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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
REST
Full Name:
RE1-silencing transcription factor
Alias:
Neural-restrictive silencer factor; NRSF; X2 box repressor; XBR
Type:
Mass (Da):
121888
Number AA:
1097
UniProt ID:
Q13127
International Prot ID:
IPI00159969
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016564
GO:0008270
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
Q
V
M
G
Q
S
S
G
G
G
G
L
F
T
Site 2
Y31
M
A
L
P
N
D
M
Y
D
L
H
D
L
S
K
Site 3
Y65
V
N
G
S
C
C
D
Y
L
V
G
E
E
R
Q
Site 4
S85
P
V
G
D
N
N
F
S
D
S
E
E
G
E
G
Site 5
S87
G
D
N
N
F
S
D
S
E
E
G
E
G
L
E
Site 6
S96
E
G
E
G
L
E
E
S
A
D
I
K
G
E
P
Site 7
S113
L
E
N
M
E
L
R
S
L
E
L
S
V
V
E
Site 8
S117
E
L
R
S
L
E
L
S
V
V
E
P
Q
P
V
Site 9
Y134
A
S
G
A
P
D
I
Y
S
S
N
K
D
L
P
Site 10
S135
S
G
A
P
D
I
Y
S
S
N
K
D
L
P
P
Site 11
T144
N
K
D
L
P
P
E
T
P
G
A
E
D
K
G
Site 12
S153
G
A
E
D
K
G
K
S
S
K
T
K
P
F
R
Site 13
Y166
F
R
C
K
P
C
Q
Y
E
A
E
S
E
E
Q
Site 14
S201
K
Q
A
K
A
R
E
S
G
S
S
T
A
E
E
Site 15
S203
A
K
A
R
E
S
G
S
S
T
A
E
E
G
D
Site 16
S204
K
A
R
E
S
G
S
S
T
A
E
E
G
D
F
Site 17
T205
A
R
E
S
G
S
S
T
A
E
E
G
D
F
S
Site 18
S212
T
A
E
E
G
D
F
S
K
G
P
I
R
C
D
Site 19
Y228
C
G
Y
N
T
N
R
Y
D
H
Y
T
A
H
L
Site 20
Y231
N
T
N
R
Y
D
H
Y
T
A
H
L
K
H
H
Site 21
Y248
A
G
D
N
E
R
V
Y
K
C
I
I
C
T
Y
Site 22
Y261
T
Y
T
T
V
S
E
Y
H
W
R
K
H
L
R
Site 23
Y276
N
H
F
P
R
K
V
Y
T
C
G
K
C
N
Y
Site 24
Y283
Y
T
C
G
K
C
N
Y
F
S
D
R
K
N
N
Site 25
Y291
F
S
D
R
K
N
N
Y
V
Q
H
V
R
T
H
Site 26
T299
V
Q
H
V
R
T
H
T
G
E
R
P
Y
K
C
Site 27
Y304
T
H
T
G
E
R
P
Y
K
C
E
L
C
P
Y
Site 28
Y311
Y
K
C
E
L
C
P
Y
S
S
S
Q
K
T
H
Site 29
S312
K
C
E
L
C
P
Y
S
S
S
Q
K
T
H
L
Site 30
S313
C
E
L
C
P
Y
S
S
S
Q
K
T
H
L
T
Site 31
S314
E
L
C
P
Y
S
S
S
Q
K
T
H
L
T
R
Site 32
T317
P
Y
S
S
S
Q
K
T
H
L
T
R
H
M
R
Site 33
T320
S
S
Q
K
T
H
L
T
R
H
M
R
T
H
S
Site 34
T325
H
L
T
R
H
M
R
T
H
S
G
E
K
P
F
Site 35
S327
T
R
H
M
R
T
H
S
G
E
K
P
F
K
C
Site 36
Y339
F
K
C
D
Q
C
S
Y
V
A
S
N
Q
H
E
Site 37
Y368
L
N
C
P
H
C
D
Y
K
T
A
D
R
S
N
Site 38
S374
D
Y
K
T
A
D
R
S
N
F
K
K
H
V
E
Site 39
Y396
F
N
C
P
V
C
D
Y
A
A
S
K
K
C
N
Site 40
Y406
S
K
K
C
N
L
Q
Y
H
F
K
S
K
H
P
Site 41
T419
H
P
T
C
P
N
K
T
M
D
V
S
K
V
K
Site 42
S423
P
N
K
T
M
D
V
S
K
V
K
L
K
K
T
Site 43
T430
S
K
V
K
L
K
K
T
K
K
R
E
A
D
L
Site 44
T442
A
D
L
P
D
N
I
T
N
E
K
T
E
I
E
Site 45
T451
E
K
T
E
I
E
Q
T
K
I
K
G
D
V
A
Site 46
S465
A
G
K
K
N
E
K
S
V
K
A
E
K
R
D
Site 47
S474
K
A
E
K
R
D
V
S
K
E
K
K
P
S
N
Site 48
S480
V
S
K
E
K
K
P
S
N
N
V
S
V
I
Q
Site 49
S484
K
K
P
S
N
N
V
S
V
I
Q
V
T
T
R
Site 50
S495
V
T
T
R
T
R
K
S
V
T
E
V
K
E
M
Site 51
T506
V
K
E
M
D
V
H
T
G
S
N
S
E
K
F
Site 52
S508
E
M
D
V
H
T
G
S
N
S
E
K
F
S
K
Site 53
S510
D
V
H
T
G
S
N
S
E
K
F
S
K
T
K
Site 54
S514
G
S
N
S
E
K
F
S
K
T
K
K
S
K
R
Site 55
S519
K
F
S
K
T
K
K
S
K
R
K
L
E
V
D
Site 56
S529
K
L
E
V
D
S
H
S
L
H
G
P
V
N
D
Site 57
S539
G
P
V
N
D
E
E
S
S
T
K
K
K
K
K
Site 58
S549
K
K
K
K
K
V
E
S
K
S
K
N
N
S
Q
Site 59
S551
K
K
K
V
E
S
K
S
K
N
N
S
Q
E
V
Site 60
S555
E
S
K
S
K
N
N
S
Q
E
V
P
K
G
D
Site 61
S563
Q
E
V
P
K
G
D
S
K
V
E
E
N
K
K
Site 62
S578
Q
N
T
C
M
K
K
S
T
K
K
K
T
L
K
Site 63
T583
K
K
S
T
K
K
K
T
L
K
N
K
S
S
K
Site 64
S588
K
K
T
L
K
N
K
S
S
K
K
S
S
K
P
Site 65
S589
K
T
L
K
N
K
S
S
K
K
S
S
K
P
P
Site 66
S592
K
N
K
S
S
K
K
S
S
K
P
P
Q
K
E
Site 67
S593
N
K
S
S
K
K
S
S
K
P
P
Q
K
E
P
Site 68
T696
P
P
M
E
T
A
Q
T
E
V
A
Q
M
G
P
Site 69
S734
E
P
V
Q
M
E
L
S
P
P
M
E
V
V
Q
Site 70
S750
E
P
V
Q
I
E
L
S
P
P
M
E
V
V
Q
Site 71
S782
E
P
V
Q
M
E
L
S
P
P
M
G
V
V
Q
Site 72
S811
P
L
H
M
E
P
I
S
K
K
P
P
L
R
K
Site 73
S824
R
K
D
K
K
E
K
S
N
M
Q
S
E
R
A
Site 74
S828
K
E
K
S
N
M
Q
S
E
R
A
R
K
E
Q
Site 75
S854
D
S
W
L
L
K
E
S
V
S
T
E
D
L
S
Site 76
S856
W
L
L
K
E
S
V
S
T
E
D
L
S
P
P
Site 77
T857
L
L
K
E
S
V
S
T
E
D
L
S
P
P
S
Site 78
S861
S
V
S
T
E
D
L
S
P
P
S
P
P
L
P
Site 79
S864
T
E
D
L
S
P
P
S
P
P
L
P
K
E
N
Site 80
S877
E
N
L
R
E
E
A
S
G
D
Q
K
L
L
N
Site 81
S905
G
A
E
E
A
D
E
S
L
P
G
L
A
A
N
Site 82
S916
L
A
A
N
I
N
E
S
T
H
I
S
S
S
G
Site 83
T917
A
A
N
I
N
E
S
T
H
I
S
S
S
G
Q
Site 84
S920
I
N
E
S
T
H
I
S
S
S
G
Q
N
L
N
Site 85
S922
E
S
T
H
I
S
S
S
G
Q
N
L
N
T
P
Site 86
T928
S
S
G
Q
N
L
N
T
P
E
G
E
T
L
N
Site 87
S942
N
G
K
H
Q
T
D
S
I
V
C
E
M
K
M
Site 88
T955
K
M
D
T
D
Q
N
T
R
E
N
L
T
G
I
Site 89
S964
E
N
L
T
G
I
N
S
T
V
E
E
P
V
S
Site 90
S971
S
T
V
E
E
P
V
S
P
M
L
P
P
S
A
Site 91
S977
V
S
P
M
L
P
P
S
A
V
E
E
R
E
A
Site 92
T988
E
R
E
A
V
S
K
T
A
L
A
S
P
P
A
Site 93
T996
A
L
A
S
P
P
A
T
M
A
A
N
E
S
Q
Site 94
S1013
D
E
D
E
G
I
H
S
H
E
G
S
D
L
S
Site 95
S1017
G
I
H
S
H
E
G
S
D
L
S
D
N
M
S
Site 96
S1020
S
H
E
G
S
D
L
S
D
N
M
S
E
G
S
Site 97
S1024
S
D
L
S
D
N
M
S
E
G
S
D
D
S
G
Site 98
S1027
S
D
N
M
S
E
G
S
D
D
S
G
L
H
G
Site 99
S1030
M
S
E
G
S
D
D
S
G
L
H
G
A
R
P
Site 100
S1042
A
R
P
V
P
Q
E
S
S
R
K
N
A
K
E
Site 101
Y1075
S
F
R
K
G
K
D
Y
S
K
H
L
N
R
H
Site 102
S1076
F
R
K
G
K
D
Y
S
K
H
L
N
R
H
L
Site 103
Y1088
R
H
L
V
N
V
Y
Y
L
E
E
A
A
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation