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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX10
Full Name:
Probable ATP-dependent RNA helicase DDX10
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; DEAD box protein 10; HRH-J8
Type:
Helicase; EC 3.6.1.-
Mass (Da):
100888
Number AA:
875
UniProt ID:
Q13206
International Prot ID:
IPI00297900
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005886
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
G
K
T
A
N
S
P
G
S
G
Site 2
S7
_
M
G
K
T
A
N
S
P
G
S
G
A
R
P
Site 3
S10
K
T
A
N
S
P
G
S
G
A
R
P
D
P
V
Site 4
S19
A
R
P
D
P
V
R
S
F
N
R
W
K
K
K
Site 5
S52
E
W
Q
V
E
R
E
S
I
S
R
L
M
Q
N
Site 6
Y60
I
S
R
L
M
Q
N
Y
E
K
I
N
V
N
E
Site 7
S72
V
N
E
I
T
R
F
S
D
F
P
L
S
K
K
Site 8
S77
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Site 9
Y89
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
Site 10
T93
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
Site 11
T157
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
Site 12
T208
L
L
Q
H
M
D
E
T
V
S
F
H
A
T
D
Site 13
S210
Q
H
M
D
E
T
V
S
F
H
A
T
D
L
Q
Site 14
T249
N
L
P
K
K
R
Q
T
L
L
F
S
A
T
Q
Site 15
T255
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
Site 16
S259
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
Site 17
S267
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
Site 18
Y273
L
S
L
K
N
P
E
Y
V
W
V
H
E
K
A
Site 19
Y282
W
V
H
E
K
A
K
Y
S
T
P
A
T
L
E
Site 20
T284
H
E
K
A
K
Y
S
T
P
A
T
L
E
Q
N
Site 21
T287
A
K
Y
S
T
P
A
T
L
E
Q
N
Y
I
V
Site 22
Y292
P
A
T
L
E
Q
N
Y
I
V
C
E
L
Q
Q
Site 23
S302
C
E
L
Q
Q
K
I
S
V
L
Y
S
F
L
R
Site 24
Y305
Q
Q
K
I
S
V
L
Y
S
F
L
R
S
H
L
Site 25
S306
Q
K
I
S
V
L
Y
S
F
L
R
S
H
L
K
Site 26
S310
V
L
Y
S
F
L
R
S
H
L
K
K
K
S
I
Site 27
S316
R
S
H
L
K
K
K
S
I
V
F
F
S
S
C
Site 28
S321
K
K
S
I
V
F
F
S
S
C
K
E
V
Q
Y
Site 29
Y328
S
S
C
K
E
V
Q
Y
L
Y
R
V
F
C
R
Site 30
Y330
C
K
E
V
Q
Y
L
Y
R
V
F
C
R
L
R
Site 31
Y358
Q
M
R
R
M
E
V
Y
N
E
F
V
R
K
R
Site 32
T398
D
C
P
E
D
A
N
T
Y
I
H
R
A
G
R
Site 33
Y399
C
P
E
D
A
N
T
Y
I
H
R
A
G
R
T
Site 34
Y409
R
A
G
R
T
A
R
Y
K
E
D
G
E
A
L
Site 35
Y480
V
S
Y
V
R
S
V
Y
L
M
K
D
K
E
V
Site 36
S491
D
K
E
V
F
D
V
S
K
L
P
I
P
E
Y
Site 37
S527
P
T
K
E
L
V
R
S
Q
A
D
K
V
I
E
Site 38
S539
V
I
E
P
R
A
P
S
L
T
N
D
E
V
E
Site 39
T541
E
P
R
A
P
S
L
T
N
D
E
V
E
E
F
Site 40
Y551
E
V
E
E
F
R
A
Y
F
N
E
K
M
S
I
Site 41
S557
A
Y
F
N
E
K
M
S
I
L
Q
K
G
G
K
Site 42
T569
G
G
K
R
L
E
G
T
E
H
R
Q
D
N
D
Site 43
T577
E
H
R
Q
D
N
D
T
G
N
E
E
Q
E
E
Site 44
S602
K
L
A
K
A
K
G
S
Q
A
P
S
L
P
N
Site 45
S606
A
K
G
S
Q
A
P
S
L
P
N
T
S
E
A
Site 46
T610
Q
A
P
S
L
P
N
T
S
E
A
Q
K
I
K
Site 47
T653
L
D
L
K
D
E
K
T
L
Q
K
K
E
P
S
Site 48
S662
Q
K
K
E
P
S
K
S
S
I
K
K
K
M
T
Site 49
S663
K
K
E
P
S
K
S
S
I
K
K
K
M
T
K
Site 50
T669
S
S
I
K
K
K
M
T
K
V
A
E
A
K
K
Site 51
T689
F
K
V
N
K
K
I
T
F
T
D
E
G
E
L
Site 52
S706
Q
W
P
Q
M
Q
K
S
A
I
K
D
A
E
E
Site 53
T717
D
A
E
E
D
D
D
T
G
G
I
N
L
H
K
Site 54
S780
E
E
A
F
L
D
W
S
D
D
D
D
D
D
D
Site 55
S793
D
D
D
G
F
D
P
S
T
L
P
D
P
D
K
Site 56
T794
D
D
G
F
D
P
S
T
L
P
D
P
D
K
Y
Site 57
Y801
T
L
P
D
P
D
K
Y
R
S
S
E
D
S
D
Site 58
S803
P
D
P
D
K
Y
R
S
S
E
D
S
D
S
E
Site 59
S804
D
P
D
K
Y
R
S
S
E
D
S
D
S
E
D
Site 60
S807
K
Y
R
S
S
E
D
S
D
S
E
D
M
E
N
Site 61
S809
R
S
S
E
D
S
D
S
E
D
M
E
N
K
I
Site 62
S817
E
D
M
E
N
K
I
S
D
T
K
K
K
Q
G
Site 63
S829
K
Q
G
M
K
K
R
S
N
S
E
V
E
D
V
Site 64
S831
G
M
K
K
R
S
N
S
E
V
E
D
V
G
P
Site 65
S840
V
E
D
V
G
P
T
S
H
N
R
K
K
A
R
Site 66
T850
R
K
K
A
R
W
D
T
L
E
P
L
D
T
G
Site 67
T856
D
T
L
E
P
L
D
T
G
L
S
L
A
E
D
Site 68
S859
E
P
L
D
T
G
L
S
L
A
E
D
E
E
L
Site 69
S873
L
V
L
H
L
L
R
S
Q
S
_
_
_
_
_
Site 70
S875
L
H
L
L
R
S
Q
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation