KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FLII
Full Name:
Protein flightless-1 homolog
Alias:
FLI; Fli1; Flightless I; Flightless I homologue variant; Flightless-I protein homolog; FLIH; FLIL; MGC39265
Type:
Nuclear receptor co-regulator; Actin binding protein
Mass (Da):
144751
Number AA:
1269
UniProt ID:
Q13045
International Prot ID:
IPI00031023
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006936
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
E
A
T
G
V
L
P
F
V
R
Site 2
S16
F
V
R
G
V
D
L
S
G
N
D
F
K
G
G
Site 3
Y24
G
N
D
F
K
G
G
Y
F
P
E
N
V
K
A
Site 4
S34
E
N
V
K
A
M
T
S
L
R
W
L
K
L
N
Site 5
T43
R
W
L
K
L
N
R
T
G
L
C
Y
L
P
E
Site 6
S62
L
Q
K
L
E
H
L
S
V
S
H
N
N
L
T
Site 7
S64
K
L
E
H
L
S
V
S
H
N
N
L
T
T
L
Site 8
T70
V
S
H
N
N
L
T
T
L
H
G
E
L
S
S
Site 9
S76
T
T
L
H
G
E
L
S
S
L
P
S
L
R
A
Site 10
S94
R
A
N
S
L
K
N
S
G
V
P
D
D
I
F
Site 11
S112
D
L
S
V
L
D
L
S
H
N
Q
L
T
E
C
Site 12
T117
D
L
S
H
N
Q
L
T
E
C
P
R
E
L
E
Site 13
Y155
I
N
L
T
D
L
L
Y
L
D
L
S
E
N
R
Site 14
S159
D
L
L
Y
L
D
L
S
E
N
R
L
E
S
L
Site 15
S165
L
S
E
N
R
L
E
S
L
P
P
Q
M
R
R
Site 16
T178
R
R
L
V
H
L
Q
T
L
V
L
N
G
N
P
Site 17
T202
P
A
M
T
A
L
Q
T
L
H
L
R
S
T
Q
Site 18
T208
Q
T
L
H
L
R
S
T
Q
R
T
Q
S
N
L
Site 19
T211
H
L
R
S
T
Q
R
T
Q
S
N
L
P
T
S
Site 20
S213
R
S
T
Q
R
T
Q
S
N
L
P
T
S
L
E
Site 21
T217
R
T
Q
S
N
L
P
T
S
L
E
G
L
S
N
Site 22
S218
T
Q
S
N
L
P
T
S
L
E
G
L
S
N
L
Site 23
S231
N
L
A
D
V
D
L
S
C
N
D
L
T
R
V
Site 24
T236
D
L
S
C
N
D
L
T
R
V
P
E
C
L
Y
Site 25
Y243
T
R
V
P
E
C
L
Y
T
L
P
S
L
R
R
Site 26
T244
R
V
P
E
C
L
Y
T
L
P
S
L
R
R
L
Site 27
S247
E
C
L
Y
T
L
P
S
L
R
R
L
N
L
S
Site 28
S254
S
L
R
R
L
N
L
S
S
N
Q
I
T
E
L
Site 29
S255
L
R
R
L
N
L
S
S
N
Q
I
T
E
L
S
Site 30
T259
N
L
S
S
N
Q
I
T
E
L
S
L
C
I
D
Site 31
T273
D
Q
W
V
H
V
E
T
L
N
L
S
R
N
Q
Site 32
S277
H
V
E
T
L
N
L
S
R
N
Q
L
T
S
L
Site 33
T282
N
L
S
R
N
Q
L
T
S
L
P
S
A
I
C
Site 34
S283
L
S
R
N
Q
L
T
S
L
P
S
A
I
C
K
Site 35
S286
N
Q
L
T
S
L
P
S
A
I
C
K
L
S
K
Site 36
Y298
L
S
K
L
K
K
L
Y
L
N
S
N
K
L
D
Site 37
S311
L
D
F
D
G
L
P
S
G
I
G
K
L
T
N
Site 38
Y390
A
D
R
A
A
E
W
Y
N
I
D
F
S
L
Q
Site 39
S406
Q
L
R
L
A
G
A
S
P
A
T
V
A
A
A
Site 40
T409
L
A
G
A
S
P
A
T
V
A
A
A
A
A
A
Site 41
S436
R
L
R
R
R
K
D
S
A
Q
D
D
Q
A
K
Site 42
S470
S
A
D
A
R
A
P
S
G
K
V
R
R
W
D
Site 43
Y487
L
E
K
P
R
L
D
Y
S
E
F
F
T
E
D
Site 44
T492
L
D
Y
S
E
F
F
T
E
D
V
G
Q
L
P
Site 45
Y523
E
A
F
H
G
K
F
Y
E
A
D
C
Y
I
V
Site 46
Y528
K
F
Y
E
A
D
C
Y
I
V
L
K
T
F
L
Site 47
S538
L
K
T
F
L
D
D
S
G
S
L
N
W
E
I
Site 48
Y546
G
S
L
N
W
E
I
Y
Y
W
I
G
G
E
A
Site 49
Y547
S
L
N
W
E
I
Y
Y
W
I
G
G
E
A
T
Site 50
Y571
H
A
V
N
L
R
N
Y
L
G
A
E
C
R
T
Site 51
T578
Y
L
G
A
E
C
R
T
V
R
E
E
M
G
D
Site 52
S587
R
E
E
M
G
D
E
S
E
E
F
L
Q
V
F
Site 53
S599
Q
V
F
D
N
D
I
S
Y
I
E
G
G
T
A
Site 54
Y600
V
F
D
N
D
I
S
Y
I
E
G
G
T
A
S
Site 55
S607
Y
I
E
G
G
T
A
S
G
F
Y
T
V
E
D
Site 56
Y610
G
G
T
A
S
G
F
Y
T
V
E
D
T
H
Y
Site 57
T611
G
T
A
S
G
F
Y
T
V
E
D
T
H
Y
V
Site 58
Y617
Y
T
V
E
D
T
H
Y
V
T
R
M
Y
R
V
Site 59
Y622
T
H
Y
V
T
R
M
Y
R
V
Y
G
K
K
N
Site 60
Y625
V
T
R
M
Y
R
V
Y
G
K
K
N
I
K
L
Site 61
Y657
L
D
R
G
L
D
I
Y
V
W
R
G
A
Q
A
Site 62
T665
V
W
R
G
A
Q
A
T
L
S
S
T
T
K
A
Site 63
S667
R
G
A
Q
A
T
L
S
S
T
T
K
A
R
L
Site 64
T669
A
Q
A
T
L
S
S
T
T
K
A
R
L
F
A
Site 65
T691
R
K
G
K
A
E
I
T
L
L
V
Q
G
Q
E
Site 66
S711
E
A
L
G
G
E
P
S
E
I
K
K
H
V
P
Site 67
Y729
W
P
P
Q
P
K
L
Y
K
V
G
L
G
L
G
Site 68
Y737
K
V
G
L
G
L
G
Y
L
E
L
P
Q
I
N
Site 69
Y745
L
E
L
P
Q
I
N
Y
K
L
S
V
E
H
K
Site 70
S748
P
Q
I
N
Y
K
L
S
V
E
H
K
Q
R
P
Site 71
S768
P
R
M
R
L
L
Q
S
L
L
D
T
R
C
V
Site 72
T818
L
H
R
P
R
H
A
T
V
S
R
S
L
E
G
Site 73
S820
R
P
R
H
A
T
V
S
R
S
L
E
G
T
E
Site 74
S822
R
H
A
T
V
S
R
S
L
E
G
T
E
A
Q
Site 75
T826
V
S
R
S
L
E
G
T
E
A
Q
V
F
K
A
Site 76
T843
K
N
W
D
D
V
L
T
V
D
Y
T
R
N
A
Site 77
Y846
D
D
V
L
T
V
D
Y
T
R
N
A
E
A
V
Site 78
S856
N
A
E
A
V
L
Q
S
P
G
L
S
G
K
V
Site 79
S860
V
L
Q
S
P
G
L
S
G
K
V
K
R
D
A
Site 80
T878
D
Q
M
K
A
D
L
T
A
L
F
L
P
R
Q
Site 81
S889
L
P
R
Q
P
P
M
S
L
A
E
A
E
Q
L
Site 82
Y929
E
E
E
F
G
H
F
Y
T
Q
D
C
Y
V
F
Site 83
Y946
R
Y
W
V
P
V
E
Y
E
E
E
E
K
K
E
Site 84
T999
A
S
N
M
G
W
L
T
F
T
F
S
L
Q
K
Site 85
T1001
N
M
G
W
L
T
F
T
F
S
L
Q
K
K
F
Site 86
S1003
G
W
L
T
F
T
F
S
L
Q
K
K
F
E
S
Site 87
T1022
K
L
E
V
V
R
M
T
Q
Q
Q
E
N
P
K
Site 88
S1055
V
Q
G
A
Q
Q
P
S
L
Y
Q
I
R
T
N
Site 89
Y1057
G
A
Q
Q
P
S
L
Y
Q
I
R
T
N
G
S
Site 90
T1061
P
S
L
Y
Q
I
R
T
N
G
S
A
L
C
T
Site 91
T1075
T
R
C
I
Q
I
N
T
D
S
S
L
L
N
S
Site 92
S1078
I
Q
I
N
T
D
S
S
L
L
N
S
E
F
C
Site 93
Y1102
E
D
N
Q
G
I
V
Y
A
W
V
G
R
A
S
Site 94
S1109
Y
A
W
V
G
R
A
S
D
P
D
E
A
K
L
Site 95
T1123
L
A
E
D
I
L
N
T
M
F
D
T
S
Y
S
Site 96
Y1129
N
T
M
F
D
T
S
Y
S
K
Q
V
I
N
E
Site 97
Y1154
G
I
G
A
Q
K
P
Y
D
D
D
A
E
Y
M
Site 98
Y1160
P
Y
D
D
D
A
E
Y
M
K
H
T
R
L
F
Site 99
Y1175
R
C
S
N
E
K
G
Y
F
A
V
T
E
K
C
Site 100
T1179
E
K
G
Y
F
A
V
T
E
K
C
S
D
F
C
Site 101
Y1205
L
D
N
G
Q
E
V
Y
M
W
V
G
T
Q
T
Site 102
S1213
M
W
V
G
T
Q
T
S
Q
V
E
I
K
L
S
Site 103
Y1227
S
L
K
A
C
Q
V
Y
I
Q
H
M
R
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation