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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPP2
Full Name:
Secreted phosphoprotein 24
Alias:
Secreted phosphoprotein 2; Secreted phosphoprotein 2, 24kDa; Secreted phosphoprotein 24; SPP24; Spp-24
Type:
Inhibitor protein
Mass (Da):
24338
Number AA:
211
UniProt ID:
Q13103
International Prot ID:
IPI00011832
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004866
PhosphoSite+
KinaseNET
Biological Process:
GO:0046849
GO:0001501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
S
C
S
G
F
P
V
Y
D
Y
D
P
S
S
L
Site 2
Y35
S
G
F
P
V
Y
D
Y
D
P
S
S
L
R
D
Site 3
S39
V
Y
D
Y
D
P
S
S
L
R
D
A
L
S
A
Site 4
S47
L
R
D
A
L
S
A
S
V
V
K
V
N
S
Q
Site 5
S55
V
V
K
V
N
S
Q
S
L
S
P
Y
L
F
R
Site 6
S57
K
V
N
S
Q
S
L
S
P
Y
L
F
R
A
F
Site 7
Y59
N
S
Q
S
L
S
P
Y
L
F
R
A
F
R
S
Site 8
T90
L
E
F
S
I
R
E
T
T
C
R
K
D
S
G
Site 9
T91
E
F
S
I
R
E
T
T
C
R
K
D
S
G
E
Site 10
S96
E
T
T
C
R
K
D
S
G
E
D
P
A
T
C
Site 11
T102
D
S
G
E
D
P
A
T
C
A
F
Q
R
D
Y
Site 12
Y109
T
C
A
F
Q
R
D
Y
Y
V
S
T
A
V
C
Site 13
Y110
C
A
F
Q
R
D
Y
Y
V
S
T
A
V
C
R
Site 14
T119
S
T
A
V
C
R
S
T
V
K
V
S
A
Q
Q
Site 15
S135
Q
G
V
H
A
R
C
S
W
S
S
S
T
S
E
Site 16
S137
V
H
A
R
C
S
W
S
S
S
T
S
E
S
Y
Site 17
S138
H
A
R
C
S
W
S
S
S
T
S
E
S
Y
S
Site 18
S139
A
R
C
S
W
S
S
S
T
S
E
S
Y
S
S
Site 19
S141
C
S
W
S
S
S
T
S
E
S
Y
S
S
E
E
Site 20
S143
W
S
S
S
T
S
E
S
Y
S
S
E
E
M
I
Site 21
S145
S
S
T
S
E
S
Y
S
S
E
E
M
I
F
G
Site 22
S146
S
T
S
E
S
Y
S
S
E
E
M
I
F
G
D
Site 23
Y164
S
H
K
W
R
N
N
Y
L
F
G
L
I
S
D
Site 24
S170
N
Y
L
F
G
L
I
S
D
E
S
I
S
E
Q
Site 25
S173
F
G
L
I
S
D
E
S
I
S
E
Q
F
Y
D
Site 26
S175
L
I
S
D
E
S
I
S
E
Q
F
Y
D
R
S
Site 27
Y179
E
S
I
S
E
Q
F
Y
D
R
S
L
G
I
M
Site 28
S182
S
E
Q
F
Y
D
R
S
L
G
I
M
R
R
V
Site 29
Y197
L
P
P
G
N
R
R
Y
P
N
H
R
H
R
A
Site 30
T208
R
H
R
A
R
I
N
T
D
F
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation