S
G
K
E
S
P
P
V
Site 3
S17
S
Q
V
S
G
K
E
S
P
P
V
S
D
T
P
Site 4
S21
G
K
E
S
P
P
V
S
D
T
P
D
E
G
D
Site 5
T23
E
S
P
P
V
S
D
T
P
D
E
G
D
E
P
Site 6
S38
M
P
I
P
E
D
L
S
T
T
S
G
G
Q
Q
Site 7
T39
P
I
P
E
D
L
S
T
T
S
G
G
Q
Q
S
Site 8
S41
P
E
D
L
S
T
T
S
G
G
Q
Q
S
S
K
Site 9
S47
T
S
G
G
Q
Q
S
S
K
S
D
R
V
V
A
Site 10
S49
G
G
Q
Q
S
S
K
S
D
R
V
V
A
S
N
Site 11
T61
A
S
N
V
K
V
E
T
Q
S
D
E
E
N
G
Site 12
S63
N
V
K
V
E
T
Q
S
D
E
E
N
G
R
A
Site 13
S88
D
L
R
M
L
D
A
S
G
E
K
M
N
G
S
Site 14
S95
S
G
E
K
M
N
G
S
H
R
D
Q
G
S
S
Site 15
S101
G
S
H
R
D
Q
G
S
S
A
L
S
G
V
G
Site 16
S102
S
H
R
D
Q
G
S
S
A
L
S
G
V
G
G
Site 17
S105
D
Q
G
S
S
A
L
S
G
V
G
G
I
R
L
Site 18
T140
M
V
H
K
R
S
H
T
G
E
R
P
F
Q
C
Site 19
S168
L
R
H
I
K
L
H
S
G
E
K
P
F
K
C
Site 20
T189
C
R
R
R
D
A
L
T
G
H
L
R
T
H
S
Site 21
S196
T
G
H
L
R
T
H
S
V
G
K
P
H
K
C
Site 22
Y205
G
K
P
H
K
C
G
Y
C
G
R
S
Y
K
Q
Site 23
Y210
C
G
Y
C
G
R
S
Y
K
Q
R
S
S
L
E
Site 24
S215
R
S
Y
K
Q
R
S
S
L
E
E
H
K
E
R
Site 25
Y226
H
K
E
R
C
H
N
Y
L
E
S
M
G
L
P
Site 26
S229
R
C
H
N
Y
L
E
S
M
G
L
P
G
T
L
Site 27
T235
E
S
M
G
L
P
G
T
L
Y
P
V
I
K
E
Site 28
S247
I
K
E
E
T
N
H
S
E
M
A
E
D
L
C
Site 29
S258
E
D
L
C
K
I
G
S
E
R
S
L
V
L
D
Site 30
S261
C
K
I
G
S
E
R
S
L
V
L
D
R
L
A
Site 31
S269
L
V
L
D
R
L
A
S
N
V
A
K
R
K
S
Site 32
S276
S
N
V
A
K
R
K
S
S
M
P
Q
K
F
L
Site 33
S277
N
V
A
K
R
K
S
S
M
P
Q
K
F
L
G
Site 34
S289
F
L
G
D
K
G
L
S
D
T
P
Y
D
S
S
Site 35
T291
G
D
K
G
L
S
D
T
P
Y
D
S
S
A
S
Site 36
Y293
K
G
L
S
D
T
P
Y
D
S
S
A
S
Y
E
Site 37
S295
L
S
D
T
P
Y
D
S
S
A
S
Y
E
K
E
Site 38
S296
S
D
T
P
Y
D
S
S
A
S
Y
E
K
E
N
Site 39
S298
T
P
Y
D
S
S
A
S
Y
E
K
E
N
E
M
Site 40
Y299
P
Y
D
S
S
A
S
Y
E
K
E
N
E
M
M
Site 41
Y321
A
I
N
N
A
I
N
Y
L
G
A
E
S
L
R
Site 42
T333
S
L
R
P
L
V
Q
T
P
P
G
G
S
E
V
Site 43
S345
S
E
V
V
P
V
I
S
P
M
Y
Q
L
H
K
Site 44
T358
H
K
P
L
A
E
G
T
P
R
S
N
H
S
A
Site 45
S361
L
A
E
G
T
P
R
S
N
H
S
A
Q
D
S
Site 46
S364
G
T
P
R
S
N
H
S
A
Q
D
S
A
V
E
Site 47
S368
S
N
H
S
A
Q
D
S
A
V
E
N
L
L
L
Site 48
S377
V
E
N
L
L
L
L
S
K
A
K
L
V
P
S
Site 49
S384
S
K
A
K
L
V
P
S
E
R
E
A
S
P
S
Site 50
S389
V
P
S
E
R
E
A
S
P
S
N
S
C
Q
D
Site 51
S391
S
E
R
E
A
S
P
S
N
S
C
Q
D
S
T
Site 52
S393
R
E
A
S
P
S
N
S
C
Q
D
S
T
D
T
Site 53
S397
P
S
N
S
C
Q
D
S
T
D
T
E
S
N
N
Site 54
T398
S
N
S
C
Q
D
S
T
D
T
E
S
N
N
E
Site 55
T400
S
C
Q
D
S
T
D
T
E
S
N
N
E
E
Q
Site 56
S402
Q
D
S
T
D
T
E
S
N
N
E
E
Q
R
S
Site 57
S409
S
N
N
E
E
Q
R
S
G
L
I
Y
L
T
N
Site 58
Y413
E
Q
R
S
G
L
I
Y
L
T
N
H
I
A
P
Site 59
T415
R
S
G
L
I
Y
L
T
N
H
I
A
P
H
A
Site 60
Y435
L
K
E
E
H
R
A
Y
D
L
L
R
A
A
S
Site 61
S442
Y
D
L
L
R
A
A
S
E
N
S
Q
D
A
L
Site 62
S445
L
R
A
A
S
E
N
S
Q
D
A
L
R
V
V
Site 63
S453
Q
D
A
L
R
V
V
S
T
S
G
E
Q
M
K
Site 64
S455
A
L
R
V
V
S
T
S
G
E
Q
M
K
V
Y
Site 65
Y462
S
G
E
Q
M
K
V
Y
K
C
E
H
C
R
V
Site 66
Y503
G
Y
H
S
Q
D
R
Y
E
F
S
S
H
I
T
Site 67
S507
Q
D
R
Y
E
F
S
S
H
I
T
R
G
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation