KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SP140
Full Name:
Nuclear body protein SP140
Alias:
Lymphoid-restricted homolog of Sp100;Nuclear autoantigen Sp-140;Speckled 140 kDa
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
99870
Number AA:
882
UniProt ID:
Q13342
International Prot ID:
IPI00012793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005635
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006952
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
Q
Q
G
Q
M
A
S
G
D
S
N
L
N
F
Site 2
S71
L
M
G
L
R
D
R
S
F
I
S
E
Q
M
Y
Site 3
Y78
S
F
I
S
E
Q
M
Y
E
H
F
Q
E
A
F
Site 4
T105
V
L
S
E
L
E
K
T
F
G
W
S
H
L
E
Site 5
Y123
S
R
I
N
L
M
A
Y
P
D
L
N
E
I
Y
Site 6
Y138
R
S
F
Q
N
V
C
Y
E
H
S
P
L
Q
M
Site 7
S183
A
V
P
Q
E
A
L
S
S
S
P
R
C
E
P
Site 8
S184
V
P
Q
E
A
L
S
S
S
P
R
C
E
P
G
Site 9
S185
P
Q
E
A
L
S
S
S
P
R
C
E
P
G
F
Site 10
S193
P
R
C
E
P
G
F
S
S
E
S
C
E
Q
L
Site 11
S196
E
P
G
F
S
S
E
S
C
E
Q
L
A
L
P
Site 12
S215
G
D
A
E
D
A
P
S
L
L
P
G
G
G
V
Site 13
Y244
E
M
P
K
L
L
P
Y
D
T
E
V
L
E
S
Site 14
T246
P
K
L
L
P
Y
D
T
E
V
L
E
S
N
G
Site 15
Y261
M
I
D
A
A
R
T
Y
S
T
A
P
G
E
K
Site 16
S262
I
D
A
A
R
T
Y
S
T
A
P
G
E
K
Q
Site 17
S277
G
E
E
E
G
R
N
S
P
R
K
R
N
Q
D
Site 18
Y288
R
N
Q
D
K
E
K
Y
Q
E
S
P
E
G
R
Site 19
S291
D
K
E
K
Y
Q
E
S
P
E
G
R
D
K
E
Site 20
T299
P
E
G
R
D
K
E
T
F
D
L
K
T
P
Q
Site 21
T304
K
E
T
F
D
L
K
T
P
Q
V
T
N
E
G
Site 22
S328
P
G
E
G
E
E
G
S
D
D
C
S
E
M
C
Site 23
S332
E
E
G
S
D
D
C
S
E
M
C
D
G
E
E
Site 24
S346
E
P
Q
E
A
S
S
S
L
A
R
C
G
S
V
Site 25
T365
A
E
T
F
D
L
K
T
P
Q
V
T
N
E
G
Site 26
S379
G
E
P
E
K
E
L
S
L
L
P
G
E
G
E
Site 27
S406
E
E
R
Q
E
A
S
S
S
L
A
R
R
G
S
Site 28
S407
E
R
Q
E
A
S
S
S
L
A
R
R
G
S
V
Site 29
S413
S
S
L
A
R
R
G
S
V
S
S
E
L
E
N
Site 30
S415
L
A
R
R
G
S
V
S
S
E
L
E
N
H
P
Site 31
S416
A
R
R
G
S
V
S
S
E
L
E
N
H
P
M
Site 32
S429
P
M
N
E
E
G
E
S
E
E
L
A
S
S
L
Site 33
S434
G
E
S
E
E
L
A
S
S
L
L
Y
D
N
V
Site 34
S435
E
S
E
E
L
A
S
S
L
L
Y
D
N
V
P
Site 35
Y438
E
L
A
S
S
L
L
Y
D
N
V
P
G
A
E
Site 36
Y449
P
G
A
E
Q
S
A
Y
E
N
E
K
C
S
C
Site 37
S467
F
S
E
E
V
P
G
S
P
E
A
R
T
E
S
Site 38
T472
P
G
S
P
E
A
R
T
E
S
D
Q
A
C
G
Site 39
S474
S
P
E
A
R
T
E
S
D
Q
A
C
G
T
M
Site 40
T483
Q
A
C
G
T
M
D
T
V
D
I
A
N
N
S
Site 41
S490
T
V
D
I
A
N
N
S
T
L
G
K
P
K
R
Site 42
S518
R
M
R
R
Q
E
N
S
Q
Q
N
D
N
S
K
Site 43
S532
K
A
D
G
Q
V
V
S
S
E
K
K
A
N
V
Site 44
S545
N
V
N
L
K
D
L
S
K
I
R
G
R
K
R
Site 45
T557
R
K
R
G
K
P
G
T
R
F
T
Q
S
D
R
Site 46
T560
G
K
P
G
T
R
F
T
Q
S
D
R
A
A
Q
Site 47
S562
P
G
T
R
F
T
Q
S
D
R
A
A
Q
K
R
Site 48
S572
A
A
Q
K
R
V
R
S
R
A
S
R
K
H
K
Site 49
S575
K
R
V
R
S
R
A
S
R
K
H
K
D
E
T
Site 50
T582
S
R
K
H
K
D
E
T
V
D
F
K
A
P
L
Site 51
T624
T
E
D
G
K
W
F
T
P
T
E
F
E
I
K
Site 52
T626
D
G
K
W
F
T
P
T
E
F
E
I
K
G
G
Site 53
S637
I
K
G
G
H
A
R
S
K
N
W
R
L
S
V
Site 54
Y668
P
D
P
P
R
I
R
Y
R
K
K
K
R
I
L
Site 55
S677
K
K
K
R
I
L
K
S
Q
N
N
S
S
V
D
Site 56
S681
I
L
K
S
Q
N
N
S
S
V
D
P
C
M
R
Site 57
S682
L
K
S
Q
N
N
S
S
V
D
P
C
M
R
N
Site 58
T726
P
P
V
E
A
E
R
T
P
W
N
C
I
F
C
Site 59
S741
R
M
K
E
S
P
G
S
Q
Q
C
C
Q
E
S
Site 60
Y784
S
F
F
A
K
I
P
Y
Y
Y
Y
I
R
E
A
Site 61
Y786
F
A
K
I
P
Y
Y
Y
Y
I
R
E
A
C
Q
Site 62
Y787
A
K
I
P
Y
Y
Y
Y
I
R
E
A
C
Q
G
Site 63
Y813
K
R
L
N
E
H
G
Y
P
Q
V
E
G
F
V
Site 64
Y834
F
Q
N
H
R
A
S
Y
K
Y
K
D
F
G
Q
Site 65
Y836
N
H
R
A
S
Y
K
Y
K
D
F
G
Q
M
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation