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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRJ
Full Name:
Receptor-type tyrosine-protein phosphatase eta
Alias:
CD148; CD148 antigen; Density-enhanced phosphatase 1; DEP1; EC 3.1.3.48; HPTP eta; HPTPeta; Human density enhanced phosphatase-1; Protein tyrosine phosphatase, receptor type, J; Protein-tyrosine phosphatase receptor type J; Receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; SCC1
Type:
Receptor protein phosphatase, tyrosine; EC 3.1.3.48
Mass (Da):
145941
Number AA:
1337
UniProt ID:
Q12913
International Prot ID:
IPI00290328
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005887
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005001
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0006470
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
A
R
L
P
P
R
S
P
G
L
R
W
A
L
Site 2
S1009
D
A
K
N
N
E
V
S
F
S
Q
I
K
P
K
Site 3
S1011
K
N
N
E
V
S
F
S
Q
I
K
P
K
K
S
Site 4
S1018
S
Q
I
K
P
K
K
S
K
L
I
R
V
E
N
Site 5
Y1029
R
V
E
N
F
E
A
Y
F
K
K
Q
Q
A
D
Site 6
S1037
F
K
K
Q
Q
A
D
S
N
C
G
F
A
E
E
Site 7
Y1045
N
C
G
F
A
E
E
Y
E
D
L
K
L
V
G
Site 8
Y1058
V
G
I
S
Q
P
K
Y
A
A
E
L
A
E
N
Site 9
Y1071
E
N
R
G
K
N
R
Y
N
N
V
L
P
Y
D
Site 10
Y1077
R
Y
N
N
V
L
P
Y
D
I
S
R
V
K
L
Site 11
S1080
N
V
L
P
Y
D
I
S
R
V
K
L
S
V
Q
Site 12
S1085
D
I
S
R
V
K
L
S
V
Q
T
H
S
T
D
Site 13
T1091
L
S
V
Q
T
H
S
T
D
D
Y
I
N
A
N
Site 14
Y1094
Q
T
H
S
T
D
D
Y
I
N
A
N
Y
M
P
Site 15
Y1099
D
D
Y
I
N
A
N
Y
M
P
G
Y
H
S
K
Site 16
Y1103
N
A
N
Y
M
P
G
Y
H
S
K
K
D
F
I
Site 17
T1112
S
K
K
D
F
I
A
T
Q
G
P
L
P
N
T
Site 18
T1119
T
Q
G
P
L
P
N
T
L
K
D
F
W
R
M
Site 19
Y1152
G
R
T
K
C
E
E
Y
W
P
S
K
Q
A
Q
Site 20
Y1161
P
S
K
Q
A
Q
D
Y
G
D
I
T
V
A
M
Site 21
T1165
A
Q
D
Y
G
D
I
T
V
A
M
T
S
E
I
Site 22
T1183
E
W
T
I
R
D
F
T
V
K
N
I
Q
T
S
Site 23
S1192
K
N
I
Q
T
S
E
S
H
P
L
R
Q
F
H
Site 24
S1202
L
R
Q
F
H
F
T
S
W
P
D
H
G
V
P
Site 25
T1211
P
D
H
G
V
P
D
T
T
D
L
L
I
N
F
Site 26
T1212
D
H
G
V
P
D
T
T
D
L
L
I
N
F
R
Site 27
Y1220
D
L
L
I
N
F
R
Y
L
V
R
D
Y
M
K
Site 28
Y1225
F
R
Y
L
V
R
D
Y
M
K
Q
S
P
P
E
Site 29
S1229
V
R
D
Y
M
K
Q
S
P
P
E
S
P
I
L
Site 30
S1233
M
K
Q
S
P
P
E
S
P
I
L
V
H
C
S
Site 31
Y1257
I
A
I
D
R
L
I
Y
Q
I
E
N
E
N
T
Site 32
Y1268
N
E
N
T
V
D
V
Y
G
I
V
Y
D
L
R
Site 33
Y1272
V
D
V
Y
G
I
V
Y
D
L
R
M
H
R
P
Site 34
S1301
C
V
L
D
I
V
R
S
Q
K
D
S
K
V
D
Site 35
S1305
I
V
R
S
Q
K
D
S
K
V
D
L
I
Y
Q
Site 36
Y1311
D
S
K
V
D
L
I
Y
Q
N
T
T
A
M
T
Site 37
T1314
V
D
L
I
Y
Q
N
T
T
A
M
T
I
Y
E
Site 38
Y1320
N
T
T
A
M
T
I
Y
E
N
L
A
P
V
T
Site 39
T1328
E
N
L
A
P
V
T
T
F
G
K
T
N
G
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation