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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH2
Full Name:
Potassium voltage-gated channel subfamily H member 2
Alias:
Cause of long QT syndrome type 2; Eag-related 1; ERG; ERG1; Ether-a-go-go-related 1; Ether-a-go-go-related potassium channel 1; HERG; Kv11.1; LQT2; Potassium voltage-gated channel H 2; Potassium voltage-gated channel, subfamily H (eag-related) member 2; SQT1
Type:
Channel, potassium
Mass (Da):
126655
Number AA:
1159
UniProt ID:
Q12809
International Prot ID:
IPI00029662
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005251
GO:0030955
GO:0000155
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006936
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
G
H
V
A
P
Q
N
T
F
L
D
T
I
I
R
Site 2
T17
P
Q
N
T
F
L
D
T
I
I
R
K
F
E
G
Site 3
T74
D
F
L
H
G
P
R
T
Q
R
R
A
A
A
Q
Site 4
Y99
R
K
V
E
I
A
F
Y
R
K
D
G
S
C
F
Site 5
S140
M
E
K
D
M
V
G
S
P
A
H
D
T
N
H
Site 6
T145
V
G
S
P
A
H
D
T
N
H
R
G
P
P
T
Site 7
T152
T
N
H
R
G
P
P
T
S
W
L
A
P
G
R
Site 8
S153
N
H
R
G
P
P
T
S
W
L
A
P
G
R
A
Site 9
T162
L
A
P
G
R
A
K
T
F
R
L
K
L
P
A
Site 10
S178
L
A
L
T
A
R
E
S
S
V
R
S
G
G
A
Site 11
S179
A
L
T
A
R
E
S
S
V
R
S
G
G
A
G
Site 12
S182
A
R
E
S
S
V
R
S
G
G
A
G
G
A
G
Site 13
S207
L
T
P
A
A
P
S
S
E
S
L
A
L
D
E
Site 14
S239
R
A
L
V
G
P
G
S
P
P
R
S
A
P
G
Site 15
S243
G
P
G
S
P
P
R
S
A
P
G
Q
L
P
S
Site 16
S250
S
A
P
G
Q
L
P
S
P
R
A
H
S
L
N
Site 17
S255
L
P
S
P
R
A
H
S
L
N
P
D
A
S
G
Site 18
S261
H
S
L
N
P
D
A
S
G
S
S
C
S
L
A
Site 19
S263
L
N
P
D
A
S
G
S
S
C
S
L
A
R
T
Site 20
S266
D
A
S
G
S
S
C
S
L
A
R
T
R
S
R
Site 21
T270
S
S
C
S
L
A
R
T
R
S
R
E
S
C
A
Site 22
S272
C
S
L
A
R
T
R
S
R
E
S
C
A
S
V
Site 23
S275
A
R
T
R
S
R
E
S
C
A
S
V
R
R
A
Site 24
S278
R
S
R
E
S
C
A
S
V
R
R
A
S
S
A
Site 25
S283
C
A
S
V
R
R
A
S
S
A
D
D
I
E
A
Site 26
S284
A
S
V
R
R
A
S
S
A
D
D
I
E
A
M
Site 27
S304
P
P
P
P
R
H
A
S
T
G
A
M
H
P
L
Site 28
T305
P
P
P
R
H
A
S
T
G
A
M
H
P
L
R
Site 29
S313
G
A
M
H
P
L
R
S
G
L
L
N
S
T
S
Site 30
S318
L
R
S
G
L
L
N
S
T
S
D
S
D
L
V
Site 31
T319
R
S
G
L
L
N
S
T
S
D
S
D
L
V
R
Site 32
S320
S
G
L
L
N
S
T
S
D
S
D
L
V
R
Y
Site 33
S322
L
L
N
S
T
S
D
S
D
L
V
R
Y
R
T
Site 34
Y327
S
D
S
D
L
V
R
Y
R
T
I
S
K
I
P
Site 35
T329
S
D
L
V
R
Y
R
T
I
S
K
I
P
Q
I
Site 36
S351
K
G
D
P
F
L
A
S
P
T
S
D
R
E
I
Site 37
S354
P
F
L
A
S
P
T
S
D
R
E
I
I
A
P
Site 38
T371
K
E
R
T
H
N
V
T
E
K
V
T
Q
V
L
Site 39
Y388
G
A
D
V
L
P
E
Y
K
L
Q
A
P
R
I
Site 40
Y427
Y
T
A
V
F
T
P
Y
S
A
A
F
L
L
K
Site 41
T443
T
E
E
G
P
P
A
T
E
C
G
Y
A
C
Q
Site 42
T474
I
L
I
N
F
R
T
T
Y
V
N
A
N
E
E
Site 43
Y475
L
I
N
F
R
T
T
Y
V
N
A
N
E
E
V
Site 44
S484
N
A
N
E
E
V
V
S
H
P
G
R
I
A
V
Site 45
Y542
V
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
Site 46
S543
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
L
Site 47
Y597
G
D
Q
I
G
K
P
Y
N
S
S
G
L
G
G
Site 48
S599
Q
I
G
K
P
Y
N
S
S
G
L
G
G
P
S
Site 49
S600
I
G
K
P
Y
N
S
S
G
L
G
G
P
S
I
Site 50
S606
S
S
G
L
G
G
P
S
I
K
D
K
Y
V
T
Site 51
Y611
G
P
S
I
K
D
K
Y
V
T
A
L
Y
F
T
Site 52
S631
S
V
G
F
G
N
V
S
P
N
T
N
S
E
K
Site 53
T634
F
G
N
V
S
P
N
T
N
S
E
K
I
F
S
Site 54
S636
N
V
S
P
N
T
N
S
E
K
I
F
S
I
C
Site 55
Y667
S
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
Site 56
S668
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
T
Site 57
T670
I
Q
R
L
Y
S
G
T
A
R
Y
H
T
Q
M
Site 58
T675
S
G
T
A
R
Y
H
T
Q
M
L
R
V
R
E
Site 59
Y700
L
R
Q
R
L
E
E
Y
F
Q
H
A
W
S
Y
Site 60
T747
C
K
P
F
R
G
A
T
K
G
C
L
R
A
L
Site 61
T760
A
L
A
M
K
F
K
T
T
H
A
P
P
G
D
Site 62
Y812
F
G
E
P
L
N
L
Y
A
R
P
G
K
S
N
Site 63
T826
N
G
D
V
R
A
L
T
Y
C
D
L
H
K
I
Site 64
T859
F
W
S
S
L
E
I
T
F
N
L
R
D
T
N
Site 65
T865
I
T
F
N
L
R
D
T
N
M
I
P
G
S
P
Site 66
S871
D
T
N
M
I
P
G
S
P
G
S
T
E
L
E
Site 67
S874
M
I
P
G
S
P
G
S
T
E
L
E
G
G
F
Site 68
T875
I
P
G
S
P
G
S
T
E
L
E
G
G
F
S
Site 69
S882
T
E
L
E
G
G
F
S
R
Q
R
K
R
K
L
Site 70
S890
R
Q
R
K
R
K
L
S
F
R
R
R
T
D
K
Site 71
T895
K
L
S
F
R
R
R
T
D
K
D
T
E
Q
P
Site 72
T899
R
R
R
T
D
K
D
T
E
Q
P
G
E
V
S
Site 73
S918
G
R
A
G
A
G
P
S
S
R
G
R
P
G
G
Site 74
S919
R
A
G
A
G
P
S
S
R
G
R
P
G
G
P
Site 75
S930
P
G
G
P
W
G
E
S
P
S
S
G
P
S
S
Site 76
S932
G
P
W
G
E
S
P
S
S
G
P
S
S
P
E
Site 77
S933
P
W
G
E
S
P
S
S
G
P
S
S
P
E
S
Site 78
S936
E
S
P
S
S
G
P
S
S
P
E
S
S
E
D
Site 79
S937
S
P
S
S
G
P
S
S
P
E
S
S
E
D
E
Site 80
S940
S
G
P
S
S
P
E
S
S
E
D
E
G
P
G
Site 81
S941
G
P
S
S
P
E
S
S
E
D
E
G
P
G
R
Site 82
S949
E
D
E
G
P
G
R
S
S
S
P
L
R
L
V
Site 83
S950
D
E
G
P
G
R
S
S
S
P
L
R
L
V
P
Site 84
S951
E
G
P
G
R
S
S
S
P
L
R
L
V
P
F
Site 85
S959
P
L
R
L
V
P
F
S
S
P
R
P
P
G
E
Site 86
S960
L
R
L
V
P
F
S
S
P
R
P
P
G
E
P
Site 87
S980
L
M
E
D
C
E
K
S
S
D
T
C
N
P
L
Site 88
S981
M
E
D
C
E
K
S
S
D
T
C
N
P
L
S
Site 89
T983
D
C
E
K
S
S
D
T
C
N
P
L
S
G
A
Site 90
S988
S
D
T
C
N
P
L
S
G
A
F
S
G
V
S
Site 91
S999
S
G
V
S
N
I
F
S
F
W
G
D
S
R
G
Site 92
Y1009
G
D
S
R
G
R
Q
Y
Q
E
L
P
R
C
P
Site 93
S1028
S
L
L
N
I
P
L
S
S
P
G
R
R
P
R
Site 94
S1029
L
L
N
I
P
L
S
S
P
G
R
R
P
R
G
Site 95
S1040
R
P
R
G
D
V
E
S
R
L
D
A
L
Q
R
Site 96
T1054
R
Q
L
N
R
L
E
T
R
L
S
A
D
M
A
Site 97
S1057
N
R
L
E
T
R
L
S
A
D
M
A
T
V
L
Site 98
T1072
Q
L
L
Q
R
Q
M
T
L
V
P
P
A
Y
S
Site 99
T1083
P
A
Y
S
A
V
T
T
P
G
P
G
P
T
S
Site 100
S1090
T
P
G
P
G
P
T
S
T
S
P
L
L
P
V
Site 101
T1091
P
G
P
G
P
T
S
T
S
P
L
L
P
V
S
Site 102
S1092
G
P
G
P
T
S
T
S
P
L
L
P
V
S
P
Site 103
T1133
E
L
P
Q
E
G
P
T
R
R
L
S
L
P
G
Site 104
S1137
E
G
P
T
R
R
L
S
L
P
G
Q
L
G
A
Site 105
T1146
P
G
Q
L
G
A
L
T
S
Q
P
L
H
R
H
Site 106
S1147
G
Q
L
G
A
L
T
S
Q
P
L
H
R
H
G
Site 107
S1155
Q
P
L
H
R
H
G
S
D
P
G
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation