PhosphoNET

           
Protein Info 
   
Short Name:  ILK
Full Name:  Integrin-linked protein kinase
Alias:  59 kDa serine/threonine protein kinase; EC 2.7.11.1; ILK1; ILK-1; Integrin-linked kinase; Kinase ILK; P59ILK
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; ILK subfamily
Mass (Da):  51419
Number AA:  452
UniProt ID:  Q13418
International Prot ID:  IPI00013219
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005925     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004674  GO:0004713 PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0007160  GO:0007229 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T23VRLWLDNTENDLNQG
Site 2T69VMNRGDDTPLHLAAS
Site 3Y164QNLNRIPYKDTFWKG
Site 4T167NRIPYKDTFWKGTTR
Site 5T172KDTFWKGTTRTRPRN
Site 6T173DTFWKGTTRTRPRNG
Site 7T181RTRPRNGTLNKHSGI
Site 8S186NGTLNKHSGIDFKQL
Site 9S204TKLNENHSGELWKGR
Site 10S228VLKVRDWSTRKSRDF
Site 11S232RDWSTRKSRDFNEEC
Site 12S246CPRLRIFSHPNVLPV
Site 13S259PVLGACQSPPAPHPT
Site 14T266SPPAPHPTLITHWMP
Site 15Y278WMPYGSLYNVLHEGT
Site 16S322IPRHALNSRSVMIDE
Site 17S324RHALNSRSVMIDEDM
Site 18S336EDMTARISMADVKFS
Site 19S343SMADVKFSFQCPGRM
Site 20Y351FQCPGRMYAPAWVAP
Site 21T368LQKKPEDTNRRSADM
Site 22S372PEDTNRRSADMWSFA
Site 23S377RRSADMWSFAVLLWE
Site 24S396EVPFADLSNMEIGMK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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