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Updated November 2019
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Protein Info
Short Name:
GTF3C1
Full Name:
General transcription factor 3C polypeptide 1
Alias:
General transcription factor IIIC, polypeptide 1, alpha 220kDa; T3C1; TF3C1; TF3C-alpha; TFIIIC 220 kDa; TFIIIC box B-binding subunit; TFIIIC220; Transcription factor IIIC-alpha
Type:
Transcription protein, initiation complex
Mass (Da):
238875
Number AA:
2109
UniProt ID:
Q12789
International Prot ID:
IPI00783560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000127
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042791
GO:0042797
GO:0009304
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
A
L
W
S
R
L
E
T
R
V
P
P
F
P
L
Site 2
T43
P
L
P
L
E
P
C
T
Q
E
F
L
W
R
A
Site 3
S58
L
A
T
H
P
G
I
S
F
Y
E
E
P
R
E
Site 4
Y60
T
H
P
G
I
S
F
Y
E
E
P
R
E
R
P
Site 5
Y75
D
L
Q
L
Q
D
R
Y
E
E
I
D
L
E
T
Site 6
S87
L
E
T
G
I
L
E
S
R
R
D
P
V
A
L
Site 7
S113
N
K
D
G
I
Q
G
S
C
R
Y
F
K
E
R
Site 8
Y116
G
I
Q
G
S
C
R
Y
F
K
E
R
K
N
I
Site 9
T129
N
I
T
N
D
I
R
T
K
S
L
Q
P
R
C
Site 10
S131
T
N
D
I
R
T
K
S
L
Q
P
R
C
T
M
Site 11
T137
K
S
L
Q
P
R
C
T
M
V
E
A
F
D
R
Site 12
T200
L
Q
R
D
L
H
T
T
A
F
K
V
D
A
G
Site 13
Y211
V
D
A
G
K
L
H
Y
H
R
K
I
L
N
K
Site 14
T233
S
H
V
I
R
L
P
T
G
A
Q
Q
H
S
I
Site 15
S253
R
F
H
V
D
R
R
S
K
Y
D
I
L
M
E
Site 16
Y255
H
V
D
R
R
S
K
Y
D
I
L
M
E
K
L
Site 17
S267
E
K
L
S
V
M
L
S
T
R
T
N
H
I
E
Site 18
T275
T
R
T
N
H
I
E
T
L
G
K
L
R
E
E
Site 19
T289
E
L
G
L
C
E
R
T
F
K
R
L
Y
Q
Y
Site 20
Y294
E
R
T
F
K
R
L
Y
Q
Y
M
L
N
A
G
Site 21
Y296
T
F
K
R
L
Y
Q
Y
M
L
N
A
G
L
A
Site 22
S354
D
E
D
E
E
V
I
S
K
T
V
P
P
V
D
Site 23
T370
V
F
E
R
D
M
L
T
Q
T
Y
D
L
I
E
Site 24
T381
D
L
I
E
R
R
G
T
K
G
I
S
Q
A
E
Site 25
S385
R
R
G
T
K
G
I
S
Q
A
E
I
R
V
A
Site 26
T425
E
D
E
G
R
Q
R
T
T
K
Y
I
S
C
V
Site 27
T426
D
E
G
R
Q
R
T
T
K
Y
I
S
C
V
F
Site 28
Y428
G
R
Q
R
T
T
K
Y
I
S
C
V
F
A
E
Site 29
S437
S
C
V
F
A
E
E
S
D
L
S
R
Q
Y
Q
Site 30
S440
F
A
E
E
S
D
L
S
R
Q
Y
Q
R
E
K
Site 31
Y443
E
S
D
L
S
R
Q
Y
Q
R
E
K
A
R
S
Site 32
S450
Y
Q
R
E
K
A
R
S
E
L
L
T
T
V
S
Site 33
S457
S
E
L
L
T
T
V
S
L
A
S
M
Q
E
E
Site 34
S465
L
A
S
M
Q
E
E
S
L
L
P
E
G
E
D
Site 35
T473
L
L
P
E
G
E
D
T
F
L
S
E
S
D
S
Site 36
S476
E
G
E
D
T
F
L
S
E
S
D
S
E
E
E
Site 37
S478
E
D
T
F
L
S
E
S
D
S
E
E
E
R
S
Site 38
S480
T
F
L
S
E
S
D
S
E
E
E
R
S
S
S
Site 39
S485
S
D
S
E
E
E
R
S
S
S
K
R
R
G
R
Site 40
S486
D
S
E
E
E
R
S
S
S
K
R
R
G
R
G
Site 41
S487
S
E
E
E
R
S
S
S
K
R
R
G
R
G
S
Site 42
S494
S
K
R
R
G
R
G
S
Q
K
D
T
R
A
S
Site 43
T498
G
R
G
S
Q
K
D
T
R
A
S
A
N
L
R
Site 44
S501
S
Q
K
D
T
R
A
S
A
N
L
R
P
K
T
Site 45
T508
S
A
N
L
R
P
K
T
Q
P
H
H
S
T
P
Site 46
S513
P
K
T
Q
P
H
H
S
T
P
T
K
G
G
W
Site 47
T514
K
T
Q
P
H
H
S
T
P
T
K
G
G
W
K
Site 48
S534
P
L
K
K
Q
P
P
S
F
P
G
A
A
E
E
Site 49
S546
A
E
E
R
A
C
Q
S
L
A
S
R
D
S
L
Site 50
S549
R
A
C
Q
S
L
A
S
R
D
S
L
L
D
T
Site 51
S552
Q
S
L
A
S
R
D
S
L
L
D
T
S
S
V
Site 52
T556
S
R
D
S
L
L
D
T
S
S
V
S
E
P
N
Site 53
S557
R
D
S
L
L
D
T
S
S
V
S
E
P
N
V
Site 54
S558
D
S
L
L
D
T
S
S
V
S
E
P
N
V
S
Site 55
S565
S
V
S
E
P
N
V
S
F
V
S
H
C
A
D
Site 56
S575
S
H
C
A
D
S
N
S
G
D
I
A
V
I
E
Site 57
S592
R
M
E
N
P
K
E
S
S
S
S
L
K
T
G
Site 58
S595
N
P
K
E
S
S
S
S
L
K
T
G
R
H
S
Site 59
T598
E
S
S
S
S
L
K
T
G
R
H
S
S
G
Q
Site 60
S602
S
L
K
T
G
R
H
S
S
G
Q
D
K
P
H
Site 61
S603
L
K
T
G
R
H
S
S
G
Q
D
K
P
H
E
Site 62
T652
E
K
Q
E
G
V
S
T
K
C
C
K
K
S
I
Site 63
S658
S
T
K
C
C
K
K
S
I
V
R
L
V
R
N
Site 64
S667
V
R
L
V
R
N
L
S
E
E
G
L
L
R
L
Site 65
Y675
E
E
G
L
L
R
L
Y
R
T
T
V
I
Q
D
Site 66
S695
V
D
L
V
V
H
P
S
M
D
Q
N
D
P
L
Site 67
S715
E
Q
V
R
F
R
I
S
N
S
S
T
A
N
R
Site 68
S717
V
R
F
R
I
S
N
S
S
T
A
N
R
V
K
Site 69
S718
R
F
R
I
S
N
S
S
T
A
N
R
V
K
T
Site 70
T719
F
R
I
S
N
S
S
T
A
N
R
V
K
T
S
Site 71
T725
S
T
A
N
R
V
K
T
S
Q
P
P
V
P
Q
Site 72
S726
T
A
N
R
V
K
T
S
Q
P
P
V
P
Q
G
Site 73
S739
Q
G
E
A
E
E
D
S
Q
G
K
E
G
P
S
Site 74
S746
S
Q
G
K
E
G
P
S
G
S
G
D
S
Q
L
Site 75
S748
G
K
E
G
P
S
G
S
G
D
S
Q
L
S
A
Site 76
S751
G
P
S
G
S
G
D
S
Q
L
S
A
S
S
R
Site 77
S754
G
S
G
D
S
Q
L
S
A
S
S
R
S
E
S
Site 78
S756
G
D
S
Q
L
S
A
S
S
R
S
E
S
G
R
Site 79
S757
D
S
Q
L
S
A
S
S
R
S
E
S
G
R
M
Site 80
S759
Q
L
S
A
S
S
R
S
E
S
G
R
M
K
K
Site 81
S761
S
A
S
S
R
S
E
S
G
R
M
K
K
S
D
Site 82
S767
E
S
G
R
M
K
K
S
D
N
K
M
G
I
T
Site 83
T774
S
D
N
K
M
G
I
T
P
L
R
N
Y
H
P
Site 84
S817
L
I
Y
G
H
P
A
S
N
T
V
E
K
P
S
Site 85
T819
Y
G
H
P
A
S
N
T
V
E
K
P
S
F
I
Site 86
S824
S
N
T
V
E
K
P
S
F
I
S
E
R
R
T
Site 87
S827
V
E
K
P
S
F
I
S
E
R
R
T
I
K
Q
Site 88
T831
S
F
I
S
E
R
R
T
I
K
Q
E
S
G
R
Site 89
S836
R
R
T
I
K
Q
E
S
G
R
A
G
V
R
P
Site 90
S844
G
R
A
G
V
R
P
S
S
S
G
S
A
W
E
Site 91
S845
R
A
G
V
R
P
S
S
S
G
S
A
W
E
A
Site 92
S846
A
G
V
R
P
S
S
S
G
S
A
W
E
A
C
Site 93
S848
V
R
P
S
S
S
G
S
A
W
E
A
C
S
E
Site 94
S854
G
S
A
W
E
A
C
S
E
A
P
S
K
G
S
Site 95
S858
E
A
C
S
E
A
P
S
K
G
S
Q
D
G
V
Site 96
S861
S
E
A
P
S
K
G
S
Q
D
G
V
T
W
E
Site 97
T866
K
G
S
Q
D
G
V
T
W
E
A
E
V
E
L
Site 98
T877
E
V
E
L
A
T
E
T
V
Y
V
D
D
A
S
Site 99
Y879
E
L
A
T
E
T
V
Y
V
D
D
A
S
W
M
Site 100
Y888
D
D
A
S
W
M
R
Y
I
P
P
I
P
V
H
Site 101
T942
N
D
P
L
K
K
H
T
L
I
R
F
L
P
R
Site 102
Y957
P
I
R
Q
Q
L
L
Y
K
R
R
Y
I
F
S
Site 103
Y961
Q
L
L
Y
K
R
R
Y
I
F
S
V
V
E
N
Site 104
S964
Y
K
R
R
Y
I
F
S
V
V
E
N
L
Q
R
Site 105
Y1012
T
T
I
C
D
P
H
Y
N
L
A
R
S
S
R
Site 106
S1017
P
H
Y
N
L
A
R
S
S
R
P
F
E
R
R
Site 107
S1018
H
Y
N
L
A
R
S
S
R
P
F
E
R
R
L
Site 108
Y1026
R
P
F
E
R
R
L
Y
V
L
N
S
M
Q
D
Site 109
S1030
R
R
L
Y
V
L
N
S
M
Q
D
V
E
N
Y
Site 110
T1048
L
Q
C
V
C
L
N
T
P
L
G
V
V
R
C
Site 111
S1062
C
P
R
V
R
K
N
S
S
T
D
Q
G
S
D
Site 112
S1063
P
R
V
R
K
N
S
S
T
D
Q
G
S
D
E
Site 113
T1064
R
V
R
K
N
S
S
T
D
Q
G
S
D
E
E
Site 114
S1068
N
S
S
T
D
Q
G
S
D
E
E
G
S
L
Q
Site 115
S1073
Q
G
S
D
E
E
G
S
L
Q
K
E
Q
E
S
Site 116
Y1096
R
K
C
A
M
L
E
Y
T
T
G
S
R
E
V
Site 117
S1122
G
A
A
G
L
D
S
S
F
Y
G
H
L
K
R
Site 118
Y1124
A
G
L
D
S
S
F
Y
G
H
L
K
R
N
W
Site 119
T1146
N
Q
A
K
K
E
N
T
A
A
E
N
G
L
T
Site 120
T1158
G
L
T
V
R
L
Q
T
F
L
S
K
R
P
M
Site 121
S1161
V
R
L
Q
T
F
L
S
K
R
P
M
P
L
S
Site 122
S1168
S
K
R
P
M
P
L
S
A
R
G
N
S
R
L
Site 123
S1173
P
L
S
A
R
G
N
S
R
L
N
I
W
G
E
Site 124
S1185
W
G
E
A
R
V
G
S
E
L
C
A
G
W
E
Site 125
S1202
F
E
V
D
R
E
P
S
L
D
R
N
R
R
V
Site 126
S1214
R
R
V
R
G
G
K
S
Q
K
R
K
R
L
K
Site 127
S1241
G
E
F
P
G
E
K
S
K
R
L
R
Y
H
D
Site 128
Y1246
E
K
S
K
R
L
R
Y
H
D
E
A
D
Q
S
Site 129
S1253
Y
H
D
E
A
D
Q
S
A
L
Q
R
M
T
R
Site 130
T1259
Q
S
A
L
Q
R
M
T
R
L
R
V
T
W
S
Site 131
T1264
R
M
T
R
L
R
V
T
W
S
M
Q
E
D
G
Site 132
S1266
T
R
L
R
V
T
W
S
M
Q
E
D
G
L
L
Site 133
T1304
V
R
D
I
L
H
A
T
F
E
E
S
L
D
K
Site 134
S1308
L
H
A
T
F
E
E
S
L
D
K
T
S
H
S
Site 135
T1312
F
E
E
S
L
D
K
T
S
H
S
V
G
R
R
Site 136
S1315
S
L
D
K
T
S
H
S
V
G
R
R
A
R
Y
Site 137
Y1322
S
V
G
R
R
A
R
Y
I
V
K
N
P
Q
A
Site 138
Y1333
N
P
Q
A
Y
L
N
Y
K
V
C
L
A
E
V
Site 139
Y1341
K
V
C
L
A
E
V
Y
Q
D
K
A
L
V
G
Site 140
Y1357
F
M
N
R
R
G
D
Y
D
D
P
K
V
C
A
Site 141
S1379
E
K
L
K
E
K
F
S
S
A
L
R
N
S
N
Site 142
S1380
K
L
K
E
K
F
S
S
A
L
R
N
S
N
L
Site 143
S1385
F
S
S
A
L
R
N
S
N
L
E
I
P
D
T
Site 144
T1392
S
N
L
E
I
P
D
T
L
Q
E
L
F
A
R
Site 145
T1412
I
G
D
E
K
D
Q
T
R
K
E
D
E
L
N
Site 146
S1420
R
K
E
D
E
L
N
S
V
D
D
I
H
F
L
Site 147
T1436
L
Q
N
L
I
Q
S
T
L
A
L
S
D
S
Q
Site 148
S1440
I
Q
S
T
L
A
L
S
D
S
Q
M
K
S
Y
Site 149
S1442
S
T
L
A
L
S
D
S
Q
M
K
S
Y
Q
S
Site 150
S1446
L
S
D
S
Q
M
K
S
Y
Q
S
F
Q
T
F
Site 151
Y1447
S
D
S
Q
M
K
S
Y
Q
S
F
Q
T
F
R
Site 152
S1449
S
Q
M
K
S
Y
Q
S
F
Q
T
F
R
L
Y
Site 153
T1452
K
S
Y
Q
S
F
Q
T
F
R
L
Y
R
E
Y
Site 154
Y1456
S
F
Q
T
F
R
L
Y
R
E
Y
K
D
H
V
Site 155
Y1459
T
F
R
L
Y
R
E
Y
K
D
H
V
L
V
K
Site 156
T1485
N
R
R
R
V
N
H
T
L
G
P
K
K
N
R
Site 157
Y1501
L
P
F
V
P
M
S
Y
Q
L
S
Q
T
Y
Y
Site 158
Y1507
S
Y
Q
L
S
Q
T
Y
Y
R
I
F
T
W
R
Site 159
Y1508
Y
Q
L
S
Q
T
Y
Y
R
I
F
T
W
R
F
Site 160
T1521
R
F
P
S
T
I
C
T
E
S
F
Q
F
L
D
Site 161
S1523
P
S
T
I
C
T
E
S
F
Q
F
L
D
R
M
Site 162
S1543
L
D
Q
P
D
R
F
S
F
K
D
Q
D
N
N
Site 163
S1560
T
N
D
M
V
A
F
S
L
D
G
P
G
G
N
Site 164
S1605
V
E
N
E
V
I
K
S
L
G
K
D
G
S
L
Site 165
S1611
K
S
L
G
K
D
G
S
L
E
D
D
E
D
E
Site 166
S1632
G
V
G
G
K
R
R
S
M
E
V
K
P
A
Q
Site 167
Y1645
A
Q
A
S
H
T
N
Y
L
L
M
R
G
Y
Y
Site 168
S1653
L
L
M
R
G
Y
Y
S
P
G
I
V
S
T
R
Site 169
S1658
Y
Y
S
P
G
I
V
S
T
R
N
L
N
P
N
Site 170
S1667
R
N
L
N
P
N
D
S
I
V
V
N
S
C
Q
Site 171
T1682
M
K
F
Q
L
R
C
T
P
V
P
A
R
L
R
Site 172
S1703
E
E
L
T
M
G
T
S
C
L
P
D
T
F
T
Site 173
T1708
G
T
S
C
L
P
D
T
F
T
K
L
I
N
P
Site 174
T1710
S
C
L
P
D
T
F
T
K
L
I
N
P
Q
E
Site 175
S1721
N
P
Q
E
N
T
C
S
L
E
E
F
V
L
Q
Site 176
Y1734
L
Q
L
E
L
S
G
Y
S
P
E
D
L
T
A
Site 177
S1735
Q
L
E
L
S
G
Y
S
P
E
D
L
T
A
A
Site 178
T1740
G
Y
S
P
E
D
L
T
A
A
L
E
I
L
E
Site 179
S1767
E
E
L
R
R
R
F
S
A
L
E
K
A
G
G
Site 180
T1779
A
G
G
G
R
T
R
T
F
A
D
C
I
Q
A
Site 181
S1816
A
W
P
W
L
L
H
S
V
R
L
K
D
R
E
Site 182
S1840
Q
A
R
P
L
E
G
S
S
S
E
D
S
P
P
Site 183
S1841
A
R
P
L
E
G
S
S
S
E
D
S
P
P
E
Site 184
S1842
R
P
L
E
G
S
S
S
E
D
S
P
P
E
G
Site 185
S1845
E
G
S
S
S
E
D
S
P
P
E
G
Q
A
P
Site 186
S1854
P
E
G
Q
A
P
P
S
H
S
P
R
G
T
K
Site 187
S1856
G
Q
A
P
P
S
H
S
P
R
G
T
K
R
R
Site 188
T1860
P
S
H
S
P
R
G
T
K
R
R
A
S
W
A
Site 189
S1865
R
G
T
K
R
R
A
S
W
A
S
E
N
G
E
Site 190
S1868
K
R
R
A
S
W
A
S
E
N
G
E
T
D
A
Site 191
T1873
W
A
S
E
N
G
E
T
D
A
E
G
T
Q
M
Site 192
T1878
G
E
T
D
A
E
G
T
Q
M
T
P
A
K
R
Site 193
T1881
D
A
E
G
T
Q
M
T
P
A
K
R
P
A
L
Site 194
S1891
K
R
P
A
L
Q
D
S
N
L
A
P
S
L
G
Site 195
S1896
Q
D
S
N
L
A
P
S
L
G
P
G
A
E
D
Site 196
S1911
G
A
E
A
Q
A
P
S
P
P
P
A
L
E
D
Site 197
T1919
P
P
P
A
L
E
D
T
A
A
A
G
A
A
Q
Site 198
S1937
E
G
V
G
E
F
S
S
P
G
Q
E
Q
L
S
Site 199
S1944
S
P
G
Q
E
Q
L
S
G
Q
A
Q
P
P
E
Site 200
S1953
Q
A
Q
P
P
E
G
S
E
D
P
R
G
F
T
Site 201
T1960
S
E
D
P
R
G
F
T
E
S
F
G
A
A
N
Site 202
S1962
D
P
R
G
F
T
E
S
F
G
A
A
N
I
S
Site 203
S1969
S
F
G
A
A
N
I
S
Q
A
A
R
E
R
D
Site 204
S1979
A
R
E
R
D
C
E
S
V
C
F
I
G
R
P
Site 205
T2012
A
M
L
Y
H
I
M
T
R
P
G
I
P
E
S
Site 206
S2019
T
R
P
G
I
P
E
S
S
L
L
R
H
Y
Q
Site 207
S2020
R
P
G
I
P
E
S
S
L
L
R
H
Y
Q
G
Site 208
Y2025
E
S
S
L
L
R
H
Y
Q
G
V
L
Q
P
V
Site 209
S2043
E
L
L
Q
G
L
E
S
L
G
C
I
R
K
R
Site 210
S2074
E
E
V
E
V
P
S
S
L
D
E
S
P
M
A
Site 211
S2078
V
P
S
S
L
D
E
S
P
M
A
F
Y
E
P
Site 212
T2090
Y
E
P
T
L
D
C
T
L
R
L
G
R
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation