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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Eps8
Full Name:
Epidermal growth factor receptor kinase substrate 8
Alias:
Epidermal growth factor receptor kinase substrate EPS8; epidermal growth factor receptor pathway substrate 8
Type:
Adapter/scaffold protein
Mass (Da):
91882
Number AA:
822
UniProt ID:
Q12929
International Prot ID:
IPI00784012
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007173
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
H
I
S
N
H
P
S
S
F
G
M
Y
P
S
Site 2
S11
H
I
S
N
H
P
S
S
F
G
M
Y
P
S
Q
Site 3
Y15
H
P
S
S
F
G
M
Y
P
S
Q
M
N
G
Y
Site 4
S17
S
S
F
G
M
Y
P
S
Q
M
N
G
Y
G
S
Site 5
Y22
Y
P
S
Q
M
N
G
Y
G
S
S
P
T
F
S
Site 6
S24
S
Q
M
N
G
Y
G
S
S
P
T
F
S
Q
T
Site 7
S25
Q
M
N
G
Y
G
S
S
P
T
F
S
Q
T
D
Site 8
T27
N
G
Y
G
S
S
P
T
F
S
Q
T
D
R
E
Site 9
S29
Y
G
S
S
P
T
F
S
Q
T
D
R
E
H
G
Site 10
T31
S
S
P
T
F
S
Q
T
D
R
E
H
G
S
K
Site 11
T39
D
R
E
H
G
S
K
T
S
A
K
A
L
Y
E
Site 12
Y45
K
T
S
A
K
A
L
Y
E
Q
R
K
N
Y
A
Site 13
Y51
L
Y
E
Q
R
K
N
Y
A
R
D
S
V
S
S
Site 14
S55
R
K
N
Y
A
R
D
S
V
S
S
V
S
D
I
Site 15
S57
N
Y
A
R
D
S
V
S
S
V
S
D
I
S
Q
Site 16
S58
Y
A
R
D
S
V
S
S
V
S
D
I
S
Q
Y
Site 17
S60
R
D
S
V
S
S
V
S
D
I
S
Q
Y
R
V
Site 18
S63
V
S
S
V
S
D
I
S
Q
Y
R
V
E
H
L
Site 19
T71
Q
Y
R
V
E
H
L
T
T
F
V
L
D
R
K
Site 20
T72
Y
R
V
E
H
L
T
T
F
V
L
D
R
K
D
Site 21
T83
D
R
K
D
A
M
I
T
V
D
D
G
I
R
K
Site 22
S115
Q
V
D
D
R
A
V
S
L
I
D
L
E
S
K
Site 23
S121
V
S
L
I
D
L
E
S
K
N
E
L
E
N
F
Site 24
S177
E
V
K
A
N
L
I
S
E
D
I
E
S
A
I
Site 25
S182
L
I
S
E
D
I
E
S
A
I
S
D
S
K
G
Site 26
S185
E
D
I
E
S
A
I
S
D
S
K
G
G
K
Q
Site 27
S203
P
D
A
L
R
M
I
S
N
A
D
P
S
I
P
Site 28
S208
M
I
S
N
A
D
P
S
I
P
P
P
P
R
A
Site 29
T223
P
A
P
A
P
P
G
T
V
T
Q
V
D
V
R
Site 30
T225
P
A
P
P
G
T
V
T
Q
V
D
V
R
S
R
Site 31
S231
V
T
Q
V
D
V
R
S
R
V
A
A
W
S
A
Site 32
S237
R
S
R
V
A
A
W
S
A
W
A
A
D
Q
G
Site 33
Y252
D
F
E
K
P
R
Q
Y
H
E
Q
E
E
T
P
Site 34
T258
Q
Y
H
E
Q
E
E
T
P
E
M
M
A
A
R
Site 35
T285
D
D
I
E
F
F
I
T
K
L
Q
K
A
A
E
Site 36
S298
A
E
A
F
S
E
L
S
K
R
K
K
N
K
K
Site 37
T317
G
P
G
E
G
V
L
T
L
R
A
K
P
P
P
Site 38
S347
N
L
L
A
K
L
K
S
H
I
Q
N
P
S
A
Site 39
S353
K
S
H
I
Q
N
P
S
A
A
D
L
V
H
F
Site 40
S383
E
L
A
S
S
V
L
S
P
L
L
N
K
D
T
Site 41
T390
S
P
L
L
N
K
D
T
I
D
F
L
N
Y
T
Site 42
Y396
D
T
I
D
F
L
N
Y
T
V
N
G
D
E
R
Site 43
T397
T
I
D
F
L
N
Y
T
V
N
G
D
E
R
Q
Site 44
T412
L
W
M
S
L
G
G
T
W
M
K
A
R
A
E
Site 45
Y429
K
E
Q
F
I
P
P
Y
V
P
R
F
R
N
G
Site 46
Y454
A
T
M
E
Q
D
L
Y
Q
L
A
E
S
V
A
Site 47
S459
D
L
Y
Q
L
A
E
S
V
A
N
V
A
E
H
Site 48
S476
K
Q
E
I
K
R
L
S
T
E
H
S
S
V
S
Site 49
T477
Q
E
I
K
R
L
S
T
E
H
S
S
V
S
E
Site 50
S480
K
R
L
S
T
E
H
S
S
V
S
E
Y
H
P
Site 51
S481
R
L
S
T
E
H
S
S
V
S
E
Y
H
P
A
Site 52
S483
S
T
E
H
S
S
V
S
E
Y
H
P
A
D
G
Site 53
Y485
E
H
S
S
V
S
E
Y
H
P
A
D
G
Y
A
Site 54
Y491
E
Y
H
P
A
D
G
Y
A
F
S
S
N
I
Y
Site 55
S494
P
A
D
G
Y
A
F
S
S
N
I
Y
T
R
G
Site 56
S495
A
D
G
Y
A
F
S
S
N
I
Y
T
R
G
S
Site 57
Y498
Y
A
F
S
S
N
I
Y
T
R
G
S
H
L
D
Site 58
T499
A
F
S
S
N
I
Y
T
R
G
S
H
L
D
Q
Site 59
S502
S
N
I
Y
T
R
G
S
H
L
D
Q
G
E
A
Site 60
S517
A
V
A
F
K
P
T
S
N
R
H
I
D
R
N
Site 61
Y525
N
R
H
I
D
R
N
Y
E
P
L
K
T
Q
P
Site 62
T530
R
N
Y
E
P
L
K
T
Q
P
K
K
Y
A
K
Site 63
S538
Q
P
K
K
Y
A
K
S
K
Y
D
F
V
A
R
Site 64
Y540
K
K
Y
A
K
S
K
Y
D
F
V
A
R
N
N
Site 65
S548
D
F
V
A
R
N
N
S
E
L
S
V
L
K
D
Site 66
S551
A
R
N
N
S
E
L
S
V
L
K
D
D
I
L
Site 67
S574
W
W
K
V
R
N
A
S
G
D
S
G
F
V
P
Site 68
S577
V
R
N
A
S
G
D
S
G
F
V
P
N
N
I
Site 69
S593
D
I
V
R
P
P
E
S
G
L
G
R
A
D
P
Site 70
Y602
L
G
R
A
D
P
P
Y
T
H
T
I
Q
K
Q
Site 71
T603
G
R
A
D
P
P
Y
T
H
T
I
Q
K
Q
R
Site 72
Y613
I
Q
K
Q
R
M
E
Y
G
P
R
P
A
D
T
Site 73
T620
Y
G
P
R
P
A
D
T
P
P
A
P
S
P
P
Site 74
S625
A
D
T
P
P
A
P
S
P
P
P
T
P
A
P
Site 75
T629
P
A
P
S
P
P
P
T
P
A
P
V
P
V
P
Site 76
T655
S
K
V
P
A
N
I
T
R
Q
N
S
S
S
S
Site 77
S659
A
N
I
T
R
Q
N
S
S
S
S
D
S
G
G
Site 78
S660
N
I
T
R
Q
N
S
S
S
S
D
S
G
G
S
Site 79
S661
I
T
R
Q
N
S
S
S
S
D
S
G
G
S
I
Site 80
S662
T
R
Q
N
S
S
S
S
D
S
G
G
S
I
V
Site 81
S664
Q
N
S
S
S
S
D
S
G
G
S
I
V
R
D
Site 82
S667
S
S
S
D
S
G
G
S
I
V
R
D
S
Q
R
Site 83
S672
G
G
S
I
V
R
D
S
Q
R
H
K
Q
L
P
Site 84
S685
L
P
V
D
R
R
K
S
Q
M
E
E
V
Q
D
Site 85
T699
D
E
L
I
H
R
L
T
I
G
R
S
A
A
Q
Site 86
S703
H
R
L
T
I
G
R
S
A
A
Q
K
K
F
H
Site 87
T722
N
V
P
V
I
N
I
T
Y
D
S
T
P
E
D
Site 88
Y723
V
P
V
I
N
I
T
Y
D
S
T
P
E
D
V
Site 89
T726
I
N
I
T
Y
D
S
T
P
E
D
V
K
T
W
Site 90
T732
S
T
P
E
D
V
K
T
W
L
Q
S
K
G
F
Site 91
T743
S
K
G
F
N
P
V
T
V
N
S
L
G
V
L
Site 92
S757
L
N
G
A
Q
L
F
S
L
N
K
D
E
L
R
Site 93
T765
L
N
K
D
E
L
R
T
V
C
P
E
G
A
R
Site 94
Y774
C
P
E
G
A
R
V
Y
S
Q
I
T
V
Q
K
Site 95
S775
P
E
G
A
R
V
Y
S
Q
I
T
V
Q
K
A
Site 96
S787
Q
K
A
A
L
E
D
S
S
G
S
S
E
L
Q
Site 97
S788
K
A
A
L
E
D
S
S
G
S
S
E
L
Q
E
Site 98
S791
L
E
D
S
S
G
S
S
E
L
Q
E
I
M
R
Site 99
S805
R
R
R
Q
E
K
I
S
A
A
A
S
D
S
G
Site 100
S809
E
K
I
S
A
A
A
S
D
S
G
V
E
S
F
Site 101
S811
I
S
A
A
A
S
D
S
G
V
E
S
F
D
E
Site 102
S815
A
S
D
S
G
V
E
S
F
D
E
G
S
S
H
Site 103
S821
E
S
F
D
E
G
S
S
H
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation