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Updated November 2019
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Protein Info
Short Name:
TP53BP1
Full Name:
Tumor suppressor p53-binding protein 1
Alias:
53BP1; P202; P531; P53-binding protein 1; TP53B; TRP53BP1; Tumor protein p53 binding protein 1
Type:
Transcription, coactivator/corepressor
Mass (Da):
213574
Number AA:
1972
UniProt ID:
Q12888
International Prot ID:
IPI00029778
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0045893
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
P
T
G
S
Q
L
D
S
D
F
S
Site 2
S10
P
T
G
S
Q
L
D
S
D
F
S
Q
Q
D
T
Site 3
S13
S
Q
L
D
S
D
F
S
Q
Q
D
T
P
C
L
Site 4
T17
S
D
F
S
Q
Q
D
T
P
C
L
I
I
E
D
Site 5
S25
P
C
L
I
I
E
D
S
Q
P
E
S
Q
V
L
Site 6
S29
I
E
D
S
Q
P
E
S
Q
V
L
E
D
D
S
Site 7
S36
S
Q
V
L
E
D
D
S
G
S
H
F
S
M
L
Site 8
S38
V
L
E
D
D
S
G
S
H
F
S
M
L
S
R
Site 9
S41
D
D
S
G
S
H
F
S
M
L
S
R
H
L
P
Site 10
S44
G
S
H
F
S
M
L
S
R
H
L
P
N
L
Q
Site 11
T52
R
H
L
P
N
L
Q
T
H
K
E
N
P
V
L
Site 12
S78
E
E
R
G
D
G
N
S
G
F
N
E
H
L
K
Site 13
S96
V
A
D
P
V
D
S
S
N
L
D
T
C
G
S
Site 14
T100
V
D
S
S
N
L
D
T
C
G
S
I
S
Q
V
Site 15
S103
S
N
L
D
T
C
G
S
I
S
Q
V
I
E
Q
Site 16
S105
L
D
T
C
G
S
I
S
Q
V
I
E
Q
L
P
Site 17
S118
L
P
Q
P
N
R
T
S
S
V
L
G
M
S
V
Site 18
S119
P
Q
P
N
R
T
S
S
V
L
G
M
S
V
E
Site 19
S124
T
S
S
V
L
G
M
S
V
E
S
A
P
A
V
Site 20
T150
E
K
E
K
E
E
D
T
S
G
N
T
T
H
S
Site 21
S151
K
E
K
E
E
D
T
S
G
N
T
T
H
S
L
Site 22
T155
E
D
T
S
G
N
T
T
H
S
L
G
A
E
D
Site 23
S157
T
S
G
N
T
T
H
S
L
G
A
E
D
T
A
Site 24
T163
H
S
L
G
A
E
D
T
A
S
S
Q
L
G
F
Site 25
S166
G
A
E
D
T
A
S
S
Q
L
G
F
G
V
L
Site 26
S176
G
F
G
V
L
E
L
S
Q
S
Q
D
V
E
E
Site 27
S178
G
V
L
E
L
S
Q
S
Q
D
V
E
E
N
T
Site 28
T185
S
Q
D
V
E
E
N
T
V
P
Y
E
V
D
K
Site 29
S197
V
D
K
E
Q
L
Q
S
V
T
T
N
S
G
Y
Site 30
S202
L
Q
S
V
T
T
N
S
G
Y
T
R
L
S
D
Site 31
Y204
S
V
T
T
N
S
G
Y
T
R
L
S
D
V
D
Site 32
S208
N
S
G
Y
T
R
L
S
D
V
D
A
N
T
A
Site 33
T214
L
S
D
V
D
A
N
T
A
I
K
H
E
E
Q
Site 34
S222
A
I
K
H
E
E
Q
S
N
E
D
I
P
I
A
Site 35
T239
S
S
K
D
I
P
V
T
A
Q
P
S
K
D
V
Site 36
S259
Q
N
P
P
P
A
R
S
E
D
M
P
F
S
P
Site 37
S265
R
S
E
D
M
P
F
S
P
K
A
S
V
A
A
Site 38
S269
M
P
F
S
P
K
A
S
V
A
A
M
E
A
K
Site 39
S287
S
A
Q
E
L
M
E
S
G
L
Q
I
Q
K
S
Site 40
S294
S
G
L
Q
I
Q
K
S
P
E
P
E
V
L
S
Site 41
S301
S
P
E
P
E
V
L
S
T
Q
E
D
L
F
D
Site 42
T302
P
E
P
E
V
L
S
T
Q
E
D
L
F
D
Q
Site 43
T313
L
F
D
Q
S
N
K
T
V
S
S
D
G
C
S
Site 44
S315
D
Q
S
N
K
T
V
S
S
D
G
C
S
T
P
Site 45
S316
Q
S
N
K
T
V
S
S
D
G
C
S
T
P
S
Site 46
S320
T
V
S
S
D
G
C
S
T
P
S
R
E
E
G
Site 47
T321
V
S
S
D
G
C
S
T
P
S
R
E
E
G
G
Site 48
S323
S
D
G
C
S
T
P
S
R
E
E
G
G
C
S
Site 49
S330
S
R
E
E
G
G
C
S
L
A
S
T
P
A
T
Site 50
S333
E
G
G
C
S
L
A
S
T
P
A
T
T
L
H
Site 51
T334
G
G
C
S
L
A
S
T
P
A
T
T
L
H
L
Site 52
T337
S
L
A
S
T
P
A
T
T
L
H
L
L
Q
L
Site 53
T338
L
A
S
T
P
A
T
T
L
H
L
L
Q
L
S
Site 54
S345
T
L
H
L
L
Q
L
S
G
Q
R
S
L
V
Q
Site 55
S349
L
Q
L
S
G
Q
R
S
L
V
Q
D
S
L
S
Site 56
S354
Q
R
S
L
V
Q
D
S
L
S
T
N
S
S
D
Site 57
S356
S
L
V
Q
D
S
L
S
T
N
S
S
D
L
V
Site 58
S359
Q
D
S
L
S
T
N
S
S
D
L
V
A
P
S
Site 59
S360
D
S
L
S
T
N
S
S
D
L
V
A
P
S
P
Site 60
S366
S
S
D
L
V
A
P
S
P
D
A
F
R
S
T
Site 61
S372
P
S
P
D
A
F
R
S
T
P
F
I
V
P
S
Site 62
T373
S
P
D
A
F
R
S
T
P
F
I
V
P
S
S
Site 63
S379
S
T
P
F
I
V
P
S
S
P
T
E
Q
E
G
Site 64
S380
T
P
F
I
V
P
S
S
P
T
E
Q
E
G
R
Site 65
T382
F
I
V
P
S
S
P
T
E
Q
E
G
R
Q
D
Site 66
T394
R
Q
D
K
P
M
D
T
S
V
L
S
E
E
G
Site 67
S395
Q
D
K
P
M
D
T
S
V
L
S
E
E
G
G
Site 68
S398
P
M
D
T
S
V
L
S
E
E
G
G
E
P
F
Site 69
S411
P
F
Q
K
K
L
Q
S
G
E
P
V
E
L
E
Site 70
S426
N
P
P
L
L
P
E
S
T
V
S
P
Q
A
S
Site 71
T427
P
P
L
L
P
E
S
T
V
S
P
Q
A
S
T
Site 72
S429
L
L
P
E
S
T
V
S
P
Q
A
S
T
P
I
Site 73
S433
S
T
V
S
P
Q
A
S
T
P
I
S
Q
S
T
Site 74
T434
T
V
S
P
Q
A
S
T
P
I
S
Q
S
T
P
Site 75
S437
P
Q
A
S
T
P
I
S
Q
S
T
P
V
F
P
Site 76
S439
A
S
T
P
I
S
Q
S
T
P
V
F
P
P
G
Site 77
T440
S
T
P
I
S
Q
S
T
P
V
F
P
P
G
S
Site 78
S447
T
P
V
F
P
P
G
S
L
P
I
P
S
Q
P
Site 79
S452
P
G
S
L
P
I
P
S
Q
P
Q
F
S
H
D
Site 80
S457
I
P
S
Q
P
Q
F
S
H
D
I
F
I
P
S
Site 81
S464
S
H
D
I
F
I
P
S
P
S
L
E
E
Q
S
Site 82
S466
D
I
F
I
P
S
P
S
L
E
E
Q
S
N
D
Site 83
S471
S
P
S
L
E
E
Q
S
N
D
G
K
K
D
G
Site 84
S482
K
K
D
G
D
M
H
S
S
S
L
T
V
E
C
Site 85
S484
D
G
D
M
H
S
S
S
L
T
V
E
C
S
K
Site 86
T486
D
M
H
S
S
S
L
T
V
E
C
S
K
T
S
Site 87
S490
S
S
L
T
V
E
C
S
K
T
S
E
I
E
P
Site 88
T492
L
T
V
E
C
S
K
T
S
E
I
E
P
K
N
Site 89
S493
T
V
E
C
S
K
T
S
E
I
E
P
K
N
S
Site 90
S500
S
E
I
E
P
K
N
S
P
E
D
L
G
L
S
Site 91
S507
S
P
E
D
L
G
L
S
L
T
G
D
S
C
K
Site 92
T509
E
D
L
G
L
S
L
T
G
D
S
C
K
L
M
Site 93
S518
D
S
C
K
L
M
L
S
T
S
E
Y
S
Q
S
Site 94
T519
S
C
K
L
M
L
S
T
S
E
Y
S
Q
S
P
Site 95
S520
C
K
L
M
L
S
T
S
E
Y
S
Q
S
P
K
Site 96
Y522
L
M
L
S
T
S
E
Y
S
Q
S
P
K
M
E
Site 97
S523
M
L
S
T
S
E
Y
S
Q
S
P
K
M
E
S
Site 98
S525
S
T
S
E
Y
S
Q
S
P
K
M
E
S
L
S
Site 99
S530
S
Q
S
P
K
M
E
S
L
S
S
H
R
I
D
Site 100
S532
S
P
K
M
E
S
L
S
S
H
R
I
D
E
D
Site 101
S533
P
K
M
E
S
L
S
S
H
R
I
D
E
D
G
Site 102
T543
I
D
E
D
G
E
N
T
Q
I
E
D
T
E
P
Site 103
T548
E
N
T
Q
I
E
D
T
E
P
M
S
P
V
L
Site 104
S552
I
E
D
T
E
P
M
S
P
V
L
N
S
K
F
Site 105
S557
P
M
S
P
V
L
N
S
K
F
V
P
A
E
N
Site 106
S566
F
V
P
A
E
N
D
S
I
L
M
N
P
A
Q
Site 107
S580
Q
D
G
E
V
Q
L
S
Q
N
D
D
K
T
K
Site 108
T586
L
S
Q
N
D
D
K
T
K
G
D
D
T
D
T
Site 109
T591
D
K
T
K
G
D
D
T
D
T
R
D
D
I
S
Site 110
T593
T
K
G
D
D
T
D
T
R
D
D
I
S
I
L
Site 111
S598
T
D
T
R
D
D
I
S
I
L
A
T
G
C
K
Site 112
T602
D
D
I
S
I
L
A
T
G
C
K
G
R
E
E
Site 113
T610
G
C
K
G
R
E
E
T
V
A
E
D
V
C
I
Site 114
T620
E
D
V
C
I
D
L
T
C
D
S
G
S
Q
A
Site 115
S625
D
L
T
C
D
S
G
S
Q
A
V
P
S
P
A
Site 116
S630
S
G
S
Q
A
V
P
S
P
A
T
R
S
E
A
Site 117
S635
V
P
S
P
A
T
R
S
E
A
L
S
S
V
L
Site 118
S639
A
T
R
S
E
A
L
S
S
V
L
D
Q
E
E
Site 119
S640
T
R
S
E
A
L
S
S
V
L
D
Q
E
E
A
Site 120
S659
E
H
H
P
E
E
G
S
S
G
S
E
V
E
E
Site 121
S660
H
H
P
E
E
G
S
S
G
S
E
V
E
E
I
Site 122
S662
P
E
E
G
S
S
G
S
E
V
E
E
I
P
E
Site 123
T670
E
V
E
E
I
P
E
T
P
C
E
S
Q
G
E
Site 124
S674
I
P
E
T
P
C
E
S
Q
G
E
E
L
K
E
Site 125
S686
L
K
E
E
N
M
E
S
V
P
L
H
L
S
L
Site 126
S692
E
S
V
P
L
H
L
S
L
T
E
T
Q
S
Q
Site 127
T694
V
P
L
H
L
S
L
T
E
T
Q
S
Q
G
L
Site 128
T696
L
H
L
S
L
T
E
T
Q
S
Q
G
L
C
L
Site 129
S698
L
S
L
T
E
T
Q
S
Q
G
L
C
L
Q
K
Site 130
S713
E
M
P
K
K
E
C
S
E
A
M
E
V
E
T
Site 131
S721
E
A
M
E
V
E
T
S
V
I
S
I
D
S
P
Site 132
S724
E
V
E
T
S
V
I
S
I
D
S
P
Q
K
L
Site 133
S727
T
S
V
I
S
I
D
S
P
Q
K
L
A
I
L
Site 134
T750
Q
E
A
W
E
E
A
T
S
E
D
S
S
V
V
Site 135
S751
E
A
W
E
E
A
T
S
E
D
S
S
V
V
I
Site 136
S754
E
E
A
T
S
E
D
S
S
V
V
I
V
D
V
Site 137
S755
E
A
T
S
E
D
S
S
V
V
I
V
D
V
K
Site 138
S765
I
V
D
V
K
E
P
S
P
R
V
D
V
S
C
Site 139
S771
P
S
P
R
V
D
V
S
C
E
P
L
E
G
V
Site 140
S782
L
E
G
V
E
K
C
S
D
S
Q
S
W
E
D
Site 141
S784
G
V
E
K
C
S
D
S
Q
S
W
E
D
I
A
Site 142
S786
E
K
C
S
D
S
Q
S
W
E
D
I
A
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S
M
Site 295
S1656
P
T
R
K
I
T
E
S
P
R
A
S
M
G
V
Site 296
S1660
I
T
E
S
P
R
A
S
M
G
V
L
S
G
K
Site 297
S1665
R
A
S
M
G
V
L
S
G
K
R
K
L
I
T
Site 298
T1672
S
G
K
R
K
L
I
T
S
E
E
E
R
S
P
Site 299
S1673
G
K
R
K
L
I
T
S
E
E
E
R
S
P
A
Site 300
S1678
I
T
S
E
E
E
R
S
P
A
K
R
G
R
K
Site 301
S1686
P
A
K
R
G
R
K
S
A
T
V
K
P
G
A
Site 302
T1688
K
R
G
R
K
S
A
T
V
K
P
G
A
V
G
Site 303
S1701
V
G
A
G
E
F
V
S
P
C
E
S
G
D
N
Site 304
S1705
E
F
V
S
P
C
E
S
G
D
N
T
G
E
P
Site 305
T1709
P
C
E
S
G
D
N
T
G
E
P
S
A
L
E
Site 306
S1742
L
L
T
M
A
T
T
S
D
K
L
A
S
R
S
Site 307
S1747
T
T
S
D
K
L
A
S
R
S
K
L
P
D
G
Site 308
S1749
S
D
K
L
A
S
R
S
K
L
P
D
G
P
T
Site 309
T1756
S
K
L
P
D
G
P
T
G
S
S
E
E
E
E
Site 310
S1758
L
P
D
G
P
T
G
S
S
E
E
E
E
E
F
Site 311
S1759
P
D
G
P
T
G
S
S
E
E
E
E
E
F
L
Site 312
S1778
F
N
K
Q
Y
T
E
S
Q
L
R
A
G
A
G
Site 313
Y1815
Q
H
C
R
T
R
K
Y
F
L
C
L
A
S
G
Site 314
Y1846
Q
L
Q
N
Y
R
N
Y
L
L
P
A
G
Y
S
Site 315
S1853
Y
L
L
P
A
G
Y
S
L
E
E
Q
R
I
L
Site 316
S1899
L
M
T
G
G
A
A
S
V
K
Q
H
H
S
S
Site 317
S1929
T
D
P
S
C
P
A
S
V
L
K
C
A
E
A
Site 318
Y1965
G
F
K
Q
H
P
K
Y
K
H
D
Y
V
S
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation