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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mGluR1
Full Name:
Metabotropic glutamate receptor 1
Alias:
glutamate receptor, metabotropic 1; GPRC1A; GRM1; metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGR1
Type:
G protein-coupled 7TM receptor, glutamate
Mass (Da):
132367
Number AA:
1194
UniProt ID:
Q13255
International Prot ID:
IPI00012363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0008066
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
E
V
S
L
L
P
R
S
P
G
R
K
V
L
L
Site 2
S33
K
V
L
L
A
G
A
S
S
Q
R
S
V
A
R
Site 3
S37
A
G
A
S
S
Q
R
S
V
A
R
M
D
G
D
Site 4
Y74
C
G
E
I
R
E
Q
Y
G
I
Q
R
V
E
A
Site 5
S103
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
Site 6
S108
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
Site 7
S112
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
Site 8
S113
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
Site 9
S119
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
Site 10
S126
S
I
E
F
I
R
D
S
L
I
S
I
R
D
E
Site 11
S129
F
I
R
D
S
L
I
S
I
R
D
E
K
D
G
Site 12
S146
R
C
L
P
D
G
Q
S
L
P
P
G
R
T
K
Site 13
T188
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
Site 14
S193
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
Site 15
T196
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
Site 16
Y200
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
Site 17
Y226
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
Site 18
T232
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
Site 19
S258
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
Site 20
Y262
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
Site 21
S263
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
Site 22
S269
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
Site 23
S317
G
E
F
S
L
I
G
S
D
G
W
A
D
R
D
Site 24
Y330
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
G
Site 25
S344
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
Site 26
S349
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
Site 27
Y353
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
Site 28
T361
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
Site 29
T363
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
Site 30
T395
P
N
F
K
R
I
C
T
G
N
E
S
L
E
E
Site 31
Y404
N
E
S
L
E
E
N
Y
V
Q
D
S
K
M
G
Site 32
S463
K
S
S
F
I
G
V
S
G
E
E
V
W
F
D
Site 33
Y479
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
Site 34
Y492
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
Site 35
Y494
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
Site 36
Y510
G
V
L
N
I
D
D
Y
K
I
Q
M
N
K
S
Site 37
S522
N
K
S
G
V
V
R
S
V
C
S
E
P
C
L
Site 38
S525
G
V
V
R
S
V
C
S
E
P
C
L
K
G
Q
Site 39
Y555
T
A
C
K
E
N
E
Y
V
Q
D
E
F
T
C
Site 40
Y585
C
E
P
I
P
V
R
Y
L
E
W
S
N
I
E
Site 41
S625
R
D
T
P
V
V
K
S
S
S
R
E
L
C
Y
Site 42
S626
D
T
P
V
V
K
S
S
S
R
E
L
C
Y
I
Site 43
T654
T
L
I
A
K
P
T
T
T
S
C
Y
L
Q
R
Site 44
Y658
K
P
T
T
T
S
C
Y
L
Q
R
L
L
V
G
Site 45
Y672
G
L
S
S
A
M
C
Y
S
A
L
V
T
K
T
Site 46
T677
M
C
Y
S
A
L
V
T
K
T
N
R
I
A
R
Site 47
T679
Y
S
A
L
V
T
K
T
N
R
I
A
R
I
L
Site 48
S689
I
A
R
I
L
A
G
S
K
K
K
I
C
T
R
Site 49
T695
G
S
K
K
K
I
C
T
R
K
P
R
F
M
S
Site 50
S735
E
P
P
M
P
I
L
S
Y
P
S
I
K
E
V
Site 51
Y736
P
P
M
P
I
L
S
Y
P
S
I
K
E
V
Y
Site 52
Y743
Y
P
S
I
K
E
V
Y
L
I
C
N
T
S
N
Site 53
Y786
A
N
F
N
E
A
K
Y
I
A
F
T
M
Y
T
Site 54
T851
R
N
V
R
S
A
F
T
T
S
D
V
V
R
M
Site 55
T852
N
V
R
S
A
F
T
T
S
D
V
V
R
M
H
Site 56
S853
V
R
S
A
F
T
T
S
D
V
V
R
M
H
V
Site 57
S869
D
G
K
L
P
C
R
S
N
T
F
L
N
I
F
Site 58
T871
K
L
P
C
R
S
N
T
F
L
N
I
F
R
R
Site 59
S888
A
G
A
G
N
A
N
S
N
G
K
S
V
S
W
Site 60
S892
N
A
N
S
N
G
K
S
V
S
W
S
E
P
G
Site 61
S894
N
S
N
G
K
S
V
S
W
S
E
P
G
G
G
Site 62
S896
N
G
K
S
V
S
W
S
E
P
G
G
G
Q
V
Site 63
T934
T
A
V
I
K
P
L
T
K
S
Y
Q
G
S
G
Site 64
S936
V
I
K
P
L
T
K
S
Y
Q
G
S
G
K
S
Site 65
S940
L
T
K
S
Y
Q
G
S
G
K
S
L
T
F
S
Site 66
S943
S
Y
Q
G
S
G
K
S
L
T
F
S
D
T
S
Site 67
T945
Q
G
S
G
K
S
L
T
F
S
D
T
S
T
K
Site 68
S947
S
G
K
S
L
T
F
S
D
T
S
T
K
T
L
Site 69
T949
K
S
L
T
F
S
D
T
S
T
K
T
L
Y
N
Site 70
T951
L
T
F
S
D
T
S
T
K
T
L
Y
N
V
E
Site 71
Y955
D
T
S
T
K
T
L
Y
N
V
E
E
E
E
D
Site 72
S969
D
A
Q
P
I
R
F
S
P
P
G
S
P
S
M
Site 73
S973
I
R
F
S
P
P
G
S
P
S
M
V
V
H
R
Site 74
S975
F
S
P
P
G
S
P
S
M
V
V
H
R
R
V
Site 75
S984
V
V
H
R
R
V
P
S
A
A
T
T
P
P
L
Site 76
T987
R
R
V
P
S
A
A
T
T
P
P
L
P
P
H
Site 77
T988
R
V
P
S
A
A
T
T
P
P
L
P
P
H
L
Site 78
T996
P
P
L
P
P
H
L
T
A
E
E
T
P
L
F
Site 79
T1000
P
H
L
T
A
E
E
T
P
L
F
L
A
E
P
Site 80
S1029
Q
P
P
P
Q
Q
K
S
L
M
D
Q
L
Q
G
Site 81
S1064
G
P
G
N
G
L
R
S
L
Y
P
P
P
P
P
Site 82
Y1066
G
N
G
L
R
S
L
Y
P
P
P
P
P
P
Q
Site 83
S1091
T
F
G
E
E
L
V
S
P
P
A
D
D
D
D
Site 84
S1100
P
A
D
D
D
D
D
S
E
R
F
K
L
L
Q
Site 85
Y1109
R
F
K
L
L
Q
E
Y
V
Y
E
H
E
R
E
Site 86
Y1111
K
L
L
Q
E
Y
V
Y
E
H
E
R
E
G
N
Site 87
T1138
L
Q
A
A
S
K
L
T
P
D
D
S
P
A
L
Site 88
S1142
S
K
L
T
P
D
D
S
P
A
L
T
P
P
S
Site 89
T1146
P
D
D
S
P
A
L
T
P
P
S
P
F
R
D
Site 90
S1149
S
P
A
L
T
P
P
S
P
F
R
D
S
V
A
Site 91
S1154
P
P
S
P
F
R
D
S
V
A
S
G
S
S
V
Site 92
S1157
P
F
R
D
S
V
A
S
G
S
S
V
P
S
S
Site 93
S1159
R
D
S
V
A
S
G
S
S
V
P
S
S
P
V
Site 94
S1160
D
S
V
A
S
G
S
S
V
P
S
S
P
V
S
Site 95
S1163
A
S
G
S
S
V
P
S
S
P
V
S
E
S
V
Site 96
S1164
S
G
S
S
V
P
S
S
P
V
S
E
S
V
L
Site 97
S1169
P
S
S
P
V
S
E
S
V
L
C
T
P
P
N
Site 98
Y1187
A
S
V
I
L
R
D
Y
K
Q
S
S
S
T
L
Site 99
S1190
I
L
R
D
Y
K
Q
S
S
S
T
L
_
_
_
Site 100
S1192
R
D
Y
K
Q
S
S
S
T
L
_
_
_
_
_
Site 101
T1193
D
Y
K
Q
S
S
S
T
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation