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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASPH
Full Name:
Aspartyl/asparaginyl beta-hydroxylase
Alias:
Aspartate beta-hydroxylase
Type:
Enzyme, oxidoreductase
Mass (Da):
85863
Number AA:
758
UniProt ID:
Q12797
International Prot ID:
IPI00294834
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005789
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004597
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0003008
GO:0003012
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
Q
R
K
N
A
K
S
S
G
N
S
S
S
S
Site 2
S10
Q
R
K
N
A
K
S
S
G
N
S
S
S
S
G
Site 3
S13
N
A
K
S
S
G
N
S
S
S
S
G
S
G
S
Site 4
S14
A
K
S
S
G
N
S
S
S
S
G
S
G
S
G
Site 5
S15
K
S
S
G
N
S
S
S
S
G
S
G
S
G
S
Site 6
S16
S
S
G
N
S
S
S
S
G
S
G
S
G
S
T
Site 7
S18
G
N
S
S
S
S
G
S
G
S
G
S
T
S
A
Site 8
S20
S
S
S
S
G
S
G
S
G
S
T
S
A
G
S
Site 9
S22
S
S
G
S
G
S
G
S
T
S
A
G
S
S
S
Site 10
T23
S
G
S
G
S
G
S
T
S
A
G
S
S
S
P
Site 11
S24
G
S
G
S
G
S
T
S
A
G
S
S
S
P
G
Site 12
S27
S
G
S
T
S
A
G
S
S
S
P
G
A
R
R
Site 13
S28
G
S
T
S
A
G
S
S
S
P
G
A
R
R
E
Site 14
S29
S
T
S
A
G
S
S
S
P
G
A
R
R
E
T
Site 15
T36
S
P
G
A
R
R
E
T
K
H
G
G
H
K
N
Site 16
S50
N
G
R
K
G
G
L
S
G
T
S
F
F
T
W
Site 17
Y90
V
L
G
K
L
G
I
Y
D
A
D
G
D
G
D
Site 18
T114
L
G
L
K
E
R
S
T
S
E
P
A
V
P
P
Site 19
S115
G
L
K
E
R
S
T
S
E
P
A
V
P
P
E
Site 20
S153
E
A
K
E
Q
I
Q
S
L
L
H
E
M
V
H
Site 21
T176
L
Q
Q
E
D
G
P
T
G
E
P
Q
Q
E
D
Site 22
T198
D
V
D
D
R
F
E
T
L
E
P
E
V
S
H
Site 23
S204
E
T
L
E
P
E
V
S
H
E
E
T
E
H
S
Site 24
T208
P
E
V
S
H
E
E
T
E
H
S
Y
H
V
E
Site 25
S211
S
H
E
E
T
E
H
S
Y
H
V
E
E
T
V
Site 26
S231
Q
D
M
E
E
M
M
S
E
Q
E
N
P
D
S
Site 27
S238
S
E
Q
E
N
P
D
S
S
E
P
V
V
E
D
Site 28
S239
E
Q
E
N
P
D
S
S
E
P
V
V
E
D
E
Site 29
T252
D
E
R
L
H
H
D
T
D
D
V
T
Y
Q
V
Site 30
Y257
H
D
T
D
D
V
T
Y
Q
V
Y
E
E
Q
A
Site 31
Y266
V
Y
E
E
Q
A
V
Y
E
P
L
E
N
E
G
Site 32
S291
E
D
N
P
V
E
D
S
Q
V
I
V
E
E
V
Site 33
T313
Q
Q
E
V
P
P
E
T
N
R
K
T
D
D
P
Site 34
T317
P
P
E
T
N
R
K
T
D
D
P
E
Q
K
A
Site 35
T340
L
L
N
K
F
D
K
T
I
K
A
E
L
D
A
Site 36
Y371
F
K
E
L
V
R
K
Y
P
Q
S
P
R
A
R
Site 37
S374
L
V
R
K
Y
P
Q
S
P
R
A
R
Y
G
K
Site 38
Y379
P
Q
S
P
R
A
R
Y
G
K
A
Q
C
E
D
Site 39
S394
D
L
A
E
K
R
R
S
N
E
V
L
R
G
A
Site 40
Y405
L
R
G
A
I
E
T
Y
Q
E
V
A
S
L
P
Site 41
S410
E
T
Y
Q
E
V
A
S
L
P
D
V
P
A
D
Site 42
S422
P
A
D
L
L
K
L
S
L
K
R
R
S
D
R
Site 43
S427
K
L
S
L
K
R
R
S
D
R
Q
Q
F
L
G
Site 44
S455
Q
L
F
P
N
D
T
S
L
K
N
D
L
G
V
Site 45
Y464
K
N
D
L
G
V
G
Y
L
L
I
G
D
N
D
Site 46
Y477
N
D
N
A
K
K
V
Y
E
E
V
L
S
V
T
Site 47
S482
K
V
Y
E
E
V
L
S
V
T
P
N
D
G
F
Site 48
T484
Y
E
E
V
L
S
V
T
P
N
D
G
F
A
K
Site 49
Y510
K
I
A
E
S
I
P
Y
L
K
E
G
I
E
S
Site 50
S517
Y
L
K
E
G
I
E
S
G
D
P
G
T
D
D
Site 51
T522
I
E
S
G
D
P
G
T
D
D
G
R
F
Y
F
Site 52
Y528
G
T
D
D
G
R
F
Y
F
H
L
G
D
A
M
Site 53
Y544
R
V
G
N
K
E
A
Y
K
W
Y
E
L
G
H
Site 54
Y565
S
V
W
Q
R
S
L
Y
N
V
N
G
L
K
A
Site 55
T577
L
K
A
Q
P
W
W
T
P
K
E
T
G
Y
T
Site 56
T584
T
P
K
E
T
G
Y
T
E
L
V
K
S
L
E
Site 57
S589
G
Y
T
E
L
V
K
S
L
E
R
N
W
K
L
Site 58
T647
A
C
K
G
A
P
K
T
C
T
L
L
E
K
F
Site 59
T649
K
G
A
P
K
T
C
T
L
L
E
K
F
P
E
Site 60
Y667
C
R
R
G
Q
I
K
Y
S
I
M
H
P
G
T
Site 61
T708
K
I
R
C
A
N
E
T
K
T
W
E
E
G
K
Site 62
T710
R
C
A
N
E
T
K
T
W
E
E
G
K
V
L
Site 63
T748
D
V
W
H
P
E
L
T
P
Q
Q
R
R
S
L
Site 64
S754
L
T
P
Q
Q
R
R
S
L
P
A
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation