PhosphoNET

           
Protein Info 
   
Short Name:  PAK1
Full Name:  Serine/threonine-protein kinase PAK 1
Alias:  ADRB2; Alpha-PAK; CDC42,RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-A; EC 2.7.11.1; Kinase PAK1; MUK2; P21 protein (Cdc42/Rac)-activated kinase 1; P65-PAK; P68-PAK; PAK 1; PAK-1; PAKA; Protein kinase MUK2; STE20, yeast
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily
Mass (Da):  60647
Number AA:  545
UniProt ID:  Q13153
International Prot ID:  IPI00656138
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0005829  GO:0005925 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005518  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0006984  GO:0006915  GO:0007010 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T20PAPPMRNTSTMIGAG
Site 2S21APPMRNTSTMIGAGS
Site 3T22PPMRNTSTMIGAGSK
Site 4T33AGSKDAGTLNHGSKP
Site 5S38AGTLNHGSKPLPPNP
Site 6Y55KKKKDRFYRSILPGD
Site 7S57KKDRFYRSILPGDKT
Site 8T64SILPGDKTNKKKEKE
Site 9S76EKERPEISLPSDFEH
Site 10S79RPEISLPSDFEHTIH
Site 11T84LPSDFEHTIHVGFDA
Site 12T109QWARLLQTSNITKSE
Site 13S110WARLLQTSNITKSEQ
Site 14S115QTSNITKSEQKKNPQ
Site 15Y131VLDVLEFYNSKKTSN
Site 16S133DVLEFYNSKKTSNSQ
Site 17S137FYNSKKTSNSQKYMS
Site 18S139NSKKTSNSQKYMSFT
Site 19Y142KTSNSQKYMSFTDKS
Site 20S144SNSQKYMSFTDKSAE
Site 21T146SQKYMSFTDKSAEDY
Site 22S149YMSFTDKSAEDYNSS
Site 23Y153TDKSAEDYNSSNALN
Site 24S155KSAEDYNSSNALNVK
Site 25S174TPAVPPVSEDEDDDD
Site 26T185DDDDDDATPPPVIAP
Site 27S199PRPEHTKSVYTRSVI
Site 28Y201PEHTKSVYTRSVIEP
Site 29S204TKSVYTRSVIEPLPV
Site 30T212VIEPLPVTPTRDVAT
Site 31T214EPLPVTPTRDVATSP
Site 32T219TPTRDVATSPISPTE
Site 33S220PTRDVATSPISPTEN
Site 34S223DVATSPISPTENNTT
Site 35T225ATSPISPTENNTTPP
Site 36T229ISPTENNTTPPDALT
Site 37T230SPTENNTTPPDALTR
Site 38T236TTPPDALTRNTEKQK
Site 39T239PDALTRNTEKQKKKP
Site 40S249QKKKPKMSDEEILEK
Site 41S262EKLRSIVSVGDPKKK
Site 42Y270VGDPKKKYTRFEKIG
Site 43S281EKIGQGASGTVYTAM
Site 44Y285QGASGTVYTAMDVAT
Site 45Y330KNPNIVNYLDSYLVG
Site 46T357GSLTDVVTETCMDEG
Site 47S382QALEFLHSNQVIHRD
Site 48T415FGFCAQITPEQSKRS
Site 49S419AQITPEQSKRSTMVG
Site 50S422TPEQSKRSTMVGTPY
Site 51T423PEQSKRSTMVGTPYW
Site 52T427KRSTMVGTPYWMAPE
Site 53Y441EVVTRKAYGPKVDIW
Site 54Y464MIEGEPPYLNENPLR
Site 55Y474ENPLRALYLIATNGT
Site 56T481YLIATNGTPELQNPE
Site 57S491LQNPEKLSAIFRDFL
Site 58S511MDVEKRGSAKELLQH
Site 59S528LKIAKPLSSLTPLIA
Site 60S529KIAKPLSSLTPLIAA
Site 61T531AKPLSSLTPLIAAAK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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